专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5026987A Mass spectrometer with in-line collision surface means 失效
标题翻译：具有在线碰撞面的质谱仪表示
公开(公告)号：US5026987A
公开(公告)日：1991-06-25
申请号：US528900
申请日：1990-05-23
申请人： Mark E. Bier , Robert G. Cooks , George C. Stafford
发明人： Mark E. Bier , Robert G. Cooks , George C. Stafford
IPC分类号： H01J49/26 , H01J49/42
CPC分类号： H01J49/0068
摘要： A mass spectrometer including at least one mass analyzer into which an ion beam to be analyzed is projected having a collision surface means in-line with the ion beam to form surface collision products which are directed into the in-line mass analyzer.
摘要翻译：一种质谱仪，包括至少一个质量分析器，其中投射有待分析的离子束具有碰撞表面，其与离子束一致，以形成被引导到在线质量分析器中的表面碰撞产物。

2. 发明授权

US4791292A Capillary membrane interface for a mass spectrometer 失效
标题翻译：用于质谱仪的毛细管膜界面
公开(公告)号：US4791292A
公开(公告)日：1988-12-13
申请号：US855894
申请日：1986-04-24
申请人： Robert G. Cooks , Mark E. Bier , Jennifer S. Brodbelt , James C. Tou , Lemoyne B. Westover
发明人： Robert G. Cooks , Mark E. Bier , Jennifer S. Brodbelt , James C. Tou , Lemoyne B. Westover
IPC分类号： H01J49/04 , H01J41/04
CPC分类号： H01J49/0404 , H01J49/0436
摘要： A device for introducing a sample into a mass spectrometer which generally comprises a probe which is connected to the mass spectrometer and a semipermeable capillary tube connected at the end of the probe. The probe includes conduit passageways for permitting bidirectional fluid flow through the probe, and the capillary tube is connected to the end of the probe so as to permit the flow of a fluid containing the sample to be analyzed through the probe and the capillary tube. This fluid flow through the capillary tube will enable at least a portion of the sample to be transferred into the mass spectrometer via diffusion through the capillary tube.
摘要翻译：用于将样品引入质谱仪的装置，其通常包括连接到质谱仪的探针和连接在探针末端的半透性毛细管。探头包括用于允许双向流体流过探针的导管通道，并且毛细管连接到探针的端部，以允许含有待分析样品的流体通过探针和毛细管流动。流经毛细管的流体将使至少一部分样品通过毛细管的扩散而被转移到质谱仪中。

3. 再颁专利

USRE33007E Method of vaporizing multicomponent liquids 失效
标题翻译：蒸发多组分液体的方法
公开(公告)号：USRE33007E
公开(公告)日：1989-08-01
申请号：US153878
申请日：1988-02-09
申请人： Mark E. Bier
发明人： Mark E. Bier
IPC分类号： A61L2/20 , B01D3/10 , C01B15/01
CPC分类号： A61L2/20 , B01D3/10 , C01B15/01
摘要： A method of vaporizing a multicomponent liquid, such as a hydrogen peroxide and water solution, for injection into a vacuum chamber including the steps of metering successive predetermined increments of the liquid at a predetermined rate onto a heated surface in a vaporization chamber. Upon exposure to the heated surface, each liquid increment is substantially instantaneously vaporized before the next succeeding liquid increment is metered onto the heated surface to produce a multi-component vapor increment having substantially the same weight percent composition as the multicomponent liquid increment. Each vapor increment is passed into the vacuum chamber.

4. 发明授权

US5750993A Method of reducing noise in an ion trap mass spectrometer coupled to an atmospheric pressure ionization source 失效
标题翻译：耦合到大气压电离源的离子阱质谱仪中降低噪声的方法
公开(公告)号：US5750993A
公开(公告)日：1998-05-12
申请号：US647297
申请日：1996-05-09
申请人： Mark E. Bier
发明人： Mark E. Bier
IPC分类号： H01J49/04 , H01J49/42
CPC分类号： H01J49/06
摘要： A method of reducing noise due to undesolved charged droplets or charged particles in an ion trap mass spectrometer coupled to an atmospheric pressure ionization source.
摘要翻译：在与大气压电离源耦合的离子阱质谱仪中降低由于未加电荷的液滴或带电粒子引起的噪声的方法。

5. 发明授权

US08395112B1 Mass spectrometer and method for using same 有权
标题翻译：质谱仪及其使用方法
公开(公告)号：US08395112B1
公开(公告)日：2013-03-12
申请号：US12898264
申请日：2010-10-05
申请人： Mark E. Bier
发明人： Mark E. Bier
IPC分类号： H01J49/34 , B01D59/44
CPC分类号： H01J49/422 , C12Q1/6872 , G01N21/53 , G01N21/6428 , G01N2021/6439 , G01N2021/6465 , G01N2021/6467 , G01N2021/6482 , G01N2021/6493 , H01J49/4255
摘要： Apparatus including an ion trap, a controller connected to the ion trap, wherein the controller includes a memory containing computer readable instructions which, when executed, cause the controller to send control signals to the ion trap so that the ion trap produce and maintain a trapping field in the ion trap, a waveform generator to change the trapping field so that ions of a predetermined mass in the trapping chamber are selectively moved; a secondary waveform generator to change the orbits of the ions; an energy source to excite ions to emit photons, an optical detector to detect the emitted photons, and a processor which can apply fast-Fourier transform analysis of the time-domain signal of the detected emitted photons to generate a frequency or mass spectrum related to mass-to-charge ratio of the ions.
摘要翻译：包括离子阱的装置，连接到离子阱的控制器，其中所述控制器包括含有计算机可读指令的存储器，所述计算机可读指令在执行时使所述控制器向所述离子阱发送控制信号，使得所述离子阱产生并保持捕集波形发生器，用于改变俘获场，使得俘获室中的预定质量的离子被选择性地移动; 次级波形发生器，用于改变离子的轨道; 用于激发离子发射光子的能量源，用于检测发射的光子的光学检测器，以及可以对所检测到的发射光子的时域信号进行快速傅里叶变换分析的处理器，以产生与离子的质荷比。

6. 发明授权

US5756996A Ion source assembly for an ion trap mass spectrometer and method 失效
标题翻译：离子源组件用于离子阱质谱仪和方法
公开(公告)号：US5756996A
公开(公告)日：1998-05-26
申请号：US675966
申请日：1996-07-05
申请人： Mark E. Bier , John E. P. Syka , Dennis M. Taylor , William J. Fies
发明人： Mark E. Bier , John E. P. Syka , Dennis M. Taylor , William J. Fies
IPC分类号： H01J49/04 , H01J49/14 , H01J49/42
CPC分类号： H01J49/147 , H01J49/145
摘要： An external ion source assembly in which ion are formed in an ion volume by the interaction of energetic electrons and gas molecules. The effective energy of the electrons entering the ion volume is controlled by changing the voltage between the electron source (filament) and the ionization volume whereby ions having sufficient energy for ionizing atoms and molecules leave the electron source and enter the ionization volume only during an ionization period. The ion source assembly can be used both for electron impact ionization (EI) and for chemical ionization (CI).
摘要翻译：外部离子源组件，其中通过能量电子和气体分子的相互作用在离子体中形成离子。通过改变电子源（细丝）和离子化体积之间的电压来控制进入离子体积的电子的有效能量，由此离子具有足够的电离原子和分子的能量离开电子源并且仅在电离过程中进入离子化体积期。离子源组件可用于电子碰撞电离（EI）和化学电离（CI）。

7. 发明授权

US5420425A Ion trap mass spectrometer system and method 失效
标题翻译：离子阱质谱仪系统及方法
公开(公告)号：US5420425A
公开(公告)日：1995-05-30
申请号：US250156
申请日：1994-05-27
申请人： Mark E. Bier , John E. P. Syka
发明人： Mark E. Bier , John E. P. Syka
IPC分类号： G01N27/62 , H01J49/34 , H01J49/42
CPC分类号： H01J49/423 , H01J49/424
摘要： The present invention relates generally to an ion trap mass spectrometer for analyzing ions and more particularly to a substantially quadrupole ion trap mass spectrometer with an enlarged ion occupied volume. Described herein are electrode geometries that enlarge the ion occupied volume. Improved ion sensitivities, detection limits and dynamic range should be realized for the same charge density in these devices because the increased ion occupied volume allows for the storage of a greater number of ions. The essence of this invention is that these ion trap geometries may apply all modes of operation of substantially quadrupole ion traps such as the mass selective instability mode, resonance excitation/ejection, and MS.sup.n.
摘要翻译：本发明一般涉及一种用于分析离子的离子阱质谱仪，更具体地涉及具有增大的离子占据体积的基本四极离子阱质谱仪。这里描述了放大离子占据体积的电极几何形状。对于这些器件中相同的电荷密度，应该实现改进的离子灵敏度，检测限和动态范围，因为增加的离子占据体积允许存储更多数量的离子。本发明的实质是这些离子阱几何可以应用基本上四极离子阱的所有操作模式，例如质量选择不稳定模式，共振激发/喷射和MSn。

8. 发明授权

US5162650A Method and apparatus for multi-stage particle separation with gas addition for a mass spectrometer 失效
标题翻译：使用气相色谱仪进行多级粒子分离的方法和装置
公开(公告)号：US5162650A
公开(公告)日：1992-11-10
申请号：US645649
申请日：1991-01-25
申请人： Mark E. Bier
发明人： Mark E. Bier
IPC分类号： G01N30/72 , H01J49/04 , H01J49/42
CPC分类号： H01J49/067 , G01N30/7273 , G01N30/7293 , H01J49/044 , H01J49/045 , G01N30/724
摘要： Disclosed is a multi-stage particle separator for separating analyte from non-analyte solvent in a fluid sample having nebulizing means to form droplets from the liquid sample and means coupled to the nebulizing means for adding helium to the nebulizing means. Furthermore, the multi-stage particle separator has a desolvation chamber for receiving the droplets, the desolvation chamber terminating in a nozzle, a multi-stage momentum separator including skimmers, and means for introducing a gas into one or more of the states to increase pressure of the latter stage so that the particles leave the multi-stage separator substantially free of solvent.
摘要翻译：公开了一种多级颗粒分离器，用于在具有雾化装置的流体样品中从非分析物溶剂中分离分析物，以从液体样品形成液滴，并且耦合到雾化装置的装置，用于将氦添加到雾化装置。此外，多级粒子分离器具有用于接收液滴的去溶剂化室，终止在喷嘴中的去溶剂化室，包含脱水器的多级动量分离器，以及用于将气体引入一种或多种状态以增加压力的装置使得颗粒离开多级分离器基本上不含溶剂。

9. 发明授权

US4642165A Method of vaporizing multicomponent liquids 失效
标题翻译：蒸发多组分液体的方法
公开(公告)号：US4642165A
公开(公告)日：1987-02-10
申请号：US684461
申请日：1984-12-21
申请人： Mark E. Bier
发明人： Mark E. Bier
IPC分类号： B01D1/00 , B01D3/42
CPC分类号： B01D1/0082
摘要： A method of vaporizing a multicomponent liquid, such as a hydrogen peroxide and water solution, for injection into a vacuum chamber including the steps of metering successive predetermined increments of the liquid at a predetermined rate onto a heated surface in a vaporization chamber. Upon exposure to the heated surface, each liquid increment is substantially instantaneously vaporized before the next succeeding liquid increment is metered onto the heated surface to produce a multicomponent vapor increment having substantially the same weight percent composition as the multicomponent liquid increment. Each vapor increment is passed into the vacuum chamber.
摘要翻译：蒸发诸如过氧化氢和水溶液的多组分液体的方法用于注入真空室，包括以预定速率将液体的连续预定增量计量到蒸发室中的加热表面上的步骤。在暴露于被加热的表面之后，在接下来的后续液体增量计量到加热的表面上之前，每个液体增量基本上瞬间蒸发，以产生具有与多组分液体增量基本相同的重量百分比组成的多组分蒸气增量。每个蒸汽增量都被送入真空室。

10. 发明授权

US08809773B2 Membrane interface apparatus and method for mass spectrometry 有权
标题翻译：膜接口装置及质谱法
公开(公告)号：US08809773B2
公开(公告)日：2014-08-19
申请号：US11886890
申请日：2006-03-22
申请人： Mark E. Bier
发明人： Mark E. Bier
IPC分类号： H01J49/00 , B01D59/44 , G01N1/00 , G01N1/28
CPC分类号： B01D59/44 , G01N1/00 , G01N1/22 , G01N1/28 , G01N35/1095
摘要： The disclosed method and apparatus couple a membrane interface directly to a mass spectrometer at atmospheric pressure. The membrane may be in capillary or sheet form and allows the introduction of a liquid or gaseous sample to one side of the membrane while the other side of the membrane is bathed with a solution that can easily be used in an atmospheric pressure ionization source. Volatile molecules permeate through a suitable membrane such as poly-dimethyl silicone (PDMS), mix into the appropriate solvent, and are ionized. Because of the rules governing abstracts, this abstract should not be used in construing the claims.
摘要翻译：所公开的方法和装置在大气压力下将膜界面直接耦合到质谱仪。膜可以是毛细管或片状，并且允许将液体或气体样品引入膜的一侧，同时膜的另一侧用可容易地用于大气压电离源的溶液洗涤。挥发性分子渗透通过合适的膜，例如聚二甲基硅氧烷（PDMS），混合到合适的溶剂中并被电离。由于管理摘要的规则，本摘要不应用于解释索赔。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式