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1. 发明授权

US5026987A Mass spectrometer with in-line collision surface means 失效
标题翻译：具有在线碰撞面的质谱仪表示
公开(公告)号：US5026987A
公开(公告)日：1991-06-25
申请号：US528900
申请日：1990-05-23
申请人： Mark E. Bier , Robert G. Cooks , George C. Stafford
发明人： Mark E. Bier , Robert G. Cooks , George C. Stafford
IPC分类号： H01J49/26 , H01J49/42
CPC分类号： H01J49/0068
摘要： A mass spectrometer including at least one mass analyzer into which an ion beam to be analyzed is projected having a collision surface means in-line with the ion beam to form surface collision products which are directed into the in-line mass analyzer.
摘要翻译：一种质谱仪，包括至少一个质量分析器，其中投射有待分析的离子束具有碰撞表面，其与离子束一致，以形成被引导到在线质量分析器中的表面碰撞产物。

2. 再颁专利

USRE34000E Method of operating ion trap detector in MS/MS mode 失效
公开(公告)号：USRE34000E
公开(公告)日：1992-07-21
申请号：US499947
申请日：1990-03-27
申请人： John E. P. Syka , John N. Louris , Paul E. Kelley , George C. Stafford , Walter E. Reynolds
发明人： John E. P. Syka , John N. Louris , Paul E. Kelley , George C. Stafford , Walter E. Reynolds
IPC分类号： G01N27/62 , G21K1/087 , H01J49/42
CPC分类号： H01J49/424 , H01J49/0063 , H01J49/0081 , H01J49/429
摘要： A simple and economical method of mass analyzing a sample by means of a quadrupole ion trap mass spectrometer in an MS/MS mode comprises the steps of forming ions within a trap structure, changing the RF and DC voltages in such a way that the ions with mass-to-charge ratios within a desired range will be and remain trapped within the trap structure, dissociating such ions into fragments by collisions and increasing the field intensity again so that the generated fragments will become unstable and exit the trap volume sequentially to be detected. A supplementary AC field may be applied additionally to provide various scan modes as well as dissociate the ions.

3. 发明授权

US4736101A Method of operating ion trap detector in MS/MS mode 失效
标题翻译：在MS / MS模式下操作离子阱检测器的方法
公开(公告)号：US4736101A
公开(公告)日：1988-04-05
申请号：US84518
申请日：1987-08-11
申请人： John E. P. Syka , John N. Louris , Paul E. Kelley , George C. Stafford , Walter E. Reynolds
发明人： John E. P. Syka , John N. Louris , Paul E. Kelley , George C. Stafford , Walter E. Reynolds
IPC分类号： G01N27/62 , G21K1/087 , H01J49/42
CPC分类号： H01J49/424 , H01J49/0063 , H01J49/0081 , H01J49/429
摘要： A simple and economical method of mass analyzing a sample by means of a quadrupole ion trap mass spectrometer in an MS/MS mode comprises the steps of forming ions within a trap structure, changing the RF and DC voltages in such a way that the ions with mass-to-charge ratios within a desired range will be and remain trapped within the trap structure, dissociating such ions into fragments by collisions and increasing the field intensity again so that the generated fragments will become unstable and exit the trap volume sequentially to be detected. A supplementary AC field may be applied additionally to provide various scan modes as well as dissociate the ions.
摘要翻译：以MS / MS模式通过四极离子阱质谱仪对样品进行质量分析的简单而经济的方法包括以下步骤：在捕获结构内形成离子，改变RF和DC电压，使得离子与在所需范围内的质荷比将被捕获在陷阱结构内，并且通过碰撞将这些离子解离成碎片，并再次增加场强，使得所产生的片段将变得不稳定并顺序地离开陷阱体积以被检测。附加的AC场可以另外施加以提供各种扫描模式以及离子离解。

4. 发明申请

US20080245963A1 Method and Apparatus for Generation of Reagent Ions in a Mass Spectrometer 审中-公开
标题翻译：用于在质谱仪中产生试剂离子的方法和装置
公开(公告)号：US20080245963A1
公开(公告)日：2008-10-09
申请号：US11962009
申请日：2007-12-20
申请人： Adrian Land , Lee Earley , George C. Stafford
发明人： Adrian Land , Lee Earley , George C. Stafford
IPC分类号： H01J49/14
CPC分类号： H01J49/0072
摘要： A front-end ion source for a mass spectrometer generates both analyte and reagent ions. The reagent source may include a heater for vaporizing a condensed-phase reagent substance and an electron source for ionizing reagent molecules. The interior of the reagent ionization chamber is purged with a purge gas to avoid or minimize reaction of the reagent ions with oxygen or other reactive species, thereby enabling operation of the reagent ionization chamber at or near atmospheric pressure. The reagent and analyte ions are directed into a reduced-pressure chamber through separate passageways. An ion transport optic selectively transmits one of the analyte ions or the reagent ions from the reduced-pressure chamber to downstream regions of the mass spectrometer.
摘要翻译：用于质谱仪的前端离子源产生分析物和试剂离子。试剂源可以包括用于蒸发冷凝相试剂物质的加热器和用于电离试剂分子的电子源。试剂电离室的内部用净化气体吹扫，以避免或最小化试剂离子与氧或其它反应物质的反应，从而使试剂电离室在大气压力或接近大气压力下操作。试剂和分析物离子通过单独的通道导入减压室。离子传输光学选择性地将分析物离子或试剂离子中的一种从减压室传输到质谱仪的下游区域。

5. 发明授权

US4540884A Method of mass analyzing a sample by use of a quadrupole ion trap 失效
标题翻译：通过使用四极离子阱对样品进行质量分析的方法
公开(公告)号：US4540884A
公开(公告)日：1985-09-10
申请号：US454351
申请日：1982-12-29
申请人： George C. Stafford , Paul E. Kelley , David R. Stephens
发明人： George C. Stafford , Paul E. Kelley , David R. Stephens
IPC分类号： H01J49/38 , G01N27/62 , H01J49/42 , B01D59/44
CPC分类号： H01J49/424 , H01J49/429
摘要： In a quadrupole ion store or ion trap type mass spectometer, significantly improved mass selection is achieved by simultaneously trapping ions within the mass range of interest and then scanning the applied RF and DC voltages or the frequency .omega. to sequentially render unstable trapped ions of consecutive specific masses. These are passed out through apertures in an end cap to a high gain electron multiplier to provide a signal indicative of the ion mass. Sensitivity and mass resolution is also enhanced by operating the ion trap at a relatively high pressure in the range 1.times.10.sup.-1 to 1.times.10.sup.-5 torr. The presence of collision gas molecules, such as helium, improves sensitivity and mass resolution. In addition, the structure itself is built of stacked units, sealed by O-rings, which are easily disassembled for cleaning.
摘要翻译：在四极离子存储或离子阱型质谱仪中，通过在感兴趣的质量范围内同时捕获离子然后扫描所施加的RF和DC电压或频率ω，来实现显着改进的质量选择，以顺序地呈现连续特定的不稳定捕获的离子群众它们通过端盖中的孔传递到高增益电子倍增器，以提供指示离子质量的信号。通过在1x10-1至1×10-5乇范围内的较高压力下操作离子阱也可以提高灵敏度和质量分辨率。碰撞气体分子（如氦气）的存在提高了灵敏度和质量分辨率。此外，结构本身由堆叠单元构成，由O型圈密封，易于拆卸清洁。

6. 发明授权

US4447728A Ionizer including discharge ion source and method 失效
标题翻译：离子发生器包括放电离子源和方法
公开(公告)号：US4447728A
公开(公告)日：1984-05-08
申请号：US346288
申请日：1982-02-05
申请人： George C. Stafford , Donald C. Bradford
发明人： George C. Stafford , Donald C. Bradford
IPC分类号： H01J27/02 , H01J49/14
CPC分类号： H01J27/02 , H01J49/14
摘要： An ionizer for ionizing a sample by bombardment with energetic particles. The ionizer incudes an ion chamber and an adjacent gas discharge region formed with an electrode cooperating wih the ion chamber. Said region serving to discharge a gas to form neutral and charged gas particles. The cooperation of the electrode and chamber accelerates the charged particles and causes charged and uncharged particles to flow into the ion chamber to strike and ionize a sample in the ion chamber.
摘要翻译：用于通过用高能粒子轰击使样品电离的离子发生器。电离器包括离子室和形成有与离子室配合的电极的相邻气体放电区域。所述区域用于排放气体以形成中性和带电气体颗粒。电极和腔室的配合加速了带电粒子，并使带电和不带电的粒子流入离子室，从而使离子室中的样品离子化并离子化。

7. 再颁专利

USRE33344E Apparatus and method for detecting negative ions 失效
标题翻译：负离子检测装置及方法
公开(公告)号：USRE33344E
公开(公告)日：1990-09-18
申请号：US813880
申请日：1985-12-24
申请人： George C. Stafford
发明人： George C. Stafford
IPC分类号： G01T1/28 , H01J27/02 , H01J43/02 , H01J43/00 , H01J49/02
CPC分类号： H01J43/02 , G01T1/28 , H01J27/028
摘要： .[.A negative ion detector converts negative ions to positive ions by means of a conversion anode which is maintained at a relatively high positive voltage. The resultant positive ions are detected by a standard continuous dynode electron multiplier which has its detection signal output at ground potential..]. .Iadd.Apparatus for detecting the abundance of negative ions from a source of negative ions, having a first conversion dynode and an electron multiplier, the electron multiplier having a second conversion dynode. The first conversion dynode is operated at a high positive potential to attract the negative ions whereby the negative ions impact the first conversion dynode with a substantial portion of the negative ions being converted to secondary positive ions. The second conversion dynode is operated at a potential which is less positive than the positive potential on the first conversion dynode to attract the secondary positive ions and to cause the secondary positive ions to be converted to electrons which are multiplied in the electron multiplier to provide an output signal indicative of the abundance of negative ions emanating from the source. .Iaddend.

8. 发明授权

US4423324A Apparatus for detecting negative ions 失效
标题翻译：用于检测负离子的装置
公开(公告)号：US4423324A
公开(公告)日：1983-12-27
申请号：US59961
申请日：1979-07-23
申请人： George C. Stafford
发明人： George C. Stafford
IPC分类号： G01T1/28 , G21K1/14 , H01J43/02 , H01J49/02 , H01J49/42 , B01D59/44 , H01J27/00
CPC分类号： H01J49/025 , G01T1/28 , G21K1/14 , H01J43/02 , H01J49/0095
摘要： A negative ion detector converts negative ions to positive ions by means of a conversion anode which is maintained at a relatively high positive voltage. The resultant positive ions are detected by a standard continuous dynode electron multiplier which has its detection signal output at ground potential.
摘要翻译：负离子检测器通过转换阳极将负离子转换成正离子，转换阳极保持在相对较高的正电压。所得到的正离子由标准的连续倍增电子倍增器检测，其具有其接地电位的检测信号输出。

9. 发明授权

US4388531A Ionizer having interchangeable ionization chamber 失效
标题翻译：电离器具有可互换电离室
公开(公告)号：US4388531A
公开(公告)日：1983-06-14
申请号：US241083
申请日：1981-03-06
申请人： George C. Stafford , David R. Stephens
发明人： George C. Stafford , David R. Stephens
IPC分类号： H01J49/10 , G01N27/62 , H01J49/14 , H01J27/00
CPC分类号： H01J49/147
摘要： An ionizer adapted to be placed in a vacuum envelope for providing ions of a sample to be analyzed is disclosed herein and includes an electron source, ion accelerating and focusing electrodes and an interchangeable ionization chamber including a first opening for allowing electrons to enter the chamber and an exit opening to allow ions to exit said chamber. The ionization chamber is supported in cooperative relationship with the electron source and accelerating and focusing electrodes whereby electrons enter the chamber through the first opening and form sample ions in the chamber which then exit the chamber through the exit opening toward said accelerating and focusing electrodes.
摘要翻译：本文公开了一种适于放置在用于提供要分析的样品的离子的真空外壳中的电离器，其包括电子源，离子加速和聚焦电极以及可互换电离室，其包括用于允许电子进入腔室的第一开口，出口开口，允许离子离开所述室。电离室与电子源和加速聚焦电极配合关系，电子通过第一开口进入腔室，并在腔室中形成样品离子，然后通过出口朝向所述加速和聚焦电极离开腔室。

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