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1. 发明授权

US07176243B2 CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis 失效
标题翻译： CaR受体作为迁移性细胞趋化性和/或趋化因子的介质
公开(公告)号：US07176243B2
公开(公告)日：2007-02-13
申请号：US10002854
申请日：2001-11-01
申请人： Mark C. Poznansky , David T. Scadden , Ivona T. Olszak , Edward M. Brown
发明人： Mark C. Poznansky , David T. Scadden , Ivona T. Olszak , Edward M. Brown
IPC分类号： A01N33/02
CPC分类号： A61L27/3821 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/59 , A61K38/195 , A61K38/2006 , A61K45/06 , A61L27/3804 , A61L27/3847 , A61K2300/00
摘要： This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating hematopoeitic progenitor cells and related products. In particular the invention includes methods and products for using CaR receptor-related compositions to enhance mobilization of hematopoietic progenitor cells, to improve the efficiency of targeting cells to the bone marrow, and/or to modulate hematopoietic progenitor cell function.
摘要翻译：本发明涉及用迁移能力调节真核细胞运动的方法和组合物。更具体地，本发明涉及用于调节受试者的特定部位中造血，神经，上皮，内皮或间质来源的CaR受体表达细胞的运动的方法和组合物。前述内容尤其可用于治疗特征在于需要调节与受试者中特定部位相关的迁移细胞运动的病症。特定部位包括炎症部位和迁移细胞运动的调节是远离药剂来源或排斥的运动。本发明还涉及操纵造血祖细胞和相关产品的方法。特别地，本发明包括使用CaR受体相关组合物来增强造血祖细胞的动员，提高靶向细胞到骨髓的效率和/或调节造血祖细胞功能的方法和产品。

2. 发明申请

US20120329153A1 CAR RECEPTOR AS A MEDIATOR OF MIGRATORY CELL CHEMOTAXIS AND/OR CHEMOKINESIS 审中-公开
标题翻译： CAR受体作为转染细胞化学和/或化学反应的介质
公开(公告)号：US20120329153A1
公开(公告)日：2012-12-27
申请号：US13118511
申请日：2011-05-30
申请人： Mark C. Poznansky , Edward M. Brown , David T. Scadden , Ivona T. Olszak
发明人： Mark C. Poznansky , Edward M. Brown , David T. Scadden , Ivona T. Olszak
IPC分类号： C12N5/0789 , C12N5/077
CPC分类号： A61L27/3821 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/59 , A61K38/195 , A61K38/2006 , A61K45/06 , A61L27/3804 , A61L27/3847 , A61K2300/00
摘要： This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating io hematopoeitic progenitor cells and related products. In particular the invention includes methods and products for using CaR receptor-related compositions to enhance mobilization of hematopoietic progenitor cells, to improve the efficiency of targeting cells to the bone marrow, and/or to modulate hematopoietic progenitor cell function.
摘要翻译：本发明涉及用迁移能力调节真核细胞运动的方法和组合物。更具体地，本发明涉及用于调节受试者的特定部位中造血，神经，上皮，内皮或间质来源的CaR受体表达细胞的运动的方法和组合物。前述内容尤其可用于治疗特征在于需要调节与受试者中特定部位相关的迁移细胞运动的病症。特定部位包括炎症部位和迁移细胞运动的调节是远离药剂来源或排斥的运动。本发明还涉及用于操作io血型祖细胞和相关产品的方法。特别地，本发明包括使用CaR受体相关组合物来增强造血祖细胞的动员，提高靶向细胞到骨髓的效率和/或调节造血祖细胞功能的方法和产品。

3. 发明授权

US07951364B2 CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis 有权
标题翻译： CaR受体作为迁移性细胞趋化性和/或趋化因子的介质
公开(公告)号：US07951364B2
公开(公告)日：2011-05-31
申请号：US11429902
申请日：2006-05-08
申请人： Mark C. Poznansky , Edward M. Brown , David T. Scadden , Ivona T. Olszak
发明人： Mark C. Poznansky , Edward M. Brown , David T. Scadden , Ivona T. Olszak
IPC分类号： A01N63/00
CPC分类号： A61L27/3821 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/59 , A61K38/195 , A61K38/2006 , A61K45/06 , A61L27/3804 , A61L27/3847 , A61K2300/00
摘要： This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating hematopoeitic progenitor cells and related products. In particular the invention includes methods and products for using CaR receptor-related compositions to enhance mobilization of hematopoietic progenitor cells, to improve the efficiency of targeting cells to the bone marrow, and/or to modulate hematopoietic progenitor cell function.
摘要翻译：本发明涉及用迁移能力调节真核细胞运动的方法和组合物。更具体地，本发明涉及用于调节受试者的特定部位中造血，神经，上皮，内皮或间质来源的CaR受体表达细胞的运动的方法和组合物。前述内容尤其可用于治疗特征在于需要调节与受试者中特定部位相关的迁移细胞运动的病症。特定部位包括炎症部位和迁移细胞运动的调节是远离药剂来源或排斥的运动。本发明还涉及操纵造血祖细胞和相关产品的方法。特别地，本发明包括使用CaR受体相关组合物来增强造血祖细胞的动员，提高靶向细胞到骨髓的效率和/或调节造血祖细胞功能的方法和产品。

4. 发明授权

US07192769B2 Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices 失效
标题翻译：来自造血祖细胞的三维装置中的淋巴组织特异性细胞产生
公开(公告)号：US07192769B2
公开(公告)日：2007-03-20
申请号：US10161097
申请日：2002-05-31
申请人： Mark J. Pykett , Michael Rosenzweig , David T. Scadden , Mark C. Poznansky
发明人： Mark J. Pykett , Michael Rosenzweig , David T. Scadden , Mark C. Poznansky
IPC分类号： C12N5/06
CPC分类号： C12Q1/24 , A61K2035/122 , A61K2035/124 , A61K2039/5158 , C12N5/0636 , C12N5/0647 , C12N2501/23 , C12N2501/59 , C12N2502/11 , G01N33/5008 , G01N33/5011 , G01N33/505 , G01N33/5073 , G01N33/5094 , G01N2500/00
摘要： The invention relates to a method for lymphoid tissue-specific cell production from hematopoietic progenitor cells in unique, three-dimensional culture devices, in the presence of antigen presenting cells and lymphoreticular stromal cells, and in the absence of exogenously added growth factors. The resulting lymphoid tissue-specific cells may be isolated at any sequential stage of differentiation and further expanded. The lymphoid tissue-specific cells also may be genetically altered at any stage of the process.
摘要翻译：本发明涉及在存在抗原呈递细胞和淋巴网状基质细胞的情况下以及在不存在外源性生长因子的情况下，在独特的三维培养装置中由造血祖细胞产生淋巴组织特异性细胞的方法。所得到的淋巴组织特异性细胞可以在任何分化阶段分离并进一步扩增。淋巴组织特异性细胞也可以在该过程的任何阶段进行遗传改变。

5. 发明授权

US06548299B1 Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices 失效
标题翻译：来自造血祖细胞的三维装置中的淋巴组织特异性细胞产生
公开(公告)号：US06548299B1
公开(公告)日：2003-04-15
申请号：US09574749
申请日：2000-05-18
申请人： Mark J. Pykett , Michael Rosenzweig , David T. Scadden , Mark C. Poznansky
发明人： Mark J. Pykett , Michael Rosenzweig , David T. Scadden , Mark C. Poznansky
IPC分类号： C12N506
CPC分类号： C12Q1/24 , A61K2035/122 , A61K2035/124 , A61K2039/5158 , C12N5/0636 , C12N5/0647 , C12N2501/23 , C12N2501/59 , C12N2502/11 , G01N33/5008 , G01N33/5011 , G01N33/505 , G01N33/5073 , G01N33/5094 , G01N2500/00
摘要： The invention relates to a method for lymphoid tissue-specific cell production from hematopoietic progenitor cells in unique, three-dimensional culture devices, in the presence of lymphoreticular stromal cells and in the absence of exogenously added growth factors. The resulting differentiated progeny. The lymphoid tissue-specific cells may be isolated at any sequential stage of differentiation and further expanded. The lymphoid tissue-specific cells also may be genetically altered at any stage of the process.
摘要翻译：本发明涉及在独特的三维培养装置中，在淋巴网状基质细胞存在下和在不存在外源性生长因子的情况下由造血祖细胞产生淋巴组织特异性细胞的方法。所产生的差异后代。可以在分化的任何顺序阶段分离淋巴组织特异性细胞并进一步扩增。淋巴组织特异性细胞也可以在该过程的任何阶段进行遗传改变。

6. 发明授权

US07141363B2 Purposeful movement of human migratory cells away from an agent source 有权
公开(公告)号：US07141363B2
公开(公告)日：2006-11-28
申请号：US10191988
申请日：2002-07-09
申请人： Mark C. Poznansky , Andrew D. Luster , David T. Scadden
发明人： Mark C. Poznansky , Andrew D. Luster , David T. Scadden
IPC分类号： C12Q3/00 , A61K39/00
CPC分类号： G01N33/5029 , A61K38/00 , C07K14/521 , C07K14/8114 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/5064 , G01N33/5088
摘要： This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of cells of hematopoietic, neural, epithelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. More specifically, specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. Other sites include tumor sites, sites of pathogenic infection, and germ cell bearing sites.

7. 发明授权

US06448054B1 Purposeful movement of human migratory cells away from an agent source 有权
标题翻译：人类迁徙细胞有目的地移动远离代理来源
公开(公告)号：US06448054B1
公开(公告)日：2002-09-10
申请号：US09546153
申请日：2000-04-07
申请人： Mark C. Poznansky , Andrew T. Luster , David T. Scadden
发明人： Mark C. Poznansky , Andrew T. Luster , David T. Scadden
IPC分类号： C12N999
CPC分类号： G01N33/5029 , A61K38/00 , C07K14/521 , C07K14/8114 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/5064 , G01N33/5088
摘要： This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of cells of hematopoietic, neural, epithelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. More specifically, specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. Other sites include tumor sites, sites of pathogenic infection, and germ cell bearing sites.
摘要翻译：本发明涉及用迁移能力调节真核细胞运动的方法和组合物。更具体地，本发明涉及用于调节受试者的特定部位中造血，神经，上皮或间质来源的细胞运动的方法和组合物。前述内容尤其可用于治疗特征在于需要调节与受试者中特定部位相关的迁移细胞运动的病症。更具体地，特定部位包括炎症部位和迁移细胞运动的调节是远离药剂来源的运动或排斥。其他部位包括肿瘤部位，病原体感染部位和生殖细胞承载部位。

8. 发明授权

US07775469B2 Purposeful movement of human migratory cells away from an agent source 有权
标题翻译：人类迁徙细胞有目的地移动远离代理来源
公开(公告)号：US07775469B2
公开(公告)日：2010-08-17
申请号：US11407477
申请日：2006-04-20
申请人： Mark C. Poznansky , Andrew D. Luster , David T. Scadden
发明人： Mark C. Poznansky , Andrew D. Luster , David T. Scadden
IPC分类号： A61K39/00 , A61K45/00
CPC分类号： G01N33/5029 , A61K38/00 , C07K14/521 , C07K14/8114 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/5064 , G01N33/5088
摘要： This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of cells of hematopoietic, neural, epithelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. More specifically, specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. Other sites include tumor sites, sites of pathogenic infection, and germ cell bearing sites.
摘要翻译：本发明涉及用迁移能力调节真核细胞运动的方法和组合物。更具体地，本发明涉及用于调节受试者的特定部位中造血，神经，上皮或间质来源的细胞运动的方法和组合物。前述内容尤其可用于治疗特征在于需要调节与受试者中特定部位相关的迁移细胞运动的病症。更具体地，特定部位包括炎症部位和迁移细胞运动的调节是远离药剂来源的运动或排斥。其他部位包括肿瘤部位，病原体感染部位和生殖细胞承载部位。

9. 发明申请

US20140206624A1 TREATMENT OF LEUKEMIA 审中-公开
标题翻译：治疗白血病
公开(公告)号：US20140206624A1
公开(公告)日：2014-07-24
申请号：US13983325
申请日：2012-02-06
申请人： Stephen Matthew Sykes , David T. Scadden , Dwight Gary Gilliland
发明人： Stephen Matthew Sykes , David T. Scadden , Dwight Gary Gilliland
IPC分类号： A61K31/713 , A61K45/06 , A61K31/436
CPC分类号： A61K31/713 , A61K31/436 , A61K31/454 , A61K31/52 , A61K45/06 , A61K48/005 , C12N9/1205 , C12N15/113 , C12N2310/14 , A61K2300/00
摘要： Compositions and methods for the treatment of leukemia by inhibiting FOXO signaling are described.
摘要翻译：描述了通过抑制FOXO信号治疗白血病的组合物和方法。

10. 发明授权

US08309095B2 Parathyroid hormone receptor activation and stem and progenitor cell expansion 有权
标题翻译：甲状旁腺激素受体激活和干细胞和祖细胞扩增
公开(公告)号：US08309095B2
公开(公告)日：2012-11-13
申请号：US13097664
申请日：2011-04-29
申请人： David T. Scadden , Laura M. Calvi , Gregor Adams , Henry M. Kronenberg
发明人： David T. Scadden , Laura M. Calvi , Gregor Adams , Henry M. Kronenberg
IPC分类号： A61K39/00 , A61K39/38 , A61K39/36
CPC分类号： C12N5/0602 , A01K2217/05 , A01K2227/105 , A61K35/28 , A61K38/17 , A61K38/29 , C07K14/72 , C12N5/0623 , C12N5/0647 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/37 , C12N2502/1311 , C12N2502/1394 , C12Q1/6809 , G01N33/74
摘要： The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells.
摘要翻译：本发明涉及通过激活邻近细胞中的PTH / PTHrP受体来操纵造血干细胞或祖细胞，间充质干细胞，上皮干细胞，神经干细胞和相关产物的方法。

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