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1. 发明授权

US08309095B2 Parathyroid hormone receptor activation and stem and progenitor cell expansion 有权
标题翻译：甲状旁腺激素受体激活和干细胞和祖细胞扩增
公开(公告)号：US08309095B2
公开(公告)日：2012-11-13
申请号：US13097664
申请日：2011-04-29
申请人： David T. Scadden , Laura M. Calvi , Gregor Adams , Henry M. Kronenberg
发明人： David T. Scadden , Laura M. Calvi , Gregor Adams , Henry M. Kronenberg
IPC分类号： A61K39/00 , A61K39/38 , A61K39/36
CPC分类号： C12N5/0602 , A01K2217/05 , A01K2227/105 , A61K35/28 , A61K38/17 , A61K38/29 , C07K14/72 , C12N5/0623 , C12N5/0647 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/37 , C12N2502/1311 , C12N2502/1394 , C12Q1/6809 , G01N33/74
摘要： The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells.
摘要翻译：本发明涉及通过激活邻近细胞中的PTH / PTHrP受体来操纵造血干细胞或祖细胞，间充质干细胞，上皮干细胞，神经干细胞和相关产物的方法。

2. 发明授权

US07943136B2 Parathyroid hormone receptor activation and stem and progenitor cell expansion 有权
标题翻译：甲状旁腺激素受体激活和干细胞和祖细胞扩增
公开(公告)号：US07943136B2
公开(公告)日：2011-05-17
申请号：US12621325
申请日：2009-11-18
申请人： David T. Scadden , Laura M. Calvi , Gregor Adams , Henry M. Kronenberg
发明人： David T. Scadden , Laura M. Calvi , Gregor Adams , Henry M. Kronenberg
IPC分类号： A61K39/00 , A61K39/38 , A61K35/26
CPC分类号： C12N5/0602 , A01K2217/05 , A01K2227/105 , A61K35/28 , A61K38/17 , A61K38/29 , C07K14/72 , C12N5/0623 , C12N5/0647 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/37 , C12N2502/1311 , C12N2502/1394 , C12Q1/6809 , G01N33/74
摘要： The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells.
摘要翻译：本发明涉及通过激活邻近细胞中的PTH / PTHrP受体来操纵造血干细胞或祖细胞，间充质干细胞，上皮干细胞，神经干细胞和相关产物的方法。

3. 发明授权

US07776334B2 Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion 有权
标题翻译：甲状旁腺激素受体激活和造血祖细胞扩增
公开(公告)号：US07776334B2
公开(公告)日：2010-08-17
申请号：US12200419
申请日：2008-08-28
申请人： David T. Scadden , Laura M. Calvi , Gregor Adams , Henry M. Kronenberg
发明人： David T. Scadden , Laura M. Calvi , Gregor Adams , Henry M. Kronenberg
IPC分类号： A61K39/00 , A61K39/38 , A61K35/26 , C12N5/08 , C12N5/00
CPC分类号： A61K38/29 , A01K2217/05 , A01K2227/105 , C07K14/72 , C12N5/0647 , C12N2501/37 , C12N2502/1311 , C12N2502/1394
摘要： The invention relates to methods for manipulating hematopoietic progenitor cells and related products. In one aspect the invention relates to the use of agents that activate a PTH/PTHrP receptor to enhance the growth and maintenance of hematopoietic progenitor cells in vivo and in vitro, to enhance mobilization of hematopoietic stem cells, to improve the efficiency of targeting cells to the bone marrow, and/or to modulate hematopoietic progenitor cell function.
摘要翻译：本发明涉及操纵造血祖细胞和相关产品的方法。一方面，本发明涉及活化PTH / PTHrP受体以增强体内和体外造血祖细胞的生长和维持以增强造血干细胞的动员，提高靶向细胞的效率的试剂的用途骨髓和/或调节造血祖细胞功能。

4. 发明申请

US20080112933A1 Methods and Compositions for Increasing Stem Cell Homing Using Gas Activators 审中-公开
标题翻译：使用气体活化剂增加干细胞回原点的方法和组合
公开(公告)号：US20080112933A1
公开(公告)日：2008-05-15
申请号：US11667329
申请日：2005-11-07
申请人： David T. Scadden , Henry M. Kronenberg , Gregor Adams
发明人： David T. Scadden , Henry M. Kronenberg , Gregor Adams
IPC分类号： A61K35/14 , C12N5/08
CPC分类号： G01N33/5073 , A61K48/00 , A61K2035/124 , C12N5/0647 , C12N2501/01 , G01N2333/4719
摘要： The present invention provides methods for increasing engraftment of stem cells in a subject by treating the cells with a Gαs activator. The invention further provides methods for identifying Gαs activators for use in increasing engraftment of stem cells in a subject.
摘要翻译：本发明提供了通过用Galphas活化剂处理细胞来增加受试者的干细胞植入的方法。本发明还提供了用于鉴定用于增加受试者中干细胞移植物的Galphas活化剂的方法。

5. 发明授权

US07910544B2 Conformationally constrained parthyroid hormone (PTH) analogs 有权
标题翻译：构象约束的甲状腺激素（PTH）类似物
公开(公告)号：US07910544B2
公开(公告)日：2011-03-22
申请号：US10564744
申请日：2004-07-16
申请人： Thomas J. Gardella , Naoto Shimizu , Henry M. Kronenberg , John T. Potts, Jr.
发明人： Thomas J. Gardella , Naoto Shimizu , Henry M. Kronenberg , John T. Potts, Jr.
IPC分类号： A61K38/29
CPC分类号： C07K14/635 , A61K38/00
摘要： The invention provides novel P1R polypeptide antagonists. These antagonists contain amino acid substitutions at selected positions in truncated PTH and PRHrP polypeptides and function by binding selectively to the juxtamembrane (“J”) domain of the receptor. The J domain is the region of the receptor that spans the seven transmembrane domain and the extracellular loops.
摘要翻译：本发明提供了新的P1R多肽拮抗剂。这些拮抗剂在截短的PTH和PRHrP多肽中的选定位置含有氨基酸取代，并且通过选择性地结合受体的近红外（“J”）结构域起作用。 J结构域是跨越七个跨膜结构域和细胞外环的受体区域。

6. 发明授权

US07244834B2 Nucleic acids encoding PTH functional domain conjugate peptides 失效
标题翻译：编码PTH功能结构域结合肽的核酸
公开(公告)号：US07244834B2
公开(公告)日：2007-07-17
申请号：US11366391
申请日：2006-03-03
申请人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts, Jr. , Harald Jüppner
发明人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts, Jr. , Harald Jüppner
IPC分类号： C07H21/04 , C07K14/635
CPC分类号： C07K14/635 , A61K38/00
摘要： Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1–34) fragment are disclosed that combine the N-terminal signaling domain (residues 1–9) and the C-terminal binding domain (residues 15–31) via a linker. Nucleic acid molecules and peptides for PTH(1–9)-(Gly)5-PTH(15–31) (PG5) and PTH(1–9)-(Gly)7-PTH(15–31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.
摘要翻译：公开了PTH（1-34）片段的新型甲状旁腺激素（PTH）肽及其类似物，其通过以下方式组合N末端信号结构域（残基1-9）和C-末端结合结构域（残基15-31）接头。用于PTH（1-9） - （Gly）5-PTH（15-31）（PG5）和PTH（1-9） - （Gly）7-PTH（15-31）的核酸分子和肽和新型PTH 受体。此外，公开了筛选PTH激动剂，药物组合物和治疗方法的方法。

7. 发明授权

US06495662B1 Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) 有权
标题翻译：甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP）的生物活性肽和肽衍生物
公开(公告)号：US06495662B1
公开(公告)日：2002-12-17
申请号：US09421379
申请日：1999-10-20
申请人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts, Jr. , Harald Jüppner
发明人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts, Jr. , Harald Jüppner
IPC分类号： C07K500
CPC分类号： C07K7/08 , A61K38/00 , C07K14/635
摘要： Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing said peptides, and synthetic and recombinant methods for producing said peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.
摘要翻译：公开了具有生物活性的新型甲状旁腺激素肽（PTH）和甲状旁腺激素相关肽（PTHrP）或其衍生物，以及含有所述肽的药物组合物以及用于产生所述肽的合成和重组方法。还公开了使用含有所述肽的治疗有效的药物组合物治疗哺乳动物状况的方法，其特征在于骨量减少。还公开了用于筛选本发明的候选化合物对甲状旁腺激素受体作用的拮抗作用或激动作用的方法。还公开了所述化合物的诊断和治疗方法。

8. 发明授权

US07985835B2 Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) 失效
标题翻译：甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP）的生物活性肽和肽衍生物
公开(公告)号：US07985835B2
公开(公告)日：2011-07-26
申请号：US11598011
申请日：2006-11-13
申请人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts , Harald Jüppner
发明人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts , Harald Jüppner
IPC分类号： A61K38/08 , A61K38/10 , A61K38/22 , A61K51/00 , A61K103/10 , A61P19/08
CPC分类号： C07K7/08 , A61K38/00 , C07K14/635
摘要： Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing such peptides, and synthetic and recombinant methods for producing such peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing such peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of such compounds.
摘要翻译：公开了具有生物活性的新型甲状旁腺激素肽（PTH）和甲状旁腺激素相关肽（PTHrP）或其衍生物，以及含有这些肽的药物组合物，以及用于生产这些肽的合成和重组方法。还公开了用于治疗哺乳动物病症的方法，其特征在于使用含有这种肽的治疗有效的药物组合物降低骨量。还公开了用于筛选本发明的候选化合物对甲状旁腺激素受体作用的拮抗作用或激动作用的方法。还公开了这些化合物的诊断和治疗方法。

9. 发明申请

US20110009328A1 Polypeptide Derivatives of Parathyroid Hormone (PTH) 有权
标题翻译：甲状旁腺激素多肽衍生物（PTH）
公开(公告)号：US20110009328A1
公开(公告)日：2011-01-13
申请号：US12053149
申请日：2008-03-21
申请人： Thomas J. GARDELLA , Henry M. Kronenberg , John T. Potts, JR. , Harald T. Jüppner
发明人： Thomas J. GARDELLA , Henry M. Kronenberg , John T. Potts, JR. , Harald T. Jüppner
IPC分类号： A61K38/16 , C07K7/08 , C07K14/00 , C07K7/06 , A61P19/10 , C12N5/00 , C07H21/04
CPC分类号： C07K14/635 , A61K38/00
摘要： Novel parathyroid hormone (PTH) polypeptide derivatives are disclosed, as are pharmaceutical compositions containing said polypeptides, and synthetic and recombinant methods for producing said polypeptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said polypeptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.
摘要翻译：公开了新型甲状旁腺激素（PTH）多肽衍生物，含有所述多肽的药物组合物以及用于产生所述多肽的合成和重组方法。还公开了使用含有所述多肽的治疗有效的药物组合物治疗哺乳动物状况的方法，其特征在于骨量减少。还公开了用于筛选本发明的候选化合物对甲状旁腺激素受体作用的拮抗作用或激动作用的方法。还公开了所述化合物的诊断和治疗方法。

10. 发明授权

US07521528B2 Conformationally constrained parathyroid hormone (PTH) analogs with lactam bridges 有权
标题翻译：构象约束甲状旁腺激素（PTH）类似物与内酰胺桥
公开(公告)号：US07521528B2
公开(公告)日：2009-04-21
申请号：US10542704
申请日：2003-01-24
申请人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts
发明人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts
IPC分类号： C07K14/635
CPC分类号： C07K14/635 , A61K38/29
摘要： The present invention relates to methods of treatment of mammalian conditions characterized by decreases in bone mass with conformationally constrained parathyroid hormone (PTH) analogs and derivatives of those analogs containing PTH polypeptide derivatives containing at least one Glu or Lys substitution at position 6 and/or 10, some with installed lactam bridges between the side chains of Lys and Glu. The invention provides derivatives of PTH (1-34), PTH(1-33), PTH(1-32), PTH(1-31), PTH(1-30), PTH(1-29), PTH(1-28), PTH(1-27), PTH(1-26), PTH(1-25), PTH(1-24), PTH(1-23), PTH(1-22), PTH (1-21), PTH(1-20), PTH(1-19), PTH(1-18), PTH(1-17), PTH(1-16), PTH(1-15), PTH(1-14), PTH(1-13), PTH(1-12), PTH(1-11), PTH(1-10) and PTH(1-9) polypeptide. The invention also provides methods of preparing the PTH analogs. Further, the invention encompasses treating conditions that are characterized by undesired bone loss or by the need for bone growth, e.g. in treating fractures or cartilage disorders and for raising cAMP levels in cells where deemed necessary.
摘要翻译：本发明涉及治疗哺乳动物病症的方法，其特征在于具有构象约束的甲状旁腺激素（PTH）类似物的骨量减少和含有在第6位和/或第10位含有至少一个Glu或Lys取代的PTH多肽衍生物的那些类似物的衍生物，一些在Lys和Glu的侧链之间安装了内酰胺桥。本发明提供了PTH（1-34），PTH（1-33），PTH（1-32），PTH（1-31），PTH（1-30），PTH（1-29），PTH -2TH），PTH（1-27），PTH（1-26），PTH（1-25），PTH（1-24），PTH（1-23），PTH（1-22） 21），PTH（1-20），PTH（1-19），PTH（1-18），PTH（1-17），PTH（1-16），PTH（1-15），PTH ），PTH（1-13），PTH（1-12），PTH（1-11），PTH（1-10）和PTH（1-9）多肽。本发明还提供了制备PTH类似物的方法。此外，本发明包括以不良骨丢失或骨生长需要为特征的治疗条件，例如。在治疗骨折或软骨障碍并提高认为必要的细胞中的cAMP水平。

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