专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060160741A1 Dimeric TF antagonists 审中-公开
标题翻译：二聚体TF拮抗剂
公开(公告)号：US20060160741A1
公开(公告)日：2006-07-20
申请号：US11390512
申请日：2006-03-27
申请人： Marianne Kjalke , Palle Jakobsen , Henning Stennicke
发明人： Marianne Kjalke , Palle Jakobsen , Henning Stennicke
IPC分类号： A61K38/37 , C07K14/745
CPC分类号： C12N9/96 , A61K38/00 , C12N9/64
摘要： Dimer FVII polypeptides, which binds and inhibits two TF molecules simultaneously.
摘要翻译：二聚体FVII多肽，其同时结合并抑制两个TF分子。

2. 发明授权

US08933021B2 Insulin derivative 有权
标题翻译：胰岛素衍生物
公开(公告)号：US08933021B2
公开(公告)日：2015-01-13
申请号：US12297911
申请日：2007-05-08
申请人： Frantisek Hubalek , Thomas Hoeg-Jensen , Ib Jonassen , Patrick William Garibay , Palle Jakobsen , Svend Havelund , Janos Tibor Kodra
发明人： Frantisek Hubalek , Thomas Hoeg-Jensen , Ib Jonassen , Patrick William Garibay , Palle Jakobsen , Svend Havelund , Janos Tibor Kodra
IPC分类号： C07K14/62 , A61K38/00
CPC分类号： C07K14/62 , A61K38/00
摘要： The present invention relates to novel human insulin derivatives which are soluble at physiological pH values and have a prolonged profile of action. The invention also relates to methods of providing such derivatives, to pharmaceutical compositions containing them, to methods of treating diabetes and hyperglycaemia using the insulin derivatives of the invention and to the use of such insulin derivatives in the treatment of diabetes and hyperglycaemia.
摘要翻译：本发明涉及新的人胰岛素衍生物，其在生理pH值下是可溶的并具有延长的作用特征。本发明还涉及提供这样的衍生物，含有它们的药物组合物的方法，使用本发明的胰岛素衍生物治疗糖尿病和高血糖的方法以及这种胰岛素衍生物在治疗糖尿病和高血糖中的用途。

3. 发明授权

US07879893B2 Ligands for the HisB10 Zn2 + sites of the R-state insulin hexamer 有权
标题翻译：用于R-state胰岛素六聚体的HisB10 Zn2 +位点的配体
公开(公告)号：US07879893B2
公开(公告)日：2011-02-01
申请号：US10332541
申请日：2002-09-13
申请人： Helle Birk Olsen , Niels C. Kaarsholm , Peter Madsen , Soren Ostergaard , Svend Ludvigsen , Palle Jakobsen , Anders Klarskov Petersen , Dorte Bjerre Steensgaard
发明人： Helle Birk Olsen , Niels C. Kaarsholm , Peter Madsen , Soren Ostergaard , Svend Ludvigsen , Palle Jakobsen , Anders Klarskov Petersen , Dorte Bjerre Steensgaard
IPC分类号： A61K31/41 , A61K31/40 , C07D257/00 , C07D209/82
CPC分类号： C07D257/04 , A61K31/4192 , A61K31/426 , C07D249/18 , C07D277/20 , C07D403/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07D471/04
摘要： The present invention relates to novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer having the formula A-B-C-D-X (III), wherein: A is a chemical group which reversibly binds to a HisB10 Zn2+ sites of an insulin hexamer; B is a linker; C is a fragment consisting of 0 to 5 neutral amino acids; D is a fragment comprising 1 to 20 positively charged groups independently selected from amino or guanidino groups; and X is —OH, —NH2 or a diamino group. The present invention also relates to R-state insulin hexamers comprising such ligands, and aqueous insulin preparations comprising such R-state insulin hexamers.
摘要翻译：本发明涉及具有式A-B-C-D-X（III）的R状态胰岛素六聚体的HisB10 Zn 2+位点的新配体，其中：A是可逆结合胰岛素六聚体的HisB10 Zn 2+位点的化学基团; B是一个连接子; C是由0至5个中性氨基酸组成的片段; D是包含1至20个独立地选自氨基或胍基的带正电基团的片段; X为-OH，-NH 2或二氨基。本发明还涉及包含这种配体的R状态胰岛素六聚体和包含这种R状态胰岛素六聚体的含水胰岛素制剂。

4. 发明申请

US20090123563A1 Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand 审中-公开
标题翻译：包含胰岛素，锌离子和锌结合配体的药物制剂
公开(公告)号：US20090123563A1
公开(公告)日：2009-05-14
申请号：US11814123
申请日：2006-02-06
申请人： Niels Christian Kaarsholm , Helle Birk Olsen , Peter Madsen , Soeren Ostegaard , Palle Jakobsen , Tina Moeller Tagmose
发明人： Niels Christian Kaarsholm , Helle Birk Olsen , Peter Madsen , Soeren Ostegaard , Palle Jakobsen , Tina Moeller Tagmose
IPC分类号： A61K33/30 , A61P3/10
CPC分类号： A61K38/28
摘要： Novel preparations comprising branched ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer. The preparations have a prolonged action designed for flexible injection regimes.
摘要翻译：包含R状态胰岛素六聚体的HisB10 Zn2 +位点的支链配体的新型制剂。制剂的灵活注射方案设计时间长。

5. 发明申请

US20060057636A1 Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins 审中-公开
标题翻译：用于诊断和治疗由朊病毒蛋白引起的疾病的复合肽化合物
公开(公告)号：US20060057636A1
公开(公告)日：2006-03-16
申请号：US10525533
申请日：2003-08-25
申请人： Peter Heegaard , Palle Jakobsen
发明人： Peter Heegaard , Palle Jakobsen
IPC分类号： C07K14/775 , G01N33/53
CPC分类号： C07K14/47 , A61K47/64 , C07K16/18 , C07K19/00 , G01N33/6896 , G01N2333/47 , G01N2800/2828
摘要： The present invention relates to diseases caused by prion proteins, Novel composite peptide compounds are disclosed which comprise two or more peptides or peptide fragments optionally linked to a backbone and the peptides or peptide fragments are spatially positioned relative to each other so that they together form a non-linear sequence which mimics the tertiary structure of one or more PrPSc-specific epitopes as evidenced by the test described herein. The use of such conjugates as immunogens for the production of antibodies that specifically bind to the pathogenic form of a prion protein is revealed. Other uses of the composite peptide compounds are also disclosed, such as use in diagnostic assays, production of antibodies and uses as vaccine immunogens for the prophylactic protection and therapeutic treatment of subjects against transmissible prion disease.
摘要翻译：本发明涉及由朊病毒蛋白引起的疾病，公开了新的复合肽化合物，其包含两个或更多个肽或肽片段，任选地连接至主链，并且肽或肽片段相对于彼此在空间上定位，使得它们一起形成模拟一种或多种PrP特异性表位的三级结构的非线性序列，如本文所述的测试所证明的。揭示了使用这种缀合物作为免疫原用于产生特异性结合朊病毒蛋白的致病形式的抗体。还公开了复合肽化合物的其它用途，例如用于诊断测定，抗体产生和用作疫苗免疫原用于受试者针对可传染性朊病毒疾病的预防性保护和治疗性治疗。

6. 发明授权

US06451836B1 Method of inhibiting liver glycogen phosphorylase with 2-alkylpyrrolidines 失效
标题翻译：用2-烷基吡咯烷酮抑制肝糖原磷酸化酶的方法
公开(公告)号：US06451836B1
公开(公告)日：2002-09-17
申请号：US09138712
申请日：1998-08-24
申请人： Karsten Lundgren , Palle Jakobsen , Marit Kristiansen , Leif Nørskov-Lauritsen , Lars Naerum
发明人： Karsten Lundgren , Palle Jakobsen , Marit Kristiansen , Leif Nørskov-Lauritsen , Lars Naerum
IPC分类号： A61K3140
CPC分类号： C07D207/12 , A61K31/40 , Y10S514/866
摘要： The present invention relates to (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine and other substituted 2-methylpyrrolidines and their use for inhibiting liver glycogen phosphorylase.
摘要翻译：本发明涉及（2R，3R，4R）-3,4-二羟基-2-羟甲基吡咯烷和其它取代的2-甲基吡咯烷酮及其用于抑制肝糖原磷酸化酶的用途。

7. 发明授权

US5854272A 2-alkylpyrrolidines 失效
标题翻译： 2-烷基吡咯烷酮
公开(公告)号：US5854272A
公开(公告)日：1998-12-29
申请号：US892660
申请日：1997-07-14
申请人： Karsten Lundgren , Palle Jakobsen , Marit Kristiansen , Leif N.o slashed.rskov-Lauritsen , Lars Naerum
发明人： Karsten Lundgren , Palle Jakobsen , Marit Kristiansen , Leif N.o slashed.rskov-Lauritsen , Lars Naerum
IPC分类号： C07D207/10 , A61K31/40 , A61K31/401 , A61P3/08 , A61P3/10 , A61P43/00 , C07D207/12
CPC分类号： C07D207/12 , A61K31/40 , Y10S514/866
摘要： The present invention relates to (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine and other substituted 2-methylpyrrolidines and their use for the treatment of diabetes.
摘要翻译：本发明涉及（2R，3R，4R）-3,4-二羟基-2-羟甲基吡咯烷和其它取代的2-甲基吡咯烷酮及其用于治疗糖尿病的用途。

8. 发明授权

US5019582A Piperidine compounds and their preparation and use 失效
公开(公告)号：US5019582A
公开(公告)日：1991-05-28
申请号：US407237
申请日：1989-09-14
申请人： Jorgen Drejer , Palle Jakobsen
发明人： Jorgen Drejer , Palle Jakobsen
IPC分类号： A61K31/443 , A61K31/445 , A61K31/451 , A61P3/00 , C07D211/20 , C07D211/22 , C07D405/12
CPC分类号： C07D405/12 , C07D211/20 , C07D211/22
摘要： Novel piperidine compounds having the formula ##STR1## wherein R.sup.3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.3-8 -cycloalkyl, C.sub.3-5 -alkylene or aralkoxy,R.sup.1 is straight or branched C.sub.1-8 -alkyl, C.sub.4-8 -alkoxy-C.sub.4-8 -alkyl, C.sub.4-7 -cycloalkyl, aryloxy-C.sub.3-8 -alkyl, C.sub.4-8 -alkenyl, or C.sub.4-8 -cycloalkylalkyl, or R.sup.1 may also be hydrogen or C.sub.1-3 -alkyl, when R.sup.3 is aryl, which is substituted with two or more of C.sub.1-6 - alkyl, C.sub.1-6 -alkoxy, C.sub.3-8 -cycloalkyl, aralkoxy, or with C.sub.3-5 -alkylene.X is hydrogen or halogen, and whereinY is O or Sor a salt thereof with a pharmaceutically-acceptable acid, pharmaceutical compositions thereof, method-of-treating therewith.The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.

9. 发明授权

US4985446A Piperidine compounds and pharmaceutical compositions thereof 失效
标题翻译：哌啶化合物及其药物组合物
公开(公告)号：US4985446A
公开(公告)日：1991-01-15
申请号：US486252
申请日：1990-02-28
申请人： Jorgen Drejer , Palle Jakobsen
发明人： Jorgen Drejer , Palle Jakobsen
IPC分类号： A61K31/443 , A61K31/445 , A61K31/451 , A61P3/00 , C07D211/20 , C07D211/22 , C07D405/12
CPC分类号： C07D405/12 , C07D211/20 , C07D211/22
摘要： Novel piperidine compounds having the formula ##STR1## wherein R.sup.3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.3-8 -cycloalkyl, C.sub.3-5 -alkylene or aralkoxy,R.sup.1 is straight or branched C.sub.1-8 -alkyl, C.sub.4-8 -alkoxy-C.sub.4-8 -alkyl, C.sub.4-7 -cycloalkyl, aryloxy-C.sub.3-8 -alkyl, C.sub.4-8 -alkenyl, or C.sub.4-8 -cycloalkylalkyl, or R.sup.1 may also be hydrogen or C.sub.1-3 -alkyl, when R.sup.3 is aryl, which is substituted with two or more of C.sub.1-6 -alkyl, C.sub.1-6 alkoxy, C.sub.3-8 -cycloalkyl, aralkoxy, or with C.sub.3-5 -alkylene.X is hydrogen or halogen, and whereinY is O or Sor a salt thereof with a pharmaceutically-acceptable acid, pharmaceutical compositions thereof, method-of-treating therewith.The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.

10. 发明授权

US4970232A Aryloxyphenylpropylamines and their preparation and use 失效
标题翻译：丙烯酰氧基苯基丙胺及其制备及应用
公开(公告)号：US4970232A
公开(公告)日：1990-11-13
申请号：US473862
申请日：1990-02-02
申请人： Palle Jakobsen , Jorgen Drejer
发明人： Palle Jakobsen , Jorgen Drejer
IPC分类号： A61K31/135 , A61K31/275 , A61K31/33 , A61K31/357 , A61K31/36 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/04 , A61P25/06 , A61P25/08 , C07C213/02 , C07C217/48 , C07C255/54 , C07D317/64 , C07D521/00
CPC分类号： C07D317/64 , C07C217/48 , C07C255/54 , C07C2101/02 , C07C2102/08 , C07C2102/10
摘要： Novel aryloxyphenylpropylamines having the formula ##STR1## wherein R.sup.1 is C.sub.3-7 -cycloalkyl, C.sub.3-10 -alkyl, or alkenyl which may be straight, branched or cyclic, unsubstituted or substituted with C.sub.1-4 -alkoxy, aryloxy or cycloalkyl or cycloalkylalkyl; andR.sup.2 is 3,4-methylenedioxyphenyl, aryl or heteroaryl, which are optionally substituted with one or more cyano, halogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.1-6 -alkenyl, trifluoromethyl, C.sub.3-5 -alkylene, aryloxy or aralkoxyand a salt thereof with a pharmaceutically acceptable acid.The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式