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1. 发明申请

US20050222187A1 Use of benzoylalkyl-1,2,3,6-tetrahydropyridines 失效
标题翻译：苯甲酰烷基-1,2,3,6-四氢吡啶的使用
公开(公告)号：US20050222187A1
公开(公告)日：2005-10-06
申请号：US11135998
申请日：2005-05-24
申请人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
发明人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
IPC分类号： A61K31/44 , A61K31/4409 , A61K31/4418 , A61P25/00 , A61P43/00 , C07D211/70
CPC分类号： C07D211/70 , A61K31/4418
摘要： The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
摘要翻译：本发明涉及式的化合物在制备用于治疗神经元和脑障碍的药物中的应用。本发明还涉及下式的化合物：其制备方法和含有它们的药物组合物。

2. 发明授权

US06358965B1 Use of benzoylalkyl-1,2,3,6-tetrahydropyridines 失效
标题翻译：苯甲酰烷基-1,2,3,6-四氢吡啶的使用
公开(公告)号：US06358965B1
公开(公告)日：2002-03-19
申请号：US09331524
申请日：1999-08-05
申请人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
发明人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
IPC分类号： A61K31435
CPC分类号： C07D211/70 , A61K31/4418
摘要： The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
摘要翻译：本发明涉及用于制备治疗神经元和脑疾病的药物的配方化合物的用途。本发明还涉及式的化合物：其制备方法和含有它们的药物组合物。

3. 发明授权

US6034090A 1-Phenylalkyl-1,2,3,6-tetrahydropyridines for treating Alzheimer's disease 失效
标题翻译： 1-苯基烷基-1,2,3,6-四氢吡啶用于治疗阿尔茨海默病
公开(公告)号：US6034090A
公开(公告)日：2000-03-07
申请号：US331006
申请日：1999-07-27
申请人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi
发明人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi
IPC分类号： A61K31/4418 , A61K31/444 , A61K31/445 , A61P25/28 , C07D211/70 , C07D213/36 , C07D401/04 , A61K31/44 , C07D211/72 , C07D213/22
CPC分类号： C07D401/04 , C07D211/70
摘要： The invention relates to compounds of the formula in which: Y is --CH-- or --N--; R.sub.1 is hydrogen, a halogen or a CF.sub.3, (C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy group; R.sub.2 is a methyl or ethyl group; R.sub.3 and R.sub.4 are each hydrogen or a (C.sub.1 -C.sub.3)alkyl; and X is:(a) a (C.sub.1 -C.sub.6)alkyl, a (C.sub.1 -C.sub.6)alkoxy, a (C.sub.3 -C.sub.7)carboxyalkyl, a (C.sub.1 -C.sub.4)alkoxy-carbonyl(C.sub.1 -C.sub.6)alkyl, a (C.sub.3 -C.sub.7)carboxyalkoxy or a (C.sub.1 -C.sub.4)alkoxycarbonyl-(C.sub.1 -C.sub.6)alkoxy;(b) a radical selected from (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkoxy, (C.sub.3 -C.sub.7)-cycloalkylmethyl, (C.sub.3 -C.sub.7)cycloalkylamino and cyclohexenyl, it being possible for said radical to be substituted by a halogen, hydroxyl, (C.sub.1 -C.sub.4)-alkoxy, carboxyl, (C.sub.1 -C.sub.4)alkoxycarbonyl, amino or mono- or di-(C.sub.1 -C.sub.4)-alkylamino; or(c) a group selected from a phenyl, phenoxy, phenylamino, N-(C.sub.1 -C.sub.3)alkyl-phenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulfonyl, phenylsulfinyl and styryl, it being possible for said group to be monosubstituted or polysubstituted on the phenyl group by a halogen, CF.sub.3, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, cyano, amino, mono- or di-(C.sub.1 -C.sub.4)alkyl-amino, (C.sub.1 -C.sub.4)acylamino, carboxyl, (C.sub.1 -C.sub.4)alkoxycarbonyl, aminocarbonyl, mono- or di-(C.sub.1 -C.sub.4)alkylaminocarbonyl, amino(C.sub.1 -C.sub.4)alkyl, hydroxy(C.sub.1 -C.sub.4)alkyl or halogeno(C.sub.1 -C.sub.4)alkyl;to a method of preparing them and to the pharmaceutical compositions containing them. These compounds have neurotrophic and neuroprotective activity.
摘要翻译： PCT No.PCT / FR97 / 02286 Sec。 371日期：1999年7月27日 102（e）日期1997年7月27日PCT 1997年12月12日PCT PCT。第WO98 / 25903号公报日期：1998年6月18日本发明涉及下式的化合物，其中：Y为-CH-或-N-; R1是氢，卤素或CF3，（C1-C4）烷基或（C1-C4）烷氧基; R2是甲基或乙基; R3和R4各自为氢或（C1-C3）烷基; 并且X是：（a）（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，（C 3 -C 7）羧基烷基，（C 1 -C 4）烷氧羰基（C 1 -C 6）烷基，（C 3 -C 7）羧基烷氧基或（C 1 -C 4）烷氧基羰基 - （C 1 -C 6）烷氧基; （c）选自（C 3 -C 7）环烷基，（C 3 -C 7）环烷氧基，（C 3 -C 7） - 环烷基甲基，（C 3 -C 7）环烷基氨基和环己烯基的基团，所述基团可以被卤素，羟基，（C 1 -C 4） - 烷氧基，羧基，（C 1 -C 4）烷氧基羰基，氨基或单 - 或二 - （C 1 -C 4） - 烷基氨基; 或（c）选自苯基，苯氧基，苯基氨基，N-（C1-C3）烷基 - 苯基氨基，苯基甲基，苯基乙基，苯基羰基，苯硫基，苯基磺酰基，苯基亚磺酰基和苯乙烯基的基团，所述基团可能是单取代的或通过卤素，CF 3，（C 1 -C 4）烷基，（C 1 -C 4）烷氧基，氰基，氨基，单 - 或二 - （C 1 -C 4）烷基 - 氨基，（C 1 -C 4）酰基氨基，羧基，（C 1 -C 4）烷氧基羰基，氨基羰基，单 - 或二 - （C 1 -C 4）烷基氨基羰基，氨基（C 1 -C 4）烷基，羟基（C 1 -C 4）烷基或卤代（C 1 -C 4）涉及制备它们的方法和含有它们的药物组合物。这些化合物具有神经营养和神经保护活性。

4. 发明授权

US07151107B2 Use of benzoylalkyl-1,2,3,6-tetrahydropyridines 失效
公开(公告)号：US07151107B2
公开(公告)日：2006-12-19
申请号：US11135998
申请日：2005-05-24
申请人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
发明人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
IPC分类号： A61K31/4418 , C07D211/68
CPC分类号： C07D211/70 , A61K31/4418
摘要： The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.

5. 发明授权

US06936621B2 Use of benzoylalkyl-1,2,3,6-tetrahydropyridines 失效
公开(公告)号：US06936621B2
公开(公告)日：2005-08-30
申请号：US10729313
申请日：2003-12-05
申请人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
发明人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
IPC分类号： A61K31/44 , A61K31/4409 , A61K31/4418 , A61P25/00 , A61P43/00 , C07D211/70 , A61K31/435 , C07D211/68
CPC分类号： C07D211/70 , A61K31/4418
摘要： The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.

6. 发明授权

US07297799B2 Preparation of benzoylalkyl-1,2,3,6-tetrahydropyridines and use thereof 失效
标题翻译：苯甲酰基烷基-1,2,3,6-四氢吡啶的制备及其用途
公开(公告)号：US07297799B2
公开(公告)日：2007-11-20
申请号：US11555309
申请日：2006-11-01
申请人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
发明人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
IPC分类号： C07D211/70
CPC分类号： C07D211/70 , A61K31/4418
摘要： The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
摘要翻译：本发明涉及式的化合物在制备用于治疗神经元和脑障碍的药物中的应用。本发明还涉及下式的化合物：其制备方法和含有它们的药物组合物。

7. 发明申请

US20070054931A1 PREPARATION OF BENZOYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES AND USE THEREOF 失效
标题翻译：苯甲酰基-1,2,3,6-四氢吡啶的制备及其用途
公开(公告)号：US20070054931A1
公开(公告)日：2007-03-08
申请号：US11555309
申请日：2006-11-01
申请人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
发明人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
IPC分类号： C07D211/82 , A61K31/44
CPC分类号： C07D211/70 , A61K31/4418
摘要： The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
摘要翻译：本发明涉及式的化合物在制备用于治疗神经元和脑障碍的药物中的应用。本发明还涉及下式的化合物：其制备方法和含有它们的药物组合物。

8. 发明授权

US6124318A Diphenylalkyl-tetrahydropyridines, process for their preparation, and pharmaceutical compositions containing them 失效
标题翻译：二苯基烷基四氢吡啶，其制备方法和含有它们的药物组合物
公开(公告)号：US6124318A
公开(公告)日：2000-09-26
申请号：US331005
申请日：1999-07-27
申请人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi
发明人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/444 , A61K31/445 , A61P25/28 , C07D211/00 , C07D211/70 , C07D213/00 , C07D277/38 , C07D401/04 , C07D277/04 , C07D277/18
CPC分类号： C07D401/04 , C07D211/70
摘要： The invention relates to compounds of the formula ##STR1## in which: Y is --CH-- or --N--;R.sub.1 is a halogen or a CF.sub.3, (C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy group;R.sub.2 and R.sub.3 are each hydrogen or a (C.sub.1 -C.sub.3)alkyl;n is 0 or 1; andPh.sub.1 and Ph.sub.2 are each independently an unsubstituted, monosubstituted or polysubstituted phenyl group;to a process for their preparation and to the pharmaceutical compositions containing them.These compounds have neurotrophic and neuroprotective activity.
摘要翻译： PCT No.PCT / FR97 / 02289 371日期：1999年7月27日 102（e）日期1997年7月27日PCT 1997年12月11日PCT公布。第WO98 / 25904号公报日期：1998年6月18日本发明涉及下式的化合物，其中：Y为-CH-或-N-; R1是卤素或CF3，（C1-C4）烷基或（C1-C4）烷氧基; R2和R3各自为氢或（C1-C3）烷基; n为0或1; Ph1和Ph2各自独立地为未取代的单取代或多取代的苯基; 涉及其制备方法和含有它们的药物组合物。这些化合物具有神经营养和神经保护活性。

9. 发明授权

US5981754A 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity 失效
公开(公告)号：US5981754A
公开(公告)日：1999-11-09
申请号：US973712
申请日：1998-02-24
申请人： Domenico Badone , Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
发明人： Domenico Badone , Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
IPC分类号： A61K31/00 , A61K31/4418 , A61K31/4427 , A61K31/444 , A61K31/445 , A61K31/451 , A61K31/4523 , A61P25/00 , A61P25/28 , A61P35/00 , C07B37/04 , C07B61/00 , C07C1/32 , C07C15/14 , C07C29/34 , C07C33/46 , C07C41/48 , C07C43/174 , C07C51/353 , C07C57/58 , C07C67/343 , C07C69/65 , C07D211/52 , C07D211/70 , C07D401/04
CPC分类号： C07D401/04 , C07D211/52 , C07D211/70
摘要： The present invention relates to the compounds of formula (I) ##STR1## wherein Y is --CH-- or --N--; R.sub.1 is hydrogen, a halogen or a CF.sub.3, (C.sub.3 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy group; R.sub.2 is hydrogen, a halogen, a hydroxyl or a CF.sub.3, (C.sub.3 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy group; R.sub.3 and R.sub.4 are each hydrogen or a (C.sub.1 -C.sub.3)alkyl; and X is (a) a (C.sub.3 -C.sub.6)alkyl, a (C.sub.3 -C.sub.6)alkoxy, a (C.sub.3 -C.sub.7)carboxyalkyl, a (C.sub.1 -C.sub.4)-alkoxycarbonyl(C.sub.3 -C.sub.6)alkyl, a (C.sub.3 -C.sub.7)carboxyalkoxy or a (C.sub.1 -C.sub.4)alkoxycarbonyl(C.sub.3 -C.sub.6)alkoxy; (b) a radical selected from a (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkoxy, (C.sub.3 -C.sub.7)cycloalkylmethyl, (C.sub.3 -C.sub.7)cycloalkylamino and cyclohexenyl, it being possible for said radical to be substituted by a halogen, hydroxyl, (C.sub.1 -C.sub.4)alkoxy, carboxyl, (C.sub.1 -C.sub.4)alkoxycarbonyl, amino or mono- or di-(C.sub.1 -C.sub.4)alkylamino; or (c) a group selected from a phenyl, phenoxy, phenylamino, N-(C.sub.1 -C.sub.3)alkylphenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulfonyl, phenylsulfinyl and styryl, it being possible for said group to be monosubstituted or polysubstituted on the phenyl group by a halogen, CF.sub.3, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, cyano, amino, mono- or di-(C.sub.1 -C.sub.4)alkylamino, (C.sub.1 -C.sub.4)acylamino, carboxyl, (C.sub.1 -C.sub.4)-alkoxycarbonyl, aminocarbonyl, mono- or di-(C.sub.1 -C.sub.4)-alkyl-aminocarbonyl, amino(C.sub.1 -C.sub.4)alkyl, hydroxy(C.sub.1 -C.sub.4)alkyl or halogeno(C.sub.1 -C.sub.4)alkyl, as well as the salts and solvates thereof and the quaternary ammonium salts thereof; to a process for their preparation and to pharmaceutical compositions containing them.These compounds have a neurotrophic and neuroprotective activity.

10. 发明授权

US06509351B1 Phenyl- and pyridyl-tetrahydro-pyridines having TNF inhibiting activity 有权
标题翻译：具有TNF抑制活性的苯基 - 和吡啶基 - 四氢 - 吡啶
公开(公告)号：US06509351B1
公开(公告)日：2003-01-21
申请号：US10111045
申请日：2002-04-19
申请人： Marco Baroni , Bernard Bourrie , Rosanna Cardamone , Pierre Casellas , Umberto Guzzi
发明人： Marco Baroni , Bernard Bourrie , Rosanna Cardamone , Pierre Casellas , Umberto Guzzi
IPC分类号： C07D40106
CPC分类号： C07D401/06 , A43B7/125 , A43B9/02 , B29C2045/14844 , B29D35/0045 , B29D35/06 , B29D35/062 , B29D35/122 , B29D35/128 , B29D35/142 , C07D215/14 , C07D217/02 , C07D401/14
摘要： The present invention relates to compounds of formula (I): as well as the salts or solvates thereof, to pharmaceutical compositions containing them, to a process for preparing them and to synthetic intermediates in this process.
摘要翻译：本发明涉及式（I）化合物：以及其盐或溶剂合物，含有它们的药物组合物，其制备方法和该方法中的合成中间体。

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