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1. 发明授权

US08518947B2 (Heterocycle/tetrahydropyridine)-(piperazinyl)-1-alcanone and (heterocycle/dihydropyrrolidine)-(piperazinyl)-1-alcanone derivatives, and use thereof as p75 inhibitors 有权
标题翻译：（杂环/四氢吡啶） - （哌嗪基）-1-阿卡酮和（杂环/二氢吡咯烷） - （哌嗪基）-1-阿糖酮衍生物，及其作为p75抑制剂的用途
公开(公告)号：US08518947B2
公开(公告)日：2013-08-27
申请号：US13490905
申请日：2012-06-07
申请人： Marco Baroni , Francoise Bono , Sandrine Delbary-Gossart , Valentina Vercesi
发明人： Marco Baroni , Francoise Bono , Sandrine Delbary-Gossart , Valentina Vercesi
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D487/08 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D495/04
摘要： The disclosure relates to (heterocycle-tetrahydropyridine)(piperazinyl)-1-alkanone and (heterocycle-dihydropyrrolidine)(piperazinyl)-1-alkanone derivatives of formula (I): wherein A, B, m, n, W, and R2 are as defined in the disclosure; to the methods of preparing said derivatives, and to the therapeutic uses thereof.
摘要翻译：本公开涉及式（I）的（杂环 - 四氢吡啶）（哌嗪基）-1-烷酮和（杂环 - 二氢吡咯烷）（哌嗪基）-1-烷酮衍生物：其中A，B，m，n，W和R2为如本公开中所定义的; 涉及制备所述衍生物的方法及其治疗用途。

2. 发明申请

US20120289518A1 DERIVATIVES OF 2-OXOALKYL-1-PIPERAZIN-2-ONE, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME 审中-公开
标题翻译： 2-氧杂环戊烯-1-哌啶-2-酮的衍生物，其制备方法及其治疗方法
公开(公告)号：US20120289518A1
公开(公告)日：2012-11-15
申请号：US13556328
申请日：2012-07-24
申请人： Marco BARONI , Francoise BONO , Sandrine DELBARY-GOSSART
发明人： Marco BARONI , Francoise BONO , Sandrine DELBARY-GOSSART
IPC分类号： A61K31/496 , A61P25/08 , A61P25/28 , A61P25/16 , A61P25/14 , A61P25/00 , A61P25/18 , A61P25/24 , A61P9/04 , A61P9/10 , A61P27/02 , A61P27/06 , A61P35/00 , A61P35/04 , A61P35/02 , A61P11/00 , A61P37/08 , A61P11/06 , A61P29/00 , A61P37/06 , A61P19/08 , A61P19/10 , C07D211/70
CPC分类号： C07D401/14
摘要： The present invention relates to derivatives of 4-{2-[phenyl-3,6-dihydropyridin-1-yl]-2-oxoalkyl}-1-piperazin-2-one and 4-{2-[phenyl-2,5-dihydropyrrol-1-yl]-2-oxoalkyl}-1-piperazin-2-one having general formula (I): in which A, B, m, R3 and n are as defined herein. The invention also relates to the preparation thereof and to the therapeutic use thereof.
摘要翻译：本发明涉及4- {2- [苯基-3,6-二氢吡啶-1-基] -2-氧代烷基} -1-哌嗪-2-酮和4- {2- [苯基-2,5 - 二氢吡咯-1-基] -2-氧代烷基} -1-哌嗪-2-酮，其中A，B，m，R 3和n如本文所定义。本发明还涉及其制备及其治疗用途。

3. 发明申请

US20110312972A1 SUBSTITUTED 3-BENZOFURANYL-INDOL-2-ONE-3-ACETAMIDIDOPIPERAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF 审中-公开
标题翻译：取代的3-苯并呋喃-2-吲哚-2-酮-3-乙酰氨基哌啶衍生物，其制备方法及其治疗方法
公开(公告)号：US20110312972A1
公开(公告)日：2011-12-22
申请号：US13201141
申请日：2010-02-09
申请人： Marco Baroni , Letizia Puleo
发明人： Marco Baroni , Letizia Puleo
IPC分类号： A61K31/496 , A61P3/00 , A61P3/10 , C07D407/14 , A61P3/04
CPC分类号： A61K31/496 , A61K31/454 , C07D405/04 , C07D405/14
摘要： The invention relates to disubstituted 3-benzofuranyl-indol-2-one-3-acetamidopiperazine derivatives of the general formula (I) where R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are such as defined in claim 1, to a method for preparing same, and to the therapeutic use of said compounds.
摘要翻译：本发明涉及通式（I）的二取代3-苯并呋喃基 - 吲哚-2-酮-3-乙酰氨基哌嗪衍生物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9和n如定义在权利要求1中，涉及其制备方法和所述化合物的治疗用途。

4. 发明申请

US20110120055A1 ENCLOSING STRUCTURE FOR CONTAINER PACKAGING MACHINES AND/OR MACHINE UNITS, IN PARTICULAR CAPPING MACHINES 审中-公开
标题翻译：集装箱包装机器和/或机器单元，特别是机器的封闭结构
公开(公告)号：US20110120055A1
公开(公告)日：2011-05-26
申请号：US12989209
申请日：2009-04-20
申请人： Marco Baroni , Gianpietro Zanini
发明人： Marco Baroni , Gianpietro Zanini
IPC分类号： B65B7/00
CPC分类号： B67C3/22 , B67B3/00 , B67C7/002
摘要： A packaging machine or machine unit, as used in particular for capping containers (5), is enclosed by a structure (1) that comprises a casing (2) positioned at least in part around the active components (3) of a packaging unit (4) supplied with open containers (5). The casing (2) comprises a fixed cowl (13) encompassing the components (3) of the packaging unit (4), and a movable cowl (23) furnished with at least one sealing element (4). The movable cowl (23) is capable of movement between an open configuration, in which a gap (23a) is created between the fixed cowl (13) and the movable cowl (23) so as to place the fixed cowl (13) in fluid communication with the surrounding atmosphere, and a closed configuration in which the sealing element (24) of the movable cowl (23) engages the fixed cowl (13), occluding the gap (23a) and consequently isolating the interior of the fixed cowl (13) from the surrounding atmosphere.
摘要翻译：用于特别是封盖容器（5）的包装机器或机器单元由包括至少部分位于包装单元的有源部件（3）周围的壳体（2）的结构（1）包围， 4）提供开放式容器（5）。壳体（2）包括包围包装单元（4）的部件（3）的固定罩（13）和设置有至少一个密封元件（4）的可移动整流罩（23）。可移动整流罩23能够在打开构型之间移动，在打开构型中，在固定罩（13）和可动罩（23）之间产生间隙（23a），以便将固定罩（13）放置在流体与周围大气的通信，以及闭合构造，其中可移动整流罩（23）的密封元件（24）接合固定罩（13），闭合间隙（23a）并因此隔离固定罩（13）的内部）从周围的气氛。

5. 发明授权

US07858824B2 Aralkyltetrahydropyridines, their preparation and pharmaceutical compositions containing them 失效
标题翻译：芳烷基四氢吡啶，其制备方法和含有它们的药物组合物
公开(公告)号：US07858824B2
公开(公告)日：2010-12-28
申请号：US11958476
申请日：2007-12-18
申请人： Marco Baroni , Bernard Bourrie , Rosanna Cardamone , Pierre Casellas
发明人： Marco Baroni , Bernard Bourrie , Rosanna Cardamone , Pierre Casellas
IPC分类号： C07C61/29
CPC分类号： C07D401/04 , C07D211/70
摘要： The present invention relates to compounds of formula (IIIo): in which n is an integer from 1 to 5; Ao represents a partially saturated carbonaceous bi- or tricycle; it also relates to their salts, solvates, N-oxides, the pharmaceutical compositions containing them, a method for their preparation and synthesis intermediates in this method.
摘要翻译：本发明涉及式（IIIo）化合物：其中n为1至5的整数; Ao代表部分饱和的含碳双环或三轮车; 它还涉及它们的盐，溶剂合物，N-氧化物，含有它们的药物组合物，其制备方法和该方法中的合成中间体。

6. 发明授权

US07836664B2 Unit for fitting screw caps to the necks of respective containers 失效
标题翻译：将螺丝帽安装到各个容器的颈部的单元
公开(公告)号：US07836664B2
公开(公告)日：2010-11-23
申请号：US12227288
申请日：2007-05-15
申请人： Gianpietro Zanini , Marco Baroni
发明人： Gianpietro Zanini , Marco Baroni
IPC分类号： B67B1/06
CPC分类号： B67B3/2033
摘要： Screw caps (2) are fitted to the necks of respective containers (3) by a unit comprising a carousel equipped with a platform on which the containers are placed, a frame positioned above the platform, and a drive system by which the platform and the frame are set in rotation about a main vertical axis. The unit comprises at least one screw capping device (7) associated with the rotating frame of the carousel, located above a respective container (3) and equipped with a gripping mechanism (9) lockable onto the cap (2) of the container, also a first motion-inducing linkage (25) by which the gripping mechanism (9) is caused to rotate about an axis (Y) parallel to the main vertical axis, and a second motion-inducing linkage (37) by which the gripping mechanism (9) is moved toward or away from the respective cap (2). The screw capping device (7) is packaged internally of a box-like body (10) associated removably with the rotating frame and housing the gripping mechanism (9).
摘要翻译：螺旋盖（2）通过一个单元安装到相应容器（3）的颈部，该单元包括配备有放置容器的平台的转盘，位于平台上方的框架和驱动系统，通过该驱动系统，平台和框架围绕主垂直轴线旋转设置。该单元包括至少一个螺旋盖装置（7），其与转盘的旋转框架相关联，位于相应的容器（3）上方并配备有可锁定到容器的盖（2）上的夹紧机构（9）使夹持机构（9）围绕平行于主垂直轴的轴线（Y）旋转的第一运动诱导联动装置（25），以及第二运动诱导联动装置（37），夹紧机构 9）朝向或远离相应的盖（2）移动。螺旋盖装置（7）被包装在与旋转框架可拆卸地相关联并且容纳夹持机构（9）的盒状主体（10）的内部。

7. 发明申请

US20100192514A1 CAPPING MACHINE 有权
标题翻译：封盖机
公开(公告)号：US20100192514A1
公开(公告)日：2010-08-05
申请号：US12671142
申请日：2008-08-01
申请人： Gianpietro Zanini , Marco Baroni
发明人： Gianpietro Zanini , Marco Baroni
IPC分类号： B67B3/20
CPC分类号： B67B3/10 , B67B3/2033 , B67B3/28
摘要： A capping machine (1) of carousel design comprises a centre shaft (2) turning on a fixed base frame (3) about a vertical axis of rotation (Y), a set of capping units (4) encircling and revolving as one with the shaft (2) about the axis of rotation (Y), and a cylindrical cam (5) interposed between the shaft (2) and the capping units (4), by which the single units (4) are caused to move toward and away from the fixed base frame (3). During operation, the cam (5) is held in at least one predetermined fixed position relative to the base frame (3) by a single supporting element (6) anchored to the base frame (3), concealed internally of the rotating shaft (2) and connected to the cam (5), which represents a departure from the conventional method of supporting the cam on two or more columns located externally of the carousel structure and exposed to view.
摘要翻译：圆盘传送带设计的封盖机（1）包括围绕垂直旋转轴线（Y）转动固定基座框架（3）的中心轴（2），围绕旋转的一组封盖单元（4）轴（2）围绕旋转轴线（Y），以及插入在轴（2）和封盖单元（4）之间的圆柱形凸轮（5），单个单元（4）通过该圆筒凸轮朝向和远离从固定基架（3）。在操作期间，凸轮（5）通过锚固到基架（3）的单个支撑元件（6）相对于基架（3）保持在至少一个预定的固定位置，隐藏在旋转轴（2）的内部）并且连接到凸轮（5），这代表了偏离凸轮在传送带结构外部暴露在两个或更多个柱上的常规方法的偏离。

8. 发明授权

US07297799B2 Preparation of benzoylalkyl-1,2,3,6-tetrahydropyridines and use thereof 失效
标题翻译：苯甲酰基烷基-1,2,3,6-四氢吡啶的制备及其用途
公开(公告)号：US07297799B2
公开(公告)日：2007-11-20
申请号：US11555309
申请日：2006-11-01
申请人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
发明人： Marco Baroni , Rosanna Cardamone , Jacqueline Fournier , Umberto Guzzi , Alessandra Ielmini
IPC分类号： C07D211/70
CPC分类号： C07D211/70 , A61K31/4418
摘要： The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
摘要翻译：本发明涉及式的化合物在制备用于治疗神经元和脑障碍的药物中的应用。本发明还涉及下式的化合物：其制备方法和含有它们的药物组合物。

9. 发明授权

US07211578B2 Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity 失效
标题翻译：具有TNF活性的含氮四氢吡啶基 - 烷基 - 杂环
公开(公告)号：US07211578B2
公开(公告)日：2007-05-01
申请号：US10495890
申请日：2002-11-18
申请人： Marco Baroni , Bernard Bourrie , Pierre Casellas , Letizia Puleo
发明人： Marco Baroni , Bernard Bourrie , Pierre Casellas , Letizia Puleo
IPC分类号： C07D401/10 , A61K31/4523 , A61K31/4545
CPC分类号： C07D401/10
摘要： This invention relates to nitrogenous (tetrahydropyridyl)(alkyl)heterocycles, to pharmaceutical compositions comprising them, to processes for preparing them and to the method of use thereof in the treatment of pain and diseases related to immune and inflammatory disorders.
摘要翻译：本发明涉及含氮（四氢吡啶基）（烷基）杂环，包含它们的药物组合物，其制备方法及其用于治疗与免疫和炎性疾病相关的疼痛和疾病的方法。

10. 发明申请

US20050004132A1 Nitrogenous tetrahydropyridyl-alkyl-heterocycles with tnf activity 失效
标题翻译：具有tnf活性的含氮四氢吡啶基 - 烷基 - 杂环
公开(公告)号：US20050004132A1
公开(公告)日：2005-01-06
申请号：US10495890
申请日：2002-11-18
申请人： Marco Baroni , Bernard Bourrie , Pierre Casellas , Letizia Puleo
发明人： Marco Baroni , Bernard Bourrie , Pierre Casellas , Letizia Puleo
IPC分类号： C07D401/08 , A61K31/4545 , A61K31/497 , A61P1/00 , A61P3/10 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/02 , A61P35/00 , A61P37/02 , A61P43/00 , C07D401/10 , C07D401/14 , C07D403/08 , A61K31/506 , A61K31/444 , C07
CPC分类号： C07D401/10
摘要： This invention relates to nitrogenous (tetrahydropyridyl)(alkyl)heterocycles, to pharmaceutical compositions comprising them, to processes for preparing them and to the method of use thereof in the treatment of pain and diseases related to immune and inflammatory disorders.
摘要翻译：本发明涉及含氮（四氢吡啶基）（烷基）杂环，包含它们的药物组合物，其制备方法及其用于治疗与免疫和炎性疾病相关的疼痛和疾病的方法。

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