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1. 发明授权

US07722811B2 Tissue processor 有权
标题翻译：组织处理器
公开(公告)号：US07722811B2
公开(公告)日：2010-05-25
申请号：US11562710
申请日：2006-11-22
申请人： Marc Konrad , Stefan Künkel , Holger Metzner , Eberhard Sendobry , Markus Dobusch
发明人： Marc Konrad , Stefan Künkel , Holger Metzner , Eberhard Sendobry , Markus Dobusch
IPC分类号： G01N21/00
CPC分类号： G01N1/31 , B01L3/16 , G01N35/1067 , G01N35/1072 , Y10T436/113332
摘要： A tissue processor (1) is described, having a retort (2) for processing histological samples with different reagents, having multiple reagent reservoir vessels (3), and having a conduit system and a control device (5) for delivering reagents out of the reagent reservoir vessels (3) into the retort (2). A suction conduit (11) projects into each reagent reservoir vessel (3) through the vessel opening (7) for reagent withdrawal. A closure system (12) having an externally tapered and internally hollow closure plug (13) is provided for closing off the vessel opening (7). The suction conduit (11) is guided through a cavity (14) of the closure plug (13) for reagent withdrawal.
摘要翻译：描述了一种组织处理器（1），其具有用于用不同试剂处理组织学样品的蒸馏器（2），具有多个试剂储存容器（3），并具有导管系统和控制装置（5），用于将试剂输出试剂库容器（3）进入蒸馏器（2）。抽吸管道（11）通过容器开口（7）突出到每个试剂储存容器（3）中以用于试剂取出。提供具有外锥形和内部中空的封闭塞（13）的封闭系统（12），用于封闭容器开口（7）。吸入管道（11）被引导通过封闭塞（13）的空腔（14）以用于试剂取出。

2. 发明申请

US20070122910A1 Tissue Processor 有权
标题翻译：组织处理器
公开(公告)号：US20070122910A1
公开(公告)日：2007-05-31
申请号：US11562710
申请日：2006-11-22
申请人： Marc Konrad , Stefan Kunkel , Holger Metzner , Eberhard Sendobry , Markus Dobusch
发明人： Marc Konrad , Stefan Kunkel , Holger Metzner , Eberhard Sendobry , Markus Dobusch
IPC分类号： G01N35/02
CPC分类号： G01N1/31 , B01L3/16 , G01N35/1067 , G01N35/1072 , Y10T436/113332
摘要： A tissue processor (1) is described, having a retort (2) for processing histological samples with different reagents, having multiple reagent reservoir vessels (3), and having a conduit system and a control device (5) for delivering reagents out of the reagent reservoir vessels (3) into the retort (2). A suction conduit (11) projects into each reagent reservoir vessel (3) through the vessel opening (7) for reagent withdrawal. A closure system (12) having an externally tapered and internally hollow closure plug (13) is provided for closing off the vessel opening (7). The suction conduit (11) is guided through a cavity (14) of the closure plug (13) for reagent withdrawal.
摘要翻译：描述了一种组织处理器（1），其具有用于用不同试剂处理组织学样品的蒸馏器（2），具有多个试剂储存器容器（3），并且具有导管系统和控制装置（5），用于将试剂输出试剂库容器（3）进入蒸馏器（2）。抽吸管道（11）通过容器开口（7）突出到每个试剂储存容器（3）中以用于试剂取出。提供具有外锥形和内部中空的封闭塞（13）的封闭系统（12），用于封闭容器开口（7）。吸入管道（11）被引导通过封闭塞（13）的空腔（14）以用于试剂取出。

3. 发明授权

US08039262B2 Method for controlling a tissue processor and tissue processor 有权
标题翻译：用于控制组织处理器和组织处理器的方法
公开(公告)号：US08039262B2
公开(公告)日：2011-10-18
申请号：US12545586
申请日：2009-08-21
申请人： Marc Konrad , Holger Metzner , Udo Hermann , Frank Meder , Hermann Ulbrich , Markus Dobusch , Stefan Künkel
发明人： Marc Konrad , Holger Metzner , Udo Hermann , Frank Meder , Hermann Ulbrich , Markus Dobusch , Stefan Künkel
IPC分类号： C12Q3/00 , C12M1/36 , C12M3/00 , G01N33/48
CPC分类号： G01N35/00623 , Y10T436/11 , Y10T436/115831 , Y10T436/12
摘要： A method for controlling a tissue processor and a tissue processor for processing tissue samples is described. A retort is provided including a cover that can be opened and closed by an operator. The retort cover is closed prior to tissue processing. The actuation state of a first and a second operating element can be determined. An operator is prompted to confirm unlocking of the closed retort cover by actuating a second operating element. The tissue processing is interrupted when an actuation of the second operating element is determined and the closed retort cover is unlocked and is continued after the retort cover is once again locked. After having completed tissue processing the retort cover is unlocked. By means of the described method and tissue processor improper intervention during ongoing tissue processing is prevented.
摘要翻译：描述了一种用于控制组织处理器和用于处理组织样本的组织处理器的方法。提供了一种蒸煮器，其包括可由操作者打开和关闭的盖子。在组织处理之前关闭蒸煮盖。可以确定第一和第二操作元件的致动状态。提示操作者通过致动第二操作元件来确认关闭的蒸煮盖的解锁。当确定第二操作元件的致动并且关闭的蒸煮盖被解锁并在蒸煮盖再次被锁定之后继续时，纸巾处理被中断。在完成纸巾处理后，解冻盖子。通过所描述的方法和组织处理器，防止在持续的组织处理期间不适当的干预。

4. 发明申请

US20100055663A1 METHOD FOR CONTROLLING A TISSUE PROCESSOR AND TISSUE PROCESSOR 有权
标题翻译：用于控制组织处理器和组织处理器的方法
公开(公告)号：US20100055663A1
公开(公告)日：2010-03-04
申请号：US12545586
申请日：2009-08-21
申请人： Marc Konrad , Holger Metzner , Udo Hermann , Frank Meder , Hermann Ulbrich , Markus Dobusch , Stefan Künkel
发明人： Marc Konrad , Holger Metzner , Udo Hermann , Frank Meder , Hermann Ulbrich , Markus Dobusch , Stefan Künkel
IPC分类号： C12M1/00 , C12Q3/00
CPC分类号： G01N35/00623 , Y10T436/11 , Y10T436/115831 , Y10T436/12
摘要： A method for controlling a tissue processor and a tissue processor for processing tissue samples is described. A retort is provided comprising a cover that can be opened and closed by an operator. The retort cover is closed prior to tissue processing. The actuation state of a first and a second operating element can be determined. An operator is prompted to confirm unlocking of the closed retort cover by actuating a second operating element. The tissue processing is interrupted when an actuation of the second operating element is determined and the closed retort cover is unlocked and is continued after the retort cover is once again locked. After having completed tissue processing the retort cover is unlocked. By means of the described method and tissue processor improper intervention during ongoing tissue processing is prevented.
摘要翻译：描述了一种用于控制组织处理器和用于处理组织样本的组织处理器的方法。提供了一种蒸煮器，其包括可由操作者打开和关闭的盖子。在组织处理之前关闭蒸煮盖。可以确定第一和第二操作元件的致动状态。提示操作者通过致动第二操作元件来确认关闭的蒸煮盖的解锁。当确定第二操作元件的致动并且关闭的蒸煮盖被解锁并在蒸煮盖再次被锁定之后继续时，纸巾处理被中断。在完成纸巾处理后，解冻盖子。通过所描述的方法和组织处理器，防止在持续的组织处理期间不适当的干预。

5. 发明授权

US08557511B2 Method and apparatus for infiltrating tissue samples with paraffin 有权
标题翻译：用石蜡渗透组织样本的方法和装置
公开(公告)号：US08557511B2
公开(公告)日：2013-10-15
申请号：US12542523
申请日：2009-08-17
申请人： Hermann Ulbrich , Michael Rapp , Marc Konrad , Holger Metzner , Markus Dobusch , Eva Goedecke , Stefan Kuenkel , Udo Herrmann
发明人： Hermann Ulbrich , Michael Rapp , Marc Konrad , Holger Metzner , Markus Dobusch , Eva Goedecke , Stefan Kuenkel , Udo Herrmann
IPC分类号： C12M1/36
CPC分类号： G01N1/31 , G01N1/36
摘要： A method and an apparatus are described for infiltrating tissue samples with carrier material, preferably paraffin. A supply of carrier material is kept ready for use in a supply station. From there, the carrier material can be delivered into at least a first and a second container. In these first and second containers carrier materials of differing degrees of purity are kept ready for use, respectively, for performing various infiltration steps on tissue samples. By means of the described method and apparatus the tissue processor can be operated with as little interruptions as possible and an ease in operation is achieved.
摘要翻译：描述了用载体材料（优选石蜡）渗透组织样品的方法和装置。供应载体材料的供应准备供供应站使用。从那里，载体材料可以被输送到至少第一和第二容器中。在这些第一和第二容器中，不同程度的纯度的载体材料分别保持准备用于在组织样品上进行各种渗透步骤。通过所描述的方法和装置，组织处理器可以以尽可能少的中断进行操作并且实现易于操作。

6. 发明申请

US20100055788A1 METHOD AND APPARATUS FOR INFILTRATING TISSUE SAMPLES WITH PARAFFIN 有权
标题翻译：用PARAFFIN浸泡组织样品的方法和装置
公开(公告)号：US20100055788A1
公开(公告)日：2010-03-04
申请号：US12542523
申请日：2009-08-17
申请人： Hermann Ulbrich , Michael Rapp , Marc Konrad , Holger Metzner , Markus Dobusch , Eve Goedecke , Stefan Kuenkel , Udo Herrmann
发明人： Hermann Ulbrich , Michael Rapp , Marc Konrad , Holger Metzner , Markus Dobusch , Eve Goedecke , Stefan Kuenkel , Udo Herrmann
IPC分类号： C12N5/06 , C12M3/00
CPC分类号： G01N1/31 , G01N1/36
摘要： A method and an apparatus are described for infiltrating tissue samples with carrier material, preferably paraffin. A supply of carrier material is kept ready for use in a supply station. From there, the carrier material can be delivered into at least a first and a second container. In these first and second containers carrier materials of differing degrees of purity are kept ready for use, respectively, for performing various infiltration steps on tissue samples. By means of the described method and apparatus the tissue processor can be operated with as little interruptions as possible and an ease in operation is achieved.
摘要翻译：描述了用载体材料（优选石蜡）渗透组织样品的方法和装置。供应载体材料的供应准备供供应站使用。从那里，载体材料可以被输送到至少第一和第二容器中。在这些第一和第二容器中，不同程度的纯度的载体材料分别保持准备用于在组织样品上进行各种渗透步骤。通过所描述的方法和装置，组织处理器可以以尽可能少的中断进行操作并且实现易于操作。

7. 发明授权

US08071026B2 Tissue Processor 有权
标题翻译：组织处理器
公开(公告)号：US08071026B2
公开(公告)日：2011-12-06
申请号：US12545430
申请日：2009-08-21
申请人： Michael Rapp , Marc Konrad , Markus Dobusch , Stefan Kuenkel
发明人： Michael Rapp , Marc Konrad , Markus Dobusch , Stefan Kuenkel
IPC分类号： G01N21/00
CPC分类号： G01N1/31 , G01N2035/00306 , G01N2035/0498
摘要： A tissue processor is described that comprises a retort for processing histological samples using various reagents, a plurality of exchangeable reagent supply containers that each comprise at least one container opening, a system of conduits, a control device for conveying reagents out of the reagent supply containers through at least one reagent conduit into the retort, and system bottles. The reagent supply containers and the system bottles are connected via the pertinent reagent conduits to at least one valve. The valve is electrically connected to the control device such that at least one of filling and emptying of the system bottles with reagents from the reagent supply containers is controlled. This design allows differently dimensioned reagent supply containers while at the same time minimizing the space requirement for the reagent containers.
摘要翻译：描述了一种组织处理器，其包括用于使用各种试剂处理组织学样品的蒸馏器，多个可更换试剂供应容器，每个可更换试剂供应容器各自包括至少一个容器开口，管道系统，用于将试剂输送出试剂供应容器的控制装置通过进入蒸馏器的至少一个试剂管道和系统瓶子。试剂供应容器和系统瓶通过相关试剂导管连接至至少一个阀。该阀与控制装置电连接，从而控制用来自试剂供应容器的试剂填充和排空系统瓶中的至少一个。该设计允许不同尺寸的试剂供应容器，同时最小化试剂容器的空间要求。

8. 发明申请

US20100055777A1 TISSUE PROCESSOR 有权
标题翻译：组织加工商
公开(公告)号：US20100055777A1
公开(公告)日：2010-03-04
申请号：US12545430
申请日：2009-08-21
申请人： Michael Rapp , Marc Konrad , Markus Dobusch , Stefan Kuenkel
发明人： Michael Rapp , Marc Konrad , Markus Dobusch , Stefan Kuenkel
IPC分类号： C12M1/00
CPC分类号： G01N1/31 , G01N2035/00306 , G01N2035/0498
摘要： A tissue processor is described that comprises a retort for processing histological samples using various reagents, a plurality of exchangeable reagent supply containers that each comprise at least one container opening, a system of conduits, a control device for conveying reagents out of the reagent supply containers through at least one reagent conduit into the retort, and system bottles. The reagent supply containers and the system bottles are connected via the pertinent reagent conduits to at least one valve. The valve is electrically connected to the control device such that at least one of filling and emptying of the system bottles with reagents from the reagent supply containers is controlled. This design allows differently dimensioned reagent supply containers while at the same time minimizing the space requirement for the reagent containers.
摘要翻译：描述了一种组织处理器，其包括用于使用各种试剂处理组织学样品的蒸馏器，多个可更换试剂供应容器，每个可更换试剂供应容器各自包括至少一个容器开口，管道系统，用于将试剂输送出试剂供应容器的控制装置通过进入蒸馏器的至少一个试剂管道和系统瓶子。试剂供应容器和系统瓶通过相关试剂导管连接至至少一个阀。该阀与控制装置电连接，从而控制用来自试剂供应容器的试剂填充和排空系统瓶中的至少一个。该设计允许不同尺寸的试剂供应容器，同时最小化试剂容器的空间要求。

9. 发明申请

US20100216222A1 Tissue Infiltration Device 有权
标题翻译：组织浸润装置
公开(公告)号：US20100216222A1
公开(公告)日：2010-08-26
申请号：US12677915
申请日：2008-09-16
申请人： Hermann Ulbrich , Marc Konrad , Peter Richter
发明人： Hermann Ulbrich , Marc Konrad , Peter Richter
IPC分类号： C12M3/00
CPC分类号： G01N1/31 , Y10T436/2575
摘要： The present invention relates to a tissue infiltration device (1) for samples (34) contained in cassettes (5). The tissue infiltration device (1) comprises at least two liquid containers (7, 11a-11d, 13, 15) and a transport apparatus (6). A liquid (12, 14, 16) having a property that can be predetermined can be filled into a liquid container (7, 11a-11d, 13, 15). A plurality of cassettes (5) can be held by a transport device (4). Using the transport apparatus (6), a transport device (4) can be brought to a liquid container (7, 11a-11d, 13, 15) and/or moved away from a liquid container (7, 11a-11d, 13, 15). A sequence of operations (8) can be prescribed in which a transport device (4) runs through the liquid containers (7, 11a-11d, 13, 15) of the tissue infiltration device (1). So that an accelerated or priority processing of a transport device (4) is possible using the tissue infiltration device (1), but without using an additional liquid container (7, 11a-11d, 13, 15) provided only for this purpose, it is provided that at least two transport devices (4) can be brought into a liquid container (7, 11a-11d, 13, 15) above and/or next to one another, wherein said transport devices can have different dwell times in the liquid container (7, 11a-11d, 13, 15).
摘要翻译：本发明涉及包含在盒（5）中的样品（34）的组织浸润装置（1）。组织浸润装置（1）包括至少两个液体容器（7,11a-11d，13,15）和输送装置（6）。具有可以预定的性质的液体（12,14,16）可以填充到液体容器（7,11a-11d，13,15）中。多个盒（5）可以由传送装置（4）保持。使用运送装置（6），运送装置（4）可以被带到液体容器（7,11a-11d，13,15）和/或从液体容器（7,11a-11d，13， 15）。可以规定运输装置（4）穿过组织浸渗装置（1）的液体容器（7,11a-11d，13,15）的操作顺序（8）。因此，可以使用组织浸渗装置（1）对运输装置（4）进行加速或优先处理，但不使用仅为此目的提供的另外的液体容器（7,11a-11d，13,15）提供了至少两个输送装置（4）可以被引入到彼此上方和/或彼此相邻的液体容器（7,11a-11d，13,15）中，其中所述输送装置在液体中可以具有不同的停留时间容器（7,11a-11d，13,15）。

10. 发明授权

US08337781B2 Tissue infiltration device 有权
标题翻译：组织浸润装置
公开(公告)号：US08337781B2
公开(公告)日：2012-12-25
申请号：US12677915
申请日：2008-09-16
申请人： Hermann Ulbrich , Marc Konrad , Peter Richter
发明人： Hermann Ulbrich , Marc Konrad , Peter Richter
IPC分类号： A61B10/00
CPC分类号： G01N1/31 , Y10T436/2575
摘要： The present invention relates to a tissue infiltration device (1) for samples (34) contained in cassettes (5). The tissue infiltration device (1) comprises at least two liquid containers (7, 11a-11d, 13, 15) and a transport apparatus (6). A liquid (12, 14, 16) having a property that can be predetermined can be filled into a liquid container (7, 11a-11d, 13, 15). A plurality of cassettes (5) can be held by a transport device (4). Using the transport apparatus (6), a transport device (4) can be brought to a liquid container (7, 11a-11d, 13, 15) and/or moved away from a liquid container (7, 11a-11d, 13, 15). A sequence of operations (8) can be prescribed in which a transport device (4) runs through the liquid containers (7, 11a-11d, 13, 15) of the tissue infiltration device (1). So that an accelerated or priority processing of a transport device (4) is possible using the tissue infiltration device (1), but without using an additional liquid container (7, 11a-11d, 13, 15) provided only for this purpose, it is provided that at least two transport devices (4) can be brought into a liquid container (7, 11a-11d, 13, 15) above and/or next to one another, wherein said transport devices can have different dwell times in the liquid container (7, 11a-11d, 13, 15).
摘要翻译：本发明涉及包含在盒（5）中的样品（34）的组织浸润装置（1）。组织浸润装置（1）包括至少两个液体容器（7,11a-11d，13,15）和输送装置（6）。具有可以预定的性质的液体（12,14,16）可以填充到液体容器（7,11a-11d，13,15）中。多个盒（5）可以由传送装置（4）保持。使用运送装置（6），运送装置（4）可以被带到液体容器（7,11a-11d，13,15）和/或从液体容器（7,11a-11d，13， 15）。可以规定运输装置（4）穿过组织浸渗装置（1）的液体容器（7,11a-11d，13,15）的操作顺序（8）。因此，可以使用组织浸渗装置（1）对运输装置（4）进行加速或优先处理，但不使用仅为此目的提供的另外的液体容器（7,11a-11d，13,15）提供了至少两个输送装置（4）可以被引入到彼此上方和/或彼此相邻的液体容器（7,11a-11d，13,15）中，其中所述输送装置可以在液体中具有不同的停留时间容器（7,11a-11d，13,15）。

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