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1. 发明申请

US20110014719A1 CARTRIDGE FOR ASSAYS WITH MAGNETIC PARTICLES 审中-公开
标题翻译：用于磁性颗粒测定的盒子
公开(公告)号：US20110014719A1
公开(公告)日：2011-01-20
申请号：US12922887
申请日：2009-03-11
申请人： Mara Johanna Jacoba Sijbers , Petrus Johannes Wilhelmus Van Lankvelt , Femke Karina De Theije , Jeroen Hans Nieuwenhuis
发明人： Mara Johanna Jacoba Sijbers , Petrus Johannes Wilhelmus Van Lankvelt , Femke Karina De Theije , Jeroen Hans Nieuwenhuis
IPC分类号： G01N27/00 , G01N21/00 , G01N25/00
CPC分类号： G01N33/54333 , B03C1/282 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N27/745 , G01N33/54373 , G01N33/946 , G01N33/948 , G01N33/9486
摘要： The invention relates to a cartridge (100) and a corresponding sensor device for the detection of target components in a liquid sample. The cartridge (100) comprises a sample chamber(SC), at least two reservoirs(131, 132) that can be furnished with magnetic particles(MP, MP′), and at least two corresponding sensitive zones (121, 122) in which solved magnetic particles and/or target components can be detected. When a magnetic actuation field(B) of a given configuration is established in the sample chamber, the magnetic particles of different reservoirs migrate predominantly to different sensitive zones. Thus a mixing of magnetic particles can be avoided.
摘要翻译：本发明涉及一种用于检测液体样品中的目标组分的盒（100）和相应的传感器装置。盒（100）包括样品室（SC），至少两个可以配备有磁性颗粒（MP，MP'）和至少两个对应的敏感区域（121,122）的储存器（131,132），其中可以检测到溶解的磁性颗粒和/或目标成分。当在样品室中建立给定构造的磁致动场（B）时，不同储层的磁性颗粒主要迁移到不同的敏感区域。因此，可以避免磁性颗粒的混合。

2. 发明授权

US09557328B2 Magnetic sensor device, method of operating such a device and sample 有权
标题翻译：磁传感器装置，操作这种装置和样品的方法
公开(公告)号：US09557328B2
公开(公告)日：2017-01-31
申请号：US13381115
申请日：2010-06-24
申请人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
发明人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
IPC分类号： G01N33/543 , G01N27/74 , G01N21/552
CPC分类号： G01N33/54326 , G01N21/552 , G01N27/745 , G01N33/54366 , G01N33/54386
摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40′). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14′) from the detection of the further detectable label (40′) in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14′) falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.
摘要翻译：公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生来自所述第一检测信号在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。

3. 发明申请

US20120107961A1 MAGNETIC SENSOR DEVICE, METHOD OF OPERATING SUCH A DEVICE AND SAMPLE 有权
标题翻译：磁传感器装置，操作这种装置和样品的方法
公开(公告)号：US20120107961A1
公开(公告)日：2012-05-03
申请号：US13381115
申请日：2010-06-24
申请人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
发明人： Wendy Uyen Dittmer , Femke Karina De Theije , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
IPC分类号： G01N33/566 , G01N30/00
CPC分类号： G01N33/54326 , G01N21/552 , G01N27/745 , G01N33/54366 , G01N33/54386
摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40′). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14′) from the detection of the further detectable label (40′) in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14′) falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.
摘要翻译：公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生来自所述第一检测信号在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。

4. 发明授权

US08190372B2 Sensor device for and a method of sensing magnetic particles 有权
标题翻译：传感器装置和感应磁性颗粒的方法
公开(公告)号：US08190372B2
公开(公告)日：2012-05-29
申请号：US12528086
申请日：2007-06-25
申请人： Josephus Arnoldus Henricus Maria Kahlman , Petrus Johannes Wilhelmus Van Lankvelt , Jeroen Hans Nieuwenhuis , Allbert Hendrik Jan Immink
发明人： Josephus Arnoldus Henricus Maria Kahlman , Petrus Johannes Wilhelmus Van Lankvelt , Jeroen Hans Nieuwenhuis , Allbert Hendrik Jan Immink
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , B82Y25/00 , G01N27/745 , G01N33/54326 , G01R33/07 , G01R33/093 , G01R33/12 , G01R33/1269 , G01R33/1276
摘要： A sensor device for sensing magnetic particles, the sensor device including a substrate and a sensing unit provided on and/or in and/or near the substrate. The sensing unit is configured to sense a detection signal indicative of the presence of the magnetic particles. The sensor device further includes a magnetic field control unit which may be provided off the substrate and is configured to generate a time-dependent magnetic field for interaction with the magnetic particles.
摘要翻译：用于感测磁性颗粒的传感器装置，所述传感器装置包括衬底和设置在衬底上和/或衬底中和/或附近的感测单元。感测单元被配置为感测指示磁性颗粒的存在的检测信号。传感器装置还包括磁场控制单元，该磁场控制单元可以设置在基板之外并被配置为产生与磁性颗粒相互作用的时间依赖磁场。

5. 发明申请

US20100324828A1 SENSOR DEVICE FOR AND A METHOD OF SENSING MAGNETIC PARTICLES 有权
标题翻译：用于感应磁性颗粒的传感器装置和方法
公开(公告)号：US20100324828A1
公开(公告)日：2010-12-23
申请号：US12528086
申请日：2007-06-25
申请人： Josephus Arnoldus Henricus Maria Kahlman , Petrus Johannes Wilhelmus Van Lankvelt , Jeroen Hans Nieuwenhuis , Allbert Hendrik Jan Immink
发明人： Josephus Arnoldus Henricus Maria Kahlman , Petrus Johannes Wilhelmus Van Lankvelt , Jeroen Hans Nieuwenhuis , Allbert Hendrik Jan Immink
IPC分类号： G01N33/543 , G01R33/06
CPC分类号： G01N33/54373 , B82Y25/00 , G01N27/745 , G01N33/54326 , G01R33/07 , G01R33/093 , G01R33/12 , G01R33/1269 , G01R33/1276
摘要： A sensor device (50) for sensing magnetic particles (15), the sensor device (50) comprising a substrate (25) and a sensing unit (11, 20) provided on and/or in and/or near the substrate (25) and being adapted for sensing a detection signal indicative of the presence of the magnetic particles (15), and a magnetic field control unit (30 to 34) provided off the substrate (25) and being adapted for generating a time-dependent magnetic field for interaction with the magnetic particles (15).
摘要翻译：一种用于感测磁性颗粒（15）的传感器装置（50），所述传感器装置（50）包括衬底（25）和设置在衬底（25）上和/或之上和/或附近的感测单元（11,20）并适于感测表示磁性颗粒（15）的存在的检测信号;以及设置在基板（25）之外的磁场控制单元（30至34），并适于产生时间依赖性的磁场，用于与磁性颗粒（15）的相互作用。

6. 发明授权

US09696246B2 Sensor system with an exchangeable cartridge and a reader 有权
公开(公告)号：US09696246B2
公开(公告)日：2017-07-04
申请号：US14113832
申请日：2012-04-12
申请人： Bernardus Jozef Maria Beerling , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt , Wendela Meertens , Patrick Zuidema
发明人： Bernardus Jozef Maria Beerling , Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt , Wendela Meertens , Patrick Zuidema
IPC分类号： B01L9/00 , G01N1/28 , G01N21/03 , G01N21/552 , G01N21/64
CPC分类号： G01N1/28 , G01N21/0332 , G01N21/552 , G01N21/648 , G01N2201/0221
摘要： A sensor system (100) includes a reader (150) with a sensor unit (155, 156) and an accommodation Space (151) for an exchangeable cartridge (110). The cartridge (110) is held in the accommodation space (151) by at least one contact element (111) which has an increased thermal resistance and/or a contact area of reduced size. Thus a more homogenous temperature distribution can be achieved within the cartridge (110), reducing distortions which might adversely affect optical measurements.

7. 发明申请

US20100273269A1 METHOD OF MEASURING MOLECULES IN A FLUID USING LABEL PARTICLES 审中-公开
标题翻译：使用标签颗粒测量流体中分子的方法
公开(公告)号：US20100273269A1
公开(公告)日：2010-10-28
申请号：US12746180
申请日：2008-11-28
申请人： Petrus Johannes Wilhelmus Van Lankvelt , Jeroen Hans Nieuwenhuis
发明人： Petrus Johannes Wilhelmus Van Lankvelt , Jeroen Hans Nieuwenhuis
IPC分类号： G01N27/00 , G01N21/75
CPC分类号： G01N33/54333 , G01N21/552 , G01N27/745
摘要： The present invention provides a method of measuring the concentration of molecules in a sample fluid or analyte. Said method comprises the step of mixing the fluid with label particles within a cartridge, wherein the label particles are adapted to capture said molecules and to bind to a sensor surface of said cartridge. Then, the label particles are sedimented towards the sensor surface and the amount of label particles close to the sensor surface is measured. Subsequently, the label particles, which are not bound to the surface, are removed in a “washing” step and finally the amount of label particles close to the sensor surface is measured again.
摘要翻译：本发明提供了测量样品流体或分析物中分子浓度的方法。所述方法包括将流体与盒内的标签颗粒混合的步骤，其中标签颗粒适于捕获所述分子并结合到所述盒的传感器表面。然后，标签颗粒向传感器表面沉降，并且测量靠近传感器表面的标签颗粒的量。随后，在“洗涤”步骤中除去未结合表面的标签颗粒，最后再次测量靠近传感器表面的标签颗粒的量。

8. 发明授权

US10133978B2 Device having RFID tag and fluidics element 有权
公开(公告)号：US10133978B2
公开(公告)日：2018-11-20
申请号：US13879960
申请日：2011-10-14
申请人： Bernardus Jozef Maria Beerling , Petrus Johannes Wilhelmus Van Lankvelt , Wendela Meertens , Jeroen Hans Nieuwenhuis
发明人： Bernardus Jozef Maria Beerling , Petrus Johannes Wilhelmus Van Lankvelt , Wendela Meertens , Jeroen Hans Nieuwenhuis
IPC分类号： G06F17/00 , G06K19/077 , B01L3/00 , G01D18/00
摘要： A device such as a disposable cartridge has an RFID tag (30) having an antenna (10), and a fluidic element (20, 160), the antenna having a shape to at least partly enclose an area, at least a part of the fluidic element being located in this area. By having such a structure, the device can be made more compact or the antenna can be made larger, and hence the costs for a given performance can be reduced, or the storage space for a given number of devices can be reduced.

9. 发明申请

US20100109653A1 SENSOR DEVICE FOR AND A METHOD OF SENSING PARTICLES 有权
标题翻译：用于传感颗粒的传感器装置和方法
公开(公告)号：US20100109653A1
公开(公告)日：2010-05-06
申请号：US12521905
申请日：2007-07-26
申请人： Jeroen Hans Nieuwenhuis , Godefridus Johannes Verhoeckx , Menno Willem Jose Prins , Petrus Johannes Wilhelmus Van Lankvelt , Kim Van Ommering
发明人： Jeroen Hans Nieuwenhuis , Godefridus Johannes Verhoeckx , Menno Willem Jose Prins , Petrus Johannes Wilhelmus Van Lankvelt , Kim Van Ommering
IPC分类号： G01N27/74
CPC分类号： G01R33/12 , B82Y25/00 , G01N15/0656 , G01N2011/008 , G01N2015/0053 , G01R33/093 , G01R33/1284
摘要： A sensor device (50) for sensing particles (15) of a sample, the sensor device (50) comprising a sensing unit (11, 20) adapted for sensing a detection signal indicative of the presence of the particles (15), a viscosity measurement unit (11, 17, 20) adapted for measuring the viscosity of the sample, and a correction unit (20, 30) adapted for correcting the detection signal based on the measured viscosity.
摘要翻译：一种用于感测样品的颗粒（15）的传感器装置（50），所述传感器装置（50）包括适于感测指示所述颗粒（15）的存在的检测信号的感测单元（11,20），粘度适于测量样品粘度的测量单元（11,17,20）以及适于基于所测量的粘度校正检测信号的校正单元（20,30）。

10. 发明申请

US20090309588A1 SYSTEM AND METHODS FOR ACTUATION ON MAGNETORESISTIVE SENSORS 审中-公开
标题翻译：用于激励磁传感器的系统和方法
公开(公告)号：US20090309588A1
公开(公告)日：2009-12-17
申请号：US12299783
申请日：2007-05-09
申请人： Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
发明人： Jeroen Hans Nieuwenhuis , Petrus Johannes Wilhelmus Van Lankvelt
IPC分类号： G01N27/72 , G01R33/09
CPC分类号： G01R33/12 , B82Y25/00 , G01R33/093 , G01R33/1269
摘要： The present invention relates to systems and methods for magnetic actuation of particles from and toward the surface of a sensor with a magneto-resistive element. The orientation of magnetic fields and arrangement of magnetic field generating means with respect to the sensor maintains or restores the sensitivity of the magneto-resistive element after actuation.
摘要翻译：本发明涉及一种用于利用磁阻元件从传感器的表面磁化致动颗粒的系统和方法。相对于传感器的磁场取向和磁场产生装置的布置维持或恢复致动后磁阻元件的灵敏度。

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