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1. 发明授权

US4996004A Preparation of pharmaceutical or cosmetic dispersions 失效
标题翻译：药物或化妆品分散体的制备
公开(公告)号：US4996004A
公开(公告)日：1991-02-26
申请号：US324985
申请日：1989-03-15
申请人： Manfred Bucheler , Hans Gehringer , Bernd Klinksiek , Bernd Koglin
发明人： Manfred Bucheler , Hans Gehringer , Bernd Klinksiek , Bernd Koglin
IPC分类号： A61K8/06 , A61K9/107 , A61Q17/04 , A61Q19/00 , B01F3/08 , B01F5/02 , B01F5/06 , B01J13/00
CPC分类号： B01F5/0682 , A61K8/06 , A61K8/062 , A61K9/107 , A61Q19/00 , B01F3/0807 , B01F5/0688 , B01F5/0689 , A61Q17/04 , Y10S514/941 , Y10S514/942 , Y10S514/943 , Y10S516/925
摘要： The invention relates to a process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic phase which is insoluble or not completely soluble in water (oily phase) in which a pre-emulsion is prepared from the two phases by known emulsifying methods and in then pumped through a jet disperser, the temperature, the proportion of the aqueous and organic phases, and the pressure at the jet disperser being adjusted so that phase inversion of the emulsion is effected in the jet disperser at the same time as homogenization and fine dispersion, and in the course of which all the pressure energy is consumed in the dispersing zone and the dispersion leaves as a non-directional stream.
摘要翻译：本发明涉及一种制备由水相和有机相组成的细颗粒，稳定，药物或化妆品分散体的方法，所述水相和有机相不溶于或不完全溶于其中制备预乳液的水（油相）通过已知的乳化方法从两相中，然后通过喷射分散器泵送，调节温度，水相和有机相的比例以及喷射分散器处的压力，使得在喷嘴中进行乳液的相转化在均匀化和细分散的同时分散，并且在分散区中消耗所有压力的过程中，分散体作为非定向流离开。

2. 发明授权

US5116536A Preparation of pharmaceutical or cosmetic dispersions 失效
标题翻译：药物或化妆品分散体的制备
公开(公告)号：US5116536A
公开(公告)日：1992-05-26
申请号：US581867
申请日：1990-09-13
申请人： Manfred Bucheler , Hans Gehringer , Bernd Klinksiek , Bernd Koglin
发明人： Manfred Bucheler , Hans Gehringer , Bernd Klinksiek , Bernd Koglin
IPC分类号： A61K8/06 , A61K9/107 , A61Q17/04 , A61Q19/00 , B01F3/08 , B01F5/06
CPC分类号： B01F5/0682 , A61K8/06 , A61K8/062 , A61K9/107 , A61Q19/00 , B01F3/0807 , B01F5/06 , B01F5/0688 , B01F5/0689 , A61Q17/04 , Y10S514/941 , Y10S514/942 , Y10S514/943 , Y10S516/925
摘要： The invention relates to a process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic phase which is insoluble or not completely soluble in water (oily phase), in which a pre-emulsion is first prepared from the two phases by known emulsifying methods and is then further processed to the end product. The invention furthermore relates to apparatus for carrying out the process.
摘要翻译：本发明涉及一种制备由水相和有机相组成的细颗粒，稳定，药物或化妆品分散体的方法，所述水相和有机相不溶于或不完全溶于水（油相），其中预乳液为首先通过已知的乳化方法由两相制备，然后进一步加工成最终产物。本发明还涉及用于执行该过程的装置。

3. 发明授权

US5026208A Process for the disposal of waste 失效
标题翻译：处理废物的过程
公开(公告)号：US5026208A
公开(公告)日：1991-06-25
申请号：US441803
申请日：1989-11-27
申请人： Joachim Beyer , Bernd Koglin , Rolf Rink , John-Edwin Roth
发明人： Joachim Beyer , Bernd Koglin , Rolf Rink , John-Edwin Roth
IPC分类号： B09B1/00 , B09B3/00
CPC分类号： B09B1/00 , B09B3/00 , B09B3/0025
摘要： The accumulated waste is pressed under high pressure to form blocks or boards having high strength, low elutability and low permeability, then packed in film individually or in stacks in a dust-tight and water-tight manner and deposited in this form on a dump like building bricks. The process can be used universally for all waste which is available as bulk material and has no coarse components, such as stones, metal pieces and the like.
摘要翻译：堆积的废物在高压下压制，形成高强度，低可渗透性和低渗透性的块或板，然后以防尘和防水的方式单独或堆叠地包装在薄膜中并以这种形式沉积在倾倒式建砖该方法可以普遍用于所有可用作散装材料并且没有粗糙组分的废物，例如石头，金属片等。

4. 发明授权

US06299657B1 Process for carrying out chemical reactions using a microlaminar mixer 失效
标题翻译：使用微层混合器进行化学反应的方法
公开(公告)号：US06299657B1
公开(公告)日：2001-10-09
申请号：US09419457
申请日：1999-10-15
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel , Christine Maul
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel , Christine Maul
IPC分类号： B01F302
CPC分类号： B01F13/0066 , B01F5/0256 , B01F5/0644 , B01F13/0064 , B01F13/0094 , B01J19/0093 , B01J19/18 , B01J19/2415 , B01J2219/00085 , B01J2219/00164 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , F28F2260/02 , Y10S366/03 , Y10T137/2514 , Y10T137/2516 , Y10T137/2559 , Y10T137/2562 , Y10T137/2564
摘要： In the reaction process, at least two educts A, B are divided by a system, assigned to each of them, of slit-like microchannels 1a, 1b into spatially separate fluid lamellae, which then emerge into a common mixing and reaction space 4. The fluid lamellae here have a thickness
摘要翻译：在反应过程中，至少两个喷射管A，B被分配给它们中的每一个的狭缝状微通道1a，1b的系统划分成空间上分开的流体薄片，然后出现在共同的混合和反应空间4中。这里的流体薄片的厚度<1,000μm，优选<100μm，宽度厚度比至少为10.这里重要的是，喷射A，B可以作为薄的液体薄片6a，6b出现到混合/反应空间如图4所示，喷射管A的每个流体薄片6a被引导到混合/反应空间4中，紧邻另一个喷射B的流体薄片6b。然后相邻的流体薄片6a，6b然后通过扩散和/或湍流混合。结果，与常规反应器相比，混合操作大大加快。在快速化学反应的情况下，以这种方式大大地防止了不期望的副产物或二次产物的形成。

5. 发明授权

US5574204A Method for the mutual chemical and compaction treatment of inorganic wastes 失效
标题翻译：无机废物相互化学和压实处理方法
公开(公告)号：US5574204A
公开(公告)日：1996-11-12
申请号：US446793
申请日：1995-07-24
申请人： Thomas Menzel , Joachim Beyer , Gerd Bauer , Bernd Koglin , Rolf Rink
发明人： Thomas Menzel , Joachim Beyer , Gerd Bauer , Bernd Koglin , Rolf Rink
IPC分类号： B09B3/00
CPC分类号： B09B3/0041 , B09B3/0025
摘要： Water-containing inorganic waste materials, originally in loose form, and which contain water-soluble components capable of reacting with each other are mixed and then compacted at a pressure sufficient to reduce the space, volume between the particles of material, cause the reduced space volume to become filled with water and the reactive components to react.
摘要翻译： PCT No.PCT / EP93 / 03240 Sec。 371日期1995年7月24日 102（e）1995年7月24日PCT PCT 1993年11月19日PCT公布。公开号WO94 / 12292 日期1994年6月9日含水原料松散形式的含有能够相互反应的水溶性成分的无机废弃材料混合，然后在足以减小材料颗粒之间的空间，体积的压力下压实，使空间体积减小，充满水和反应性组分反应。

6. 发明授权

US4714456A Solid bowl centrifuge with terminal clarification device 失效
标题翻译：固体碗离心机，带终端澄清装置
公开(公告)号：US4714456A
公开(公告)日：1987-12-22
申请号：US860713
申请日：1986-05-07
申请人： Wolfgang Bender , Dieter Mrotzek , Bernd Koglin , Karl-Heinz Steiner
发明人： Wolfgang Bender , Dieter Mrotzek , Bernd Koglin , Karl-Heinz Steiner
IPC分类号： B04B1/20 , B04B7/16
CPC分类号： B04B1/20 , B04B2001/2083
摘要： The solid bowl screw centrifuge consists of a housing (1) in which a drum (2) is rotatable. A rotatably mounted conveyor screw (3) is situated inside the drum (2). The drum (2) and screw (3) rotate at slightly differing speeds of rotation when in operation. The housing (1) is cylindrical in the region of the clarifying part (I) and conical in the region of the demoisturizing part (II). The suspension inflow (5,6) opens into the hollow screw core (12) at a location between the clarifying part (I) and the demoisturizing part (II). The liquid discharge consists of an overflow weir (16) or stripping pipe (9) on the clarifying part (I). The solids discharge (4) is situated at the end of the demoisturizing part (II). The screw (3) is arranged within the clarifying part (I) on the cylindrical hollow screw core (12) whose peripheral surface is partly or completely equipped with an after-clarifying device through which fluid flows in a radial direction. The after-clarifying device consists either of a filtration device placed on the perforated screw core (12) or of a laminar separator (14). These fittings enable the degree of separation of the centrifuge to be improved, especially in the treatment of solids which sediment only slowly.
摘要翻译：固体碗螺杆离心机由其中滚筒（2）可旋转的壳体（1）组成。可旋转地安装的传送螺杆（3）位于滚筒（2）的内部。当操作时，滚筒（2）和螺钉（3）以稍微不同的旋转速度旋转。壳体（1）在澄清部分（I）的区域中是圆柱形的，并且在净化部分（II）的区域中是圆锥形的。在澄清部分（I）和净化部分（II）之间的位置处，悬浮流入物（5,6）进入中空螺杆芯（12）。液体排放由澄清部分（I）上的溢流堰（16）或剥离管（9）组成。固体排放物（4）位于生化部分（II）的末端。螺杆（3）布置在圆柱形中空螺纹芯（12）上的澄清部分（I）中，其圆周表面部分地或完全地具有流体沿径向流动的后澄清装置。后澄清装置由放置在多孔螺杆芯（12）上的过滤装置或层状分离器（14）组成。这些配件能够使离心机的分离程度得到改善，特别是在沉淀物缓慢的固体处理中。

7. 发明授权

US06321998B1 Method of producing dispersions and carrying out of chemical reactions in the disperse phase 失效
标题翻译：在分散相中产生分散体并进行化学反应的方法
公开(公告)号：US06321998B1
公开(公告)日：2001-11-27
申请号：US09068264
申请日：1998-05-05
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel
IPC分类号： A62C502
CPC分类号： B01F5/0256 , B01F5/0644 , B01F13/00 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00889 , Y10S366/03
摘要： In the process for the continuous dispersion of at least one fluid A constituting the disperse phase and at least one continuous phase constituting the enclosing phase of a fluid B, at least one fluid stream A and at least one fluid stream B are fed into a dispersion apparatus and come into contact therein in a dispersion chamber. To this end, a microstructure dispersion apparatus (1a, 1b, 3a, 3b) is used in which the fluid streams A, B are broken up into spatially separate, flowing fluid filaments by a system of microchannels (1a, 1b) associated therewith, which filaments are discharged into the dispersion chamber (4) at identical flow velocities for the particular fluid in such a manner that on discharge into the dispersion chamber (4) a fluid jet (6a) of the disperse phase is in each case immediately adjacent to a fluid jet (6b) of the continuous phase and in each case a fluid jet (6a) of the disperse phase is enclosed as it is broken up into particles in the adjacent fluid jets (6b) of the continuous phase.
摘要翻译：在构成分散相的至少一种流体A和构成流体B的封闭相的至少一个连续相的连续分散的过程中，将至少一种流体流A和至少一种流体流B进料到分散体装置并在分散室中与其接触。为此，使用通过与其相关联的微通道（1a，1b）的系统将流体流A，B分解成空间分离的流动细丝的微结构分散装置（1a，1b，3a，3b）以特定流体的相同流速将这些细丝排出到分散室（4）中，使得在排放到分散室（4）中时，分散相的流体射流（6a）在每种情况下都紧邻于在连续相的流体射流（6b）中，并且在每种情况下，分散相的流体射流（6a）被包围，因为其在连续相的相邻流体射流（6b）中被分解成颗粒。

8. 发明授权

US06264900B1 Device for carrying out chemical reactions using a microlaminar mixer 失效
标题翻译：使用微层混合器进行化学反应的装置
公开(公告)号：US06264900B1
公开(公告)日：2001-07-24
申请号：US09068322
申请日：1998-05-05
申请人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel , Christine Maul
发明人： Klaus Schubert , Wilhelm Bier , Gerd Linder , Erhard Herrmann , Bernd Koglin , Thomas Menzel , Christine Maul
IPC分类号： B01F500
CPC分类号： B01F13/0066 , B01F5/0256 , B01F5/0644 , B01F13/0064 , B01F13/0094 , B01J19/0093 , B01J19/18 , B01J19/2415 , B01J2219/00085 , B01J2219/00164 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , F28F2260/02 , Y10S366/03 , Y10T137/2514 , Y10T137/2516 , Y10T137/2559 , Y10T137/2562 , Y10T137/2564
摘要： A microstructures lamellae mixer comprising a guide component for supplying fluids to be mixed to a mixing chamber, the guide component being composed of a plurality of foils which are layered one above the other and into which microchannels are incorporated such that separate fluids supplied to the guide component are formed into spatially separated microstreams which then emerge adjacent to each other in a mixing chamber.
摘要翻译：一种微结构薄片混合器，包括用于供应要混合到混合室中的流体的引导部件，所述引导部件由多个彼此层叠的多个箔组成，并且微通道被并入到所述多个箔中，使得提供给所述引导件的单独流体组分形成空间分离的微流体，然后在混合室中彼此相邻出现。

9. 发明授权

US4299723A Microcapsules and their preparation 失效
标题翻译：微胶囊及其制备
公开(公告)号：US4299723A
公开(公告)日：1981-11-10
申请号：US128928
申请日：1980-03-10
申请人： Manfred Dahm , Gert Jabs , Bernd Koglin , Hildegard Schnoring , Kurt Riecke
发明人： Manfred Dahm , Gert Jabs , Bernd Koglin , Hildegard Schnoring , Kurt Riecke
IPC分类号： B01J13/16 , B41M5/165 , B01J13/02
CPC分类号： B01J13/16 , B41M5/1655 , Y10S428/914 , Y10T428/2985
摘要： Microcapsules containing a color-former solution which is encapsulated in the form of a solution in an organic solvent in capsules of the polyaddition product of a diisocyanate corresponding to the following general formula: ##STR1## wherein n=3-6and a diamine wherein a mixture of an alkyl naphthalene and an isoparaffin containing from 10 to 20 carbon atoms is used as the solvent for the color-former and the microcapsules are tempered for at least 2 hours at a temperature of from 60.degree. to 70.degree. C. after their formation.
摘要翻译：含有成色剂溶液的微胶囊，其以在下列通式表示的二异氰酸酯加成产物的胶囊中的有机溶剂溶液形式包封：其中n = 3-6和二胺，其中使用含有10至20个碳原子的烷基萘和异链烷烃的混合物作为成色剂的溶剂，并且微胶囊在60℃至70℃的温度下回火至少2小时。形成后。

10. 发明授权

US5618444A Method for separating a dispersion of particles in liquids into a particle-enriched and a particle-depleted partial stream 失效
标题翻译：将液体中的颗粒分散体分离成富集颗粒和不含颗粒的部分流的方法
公开(公告)号：US5618444A
公开(公告)日：1997-04-08
申请号：US666998
申请日：1996-06-21
申请人： Bernd Koglin
发明人： Bernd Koglin
IPC分类号： B01D43/00 , C12M1/00 , C12M1/26 , F01L7/06 , F02B61/02 , F02M35/16 , B01D37/00
CPC分类号： B01D43/00 , C12M47/04
摘要： The methods consists in that the suspension is made to flow as the feed stream through a narrow channel or a capillary and partial streams are drawn off from the wall on the periphery of the channel and/or the capillary through openings in the channel wall and/or capillary wall, the cross-section of which is larger than the mean particle cross-section (median value), the particle concentration being enriched in the main stream and diluted in the partial streams compared to the feed stream. The device consists in that several holes and/or (in the case of a channel) two gaps are arranged evenly distributed over the periphery of a pipe or channel in which the main stream is conveyed. The diameter of the holes is between 10% and 90% of the pipe diameter and the gap width between 10% and 30% of the channel width.
摘要翻译：这些方法包括使悬浮液随着进料流通过窄通道或毛细管而流动，并且部分流从通道周边的壁和/或毛细管通过通道壁中的开口和/ 或毛细管壁，其横截面大于平均颗粒横截面（中值），与进料流相比，主流中富集的颗粒浓度和在部分流中稀释。该装置包括几个孔和/或（在通道的情况下）两个间隙均匀地分布在主流被输送的管或通道的周边上。孔的直径在管径的10％至90％之间，间隙宽度在通道宽度的10％至30％之间。

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