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1. 发明授权

US07105570B2 Cysteine derivatives 有权
公开(公告)号：US07105570B2
公开(公告)日：2006-09-12
申请号：US10323930
申请日：2002-12-20
申请人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
发明人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
IPC分类号： A61K31/195 , A61K31/22
CPC分类号： C07C323/60 , A61K8/02 , A61K8/0212 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/411 , A61K8/447 , A61K8/45 , A61K8/46 , A61K8/494 , A61K8/60 , A61K8/63 , A61K8/676 , A61K8/678 , A61K8/86 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , A61Q19/10 , Y10S514/844 , Y10S514/847
摘要： Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

2. 发明授权

US06602492B2 Cysteine derivatives 有权
公开(公告)号：US06602492B2
公开(公告)日：2003-08-05
申请号：US10051099
申请日：2002-01-22
申请人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
发明人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
IPC分类号： A61K742
CPC分类号： C07C323/60 , A61K8/02 , A61K8/0212 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/411 , A61K8/447 , A61K8/45 , A61K8/46 , A61K8/494 , A61K8/60 , A61K8/63 , A61K8/676 , A61K8/678 , A61K8/86 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , A61Q19/10 , Y10S514/844 , Y10S514/847
摘要： Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

3. 发明授权

US06552061B1 Amino acid derivatives and anti-inflammatory agents 失效
标题翻译：氨基酸衍生物和抗炎剂
公开(公告)号：US06552061B1
公开(公告)日：2003-04-22
申请号：US09285390
申请日：1999-04-02
申请人： Manabu Kitazawa , Keiji Iwasaki , Eiji Shiojiri
发明人： Manabu Kitazawa , Keiji Iwasaki , Eiji Shiojiri
IPC分类号： C07C22928
CPC分类号： C07D233/64 , C07C229/14 , C07C229/22 , C07C229/34 , C07C237/06 , C07C237/20 , C07D207/28
摘要： Provided are an anti-inflammatory agent containing, as an active ingredient, at least one selected from amino acid derivatives represented by formula (I) wherein Ar represents an optionally substituted 2-hydroxyaryl group, n is 0 or 1, R2 represents a hydrogen atom or a side chain of an &agr;-amino acid or &bgr;-amino acid, X represents —O— or —NH—, R1 represents a hydrogen atom or a group that forms, together with R2 and an adjacent atoms, a cyclic structure of pyroglutamic acid, and R3 represents a hydrogen atom, an alkyl group having from 1 to 22 carbon atoms or an alkenyl group having from 2 to 22 carbon atoms, and salts thereof, and toiletries or skin external products containing the same. The anti-inflammatory agent of the invention inhibits expression of an inflammatory protein and activation of a gene transcription control factor that participates therein, and exhibits a good feeling upon use and a safety.
摘要翻译：提供含有选自由式（I）表示的氨基酸衍生物中的至少一种作为活性成分的抗炎剂，其中Ar表示任选取代的2-羟基芳基，n为0或1，R 2表示氢原子或α-氨基酸或β-氨基酸的侧链，X表示-O-或-NH-，R1表示氢原子或与R2和相邻原子一起形成焦谷氨酸的环状结构的基团酸，R3表示氢原子，具有1至22个碳原子的烷基或具有2至22个碳原子的烯基，以及其盐，以及含有它们的化妆品或皮肤外用产品。本发明的抗炎剂抑制炎症蛋白的表达和参与其中的基因转录控制因子的活化，并且在使用时表现出良好的感觉和安全性。

4. 发明授权

US06703031B1 Cysteine derivatives 失效
标题翻译：半胱氨酸衍生物
公开(公告)号：US06703031B1
公开(公告)日：2004-03-09
申请号：US09806937
申请日：2001-06-14
申请人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
发明人： Keiji Iwasaki , Manabu Kitazawa , Eiji Shiojiri , Kazutami Sakamoto
IPC分类号： A61K700
CPC分类号： C07C323/60 , A61K8/02 , A61K8/0212 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/411 , A61K8/447 , A61K8/45 , A61K8/46 , A61K8/494 , A61K8/60 , A61K8/63 , A61K8/676 , A61K8/678 , A61K8/86 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/02 , A61Q19/08 , A61Q19/10 , Y10S514/844 , Y10S514/847
摘要： Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.
摘要翻译：本发明的目的是提供能够抑制细胞毒性蛋白质的表达和基因转录调节因子的活化的氧化应激抑制剂，其采用这种细胞毒性蛋白质的这种表达，并且在使用和安全性方面表现出良好的感觉; 提供一种预防，延缓，减轻或治疗由于老化引起的皮肤变化或由氧化应激引起或促进的不期望的美容皮肤变化的方法; 并且提供包含氧化应激抑制剂作为有效成分的外用化妆品组合物或皮肤病学制剂，并且为了这些目的，使用氧化应激抑制剂，其包含作为有效成分的至少一种选自半胱氨酸或胱氨酸衍生物及其盐。

5. 发明授权

US5985922A Amino acid derivatives and active oxygen-resisting agent 失效
标题翻译：氨基酸衍生物和活性氧化剂
公开(公告)号：US5985922A
公开(公告)日：1999-11-16
申请号：US54508
申请日：1998-04-03
申请人： Manabu Kitazawa , Kazutami Sakamoto , Keiji Iwasaki
发明人： Manabu Kitazawa , Kazutami Sakamoto , Keiji Iwasaki
IPC分类号： A61K8/30 , A61K8/00 , A61K8/40 , A61K8/42 , A61K8/44 , A61K8/49 , A61K31/195 , A61K31/198 , A61K31/24 , A61P17/00 , A61Q1/00 , A61Q1/04 , A61Q5/02 , A61Q11/00 , A61Q19/00 , C07C229/14 , C07C229/34 , C07C229/36 , C07C237/06 , C09K15/20 , C09K15/22 , A01N37/12 , A01N37/18 , C07C229/28
CPC分类号： C07C237/06 , C07C229/14 , C07C229/36
摘要： Provided is a novel active oxygen-resisting agent which has an excellent active oxygen resistance and which exhibits a good solubility in an oil solvent. An active oxygen-resisting agent containing as an active ingredient an amino acid derivative represented by the following formula (I) ##STR1## wherein Ar represents a substituted or substituted 2-hydroxyphenyl group or a pyridyl group, said substitution being selected from the group consisting of a halogen atom, a C.sub.1-6 alkyl group, a hydroxyl group, a hydroxy C.sub.1-6 alkyl group, a nitro group, a C.sub.1-6 alkoxyl group or a carboxyl group, R.sup.1 represents a side chain of an amino acid, X represents --O-- or --NH--, R.sup.2 represents a C.sub.8-22 alkyl group, and n represents 0 or 1, or its salt.
摘要翻译：本发明提供一种具有优异的活性氧阻力并且在油溶剂中表现出良好溶解性的新型活性氧化物。作为活性成分含有由下式（I）表示的氨基酸衍生物的活性耐氧化剂，其中Ar表示取代或取代的2-羟基苯基或吡啶基，所述取代选自卤素原子，C 1-6烷基，羟基，羟基C 1-6烷基，硝基，C 1-6烷氧基或羧基，R 1表示氨基酸的侧链，X表示-O-或 - NH-，R 2表示C 8-22烷基，n表示0或1，或其盐。

6. 发明申请

US20070099888A1 Inflammation Inhibitor Comprising Zinc Salt of Acylamino Acid 审中-公开
标题翻译：包含酰氨基酸锌盐的炎症抑制剂
公开(公告)号：US20070099888A1
公开(公告)日：2007-05-03
申请号：US11610736
申请日：2006-12-14
申请人： Keiji Iwasaki , Manabu Kitazawa , Yoshinobu Takino
发明人： Keiji Iwasaki , Manabu Kitazawa , Yoshinobu Takino
IPC分类号： A61K31/555 , A61K31/315
CPC分类号： A61K31/315 , A61K8/27 , A61K8/44 , A61K31/198 , A61K31/20 , A61K31/4172 , A61K31/555 , A61Q19/08
摘要： An inflammation inhibitor for the skin is provided containing a zinc salt of an acylamino acid and further, a cosmetic containing the inflammation inhibitor.
摘要翻译：提供了含有酰氨基酸的锌盐的皮肤的炎症抑制剂，还含有含有炎症抑制剂的化妆品。

7. 发明授权

US06914075B2 Cystine derivative and agent for suppressing activation of inflammatory factors 失效
标题翻译：胱氨酸衍生物和抑制炎症因子活化的药剂
公开(公告)号：US06914075B2
公开(公告)日：2005-07-05
申请号：US10632959
申请日：2003-08-04
申请人： Takashi Nakano , Manabu Kitazawa , Keiji Iwasaki , Kazutami Sakamoto
发明人： Takashi Nakano , Manabu Kitazawa , Keiji Iwasaki , Kazutami Sakamoto
IPC分类号： A23L1/30 , A23L1/305 , A61K8/00 , A61K8/30 , A61K8/44 , A61K31/137 , A61K31/198 , A61P1/04 , A61P1/18 , A61P9/00 , A61P9/02 , A61P11/00 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/30 , A61P27/02 , A61P29/00 , A61P37/04 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q5/02 , A61Q17/04 , A61Q19/00 , C07C323/58 , A61K31/225 , C07C229/00
CPC分类号： C07C323/58 , A23L33/10
摘要： The present invention provides cystine derivatives, which may be in a free form, a salt form, a solvate form. The cystine derivatives of the present invention may be used to suppress activation of inflammatory factors. Accordingly, the present invention provides: compositions containing the cystine derivatives; a method for suppressing the activation of inflammatory factors by administering the composition; a method for preventing, ameliorating and/or therapeutically treating diseases, skin injuries or disorders involved in the activation of inflammatory factors by administering the composition; a method for preventing, delaying, ameliorating and/or therapeutically treating skin change via aging or aesthetically unfavorable skin change as induced or promoted by inflammatory factors by administering the composition; and pharmaceutical agents containing the cystine derivatives.
摘要翻译：本发明提供胱氨酸衍生物，其可以是游离形式，盐形式，溶剂合物形式。本发明的胱氨酸衍生物可用于抑制炎症因子的活化。因此，本发明提供：含有胱氨酸衍生物的组合物; 通过施用该组合物来抑制炎症因子的活化的方法; 通过施用组合物来预防，改善和/或治疗疾病，皮肤损伤或参与炎性因子活化的病症的方法; 一种通过施用该组合物来预防，延缓，改善和/或治疗由炎症因子诱导或促进的衰老或美学上不利的皮肤变化来治疗皮肤变化的方法; 和含有胱氨酸衍生物的药剂。

8. 发明授权

US5594012A Amino acid derivatives and anti-active oxygen agents 失效
标题翻译：氨基酸衍生物和抗活性氧剂
公开(公告)号：US5594012A
公开(公告)日：1997-01-14
申请号：US284668
申请日：1994-10-06
申请人： Manabu Kitazawa , Keiji Iwasaki
发明人： Manabu Kitazawa , Keiji Iwasaki
IPC分类号： C07C215/50 , C07C229/14 , C07C229/22 , C07C229/24 , C07C229/36 , C07C237/06 , C07C251/24 , C07C259/06 , C07C279/14 , C07C309/13 , C07C309/14 , C07C323/58 , C07D209/14 , C07D209/20 , C07D213/66 , C07D233/54 , C07D233/64 , C07D401/12 , A61K31/44 , C07C251/18 , C07D215/50
CPC分类号： C07D213/66 , C07C215/50 , C07C229/14 , C07C229/22 , C07C229/24 , C07C229/36 , C07C237/06 , C07C251/24 , C07C259/06 , C07C279/14 , C07C309/13 , C07C309/14 , C07C323/58 , C07D209/14 , C07D209/20 , C07D233/64 , C07D401/12 , C07C2102/26 , Y10S514/844
摘要： A novel anti-active oxygen agent which comprises as active ingredient an amino acid derivative represented by the following general formula (I): ##STR1## wherein Ar represents a 2-hydroxyphenyl, 2-hydroxy-1-naphthyl or pyridyl group, and one or more of the hydrogen atoms attached to the aromatic ring of these groups may be substituted with a halogen atom, or an alkyl, hydroxyl, hydroxyalkyl, nitro, alkoxyl or carboxyl group; R represents the side chain of an amino acid; X represents --CH.sub.2 --NH-- or --CH.dbd.N--; Y represents a hydrogen atom, --COOR.sup.1, --SO.sub.3 H, --CON(R.sup.2)R.sup.3, --CONHCH(R.sup.5)COOR.sup.4 or --CH.sub.2 OH (where each of R.sup.1 to R.sup.4 represents a hydrogen atom or an alkyl group, and R.sup.5 represents the side chain of an amino acid); and n represents an integer of 0 or 1;or its salt,and which inhibits generation of active oxygen species, has a high safety and can be prepared at relatively low costs.
摘要翻译： PCT No.PCT / JP93 / 01842 Sec。 371日期：1994年10月6日 102（e）日期1994年10月6日PCT 1993年12月20日PCT PCT。出版物WO94 / 14755 日期：1994年7月7日一种新型抗活性氧剂，其包含作为活性成分的由以下通式（I）表示的氨基酸衍生物：壬基，2-羟基-1-萘基或吡啶基，以及一种或多种与这些基团的芳香环连接的氢原子可以被卤素原子或烷基，羟基，羟烷基，硝基，烷氧基或羧基取代; R表示氨基酸的侧链; X表示-CH 2 -NH-或-CH = N-; Y表示氢原子，-COOR 1，-SO 3 H，-CON（R 2）R 3，-CONHCH（R 5）COOR 4或-CH 2 OH（其中，R 1〜R 4各自表示氢原子或烷基，R 5表示侧链的氨基酸）; n表示0或1的整数; 或其盐，并且其抑制活性氧的产生具有高安全性并且可以以相对低的成本制备。

9. 发明申请

US20050271606A1 Composition for treating inflammation which contains zinc pyrrolidonecarboxylate 审中-公开
标题翻译：用于治疗含有吡咯烷酮羧酸锌的炎症的组合物
公开(公告)号：US20050271606A1
公开(公告)日：2005-12-08
申请号：US11146111
申请日：2005-06-07
申请人： Keiji Iwasaki , Manabu Kitazawa , Yoshinobu Takino
发明人： Keiji Iwasaki , Manabu Kitazawa , Yoshinobu Takino
IPC分类号： A61K8/49 , A61K31/40 , A61K31/4015 , A61K31/555 , A61K33/30 , A61P17/00 , A61P17/16 , A61P29/00 , A61P39/00 , A61Q1/02 , A61Q5/00 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K7/42
CPC分类号： A61K31/555 , A61K8/4913 , A61K31/4015 , A61Q1/02 , A61Q5/00 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/08
摘要： The present invention provides a composition which suppresses inflammation of the skin. The composition of the present invention contains zinc pyrrolidonecarboxylate. The composition of the present invention may be formulated as a cosmetic or any externally applied agent.
摘要翻译：本发明提供抑制皮肤炎症的组合物。本发明的组合物含有吡咯烷酮羧酸锌。本发明的组合物可以配制成化妆品或任何外用剂。

10. 发明授权

US07879863B2 Aniline derivatives 失效
标题翻译：苯胺衍生物
公开(公告)号：US07879863B2
公开(公告)日：2011-02-01
申请号：US11537139
申请日：2006-09-29
申请人： Munetaka Tokumasu , Masayuki Sugiki , Haruko Hirashima , Hideki Matsumoto , Toshihiko Yoshimura , Yasuko Nogi , Mitsuo Takahashi , Manabu Kitazawa , Akiko Oonuki , Naoyuki Fukuchi , Yoichiro Shima
发明人： Munetaka Tokumasu , Masayuki Sugiki , Haruko Hirashima , Hideki Matsumoto , Toshihiko Yoshimura , Yasuko Nogi , Mitsuo Takahashi , Manabu Kitazawa , Akiko Oonuki , Naoyuki Fukuchi , Yoichiro Shima
IPC分类号： A61K31/52 , A61K31/47 , A61K31/445 , A61K31/44 , C07D487/00 , C07D215/02 , C07D211/68
CPC分类号： A61K31/52 , A61K31/165 , A61K31/18 , A61K31/198 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/41 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/4355 , A61K31/4375 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/506 , C07C233/26 , C07C233/35 , C07C233/40 , C07C233/62 , C07C233/78 , C07C235/34 , C07C235/78 , C07C237/06 , C07C237/10 , C07C237/20 , C07C237/34 , C07C311/13 , C07C311/18 , C07C317/32 , C07C323/62 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/34 , C07D209/08 , C07D209/18 , C07D209/20 , C07D209/38 , C07D211/32 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/58 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/06 , C07D215/48 , C07D233/26 , C07D233/58 , C07D233/61 , C07D233/64 , C07D233/90 , C07D235/08 , C07D235/30 , C07D239/42 , C07D241/24 , C07D249/18 , C07D257/04 , C07D277/30 , C07D277/64 , C07D277/82 , C07D295/155 , C07D295/185 , C07D295/192 , C07D317/60 , C07D333/24 , C07D333/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D473/00 , C07D491/12
摘要： The present invention provides a novel compound having a kininogenase-inhibitory action and its pharmaceutical use. The compounds are represented by the formulas (A), (B), (C), (E) and (H): wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有激肽原酶抑制作用的新化合物及其药物用途。化合物由式（A），（B），（C），（E）和（H）表示：其中各符号如说明书中所定义，或其药学上可接受的盐。

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