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    • 6. 发明授权
    • Tubular prosthesis having a composite structure
    • 具有复合结构的管状假体
    • US4822361A
    • 1989-04-18
    • US945971
    • 1986-12-24
    • Koichi OkitaShigeru AsakoKatsuya YamadaKazuhiro OkabeTohru Kashiwagi
    • Koichi OkitaShigeru AsakoKatsuya YamadaKazuhiro OkabeTohru Kashiwagi
    • A61F2/06A61L27/16A61L27/34A61F2/04
    • A61L27/34A61F2/06A61L27/16
    • A tubular prosthesis having a composite structure comprising (i) tubular polytetrafluoroethylene having a microfibrous structure comprising small nodes interconnected with fibrils and (ii) materials which can be absorbed by a living body wherein (a) said polytetrafluoroethylene has a greater average fibril length on the outer surface than on the inner surface, and the fibrous structure of said polytetrafluoroethylene varies continuously across the thickness of the tube wall wherein said inner surface has said fibrous structure being predominantly oriented along the axial direction and said outer surface has said fibrous structure being predominantly oriented along the concentric direction; and (b) said materials which can be absorbed by a living body are collagen, at least one of albumin and chitosan, and heparin, and are distributed in such a manner that collagen is present in the portion of the tube wall which is closest to the outer surface thereof while at least one of albumin and chitosan is present in the portion of the tube wall which is closest to the inner surface thereof, and heparin is present in the inner surface of the tube wall.
    • 一种具有复合结构的管状假体,包括(i)具有微纤维结构的管状聚四氟乙烯,其包含与原纤维互连的小节点和(ii)可被活体吸收的材料,其中(a)所述聚四氟乙烯具有较大的平均原纤维长度 所述聚四氟乙烯的纤维结构在所述管壁的厚度上连续变化,其中所述内表面具有主要沿轴向方向的所述纤维结构,并且所述外表面具有主要取向的所述纤维结构 沿同心方向; 和(b)可以被活体吸收的所述物质是胶原蛋白,白蛋白和壳聚糖和肝素中的至少一种,并且以这样的方式分布,使得胶管存在于管壁的最接近 其外表面,而白蛋白和壳聚糖中的至少一种存在于最靠近其内表面的管壁部分中,并且肝素存在于管壁的内表面中。