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1. 发明授权

US08435781B2 Porous sheet-form material for cell culture, and bioreactor and culturing method utilizing same 失效
标题翻译：用于细胞培养的多孔片状材料，以及利用其的生物反应器和培养方法
公开(公告)号：US08435781B2
公开(公告)日：2013-05-07
申请号：US11574006
申请日：2005-08-12
申请人： Makoto Kodama
发明人： Makoto Kodama
IPC分类号： C12M1/14 , C12M3/04 , C12M1/00 , C12M3/00
CPC分类号： C12M23/04 , C12M23/34 , C12M25/02 , C12M29/04
摘要： The present invention provides a bioreactor having a system that can grow cells, tissue, etc. while maintaining or improving their function, and finally recover the cells as they are with good efficiency. The bioreactor has a porous sheet-form material disposed in its main body, the porous sheet-form material being formed from a nonwoven fabric, etc. having high cell affinity in order to retain cells. This porous sheet-form material has a thermosensitive polymer and a cell-adhesive substance incorporated thereinto, and the porous sheet-form material is not only cell-adhesive but also allows cells and tissue to be detached from the porous sheet-form material as they are by, for example, cooling from 37° C. to 25° C. Furthermore, in order to efficiently ensure the bioactivity or the survival of the cells, it is arranged so that circulation of a culture medium in a culturing space of the bioreactor is of a radial flow type.
摘要翻译：本发明提供一种生物反应器，其具有能够在保持或改善其功能的同时生长细胞，组织等的系统，并且最终以良好的效率原样回收细胞。生物反应器具有设置在其主体中的多孔片状材料，多孔片状材料由具有高细胞亲和力的无纺布等形成，以保留细胞。该多孔片状材料具有热敏性聚合物和结合在其中的细胞粘合剂物质，并且多孔片状材料不仅具有细胞粘附性，而且允许细胞和组织从多孔片状材料中分离，因为它们通过例如从37℃冷却至25℃。此外，为了有效地确保细胞的生物活性或存活，布置成使生物反应器的培养空间中的培养基循环是径向流型。

2. 发明申请

US20090017541A1 Porous Sheet-Form Material For Cell Culture, And Bioreactor And Culturing Method Utilizing Same 失效
标题翻译：用于细胞培养，生物反应器和利用其的培养方法的多孔片状材料
公开(公告)号：US20090017541A1
公开(公告)日：2009-01-15
申请号：US11574006
申请日：2005-08-12
申请人： Makoto Kodama
发明人： Makoto Kodama
IPC分类号： C12N5/06 , C12M1/00
CPC分类号： C12M23/04 , C12M23/34 , C12M25/02 , C12M29/04
摘要： The present invention provides a bioreactor having a system that can grow cells, tissue, etc. while maintaining or improving their function, and finally recover the cells as they are with good efficiency. The bioreactor has a porous sheet-form material disposed in its main body, the porous sheet-form material being formed from a nonwoven fabric, etc. having high cell affinity in order to retain cells. This porous sheet-form material has a thermosensitive polymer and a cell-adhesive substance incorporated thereinto, and the porous sheet-form material is not only cell-adhesive but also allows cells and tissue to be detached from the porous sheet-form material as they are by, for example, cooling from 37° C. to 25° C. Furthermore, in order to efficiently ensure the bioactivity or the survival of the cells, it is arranged so that circulation of a culture medium in a culturing space of the bioreactor is of a radial flow type.
摘要翻译：本发明提供一种生物反应器，其具有能够在保持或改善其功能的同时生长细胞，组织等的系统，并且最终以良好的效率原样回收细胞。生物反应器具有设置在其主体中的多孔片状材料，多孔片状材料由具有高细胞亲和力的无纺布等形成，以保留细胞。该多孔片状材料具有热敏性聚合物和结合在其中的细胞粘合剂物质，并且多孔片状材料不仅具有细胞粘附性，而且允许细胞和组织从多孔片状材料中分离，因为它们通过例如从37℃冷却至25℃。此外，为了有效地确保细胞的生物活性或存活，布置成使生物反应器的培养空间中的培养基循环是径向流型。

3. 发明申请

US20080281408A1 Artificial Blood Vessel 审中-公开
标题翻译：人造血管
公开(公告)号：US20080281408A1
公开(公告)日：2008-11-13
申请号：US11574538
申请日：2005-08-29
申请人： Makoto Kodama , Takashi Kitajima
发明人： Makoto Kodama , Takashi Kitajima
IPC分类号： A61F2/82
CPC分类号： A61L27/34 , A61L27/507 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , C08L77/04 , C08L75/04
摘要： It is an object of the present invention to retain on an artificial blood vessel material an endothelial cell growth-promoting agent, for example the angiogenic factor HGF, without impairing its activity, thereby providing an artificial blood vessel having the function of promoting endothelialization. Such an object can be attained by an artificial blood vessel that includes a porous tubular structure formed from, for example, polytetrafluoroethylene and, layered and immobilized in sequence onto at least the inner surface thereof, (1) a polyamino acid urethane copolymer, (2) collagen or gelatin, and (3) an endothelial cell growth-promoting agent having collagen-binding activity. Preferred examples of the endothelial cell growth-promoting agent include a fusion protein of a polypeptide having collagen-binding activity such as, for example, a fibronectin-derived polypeptide and an angiogenic factor, in particular, HGF.
摘要翻译：本发明的目的是在人造血管材料上保留内皮细胞生长促进剂，例如血管生成因子HGF，而不损害其活性，从而提供具有促进内皮化功能的人造血管。这样的目的可以通过人造血管来实现，该人造血管包括由例如聚四氟乙烯形成的多孔管状结构，并且至少在其内表面依次分层固定，（1）聚氨基酸氨基甲酸酯共聚物，（2 ）胶原或明胶，和（3）具有胶原结合活性的内皮细胞生长促进剂。内皮细胞生长促进剂的优选实例包括具有胶原结合活性的多肽的融合蛋白，例如来自纤连蛋白的多肽和血管生成因子，特别是HGF。

4. 发明授权

US5597456A Method for producing medical materials 失效
标题翻译：生产医疗材料的方法
公开(公告)号：US5597456A
公开(公告)日：1997-01-28
申请号：US595835
申请日：1996-02-02
申请人： Tohru Maruyama , Michio Abe , Hiroaki Nomiyama , Sachiko Okazaki , Masuhiro Kogoma , Makoto Kodama
发明人： Tohru Maruyama , Michio Abe , Hiroaki Nomiyama , Sachiko Okazaki , Masuhiro Kogoma , Makoto Kodama
IPC分类号： A61L29/00 , A61L33/00 , B29C59/14 , B29C71/04 , B29D23/00 , C08J7/00 , B01K1/00 , B05D3/06
CPC分类号： A61L33/0094 , B29C59/142
摘要： A plastic tube extruded from an extruder is conveyed through a plasma treatment apparatus. The plasma treatment apparatus is equipped with a tubular electrode body having a high-voltage side electrode and a grounded-side electrode disposed on a tubular insulator and a high frequency electric power source connected to the electrodes. When the plastic tube is conveyed through the electrode body with one end of the tube open to the atmosphere, a mixture of a glow discharge-stabilizing gas and a treating gas is fed into the other end of the tube and an alternating-current high-voltage is applied to generate a plasma region at a pressure near to atmospheric pressure in which the tube is treated with a glow discharge plasma. This method allows an interior and/or exterior surface of a plastic tube designed to convey a medical fluid to be continuously treated by a glow discharge plasma at atmospheric pressure to form an anti-thrombotic and blood-compatible film on the surface treated. The resulting surface-treated medical material can be produced at a comparatively low cost and maintains its original bulk material properties.
摘要翻译：从挤出机挤出的塑料管被输送通过等离子体处理装置。等离子体处理装置配备有管状电极体，其具有设置在管状绝缘体上的高压侧电极和接地侧电极以及与电极连接的高频电力源。当塑料管通过电极体输送到管的一端向大气开放时，辉光放电稳定气体和处理气体的混合物被供给到管的另一端，施加电压以在接近大气压的压力下产生等离子体区域，其中用辉光放电等离子体处理管。该方法允许塑料管的内表面和/或外表面设计成输送在大气压下由辉光放电等离子体连续处理的医用流体，以在被处理的表面上形成抗血栓形成和血液相容性膜。得到的经表面处理的医用材料可以以相对较低的成本制造并保持其原始的散装材料性质。

5. 外观设计

USD268999S Motorcycle 失效
公开(公告)号：USD268999S
公开(公告)日：1983-05-17
申请号：US246054
申请日：1981-03-20
申请人： Kouji Nakano , Makoto Kodama
设计人： Kouji Nakano , Makoto Kodama

6. 外观设计

USD410215S Motor-assisted vehicle 失效
公开(公告)号：USD410215S
公开(公告)日：1999-05-25
申请号：US80841
申请日：1997-11-26
申请人： Yutaka Murata , Makoto Kodama
设计人： Yutaka Murata , Makoto Kodama

7. 发明授权

US5028597A Antithrombogenic materials 失效
标题翻译：抗血栓形成材料
公开(公告)号：US5028597A
公开(公告)日：1991-07-02
申请号：US515768
申请日：1990-04-13
申请人： Makoto Kodama , Tsukasa Sakai , Keishiro Tsuda , Koichi Okita , Shigeru Asako , Masaharu Komamiya , Hiroshi Oinuma
发明人： Makoto Kodama , Tsukasa Sakai , Keishiro Tsuda , Koichi Okita , Shigeru Asako , Masaharu Komamiya , Hiroshi Oinuma
IPC分类号： A61L33/00 , A61L33/06
CPC分类号： A61L33/0029 , A61L33/062 , Y10S128/08
摘要： An antithrombogenic material is described, comprising an expanded polytetrafluoroethylene base having a collagen layer provided on the surface thereof, and further provided thereon a composite layer of collagen and a mucopolysaccharide, and said collagen is crosslinked with a crosslinking agent.
摘要翻译：描述了抗血栓形成材料，其包括在其表面上具有胶原层的膨胀聚四氟乙烯基底，并且还在其上设置有胶原和粘多糖的复合层，并且所述胶原蛋白与交联剂交联。

8. 发明授权

US4196907A Record player 失效
标题翻译：记录播放器
公开(公告)号：US4196907A
公开(公告)日：1980-04-08
申请号：US878658
申请日：1978-02-16
申请人： Kazuyuki Takizawa , Toshio Sato , Makoto Kodama , Shiro Yasuda
发明人： Kazuyuki Takizawa , Toshio Sato , Makoto Kodama , Shiro Yasuda
IPC分类号： G11B17/08 , G11B17/04 , G11B15/00
CPC分类号： G11B17/05
摘要： A record player with a turntable mounted for rotation in a substantially fixed horizontal plane on a chassis and a tone arm for reproducing signals recorded on the surface of a record disc which faces upwardly when the disc is rotatably supported on the turntable, is provided with a record turn-over mechanism comprised of a support structure, for example, in the form of lever assemblies, mounted on the chassis for swinging between raised and lowered positions about an axis which extends parallel to a diameter of the turntable and is disposed to one side of the latter, a pair of spaced apart gripping devices directed inwardly towards each other from end portions, respectively, of the support structure and being axially movable between gripping positions at which the gripping devices are engageable with diametrically opposed locations on the periphery of a record disc and released positions, the gripping devices also being turnable relative to the support structure about a common axis parallel with the axis of swinging movement of the support structure, and cams for effecting the swinging movements of the support structure and the axial and turnable movements of the gripping devices through an operating cycle in which the gripping devices are made to engage a record disc on the turntable with the support structure in its lowered position and then the support structure is moved to its raised position for lifting the engaged disc from the turntable, whereupon the gripping devices are turned through 180.degree. for inverting the lifted record disc and the support structure is then returned to its lowered position and the gripping devices are released for freeing the inverted record disc on the turntable.
摘要翻译：具有转盘的记录播放器，其安装成用于在基座上基本上固定的水平平面中旋转，并且用于再现当盘被可旋转地支撑在转台上时面向上的记录盘的表面上记录的信号的色调臂，记录翻转机构包括一个支撑结构，例如杠杆组件的形式，安装在底盘上，用于围绕平行于转盘的直径延伸的轴线的升高和降低位置之间摆动，并设置在一侧后者的一对间隔开的夹持装置分别从支撑结构的端部朝向彼此指向，并且可在夹持位置之间轴向移动，在夹持位置处，夹持装置可与记录的周边上的直径相对的位置接合盘和释放位置，夹持装置也可围绕公共轴线pa相对于支撑结构转动与支撑结构的摆动运动的轴线平行，以及用于实现支撑结构的摆动运动和夹持装置的轴向和可转动运动的凸轮，其中夹持装置使夹持装置与记录盘接合使支撑结构处于其降低位置的转盘，然后将支撑结构移动到其升起位置，用于将转盘从转盘上提升，于是夹持装置转过180度，以使提升的记录盘反转，并且支撑结构然后返回到其降低的位置，释放夹紧装置以释放转盘上的倒置记录盘。

9. 发明授权

US4464743A Record playing apparatus 失效
标题翻译：录音播放器
公开(公告)号：US4464743A
公开(公告)日：1984-08-07
申请号：US548031
申请日：1983-11-02
申请人： Kazuyuki Takizawa , Takao Izumi , Makoto Kodama
发明人： Kazuyuki Takizawa , Takao Izumi , Makoto Kodama
IPC分类号： G11B3/095 , G11B17/04 , G11B19/02 , G11B33/02 , G11B1/00
CPC分类号： G11B17/056 , G11B19/02 , G11B3/0952 , G11B33/027
摘要： Record playing apparatus includes a housing having an opening at its front end; a record carrier assembly having a turntable for supporting a record disc and a tone arm assembly for reproducing signals from the disc; guide rollers which support the record carrier assembly for horizontal movement through the opening between a first position within the housing and a second position withdrawn from the housing; a dust cover; a pair of elongated arms pivotally mounted at one end thereof to opposing sides of the record carrier assembly and having the dust cover connected to the free ends thereof; springs for biasing the arms to move the dust cover to a first cover position in blocking relation to the opening when the record carrier assembly is moved to its first position; and cam bars for biasing the arms against the force of the springs when the record carrier assembly is moved to its second position so as to move the dust cover out of the aforementioned blocking relation and into a slot formed in a mounting frame secured to the front end of the record carrier assembly.
摘要翻译：记录播放装置包括在其前端具有开口的壳体; 记录载体组件，其具有用于支撑记录盘的转台和用于从盘再现信号的音调臂组件; 引导辊，其支撑记录载体组件，用于通过壳体内的第一位置和从壳体撤回的第二位置之间的开口水平移动; 防尘罩一对细长臂，其一端枢转地安装在记录载体组件的相对侧上，并且防尘盖连接到其自由端; 弹簧，用于当记录载体组件移动到其第一位置时偏压臂以将防尘罩移动到与开口处阻塞的第一盖位置; 以及凸轮杆，用于当记录载体组件移动到其第二位置时抵抗弹簧的力偏压臂，以便将防尘盖移出上述阻挡关系，并进入形成在固定到前面的安装框架中的槽中记录载体组件的末端。

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