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1. 发明申请

US20110286937A1 SYNTHETIC GLYCOLIPID-CONTAINING LIPOSOME 审中-公开
标题翻译：含有合成的含有甘油的脂质体
公开(公告)号：US20110286937A1
公开(公告)日：2011-11-24
申请号：US12918467
申请日：2009-02-18
申请人： Makoto Kiso , Hideharu Ishida , Taiji Yamashita , Koichi Igarashi , Masahiko Hirai
发明人： Makoto Kiso , Hideharu Ishida , Taiji Yamashita , Koichi Igarashi , Masahiko Hirai
IPC分类号： A61K49/18 , A61K49/00 , A61K39/395 , A61K38/48 , A61K38/47 , A61K38/38 , A61K38/02 , A61K33/24 , A61K31/573 , A61K48/00 , A61K31/7105 , A61K31/225 , A61K31/727 , A61K31/551 , A61K31/663 , A61K31/722 , A61K9/127
CPC分类号： A61K9/1272 , A61K31/22 , A61K31/551 , A61K31/573 , A61K31/663 , A61K31/722 , A61K31/727 , A61K38/38 , A61K38/47 , A61K38/4886 , A61K38/49 , A61K47/549 , A61K47/6911 , C12N15/88 , C12N2810/859
摘要： The present invention provides a glycolipid-containing liposome. In such a glycolipid-containing liposome, the glycolipid includes a plant ceramide portion and a sugar chain portion. The present invention also provides a method of producing a glycolipid-containing liposome. This method includes the following steps of: A) providing a glycolipid in which the glycolipid includes a plant ceramide portion and a sugar chain portion; and B) mixing the provided glycolipid with a liposome raw material and subjecting the mixture to conditions in which a liposome is formed.
摘要翻译：本发明提供了含糖脂的脂质体。在这种含糖脂的脂质体中，糖脂包括植物神经酰胺部分和糖链部分。本发明还提供了含糖脂的脂质体的制造方法。该方法包括以下步骤：A）提供糖脂，其中糖脂包含植物神经酰胺部分和糖链部分; 和B）将所提供的糖脂与脂质体原料混合并使混合物进入其中形成脂质体的条件。

2. 发明申请

US20100034874A1 LIPOSOME ENCAPSULATING AMMINE-PLATINUM COMPLEX AT HIGH CONCENTRATION, AND METHOD FOR PRODUCTION OF THE LIPOSOME 审中-公开
标题翻译：在高浓度下的脂质体包封的铂 - 铂复合物，以及生产脂质体的方法
公开(公告)号：US20100034874A1
公开(公告)日：2010-02-11
申请号：US12300496
申请日：2007-12-07
申请人： Masahiko Hirai , Koichi Igarashi , Masahiko Chikuma , Kazunori Oie
发明人： Masahiko Hirai , Koichi Igarashi , Masahiko Chikuma , Kazunori Oie
IPC分类号： A61K9/127 , A61K33/24 , A61P35/00
CPC分类号： A61K33/22 , A61K9/127 , A61K33/24
摘要： The present invention provides a method of producing a liposome encapsulating an ammine platinum complex. The method includes A) providing a water-soluble ammine platinum complex, platinum complex raw materials or the combination thereof; B) providing a liposome, liposome raw materials or the combination; and C) preparing a mixture of the water-soluble ammine platinum complex, platinum complex raw materials or the combination thereof and the liposome, liposome raw materials or the combination thereof and subjecting it to a liposome-forming/maintaining condition, wherein the salt of the platinum complex forms when the liposome is in a water-soluble form.
摘要翻译：本发明提供一种生产包封氨基铂络合物的脂质体的方法。该方法包括：A）提供水溶性氨络铂络合物，铂络合物原料或其组合; B）提供脂质体，脂质体原料或组合; 和C）制备水溶性氨络铂络合物，铂络合物原料或其组合的混合物和脂质体，脂质体原料或其组合，并使其成为脂质体形成/保持条件，其中盐当脂质体是水溶性形式时，形成铂络合物。

3. 发明申请

US20130011466A1 LIPOSOME ENCAPSULATING AMMINE-PLATINUM COMPLEX AT HIGH CONCENTRATION, AND METHOD FOR PRODUCTION OF THE LIPOSOME 审中-公开
标题翻译：在高浓度下的脂质体包封的铂 - 铂复合物，以及生产脂质体的方法
公开(公告)号：US20130011466A1
公开(公告)日：2013-01-10
申请号：US13603195
申请日：2012-09-04
申请人： Masahiko Hirai , Koichi Igarashi , Masahiko Chikuma , Kazunori Oie
发明人： Masahiko Hirai , Koichi Igarashi , Masahiko Chikuma , Kazunori Oie
IPC分类号： A61K9/127 , A61K33/24
CPC分类号： A61K33/22 , A61K9/127 , A61K33/24
摘要： The present invention provides a method of producing a liposome encapsulating an ammine platinum complex. The method includes A) providing a water-soluble ammine platinum complex, platinum complex raw materials or the combination thereof; B) providing a liposome, liposome raw materials or the combination; and C) preparing a mixture of the water-soluble ammine platinum complex, platinum complex raw materials or the combination thereof and the liposome, liposome raw materials or the combination thereof and subjecting it to a liposome-forming/maintaining condition, wherein the salt of the platinum complex forms when the liposome is in a water-soluble form.
摘要翻译：本发明提供一种生产包封氨基铂络合物的脂质体的方法。该方法包括：A）提供水溶性氨络铂络合物，铂络合物原料或其组合; B）提供脂质体，脂质体原料或组合; 和C）制备水溶性氨络铂络合物，铂络合物原料或其组合的混合物和脂质体，脂质体原料或其组合，并使其成为脂质体形成/保持条件，其中盐当脂质体是水溶性形式时，形成铂络合物。

4. 发明授权

US6130485A Semiconductor integrated circuit and layout method thereof 失效
标题翻译：半导体集成电路及其布局方法
公开(公告)号：US6130485A
公开(公告)日：2000-10-10
申请号：US210673
申请日：1998-12-14
申请人： Masahiko Hirai
发明人： Masahiko Hirai
IPC分类号： H01L27/04 , H01L21/82 , H01L21/822 , H01L27/02 , H01L23/48 , H01L23/52 , H01L29/40
CPC分类号： H01L27/0207
摘要： A pad block is provided with a pad, an output buffer circuit and an internal circuit. The region between the internal circuit and the output buffer circuit serves as an element arrangement forbidden region. In this region, the internal circuit and the output buffer circuit are connected to each other by, for example, a polysilicon layer. The internal circuit is connected to a circuit formed in an internal region of a chip by using at least two wiring layers passing the element arrangement forbidden region. By laying out the wiring connecting the internal circuit within the pad block to the circuit in the internal region of the chip in the element arrangement forbidden region provided within the pad block, it is possible to reduce a space necessary for wiring and thereby to realize a highly integrated device.
摘要翻译：焊盘块设有焊盘，输出缓冲电路和内部电路。内部电路和输出缓冲电路之间的区域用作禁止区域的元件布置。在该区域中，内部电路和输出缓冲电路通过例如多晶硅层彼此连接。内部电路通过使用穿过元件布置禁区的至少两个布线层连接到形成在芯片的内部区域中的电路。通过布置将焊盘块内的内部电路连接到设置在焊盘块内的元件布置禁止区域中的芯片的内部区域中的电路，可以减少布线所需的空间，从而实现高度集成的设备。

5. 发明授权

US6061804A Pulse generating circuit for providing a low-noise microprocessor clock signal 失效
标题翻译：用于提供低噪声微处理器时钟信号的脉冲发生电路
公开(公告)号：US6061804A
公开(公告)日：2000-05-09
申请号：US96733
申请日：1998-06-12
申请人： Masahiko Hirai
发明人： Masahiko Hirai
IPC分类号： H03K5/1252 , G06F1/06
CPC分类号： H03K5/1252 , G06F1/06
摘要： A pulse generating circuit for producing the clock signal of a microcomputer is improved to reduce the dependence of noise elimination on power supply voltage. Clock pulses from an oscillator are subjected to waveform shaping and then are frequency-divided by a frequency divider circuit. A selector circuit is provided to select the input signal to or an output signal from the frequency divider circuit. A noise eliminating circuit is provided on the output side of the selector circuit. This arrangement makes it possible to generate noise-free pulses over a wide range of operating power supply voltages.
摘要翻译：改善了用于产生微计算机的时钟信号的脉冲发生电路，以减少噪声消除对电源电压的依赖性。来自振荡器的时钟脉冲经受波形整形，然后由分频器电路分频。提供选择器电路以选择来自分频器电路的输入信号或输出信号。噪声消除电路设置在选择器电路的输出侧。这种布置使得可以在宽范围的工作电源电压下产生无噪声脉冲。

6. 发明授权

US5861765A Analogue delay circuit with a constant delay time 失效
标题翻译：具有恒定延迟时间的模拟延迟电路
公开(公告)号：US5861765A
公开(公告)日：1999-01-19
申请号：US720690
申请日：1996-10-02
申请人： Masahiko Hirai
发明人： Masahiko Hirai
IPC分类号： H03H11/26 , H03K5/13 , H03K19/094 , H03K19/0952
CPC分类号： H03K5/133
摘要： In an analogue delay circuit which is constructed from a p-type MOS transistor and an n-type MOS transistor and which includes an inverter gate for inputting input signals and a capacitance having one electrode connected to ground and the other electrode connected to the drain of the inverter gate, the gate potential of the n-type MOS transistor is limited by means of a clamping circuit so as not to exceed the minimum operating voltage, and the potential of a line connected to an electrode of the capacitance is limited by another clamping circuit so as to not exceed the minimum operating voltage.
摘要翻译：在由p型MOS晶体管和n型MOS晶体管构成的模拟延迟电路中，包括用于输入输入信号的反相器门和连接到地的一个电极的电容，而与漏极连接的另一个电极逆变器栅极，n型MOS晶体管的栅极电位通过钳位电路来限制，以便不超过最小工作电压，并且连接到电容的电极的线的电位被另一个钳位限制电路不得超过最小工作电压。

7. 发明授权

US5767719A Delay circuit using capacitor and transistor 失效
标题翻译：延迟电路使用电容和晶体管
公开(公告)号：US5767719A
公开(公告)日：1998-06-16
申请号：US680975
申请日：1996-07-16
申请人： Masaki Furuchi , Masahiko Hirai
发明人： Masaki Furuchi , Masahiko Hirai
IPC分类号： H03H11/26 , H03K5/13 , H03K5/151
CPC分类号： H03K5/133 , H03K5/1515
摘要： A delay circuit comprising at least one capacitor with one electrode thereof is connected to a fixed potential, a signal transmission line, and at least one switch means between the other electrode of the capacitor and the signal transmission line. The switch means makes electrical connection or disconnection between the capacitor and the signal transmission line in accordance with an actual supply voltage value.
摘要翻译：包括具有一个电极的至少一个电容器的延迟电路连接到固定电位，信号传输线以及电容器的另一个电极与信号传输线之间的至少一个开关装置。开关装置根据实际的电源电压值进行电容器和信号传输线路的电连接或断开。

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