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1. 发明授权

US06743227B2 Intraluminal visualization system with deflectable mechanism 有权
标题翻译：具有偏转机制的管腔内可视化系统
公开(公告)号：US06743227B2
公开(公告)日：2004-06-01
申请号：US09822678
申请日：2001-03-30
申请人： Mahmoud K. Seraj , Eric Chan , James F. Kelley
发明人： Mahmoud K. Seraj , Eric Chan , James F. Kelley
IPC分类号： A61B1818
CPC分类号： A61M25/0668 , A61B18/1492 , A61B2017/22038 , A61M25/0051 , A61M25/0054 , A61M25/0138 , A61M25/0147 , A61M2025/0042 , A61M2025/0047 , A61M2025/0081 , A61M2025/0161 , A61M2025/0681 , A61M2025/1052 , A61M2025/1079 , A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： This is a combination method and system for intravascularly accessing and visualizing a body structure. A system is disclosed comprising a sheath, a balloon catheter, and a catheter deflection mechanism. A micro-deflection mechanism, which may be placed into the lumen of devices such as cardiac leads or electrophysiology catheters, is also provided for accurate guidance and placement of such devices to their target location. In one embodiment, a procedure for a lead or catheter placement is described in which a combination deflection mechanism, balloon catheter, and sheath assembly access the coronary sinus ostium via a superior approach. A distal balloon on the catheter is inflated and an occlusive venogram is obtained under fluoroscopic guidance to visualize the coronary veins. The sheath is advanced into the coronary sinus ostium and the balloon is deflated. The catheter and deflection mechanism are then removed. Next, a micro-deflection mechanism that has been inserted into the lumen of a cardiac lead is deployed through the sheath, allowing the lead to deflect with a high degree of accuracy and control as it is placed in the selected location.
摘要翻译：这是用于血管内访问和可视化身体结构的组合方法和系统。公开了一种包括护套，球囊导管和导管偏转机构的系统。还可以提供可以放置在诸如心脏引线或电生理学导管的装置的内腔中的微偏转机构，用于将这些装置精确地引导和放置到其目标位置。在一个实施例中，描述了用于引导或导管放置的过程，其中组合偏转机构，球囊导管和护套组件通过优异的方法进入冠状窦口。导管上的远端气球被充气，并且在荧光镜引导下获得闭塞静脉图以使冠状静脉可视化。鞘进入冠状窦口，气囊放气。然后取出导管和偏转机构。接下来，已经插入到心脏引线的内腔中的微偏转机构通过护套展开，从而允许引线在被放置在所选择的位置时以高度的精度和控制偏转。

2. 发明授权

US08409219B2 Method and system for placement of electrical lead inside heart 有权
标题翻译：电线内置心脏的方法和系统
公开(公告)号：US08409219B2
公开(公告)日：2013-04-02
申请号：US12570390
申请日：2009-09-30
申请人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
发明人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
IPC分类号： A61B19/00
CPC分类号： A61N1/059 , A61B17/12 , A61B17/12009 , A61B17/128 , A61B17/3468 , A61B2017/00247 , A61B2017/12018 , A61B2018/00392
摘要： A method of placing an electrical lead of an implantable cardiac device inside a heart of a patient. The method includes securing a tool to an atrial appendage of the heart to hold onto the atrial appendage, piercing the atrial appendage, and creating an aperture in the atrial appendage while holding the atrial appendage with the tool. The method also includes moving a distal end of the electrical lead into the heart through the aperture in the atrial appendage and into a ventricle of the heart. Furthermore, the method includes coupling the distal end of the electrical lead to cardiac tissue in the ventricle and delivering an electrical signal to the cardiac tissue in the ventricle of the heart to maintain a predetermined heartbeat of the heart.
摘要翻译：将可植入心脏装置的电引线放置在患者心脏内的方法。该方法包括将工具固定到心脏的心房附着物，以固定在心房附近，刺穿心房附件，以及在用该工具持有心房附件的同时创建心房附近的孔。该方法还包括通过心耳中的孔将电引线的远端移动到心脏中并进入心脏的心室。此外，该方法包括将电导线的远端耦合到心室中的心脏组织，并将电信号传送到心脏心室的心脏组织以维持心脏的预定心跳。

3. 发明授权

US06836687B2 Method and system for delivery of a medical electrical lead within a venous system 有权
标题翻译：用于在静脉系统内递送医用电线的方法和系统
公开(公告)号：US06836687B2
公开(公告)日：2004-12-28
申请号：US10131388
申请日：2002-04-25
申请人： James F. Kelley , James H. Vaughn , Stanten C. Spear , Douglas S. Hine , Kenneth C. Gardeski , Vicki L. Bjorklund , Pedro A. Meregotte , John L. Sommer , John J. Maier
发明人： James F. Kelley , James H. Vaughn , Stanten C. Spear , Douglas S. Hine , Kenneth C. Gardeski , Vicki L. Bjorklund , Pedro A. Meregotte , John L. Sommer , John J. Maier
IPC分类号： A61N105
CPC分类号： A61M25/0138 , A61B18/1492 , A61B2017/22038 , A61M25/005 , A61M25/0054 , A61M25/0141 , A61M25/0147 , A61M25/0668 , A61M39/0613 , A61M2025/0042 , A61M2025/0047 , A61M2025/0081 , A61M2025/0161 , A61M2025/0681 , A61M2025/1052 , A61M2025/1079 , A61N1/05 , A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： A system for delivering a medical electrical lead within a coronary venous system that includes an introducer kit for establishing venous access to the coronary venous system and a plurality of delivery sheaths, each corresponding to a desired approach to a coronary sinus of the coronary venous system and insertable within the coronary venous system through the navigation pathway. A hemostasis valve is coupled to a delivery sheath of the plurality of delivery sheaths, and a guide wire is inserted within the lead lumen, guiding delivery of the distal tip of the medical electrical lead to a target site within the coronary venous system through the hemostasis valve and the delivery sheath. Subsequent to the distal tip being delivered to the target sight, the hemostasis valve is advanced over the connector of the medical electrical lead to remove the hemostasis valve from the medical electrical lead.
摘要翻译：一种用于在冠状静脉系统内递送医用电线的系统，其包括用于建立对冠状静脉系统的静脉通路的引导器套件和多个输送护套，每个输送护套对应于冠状静脉系统的冠状窦所需的方法，通过导航路径插入冠状静脉系统内。止血阀联接到多个输送护套的输送护套，并且引导线插入引导腔内，通过止血将医用电导线的远端引导到冠状静脉系统内的靶位点阀门和输送护套。在远端尖端被传送到目标瞄准器之后，止血阀在医用电线的连接器上前进，以从医用电引线上除去止血阀。

4. 发明授权

US5282466A System for disabling oximeter in presence of ambient light 失效
公开(公告)号：US5282466A
公开(公告)日：1994-02-01
申请号：US770672
申请日：1991-10-03
申请人： Timothy J. Duffy , Ralph M. Kerns , James F. Kelley , Eric J. Fogt
发明人： Timothy J. Duffy , Ralph M. Kerns , James F. Kelley , Eric J. Fogt
IPC分类号： A61B5/00 , G01N21/27
CPC分类号： A61B5/14535 , A61B5/14557 , A61B5/1495 , G01N21/274 , A61B2560/0233 , G01N2201/1244 , G01N2201/1281
摘要： A system for disabling an oximetric device when radiation-carrying channels are exposed to excess ambient radiation is disclosed. It includes a transmitter channel adjacent the sample to be measured, means for isolating the channel from the sample so that it does not carry radiation reflected from or transmitted through the sample, a detector for receiving the transmitted signal, if any, and means for disabling the output in response to the transmitted signal. Preferably, the transmitter channel runs parallel to other transmitter channels in the device, and is isolated from undue ambient light. The system preferably includes means for determining when the second transmitted signal exceeds background noise and the output is disabled when the second transmitted signal exceeds background noise. In general, the sample is a fluid, usually blood, passing through a cuvette adjacent the fiber-optic channels, the cuvette defining an area of radiation absorption adjacent the transmitter channel so that the transmitter does not carry reflected or transmitted radiation from the sample. Also disclosed is a fiber-optic sensor for measuring components of a composition by detecting transmitted or reflected, usually reflected, radiation including such a system, and the cuvette therefore. Finally, a method of disabling the output of an oximetric device when the fiber-optic channels are exposed to undue ambient radiation is disclosed.

5. 发明授权

US08509916B2 Bilumen guide catheters for accessing cardiac sites 有权
标题翻译：用于进入心脏部位的腹导管导管
公开(公告)号：US08509916B2
公开(公告)日：2013-08-13
申请号：US10319245
申请日：2002-12-16
申请人： Charles L. Byrd , Kenneth C. Gardeski , Michael R. Leners , Linda L. Lach , Ralph J. Thomas , Jesse T. Torbert , James F. Kelley
发明人： Charles L. Byrd , Kenneth C. Gardeski , Michael R. Leners , Linda L. Lach , Ralph J. Thomas , Jesse T. Torbert , James F. Kelley
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0578
摘要： Bilumen catheters and methods of using same for facilitating implantation of cardiac leads for applying electrical stimulation to and/or sensing electrical activity of the heart through one or more electrode positioned at an implantation site within a heart chamber or cardiac vessel adjacent a heart chamber, and more particularly to a method and apparatus for introducing such a cardiac lead having low torqueability and pushability through a tortuous pathway to enable attachment of the cardiac lead at the implantation site employing a bilumen guide catheter are disclosed. The bilumen catheter body includes a relatively large diameter delivery lumen to introduce a small diameter cardiac lead and a small diameter guide lumen to receive a stylet or guidewire to locate the guide catheter body distal end at the implantation site. The small diameter lumen within a small diameter guide tube extends distally from the delivery exit port of the delivery lumen.
摘要翻译：白细胞导管及其使用方法，用于促进心脏引线的植入，用于通过位于心室或邻近心室的心脏腔内的植入部位的一个或多个电极施加电刺激和/或感测心脏的电活动，以及更具体地涉及一种用于通过曲折路径引入具有低可逆性和推动性的这种心脏引线以使得能够使用柏油导引导管在植入部位处附着心脏引线的方法和装置。胆囊导管主体包括相对大直径的输送腔，以引入小直径心脏引线和小直径引导腔，以接收探针或导丝，以将引导导管主体远端定位在植入部位。小直径导管内的小直径内腔从输送腔的输送出口向远端延伸。

6. 发明申请

US20100030063A1 SYSTEM AND METHOD FOR TRACKING AN INSTRUMENT 审中-公开
标题翻译：跟踪仪器的系统和方法
公开(公告)号：US20100030063A1
公开(公告)日：2010-02-04
申请号：US12183674
申请日：2008-07-31
申请人： Nathan Tyler Lee , Rick Dean McVenes , Can Cinbis , Jonathan Leslie Kuhn , James F. Kelley
发明人： Nathan Tyler Lee , Rick Dean McVenes , Can Cinbis , Jonathan Leslie Kuhn , James F. Kelley
IPC分类号： A61B5/05
CPC分类号： A61B5/06 , A61B5/065 , A61B5/6858 , A61B6/4441 , A61B6/487 , A61B34/20 , A61B2034/2046 , A61B2034/2051 , A61B2034/2055 , A61B2034/2061 , A61B2034/2072 , A61B2562/0266 , A61M25/01 , G01B11/18 , G02B6/02057
摘要： A system for tracking an instrument relative to an anatomical structure is provided. The system can include at least one tracking device, which can be coupled to the instrument. The system can also include a shape sensor coupled to the instrument that can determine a shape of the instrument. The system can include a tracking system that can track a position of the at least one tracking device relative to the anatomical structure. The system can further include a navigation system that can determine a position and shape of the instrument relative to the anatomical structure based on the position of the at least one tracking device determined by the tracking system and the shape of the instrument as sensed by the shape sensor.
摘要翻译：提供了一种用于相对于解剖结构跟踪器械的系统。该系统可以包括至少一个可以耦合到仪器的跟踪装置。该系统还可以包括耦合到仪器的形状传感器，其可以确定仪器的形状。该系统可以包括跟踪系统，其可以跟踪至少一个跟踪装置相对于解剖结构的位置。该系统还可以包括导航系统，该导航系统可以基于由跟踪系统确定的至少一个跟踪装置的位置和由形状所感测到的乐器的形状来确定乐器相对于解剖结构的位置和形状传感器。

7. 发明申请

US20090198298A1 METHODS AND SYSTEMS FOR USE IN SELECTING CARDIAC PACING SITES 有权
标题翻译：用于选择心脏病网站的方法和系统
公开(公告)号：US20090198298A1
公开(公告)日：2009-08-06
申请号：US12421176
申请日：2009-04-09
申请人： Daniel R. Kaiser , Michael R. Neidert , Nicholas David Skadsberg , Kenneth C. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
发明人： Daniel R. Kaiser , Michael R. Neidert , Nicholas David Skadsberg , Kenneth C. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
IPC分类号： A61N1/365 , A61B5/05
CPC分类号： A61B5/1107 , A61B5/1104 , A61B5/686 , A61B5/6882 , A61B2562/0209 , A61N1/0573 , A61N1/3627 , A61N1/36578 , A61N1/368 , A61N1/3684 , A61N1/3686 , A61N2001/0585
摘要： A method and system for use in selecting a cardiac pacing site includes sensors for tracking wall motion (e.g., sensors coupled to the right and left ventricular heart wall). The wall motion of one or more non-paced cardiac cycles is compared to the wall motion of one or more paced cardiac cycles to determine the effectiveness of one or more pacing sites. For example, image data may be generated to notify the user as to the effectiveness of the one or more pacing sites.
摘要翻译：用于选择心脏起搏部位的方法和系统包括用于跟踪壁运动的传感器（例如耦合到右心室壁和左心室心壁的传感器）。将一个或多个非节奏心脏周期的壁运动与一个或多个节奏心动周期的壁运动进行比较，以确定一个或多个起搏部位的有效性。例如，可以生成图像数据以通知用户关于一个或多个起搏站点的有效性。

8. 发明授权

US06205358B1 Method of making ultrasonically welded, staked of swaged components in an implantable medical device 有权
标题翻译：在可植入医疗器械中超声波焊接，锻压组件的方法
公开(公告)号：US06205358B1
公开(公告)日：2001-03-20
申请号：US09159119
申请日：1998-09-23
申请人： Daniel C. Haeg , Craig L. Wiklund , James F. Kelley
发明人： Daniel C. Haeg , Craig L. Wiklund , James F. Kelley
IPC分类号： A61N1362
CPC分类号： A61N1/375 , Y10T29/49174
摘要： The present invention generally relates to implantable medical devices and more particularly to various means for ultrasonically welding, swaging or staking various components in an implantable medical device, most preferably by employing appropriately configured covers or lids. Covers or lids are attached to header or connector modules mounted on an hermetically enclosed and sealed enclosure, where the connector or header module and enclosure comprise an implantable medical device. The covers or lids preferably trap or otherwise secure any of a number of various connector or header module components within the header or connector modules. Examples of such trapped or secured components include grommets, set screw connector blocks, seals, feedthrough wires, multi-beam contacts, electrical contacts, antennas, radio-opaque markers, connector ribbons and the like.
摘要翻译：本发明总体上涉及可植入医疗装置，更具体地说，涉及用于在植入式医疗装置中超声波焊接，锻压或铆接各种部件的各种装置，最优选地采用适当配置的盖子或盖子。盖子或盖子连接到安装在密封和密封的外壳上的插头或连接器模块，其中连接器或插头模块和外壳包括可植入的医疗装置。盖子或盖子优选地捕获或以其他方式固定头部或连接器模块内的多个连接器或头部模块组件中的任何一个。这种被捕获或固定部件的实例包括垫圈，固定螺钉连接器块，密封件，馈通线，多梁接触件，电触头，天线，不透射线的标记，连接器带等。

9. 发明授权

US6150473A Polyetherimide resin/polyester resin blends having improved properties 有权
标题翻译：具有改进性能的聚醚酰亚胺树脂/聚酯树脂共混物
公开(公告)号：US6150473A
公开(公告)日：2000-11-21
申请号：US211304
申请日：1998-12-14
申请人： Sterling Bruce Brown , Yimin Jin , James F. Kelley , Jun Liao , Michael Teruki Takemori , Raymond Lee Utley
发明人： Sterling Bruce Brown , Yimin Jin , James F. Kelley , Jun Liao , Michael Teruki Takemori , Raymond Lee Utley
IPC分类号： C08K5/00 , C08K5/1515 , C08L63/00 , C08L67/02 , C08L79/08
CPC分类号： C08L67/02 , C08K5/005 , C08K5/1515 , C08L79/08
摘要： The present invention is directed to a thermoplastic resin composition comprising one or more polyetherimide resins; one or more polyester resins; at least one epoxy compound having one or more epoxy functional groups per molecule in an amount effective to improve at least one of impact resistance, hydrolytic resistance, and tab-bending performance of a molded specimen of the composition; and optionally, at least one catalyst in an amount effective to improve at least one of impact resistance, hydrolytic resistance, and tab-bending performance of a molded specimen of the composition as compared to the same composition not containing the catalyst. It was unexpectedly found that the compositions exhibited enhanced heat, impact, hydrolytic resistance, and/or enhanced tab-bending performance over other compositions known in the art. In a preferred embodiment, the epoxy compound contains 3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexanecarboxylate and the catalyst contains sodium stearate.
摘要翻译：本发明涉及一种包含一种或多种聚醚酰亚胺树脂的热塑性树脂组合物; 一种或多种聚酯树脂; 至少一种每分子具有一个或多个环氧官能团的环氧化合物，其量可以有效地改善组合物的模制样品的抗冲击性，抗水解性和弯曲弯曲性能中的至少一种; 和任选的至少一种催化剂，其量可以有效地改善与不含催化剂的相同组合物相比，该组合物的模塑试样的耐冲击性，耐水解性和弯曲弯曲性能中的至少一种。意外地发现，与本领域已知的其它组合物相比，组合物显示出增强的热，冲击，抗水解性和/或增强的弯片弯曲性能。在优选的实施方案中，环氧化合物含有3,4-环氧环己基甲基-3,4-环氧环己烷羧酸酯，催化剂含有硬脂酸钠。

10. 发明授权

US07162309B2 Epicardial lead delivery system and method 有权
标题翻译：心外膜导联系统及方法
公开(公告)号：US07162309B2
公开(公告)日：2007-01-09
申请号：US10408426
申请日：2003-04-07
申请人： Timothy G. Laske , James F. Kelley
发明人： Timothy G. Laske , James F. Kelley
IPC分类号： A61N1/05 , A61B5/042
CPC分类号： A61N1/0587 , A61N2001/0578
摘要： A manipulator joined to a distal end of a delivery system shaft includes a plurality of arms and a collar. A proximal portion of each of the arms is joined to the shaft and a distal portion of each of the arms is joined to the collar such that the collar is substantially aligned with a lumen of the shaft. The lumen and the collar slideably and rotatably engage a medical electrical lead while a plurality of control wires, adapted to manipulate the manipulator, join to each of the plurality of manipulator arms in proximity to the distal end of the shaft.
摘要翻译：接合到输送系统轴的远端的操纵器包括多个臂和一个套环。每个臂的近端部分连接到轴，并且每个臂的远端部分连接到轴环，使得轴环基本上与轴的内腔对准。内腔和套管可滑动地和可旋转地接合医疗电引线，而适于操纵操纵器的多个控制线连接到靠近轴的远端的多个操纵臂中的每一个。

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