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1. 发明授权

US08409219B2 Method and system for placement of electrical lead inside heart 有权
标题翻译：电线内置心脏的方法和系统
公开(公告)号：US08409219B2
公开(公告)日：2013-04-02
申请号：US12570390
申请日：2009-09-30
申请人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
发明人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
IPC分类号： A61B19/00
CPC分类号： A61N1/059 , A61B17/12 , A61B17/12009 , A61B17/128 , A61B17/3468 , A61B2017/00247 , A61B2017/12018 , A61B2018/00392
摘要： A method of placing an electrical lead of an implantable cardiac device inside a heart of a patient. The method includes securing a tool to an atrial appendage of the heart to hold onto the atrial appendage, piercing the atrial appendage, and creating an aperture in the atrial appendage while holding the atrial appendage with the tool. The method also includes moving a distal end of the electrical lead into the heart through the aperture in the atrial appendage and into a ventricle of the heart. Furthermore, the method includes coupling the distal end of the electrical lead to cardiac tissue in the ventricle and delivering an electrical signal to the cardiac tissue in the ventricle of the heart to maintain a predetermined heartbeat of the heart.
摘要翻译：将可植入心脏装置的电引线放置在患者心脏内的方法。该方法包括将工具固定到心脏的心房附着物，以固定在心房附近，刺穿心房附件，以及在用该工具持有心房附件的同时创建心房附近的孔。该方法还包括通过心耳中的孔将电引线的远端移动到心脏中并进入心脏的心室。此外，该方法包括将电导线的远端耦合到心室中的心脏组织，并将电信号传送到心脏心室的心脏组织以维持心脏的预定心跳。

2. 发明申请

US20100042110A1 METHOD AND SYSTEM FOR PLACEMENT OF ELECTRICAL LEAD INSIDE HEART 有权
标题翻译：电子导管内心放置方法及系统
公开(公告)号：US20100042110A1
公开(公告)日：2010-02-18
申请号：US12570390
申请日：2009-09-30
申请人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
发明人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
IPC分类号： A61B17/00
CPC分类号： A61N1/059 , A61B17/12 , A61B17/12009 , A61B17/128 , A61B17/3468 , A61B2017/00247 , A61B2017/12018 , A61B2018/00392
摘要： A method of placing an electrical lead of an implantable cardiac device inside a heart of a patient. The method includes securing a tool to an atrial appendage of the heart to hold onto the atrial appendage, piercing the atrial appendage, and creating an aperture in the atrial appendage while holding the atrial appendage with the tool. The method also includes moving a distal end of the electrical lead into the heart through the aperture in the atrial appendage and into a ventricle of the heart. Furthermore, the method includes coupling the distal end of the electrical lead to cardiac tissue in the ventricle and delivering an electrical signal to the cardiac tissue in the ventricle of the heart to maintain a predetermined heartbeat of the heart.
摘要翻译：将可植入心脏装置的电引线放置在患者心脏内的方法。该方法包括将工具固定到心脏的心房附着物，以固定在心房附近，刺穿心房附件，以及在用该工具持有心房附件的同时创建心房附近的孔。该方法还包括通过心耳中的孔将电引线的远端移动到心脏中并进入心脏的心室。此外，该方法包括将电导线的远端耦合到心室中的心脏组织，并将电信号传送到心脏心室的心脏组织以维持心脏的预定心跳。

3. 发明申请

US20120165795A1 THERAPEUTIC AGENT RESERVOIR DELIVERY SYSTEM 有权
标题翻译：治疗药剂储存系统
公开(公告)号：US20120165795A1
公开(公告)日：2012-06-28
申请号：US12979580
申请日：2010-12-28
申请人： Peter M. Seiler , Kenneth E. Cobian , Genevieve L. Gallagher , Zhongping C. Yang
发明人： Peter M. Seiler , Kenneth E. Cobian , Genevieve L. Gallagher , Zhongping C. Yang
IPC分类号： A61M5/00 , A61K31/65 , A61P31/00 , A61K9/00
CPC分类号： A61K9/0024 , A61K9/7084 , A61K31/496 , A61K31/65 , A61K2300/00
摘要： A therapeutic agent reservoir comprises a reservoir body comprising a polymer and a therapeutic agent mixed within the polymer, and an outer coating enclosing the reservoir body, wherein at least a portion of the outer coating comprises a rate-controlling membrane configured to provide a predetermined release rate of the therapeutic agent through the rate-controlling membrane.
摘要翻译：治疗剂贮存器包括储存器本体，其包含聚合物和混合在聚合物内的治疗剂，以及封闭储存器主体的外涂层，其中外涂层的至少一部分包括速率控制膜，其配置成提供预定释放治疗剂通过速率控制膜的速率。

4. 发明申请

US20110123517A1 DISSOLVABLE PHARMACEUTICAL IMPLANT 审中-公开
标题翻译：不溶性药物植入物
公开(公告)号：US20110123517A1
公开(公告)日：2011-05-26
申请号：US12960091
申请日：2010-12-03
申请人： Genevieve L. Gallagher , Kimberly Chaffin , Zhongping C. Yang
发明人： Genevieve L. Gallagher , Kimberly Chaffin , Zhongping C. Yang
IPC分类号： A61K38/48 , A61K38/02 , A61K31/14 , A61K31/19 , A61K31/65 , A61K31/485 , A61K31/137 , A61K31/167 , A61K31/616 , A61K31/192 , A61K31/56 , A61K31/122 , A61K38/36 , A61K31/715 , A61K31/722 , A61P31/00 , A61P29/00 , A61P25/04 , A61P7/04 , A61P3/02
CPC分类号： A61K9/0024 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2095 , A61K31/122 , A61K31/137 , A61K31/14 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/485 , A61K31/56 , A61K31/616 , A61K31/65 , A61K31/715 , A61K31/722 , A61K45/06 , A61K47/02 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： A pharmaceutical implant may include a pharmaceutical and at least one excipient, and may be configured to be implanted in a body of a patient. The at least one excipient may dissolve after implantation of the pharmaceutical implant in the body of the patient and release the pharmaceutical. In some examples, the pharmaceutical implant includes at least two pharmaceuticals. The at least one excipient may be selected to provide a desired release profile of the pharmaceutical. For example, the pharmaceutical implant may be configured to dissolve and release the pharmaceutical over a length of time between about one day and about 30 days. In some examples, the pharmaceutical implant may be implanted in the body of the patient proximate to an implantable medical device.
摘要翻译：药物植入物可以包括药物和至少一种赋形剂，并且可以被配置成植入患者体内。所述至少一种赋形剂在将所述药物植入物植入患者体内后可以溶解并释放药物。在一些实例中，药物植入物包括至少两种药物。可以选择至少一种赋形剂以提供药物的期望释放曲线。例如，药物植入物可以构造成在约一天至约30天之间的一段时间内溶解和释放药物。在一些实例中，药物植入物可以植入患者体内，靠近植入式医疗装置。

5. 发明授权

US08911427B2 Therapeutic agent reservoir delivery system 有权
标题翻译：治疗剂储库输送系统
公开(公告)号：US08911427B2
公开(公告)日：2014-12-16
申请号：US12979580
申请日：2010-12-28
申请人： Peter M. Seiler , Kenneth E. Cobian , Genevieve L. Gallagher , Zhongping C. Yang
发明人： Peter M. Seiler , Kenneth E. Cobian , Genevieve L. Gallagher , Zhongping C. Yang
IPC分类号： A61K9/22 , A61K9/00 , A61K31/496 , A61K31/65 , A61K9/70
CPC分类号： A61K9/0024 , A61K9/7084 , A61K31/496 , A61K31/65 , A61K2300/00
摘要： A therapeutic agent reservoir comprises a reservoir body comprising a polymer and a therapeutic agent mixed within the polymer, and an outer coating enclosing the reservoir body, wherein at least a portion of the outer coating comprises a rate-controlling membrane configured to provide a predetermined release rate of the therapeutic agent through the rate-controlling membrane.
摘要翻译：治疗剂贮存器包括储存器本体，其包含聚合物和混合在聚合物内的治疗剂，以及封闭储存器主体的外涂层，其中外涂层的至少一部分包括速率控制膜，其配置成提供预定释放治疗剂通过速率控制膜的速率。

6. 发明申请

US20110118813A1 ELECTRODE ASSEMBLY IN A MEDICAL ELECTRICAL LEAD 有权
标题翻译：医用电线中的电极组件
公开(公告)号：US20110118813A1
公开(公告)日：2011-05-19
申请号：US12915631
申请日：2010-10-29
申请人： Zhongping C. Yang , Piotr J. Przybyszewski , Ben W. Herberg , Kevin R. Seifert , Dina L. Williams
发明人： Zhongping C. Yang , Piotr J. Przybyszewski , Ben W. Herberg , Kevin R. Seifert , Dina L. Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/375 , A61N1/05 , A61N1/086 , A61N1/3718
摘要： A medical device lead is presented that includes an electrode assembly having a first electrode located near a distal end of the electrode assembly and a second electrode located near a proximal end of the electrode assembly. The electrode assembly also includes a conductive elongated coupler that is electrically coupled to the first electrode and capacitively coupled to the second electrode. At low frequencies and DC (e.g., during delivery of stimulation therapy), the capacitive coupling between the conductive elongated coupler and the second electrode presents a high impedance allowing little current to be redirected from the first electrode to the second electrode. However, at high frequencies (e.g., during an MRI scan) the capacitive coupling between the conductive elongated coupler and the second electrode presents a low impedance, resulting in a significant amount of induced current being redirected to the second electrode and dissipated into bodily fluid surrounding the second electrode.
摘要翻译：提供了一种医疗装置引线，其包括具有位于电极组件的远端附近的第一电极的电极组件和位于电极组件的近端附近的第二电极。电极组件还包括电耦合到第一电极并电容耦合到第二电极的导电细长耦合器。在低频和DC（例如，在递送刺激疗法期间），导电细长耦合器和第二电极之间的电容耦合呈现高阻抗，允许将电流从第一电极重定向到第二电极。然而，在高频（例如，在MRI扫描期间），导电细长耦合器和第二电极之间的电容耦合呈现低阻抗，导致大量的感应电流被重定向到第二电极并且耗散到周围的体液中第二电极。

7. 发明授权

US09861814B2 Medical electrical lead having biological surface and methods of making and using same 有权
公开(公告)号：US09861814B2
公开(公告)日：2018-01-09
申请号：US12977655
申请日：2010-12-23
申请人： Zhongping C. Yang
发明人： Zhongping C. Yang
IPC分类号： A61F2/06 , A61N1/05
CPC分类号： A61N1/056
摘要： An implantable electrical lead suitable for left sided cardiac placement, the implantable medical electrical lead having an external blood contacting surface having an external coating including a monolayer of at least one biological agent that promotes endothelialization covalently attached to a polymeric lead surface.

8. 发明授权

US09014815B2 Electrode assembly in a medical electrical lead 有权
标题翻译：医用电极中的电极组件
公开(公告)号：US09014815B2
公开(公告)日：2015-04-21
申请号：US12915631
申请日：2010-10-29
申请人： Zhongping C. Yang , Piotr J. Przybyszewski , Ben W. Herberg , Kevin R. Seifert , Dina L. Williams
发明人： Zhongping C. Yang , Piotr J. Przybyszewski , Ben W. Herberg , Kevin R. Seifert , Dina L. Williams
IPC分类号： A61N1/05 , A61N1/375 , A61N1/37 , A61N1/08
CPC分类号： A61N1/375 , A61N1/05 , A61N1/086 , A61N1/3718
摘要： A medical device lead is presented that includes an electrode assembly having a first electrode located near a distal end of the electrode assembly and a second electrode located near a proximal end of the electrode assembly. The electrode assembly also includes a conductive elongated coupler that is electrically coupled to the first electrode and capacitively coupled to the second electrode. At low frequencies and DC (e.g., during delivery of stimulation therapy), the capacitive coupling between the conductive elongated coupler and the second electrode presents a high impedance allowing little current to be redirected from the first electrode to the second electrode. However, at high frequencies (e.g., during an MRI scan) the capacitive coupling between the conductive elongated coupler and the second electrode presents a low impedance, resulting in a significant amount of induced current being redirected to the second electrode and dissipated into bodily fluid surrounding the second electrode.
摘要翻译：提供了一种医疗装置引线，其包括具有位于电极组件的远端附近的第一电极的电极组件和位于电极组件的近端附近的第二电极。电极组件还包括电耦合到第一电极并电容耦合到第二电极的导电细长耦合器。在低频和DC（例如，在递送刺激疗法期间），导电细长耦合器和第二电极之间的电容耦合呈现高阻抗，允许将电流从第一电极重定向到第二电极。然而，在高频（例如，在MRI扫描期间），导电细长耦合器和第二电极之间的电容耦合呈现低阻抗，导致大量的感应电流被重定向到第二电极并且耗散到周围的体液中第二电极。

9. 发明申请

US20120165913A1 MEDICAL ELECTRICAL LEAD HAVING BIOLOGICAL SURFACE AND METHODS OF MAKING AND USING SAME 有权
标题翻译：具有生物表面的医用电线及其制造和使用方法
公开(公告)号：US20120165913A1
公开(公告)日：2012-06-28
申请号：US12977655
申请日：2010-12-23
申请人： Zhongping C. Yang
发明人： Zhongping C. Yang
IPC分类号： A61N1/05 , B05D5/00
CPC分类号： A61N1/056
摘要： An implantable electrical lead suitable for left sided cardiac placement, the implantable medical electrical lead having an external blood contacting surface having an external coating including a monolayer of at least one biological agent that promotes endothelialization covalently attached to a polymeric lead surface.
摘要翻译：一种适于左侧心脏放置的可植入电线，所述可植入医用电线具有外部血液接触表面，所述外部血液接触表面具有外部涂层，所述外部涂层包括促进共价连接至聚合物引线表面的内皮细胞的至少一种生物试剂的单层。

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