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1. 发明申请

WO2004003565A3 A SCREENING METHOD AND COMPOUNDS FOR TREATING FRIEDREICH ATAXIA 审中-公开
标题翻译：一种用于处理FRIEDREICH ATAXIA的筛选方法和化合物
公开(公告)号：WO2004003565A3
公开(公告)日：2004-10-14
申请号：PCT/EP0307006
申请日：2003-07-01
申请人： MYOCONTRACT LTD , MEIER THOMAS , JAUSLIN MATTHIAS , SCHOUMACHER FABRICE
发明人： MEIER THOMAS , JAUSLIN MATTHIAS , SCHOUMACHER FABRICE
IPC分类号： G01N33/68 , A61K31/12
CPC分类号： G01N33/6896 , G01N2500/10 , G01N2800/2835
摘要： The present invention relates to a method for identifying and/or validating candidate substances for the treatment of Friedreich Ataxia (FRDA). Furthermore, the present invention relates to the use of selenium, Ebselen and Glutathione peroxidase (GPX) mimetics for the preparation of a medicament for the treatment of FRDA. Another aspect of the present invention relates to the use of cells with reduced frataxin expression for identifying and/or validating candidate substances for the treatment of Friedreich Ataxia.
摘要翻译：本发明涉及用于鉴定和/或验证用于治疗弗里德赖希共济失调（FRDA）的候选物质的方法。此外，本发明涉及硒，依布硒和谷胱甘肽过氧化物酶（GPX）模拟物在制备用于治疗FRDA的药物中的用途。本发明的另一方面涉及具有降低的frataxin表达的细胞用于鉴定和/或验证用于治疗Friedreich共济失调的候选物质的用途。

2. 发明申请

WO0208445A2 A NOVEL METHOD AND ASSAYS FOR YEAST-BASED DRUG SCREENING 审中-公开
标题翻译：一种用于基于YEAST的药物筛选的新方法和测定
公开(公告)号：WO0208445A2
公开(公告)日：2002-01-31
申请号：PCT/EP0107984
申请日：2001-07-11
申请人： MYOCONTRACT PHARMACEUTICAL RES , MEIER THOMAS , JAUSLIN MATTHIAS , NUOFFER CLAUDE A
发明人： MEIER THOMAS , JAUSLIN MATTHIAS , NUOFFER CLAUDE A
IPC分类号： C12Q1/02 , C12Q
CPC分类号： C12Q1/025
摘要： The present invention provides a method wherein yeast mutants deficient in the expression of the yeast homolog of frataxin are applied for the identification and/or evaluation of pharmaceutically active compounds. The invention concerns especially a method wherein the yeast strain W303-1B/ DELTA ydl120w::Kan is applied for the identification and/or evaluation of chemical and biochemical compounds that protect W303-1B/ DELTA ydl120w::Kan yeast from chemical stress. Furthermore, the invention concerns the application of said method in new cell-based assays to be used for drug screening.
摘要翻译：本发明提供了一种方法，其中将缺乏弗拉他辛酵母同系物的酵母突变体用于鉴定和/或评价药物活性化合物。本发明特别涉及一种方法，其中将酵母菌株W303-1B / DELTA ydl120w :: Kan应用于鉴定和/或评估保护W303-1B / DELTA ydl120w :: Kan的化学和生化化合物，化学应力的酵母此外，本发明涉及所述方法在新的基于细胞的测定中的应用以用于药物筛选。

3. 发明申请

WO2008070539A3 STAMPED CLUTCH POCKET PLATE, METHOD FOR MAKING THE POCKET PLATE, AND CLUTCH INCLUDING THE POCKET PLATE 审中-公开
标题翻译：加盖的离合器口袋板，用于制造口袋板的方法以及包括口袋板的离合器
公开(公告)号：WO2008070539A3
公开(公告)日：2008-09-12
申请号：PCT/US2007086021
申请日：2007-11-30
申请人： MEANS IND INC , MEIER THOMAS
发明人： MEIER THOMAS
IPC分类号： F16D13/64
CPC分类号： B21D53/12 , F16D41/125
摘要： A one-way clutch (20) includes a notch plate (22), and a stamped pocket plate (24) having an annular flange (38) and a splined axial sleeve (40). Semi-pierced strut pockets (44) are stamped in the annular flange (38) of the pocket plate (24) and each includes a stamped spring pocket (46) for receiving an associated spring (28) that biases a strut (26) received within the strut pocket. Holes (48j) are initially stamped in the annular flange 38 and the spring pockets (46) are then stamped thereabout prior to the semi-piercing of the strut pockets (44). Semi- pierced pads (50) in the annular flange (38) alternate circumferentially with the strut pockets (44).
摘要翻译：单向离合器（20）包括凹口板（22）以及具有环形凸缘（38）和花键轴向套筒（40）的冲压凹口板（24）。在凹座板（24）的环形凸缘（38）中冲压出半刺穿的支柱凹座（44），每个支座凹座包括冲压的弹簧凹座（46），用于接纳偏置接收的支柱（26）的相关弹簧（28）在支柱口袋里。首先在环形凸缘38中冲压孔48j，然后在对支柱槽44进行半刺穿之前在其周围冲压弹簧套46。环形凸缘（38）中的半穿孔垫（50）与支柱袋（44）周向交替。

4. 发明申请

WO2005121361A3 SEQUENCE-SPECIFIC DETECTION OF METHYLATION IN BIOMOLECULES 审中-公开
标题翻译：生物分子中甲基化的序列特异性检测
公开(公告)号：WO2005121361A3
公开(公告)日：2006-09-28
申请号：PCT/EP2005006374
申请日：2005-06-14
申请人： HAFTEN E V MAX PLANCK GES ZUR , WEINHOLD ELMAR , MEIER THOMAS , DUEFEL HARTMUT , MARKERT-HAHN CHRISTINE , SCHMUCK RAINER
发明人： WEINHOLD ELMAR , MEIER THOMAS , DUEFEL HARTMUT , MARKERT-HAHN CHRISTINE , SCHMUCK RAINER
IPC分类号： C07H19/16 , C12Q1/68
CPC分类号： C07H19/16 , C12Q1/6827 , C12Q2537/164 , C12Q2522/101 , C12Q2521/125
摘要： The present invention relates to a method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting a biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a detectable cofactor of said methyltransferase; and (b) detecting whether the recognition sequence of said methyltransferase has been modified with the cofactor or a derivative thereof, wherein modification of the recognition sequence of said methyltransferase is indicative of an absence of methylation at said recognition sequence. The present invention also relates to a cofactor which is specific for S-adenosyl-L-methionine-dependent methyltransferases, wherein said cofactor is an N-adenosylaziridine derivative with a reporter group attached to the 6 or 7 position of the adenine ring or attached to the aziridine ring. Moreover, the present invention relates to a complex of the cofactor of the present invention and a methyltransferase which normally uses S-adenosyl-L-methionine (AdoMet) as a cofactor. In addition, the present invention relates to a diagnostic composition comprising the cofactor of the present invention or the complex of the present invention. Finally, the present invention relates to the use of the cofactor of the present invention or the complex of the present invention for detecting sequence-specific methylation in DNA molecules.
摘要翻译：本发明涉及用于检测生物分子中序列特异性甲基化的方法，其包括：（a）在所述甲基转移酶的可检测辅因子存在下使生物分子与S-腺苷-L-甲硫氨酸依赖性甲基转移酶接触; 和（b）检测所述甲基转移酶的识别序列是否已经用辅因子或其衍生物修饰，其中所述甲基转移酶的识别序列的修饰指示在所述识别序列处不存在甲基化。本发明还涉及对S-腺苷-L-甲硫氨酸依赖性甲基转移酶特异性的辅因子，其中所述辅因子是N-腺苷氮丙啶衍生物，其报告基团连接到腺嘌呤环的6或7位或附着于氮丙啶环。此外，本发明涉及本发明的辅因子与通常使用S-腺苷-L-甲硫氨酸（AdoMet）作为辅因子的甲基转移酶的复合物。此外，本发明涉及包含本发明的辅因子或本发明的复合物的诊断组合物。最后，本发明涉及本发明的辅因子或本发明的复合物用于检测DNA分子中的序列特异性甲基化的用途。

5. 发明申请

WO2005049495A2 METHOD AND DEVICE FOR OBTAINING NITROGENOUS FERTILISERS FROM ORGANIC WASTE PRODUCTS 审中-公开
标题翻译：方法和装置用于获得氮肥有机废物
公开(公告)号：WO2005049495A2
公开(公告)日：2005-06-02
申请号：PCT/EP2004013034
申请日：2004-11-15
申请人： PHOENIX BETEILIGUNGS GMBH , SPINDLER HERBERT , BAUERMEISTER UTE , MEIER THOMAS , TESKE MICHAEL
发明人： SPINDLER HERBERT , BAUERMEISTER UTE , MEIER THOMAS , TESKE MICHAEL
IPC分类号： C01C1/242 , C01C1/26 , C02F1/58 , C05C3/00 , C05D3/02 , C05F3/00 , C05F17/00 , C01C1/24 , C01F11/18
CPC分类号： C05F17/0018 , C05C3/005 , C05D3/02 , C05F3/00 , Y02A40/205 , Y02E50/343 , Y02P20/145 , Y02W30/43 , C05D9/00 , C05F3/06
摘要： The invention relates to a method and device for obtaining nitrogenous fertilisers from organic waste products in liquid phase (suspension, emulsion, solution), for the sanitation of the wastes and for emission reduction by thermal treatment using mineral or organic adjuncts. According to the invention, the above is achieved by means of a method in which the waste product is heated to a temperature of between 40 DEG C and 90 DEG C at a reduced pressure, the gas emitted, which contains carbon dioxide and ammonia, is cooled and introduced into an aqueous absorption agent, the nitrogenous fertiliser thus produced is removed and the excess unabsorbed gas containing carbon dioxide is pumped back into the waste chamber, whereby the vacuum generated at the beginning of the process by a vacuum pump is self-maintaining. The recycling of the excess gas into the circuit is advantageously achieved either directly above the waste product for treatment, or via a gas cooling system directly above the waste product for treatment, or in divided form, with a part stream through the waste product and a part stream above the waste product. A gypsum slurry is preferably used as aqueous absorption agent.
摘要翻译：本发明涉及一种用于从有机废物在液相中（悬浮液，乳液，溶液）生产氮肥料，以及用于废物消毒并减少通过使用无机或有机的添加剂的热处理排放的方法和装置。根据本发明，通过在其中在40℃，并加热至90℃之间的温度下在真空中的废产物，该气体从而逸出和含有冷却的二氧化碳和氨与引入的含水吸收介质中，形成在处理和排出的氮肥料的方法失败，则这吸收和废气含二氧化碳的被泵送回到处理容器，在通过所述处理的过程中通过真空泵产生的过程的开始的负压自发被保持。便利地携带的过量气体在循环返回，通过被任一上述废物直接引入被处理过的产物或气体冷却系统上方的废物被处理过的产物或通过废产物和废产物上方的另一部分流分割部分的电流。优选地，石膏浆料用作含水吸收剂。

6. 发明申请

WO2011054931A3 FOOD VENDING MACHINE AND IDENTIFICATION DEVICE FOR IDENTIFYING EDIBLE PRODUCTS IN A FOOD VENDING MACHINE 审中-公开
标题翻译：食品机械及零嘴鉴定的食品，机器识别设备到
公开(公告)号：WO2011054931A3
公开(公告)日：2011-06-30
申请号：PCT/EP2010066926
申请日：2010-11-05
申请人： METEOR AG , MEIER THOMAS
发明人： MEIER THOMAS
IPC分类号： G07F9/10 , A47J36/38 , G07F11/18
CPC分类号： G07F11/18 , G07F9/026 , G07F9/105 , G07F11/165 , G07F17/0078
摘要： The invention relates to a food vending machine (1), in which at least one edible product (2) can be stored, cooled and/or heated. According to the invention, a transport platform (25) is arranged for transporting the edible product (2) in the food vending machine (1). The transport platform can be moved along at least one guide rail (26) in the x-direction, y-direction and/or z-direction of a Cartesian coordinate system by means of at least one lever arm (28), which can be pivoted by a drive motor (27). The invention further relates to an identification device (29) for identifying edible products (2) in a food vending machine. The food vending machine has a drawer and comprises a mechanism for opening the packaging (4) of the edible product while the drawer (3) is being inserted into the machine (1).
摘要翻译：本发明涉及一公共饮食机（1），其中，至少一种可食用产品（2）可存储，冷却和/或加热。根据本发明的输送所述可食用产品（2）在饮食机（1）通过沿枢转杠杆臂由驱动电机的至少一个（27）的装置设置在运输平台（25）（28）具有在x方向，Y至少一个导轨（26）笛卡尔坐标系的方向和/或z方向上的可移动。此外，本发明涉及一种识别装置（29）到零嘴（2）的标识的食品自动售货机（1）。餐饮机有一个抽屉。本机采用在机器（1）的抽屉（3）的缩回期间打开所述可食用的包（4）的机构。

7. 发明申请

WO2008011365A2 FLOW FORMING CONNECTION OF METALLIC PARTS AND RESULTANT PART ASSEMBLY 审中-公开
标题翻译：流体形成金属部件和部件组件的连接
公开(公告)号：WO2008011365A2
公开(公告)日：2008-01-24
申请号：PCT/US2007073582
申请日：2007-07-16
申请人： TRANSFORM AUTOMOTIVE LLC , MEIER THOMAS
发明人： MEIER THOMAS
IPC分类号： B21D39/00 , B21D22/00
CPC分类号： B21D22/14 , B21D39/04 , Y10T29/49913
摘要： A method and apparatus (10) provide a flow formed part assembly (12) having mechanically interlocked first and second metallic parts (22) and (24).
摘要翻译：一种方法和装置（10）提供具有机械互锁的第一和第二金属部件（22）和（24）的流动形成部件组件（12）。

8. 发明申请

WO2006098988A2 TRANSMISSION UNITARY SHELL OUTPUT CARRIER AND RING GEAR 审中-公开
标题翻译：传输单元壳体输出载体和环形齿轮
公开(公告)号：WO2006098988A2
公开(公告)日：2006-09-21
申请号：PCT/US2006008277
申请日：2006-03-09
申请人： TRANSFORM AUTOMOTIVE LLC , MEIER THOMAS
发明人： MEIER THOMAS
IPC分类号： F16H3/44
CPC分类号： F16H55/17 , F16H3/66 , F16H2055/176
摘要： A transmission component (12, 12') for transferring torque about a transmission rotational axis A includes a shell output carrier (62) and a ring gear portion (64) of a unitary one-piece construction flow formed from a blank around a mandrel. The transmission component (12, 12') transfers torque between a planet gear carrier (28) of a first planetary gear set (18) and a ring gear location of a second planetary gear set (20).
摘要翻译：用于围绕变速器旋转轴线A传递扭矩的变速器部件（12,12'）包括壳体输出托架（62）和由围绕心轴的坯件形成的整体单件结构流动的齿圈部分（64）。变速器部件（12,12'）在第一行星齿轮组（18）的行星齿轮架（28）和第二行星齿轮组（20）的齿圈位置之间传递扭矩。

9. 发明申请

WO2011012270A8 ENZYMATIC SYNTHESIS OF CARBA-NAD 审中-公开
标题翻译： CARBA-NAD的酶促合成
公开(公告)号：WO2011012270A8
公开(公告)日：2012-02-23
申请号：PCT/EP2010004523
申请日：2010-07-23
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , DUEFEL HARTMUT , HEINDL DIETER , HORN CARINA , MEIER THOMAS , SCHMUCK RAINER
发明人： DUEFEL HARTMUT , HEINDL DIETER , HORN CARINA , MEIER THOMAS , SCHMUCK RAINER
IPC分类号： C12P19/32
CPC分类号： C07H19/207 , C12P19/32
摘要： The invention concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called "carba-NADs", i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose.
摘要翻译：本发明涉及烟酰胺腺嘌呤二核苷酸NAD / NADH和烟酰胺腺嘌呤二核苷酸磷酸NADP / NADPH的稳定类似物的酶合成，即所谓的“carba-NAD”，即NAD / NADH或NADP / NADPH的类似物，分别包含碳环糖代替核糖。

10. 发明申请

WO2006105875A2 METHOD AND DEVICE FOR PRODUCING NITROGEN FERTILIZER, REMOVING PHOSPHATE FROM ORGANIC WASTE PRODUCTS, AND LIMITING THE POTASSIUM CONCENTRATION 审中-公开
标题翻译：方法和装置用于获得氮肥除磷有机废物和限制钾的含量
公开(公告)号：WO2006105875A2
公开(公告)日：2006-10-12
申请号：PCT/EP2006002744
申请日：2006-03-21
申请人： NACHHALTIGE STOFFNUTZUNG MBH G , SPINDLER HERBERT , BAUERMEISTER UTE , MEIER THOMAS
发明人： SPINDLER HERBERT , BAUERMEISTER UTE , MEIER THOMAS
CPC分类号： C05B17/00 , C05C3/00 , C05F3/00 , C05F7/00 , Y02A40/205 , Y02A40/213 , Y02E50/343 , Y02P20/145 , Y02W30/47 , C05F3/06
摘要： The invention relates to a method and a device for producing nitrogen fertilizer, removing phosphate from organic waste products in liquid phase, sanitizing said waste or reducing emissions, and limiting the potassium concentration. According to the invention, the waste product is heated to temperatures ranging between 40 °C and 90 °C at a subatmospheric pressure, the escaping gas that contains carbon dioxide and ammonia is contacted with a mineral-aqueous suspension, the excess gas is conducted within the circuit while the subatmospheric pressure is autogenously stabilized, and the formed nitrogen fertilizer is discharged. In order to additionally produce phosphate fertilizer and limit the potassium concentration, the obtained fertilizer product is divided into the liquid and solid portion, and all or some of the solid portion is redirected into the stripping receptacle while the liquid waste product that is stripped of nitrogen compounds and phosphorus compounds is cooled and mixed with at least one sulfate-containing compound to limit the potassium concentration. Optionally, the viscosity of the waste product is specifically reduced and a very small amount of a basic mineral powder is added thereto. The last solid portion obtained from said treatment can be used directly as phosphate fertilizer, potassium fertilizer, or phosphate-containing and potassium-containing mixed fertilizer.
摘要翻译：本发明涉及一种方法和用于在液相中生产氮肥料和磷酸盐去除有机废物产品以及用于废物消毒，并减少排放和限制了钾含量，废物产物在真空中在温度40℃和90°之间的装置下加热，使具有在接触矿物 - 水悬浮液的逸出二氧化碳和氨的含气体，出多余的气体在自生的负压稳定在循环和所形成的氮肥排出。根据本发明， - 分离所形成的肥料产品在固体和液体馏分和固体级分返回全部或部分的剥离和冷却该贫氮和磷化合物的液体废物产物和 - 用磷酸盐肥料的额外的回收的目的，钾含量的边界限制性的钾与至少一种含硫酸盐化合物混合，任选地，其中有选择地减少了浪费产品的粘度的内容，和碱性矿物粉这是一个非常小的量添加。从该处理最后固体部分可以直接使用磷酸，磷酸钾和钾为基础的或混合肥料回收。

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