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1. 发明申请

WO2011012270A8 ENZYMATIC SYNTHESIS OF CARBA-NAD 审中-公开
标题翻译： CARBA-NAD的酶促合成
公开(公告)号：WO2011012270A8
公开(公告)日：2012-02-23
申请号：PCT/EP2010004523
申请日：2010-07-23
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , DUEFEL HARTMUT , HEINDL DIETER , HORN CARINA , MEIER THOMAS , SCHMUCK RAINER
发明人： DUEFEL HARTMUT , HEINDL DIETER , HORN CARINA , MEIER THOMAS , SCHMUCK RAINER
IPC分类号： C12P19/32
CPC分类号： C07H19/207 , C12P19/32
摘要： The invention concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called "carba-NADs", i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose.
摘要翻译：本发明涉及烟酰胺腺嘌呤二核苷酸NAD / NADH和烟酰胺腺嘌呤二核苷酸磷酸NADP / NADPH的稳定类似物的酶合成，即所谓的“carba-NAD”，即NAD / NADH或NADP / NADPH的类似物，分别包含碳环糖代替核糖。

2. 发明申请

WO2005121361A3 SEQUENCE-SPECIFIC DETECTION OF METHYLATION IN BIOMOLECULES 审中-公开
标题翻译：生物分子中甲基化的序列特异性检测
公开(公告)号：WO2005121361A3
公开(公告)日：2006-09-28
申请号：PCT/EP2005006374
申请日：2005-06-14
申请人： HAFTEN E V MAX PLANCK GES ZUR , WEINHOLD ELMAR , MEIER THOMAS , DUEFEL HARTMUT , MARKERT-HAHN CHRISTINE , SCHMUCK RAINER
发明人： WEINHOLD ELMAR , MEIER THOMAS , DUEFEL HARTMUT , MARKERT-HAHN CHRISTINE , SCHMUCK RAINER
IPC分类号： C07H19/16 , C12Q1/68
CPC分类号： C07H19/16 , C12Q1/6827 , C12Q2537/164 , C12Q2522/101 , C12Q2521/125
摘要： The present invention relates to a method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting a biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a detectable cofactor of said methyltransferase; and (b) detecting whether the recognition sequence of said methyltransferase has been modified with the cofactor or a derivative thereof, wherein modification of the recognition sequence of said methyltransferase is indicative of an absence of methylation at said recognition sequence. The present invention also relates to a cofactor which is specific for S-adenosyl-L-methionine-dependent methyltransferases, wherein said cofactor is an N-adenosylaziridine derivative with a reporter group attached to the 6 or 7 position of the adenine ring or attached to the aziridine ring. Moreover, the present invention relates to a complex of the cofactor of the present invention and a methyltransferase which normally uses S-adenosyl-L-methionine (AdoMet) as a cofactor. In addition, the present invention relates to a diagnostic composition comprising the cofactor of the present invention or the complex of the present invention. Finally, the present invention relates to the use of the cofactor of the present invention or the complex of the present invention for detecting sequence-specific methylation in DNA molecules.
摘要翻译：本发明涉及用于检测生物分子中序列特异性甲基化的方法，其包括：（a）在所述甲基转移酶的可检测辅因子存在下使生物分子与S-腺苷-L-甲硫氨酸依赖性甲基转移酶接触; 和（b）检测所述甲基转移酶的识别序列是否已经用辅因子或其衍生物修饰，其中所述甲基转移酶的识别序列的修饰指示在所述识别序列处不存在甲基化。本发明还涉及对S-腺苷-L-甲硫氨酸依赖性甲基转移酶特异性的辅因子，其中所述辅因子是N-腺苷氮丙啶衍生物，其报告基团连接到腺嘌呤环的6或7位或附着于氮丙啶环。此外，本发明涉及本发明的辅因子与通常使用S-腺苷-L-甲硫氨酸（AdoMet）作为辅因子的甲基转移酶的复合物。此外，本发明涉及包含本发明的辅因子或本发明的复合物的诊断组合物。最后，本发明涉及本发明的辅因子或本发明的复合物用于检测DNA分子中的序列特异性甲基化的用途。

3. 发明专利

AU2012251584B2 Amino acid sequence presenting fusion polypeptide and its use 未知
公开(公告)号：AU2012251584B2
公开(公告)日：2016-07-28
申请号：AU2012251584
申请日：2012-05-04
申请人： HOFFMANN LA ROCHE
发明人： ANDRES HERBERT , CASAGOLDA VALLRIBERA DAVID , DUEFEL HARTMUT , GERG MICHAEL , SCHOLZ CHRISTIAN , SCHRAEML MICHAEL
IPC分类号： C12N9/90 , C07K14/195 , C07K14/415 , C07K14/47 , C07K16/22
摘要： Herein is reported a fusion polypeptide according to formula (I): NH

4. 发明专利

HK1209784A1 CHAPERONE CHAPERONE FUSION POLYPEPTIDES FOR REDUCTION OF INTERFERENCE AND STABILIZATION OF IMMUNOASSAYS 未知
公开(公告)号：HK1209784A1
公开(公告)日：2016-04-08
申请号：HK15110433
申请日：2015-10-23
申请人： HOFFMANN LA ROCHE
发明人： DUEFEL HARTMUT , RIEDEL ALEXANDER , SCHAARSCHMIDT PETER , SCHMITT URBAN , SCHOLZ CHRISTIAN
IPC分类号： C12N20060101

5. 发明专利

MX2013012688A POLIPEPTIDO DE FUSION PRESENTADOR DE UNA SECUENCIA DE AMINOACIDOS Y USO DEL MISMO. 未知
公开(公告)号：MX2013012688A
公开(公告)日：2013-12-02
申请号：MX2013012688
申请日：2012-05-04
申请人： HOFFMANN LA ROCHE
发明人： SCHOLZ CHRISTIAN , SCHRAEML MICHAEL , ANDRES HERBERT , VALLRIBERA DAVID CASAGOLDA , DUEFEL HARTMUT , GERG MICHAEL
IPC分类号： C12N9/90 , C07K14/195 , C07K14/415 , C07K14/47 , C07K16/22
摘要： En la presente descripcion se da a conocer un polipéptido de fusión según la fórmula I: NH2-S2-X1-S1-COOH en donde: X1 comprende una secuencia de aminoácidos aleatoria o una secuencia de aminoácidos derivada de un primer polipéptido, S2 y S1 son secuencias de aminoácidos no solapantes derivadas de un segundo polipéptido, y se refiere a un enlace peptídico, en donde el segundo polipéptido es un polipéptido con actividad de peptidil-prolil cis/transisomerasa (actividad de PPIasa) o se deriva de la familia de dominios de pliegue de FKBP, en donde X1 se inserta en lugar del dominio de inserción en solapa del segundo polipéptido.

6. 发明专利

AU2012251584A1 Amino acid sequence presenting fusion polypeptide and its use 未知
公开(公告)号：AU2012251584A1
公开(公告)日：2013-11-07
申请号：AU2012251584
申请日：2012-05-04
申请人： HOFFMANN LA ROCHE
发明人： ANDRES HERBERT , CASAGOLDA VALLRIBERA DAVID , DUEFEL HARTMUT , GERG MICHAEL , SCHOLZ CHRISTIAN , SCHRAEML MICHAEL
IPC分类号： C12N9/90 , C07K14/195 , C07K14/415 , C07K14/47 , C07K16/22
摘要： Herein is reported a fusion polypeptide according to formula (I): NH

7. 发明专利

CA2679647A1 PEPTIDE-COMPLEMENT CONJUGATES 未知
公开(公告)号：CA2679647A1
公开(公告)日：2008-09-18
申请号：CA2679647
申请日：2008-03-11
申请人： HOFFMANN LA ROCHE
发明人： LEIN IRIS , SCHMUCK RAINER , TISCHER WILHELM , FALKENSTEIN ROBERTO , DUEFEL HARTMUT
IPC分类号： C07K14/16 , C07K14/47 , C12N15/62
摘要： The current invention reports a polypeptide conjugate, wherein the conjug ate comprises a first polypeptide selected from the group of polypeptides co mprising SEQ ID NO: 01 and fragments thereof, and a second polypeptide selec ted from the group of antifusogenic peptides.

8. 发明专利

CA2881411C CHAPERONE-CHAPERONE FUSION POLYPEPTIDES FOR REDUCTION OF INTERFERENCE AND STABILIZATION OF IMMUNOASSAYS 未知
公开(公告)号：CA2881411C
公开(公告)日：2017-01-03
申请号：CA2881411
申请日：2013-09-04
申请人： HOFFMANN LA ROCHE
发明人： DUEFEL HARTMUT , RIEDEL ALEXANDER , SCHAARSCHMIDT PETER , SCHMITT URBAN , SCHOLZ CHRISTIAN
IPC分类号： C07K19/00 , C07K14/47 , C12N9/90 , C12N15/62 , C12Q1/00
摘要： The invention concerns a fusion polypeptide comprising several molecules of folding helper polypeptides, comprising one multimerization domain, in particular Skp, and at least one molecule of SlyD or SlpA, wherein no further target polypeptide sequences are fused to said fusion polypeptide. The invention further concerns an immunoassay and the use of said fusion polypeptide in an immunoassay for reduction of interferences or minimizing false positive results or for stabilizing proteinaceous assay reagents. Further the invention concerns a reagent kit for use in an immunoassay comprising said fusion polypeptide.

9. 发明专利

ZA201308251B AMINO ACID SEQUENCE PRESENTING FUSION POLYPEPTIDE AND ITS USE 未知
公开(公告)号：ZA201308251B
公开(公告)日：2014-08-27
申请号：ZA201308251
申请日：2013-11-04
申请人： HOFFMANN LA ROCHE
发明人： ANDRES HERBERT , DUEFEL HARTMUT , SCHOLZ CHRISTIAN , CASAGOLDA VALLRIBERA DAVID , GERG MICHAEL , SCHRAEML MICHAEL
IPC分类号： C12N20060101 , C07K20060101
摘要： Isolated antibodies that specifically bind to an epitope comprised in the stretch of amino acids ranging from amino acid 76 to amino acid 84 of human insulin-like growth factor-1 precursor (SEQ ID NO:1). Use of the novel antibodies for the sensitive and specific detection of insulin-like growth factor-1, in some embodiments while in the presence of high excess concentration of insulin-like growth factor-2, for example in a bodily fluid sample.

10. 发明专利

SG194707A1 AMINO ACID SEQUENCE PRESENTING FUSION POLYPEPTIDE AND ITS USE 未知
公开(公告)号：SG194707A1
公开(公告)日：2013-12-30
申请号：SG2013080544
申请日：2012-05-04
申请人： HOFFMANN LA ROCHE
发明人： ANDRES HERBERT , CASAGOLDA VALLRIBERA DAVID , DUEFEL HARTMUT , GERG MICHAEL , SCHOLZ CHRISTIAN , SCHRAEML MICHAEL

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