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1. 发明公开

EP1057489A4 PREVENTIVES OR REMEDIES FOR ISCHEMIC DISEASES 有权
标题翻译： VORBEUGUNGSMEDIZIN UND HEILMITTELFÜRISCHÄMISCHEKRANKHEITEN
公开(公告)号：EP1057489A4
公开(公告)日：2004-10-27
申请号：EP98944236
申请日：1998-09-25
申请人： MURAMATSU TAKASHI , YOSHIDA YOSHIHIRO
发明人： YOSHIDA YOSHIHIRO , IKEMATSU SHINYA , SAKUMA SADATOSHI , ODA MUNEHIRO
IPC分类号： A61K38/18 , A61K38/17
CPC分类号： A61K38/18
摘要： Drugs for treating or preventing cell injury caused by ischemia which contain as the active ingredient midkine family proteins; and drugs for treating or preventing ischemic diseases which contain as the active ingredient midkine family proteins. It has been clarified that midkine is efficacious in treating or preventing ischemic diseases and treating or preventing cell injury caused by ischemia and that it can remarkably prevent, for example, the onset of brain infarction which is a typical example of ischemic brain diseases. These remedies and preventives are efficacious against ischemic brain diseases such as brain infarction, transient cerebral ischemia and head injury. In addition, they are efficacious in treating and preventing, for example, cerebrovascular contraction following subarachnoid bleeding, Alzheimer's disease, senile dementia of Alzheimer's type, cerebrovascular dementia and other cerebrovascular diseases, Parkinson's disease, Huntington's chorea and degenerative amyotrophic diseases.
摘要翻译：提供了用于治疗或预防由缺血引起的细胞病变的药物组合物，其包含中期因子家族蛋白质作为活性成分，以及用于治疗或预防缺血性疾病的药物组合物，其包含中期因子家族蛋白作为活性成分。 midkine有效治疗或预防局部缺血引起的缺血性疾病和细胞病变，并且可以显着地预防例如缺血性脑障碍的代表性脑梗死的发展。本发明的药物组合物对于例如脑缺血障碍如蛛网膜下腔出血后脑血管痉挛，阿尔茨海默氏病，阿尔茨海默氏型老年性痴呆和脑血管性老年性痴呆，以及脑缺血，短暂性脑缺血疾病和头部创伤以及其他脑血管疾病如帕金森病，亨廷顿舞蹈病和肌萎缩性退行性疾病。

2. 发明专利

DE69836830T2 未知
公开(公告)号：DE69836830T2
公开(公告)日：2007-10-11
申请号：DE69836830
申请日：1998-09-25
申请人： MURAMATSU TAKASHI , YOSHIDA YOSHIHIRO
发明人： YOSHIDA YOSHIHIRO , IKEMATSU SHINYA , SAKUMA SADATOSHI , ODA MUNEHIRO
IPC分类号： A61K38/17 , A61K38/18 , A61P9/10
摘要： A pharmaceutical composition for treating or preventing cytopathy caused by ischemia, comprising a midkine family protein as an active ingredient, and a pharmaceutical composition for treating or preventing ischemic disorders, comprising a midkine family protein as an active ingredient, are provided. Midkine is efficacious in treating or preventing ischemic disorders and cytopathy caused by ischemia and can remarkably prevent, for example, the development of cerebral infarction, a representative of ischemic brain disorders. The pharmaceutical composition of the present invention is also efficacious against, for example, cerebral ischemic disorders such as cerebrovascular spasm following a subarachnoid hemorrhage, Alzheimer's disease, senile dementia of Alzheimer's type, and cerebrovascular senile dementia, as well as cerebral ischemia, transient cerebral ischemic disease, and head trauma, and other cerebrovascular diseases such as Parkinson's disease, Huntington's chorea, and amyotrophic regressive disorders.

3. 发明专利

AT350051T 未知
公开(公告)号：AT350051T
公开(公告)日：2007-01-15
申请号：AT98944236
申请日：1998-09-25
申请人： MURAMATSU TAKASHI , YOSHIDA YOSHIHIRO
发明人： YOSHIDA YOSHIHIRO , IKEMATSU SHINYA , SAKUMA SADATOSHI , ODA MUNEHIRO
IPC分类号： A61K38/18 , A61K38/17 , A61P9/10
摘要： A pharmaceutical composition for treating or preventing cytopathy caused by ischemia, comprising a midkine family protein as an active ingredient, and a pharmaceutical composition for treating or preventing ischemic disorders, comprising a midkine family protein as an active ingredient, are provided. Midkine is efficacious in treating or preventing ischemic disorders and cytopathy caused by ischemia and can remarkably prevent, for example, the development of cerebral infarction, a representative of ischemic brain disorders. The pharmaceutical composition of the present invention is also efficacious against, for example, cerebral ischemic disorders such as cerebrovascular spasm following a subarachnoid hemorrhage, Alzheimer's disease, senile dementia of Alzheimer's type, and cerebrovascular senile dementia, as well as cerebral ischemia, transient cerebral ischemic disease, and head trauma, and other cerebrovascular diseases such as Parkinson's disease, Huntington's chorea, and amyotrophic regressive disorders.

4. 发明申请

WO0002578A8 REMEDIES FOR APOPTOSIS-ASSOCIATED DISEASES 审中-公开
标题翻译：用于治疗相关疾病的补救措施
公开(公告)号：WO0002578A8
公开(公告)日：2001-03-15
申请号：PCT/JP9903740
申请日：1999-07-09
申请人： MEIJI MILK PROD CO LTD , MURAMATSU TAKASHI , IKEMATSU SHINYA , YOSHIDA YOSHIHIRO , KADOMATSU KENJI , ODA MUNEHIRO , SAKUMA SADATOSHI , ASHIDA KIN YA , KINO KOHSUKE
发明人： MURAMATSU TAKASHI , IKEMATSU SHINYA , YOSHIDA YOSHIHIRO , KADOMATSU KENJI , ODA MUNEHIRO , SAKUMA SADATOSHI , ASHIDA KIN-YA , KINO KOHSUKE
IPC分类号： A61K38/18 , A61K38/17
CPC分类号： A61K38/18
摘要： It is found out that a protein belonging to the midkine (MK) family inhibits the induction of apoptosis caused by anticancer agents, ultraviolet irradiation and ischemic stress. This finding makes it possible to provide novel drugs containing the protein belonging to the MK family as the active ingredient for treating and preventing any diseases caused by apoptosis, for example, heart diseases, renal diseases, nervous diseases or liver diseases.
摘要翻译：发现属于中期因子（MK）家族的蛋白质抑制由抗癌剂引起的凋亡诱导，紫外线照射和缺血应激。该发现使得可以提供含有属于MK家族的蛋白质的新药物作为治疗和预防由凋亡引起的任何疾病，例如心脏病，肾脏疾病，神经疾病或肝脏疾病的活性成分。

5. 发明专利

AU780957B2 Early cancer tumor marker 未知
公开(公告)号：AU780957B2
公开(公告)日：2005-04-28
申请号：AU6876000
申请日：2000-09-08
申请人： MURAMATSU TAKASHI
发明人： MURAMATSU TAKASHI , OKAMOTO KOHJI , IKEMATSU SHINYA , SAKUMA SADATOSHI , ODA MUNEHIRO , KUMAI HIDESHI
IPC分类号： G01N33/574
摘要： MK (midkine) was found to rise in the blood or urine of patients with various types of cancers at early stage. Based on this finding, a method for detecting early cancer, comprising the step of measuring MK in blood or urine was completed.

6. 发明专利

AU6876000A Early cancer tumor marker 未知
公开(公告)号：AU6876000A
公开(公告)日：2001-04-17
申请号：AU6876000
申请日：2000-09-08
申请人： MEIJI MILK PROD CO LTD , MURAMATSU TAKASHI
发明人： MURAMATSU TAKASHI , OKAMOTO KOHJI , IKEMATSU SHINYA , ODA MUNEHIRO , KUMAI HIDESHI , SAKUMA SADATOSHI
IPC分类号： G01N33/574
摘要： MK (midkine) was found to rise in the blood or urine of patients with various types of cancers at early stage. Based on this finding, a method for detecting early cancer, comprising the step of measuring MK in blood or urine was completed.

7. 发明专利

AU3459397A Novel use of mk family as hematopoietic factor 未知
公开(公告)号：AU3459397A
公开(公告)日：1998-02-02
申请号：AU3459397
申请日：1997-07-10
申请人： MURAMATSU TAKASHI
发明人： KIKUCHI MAKOTO , IKEMATSU SHINYA , ODA MUNEHIRO , SAKUMA SADATOSHI , MURAMATSU TAKASHI
IPC分类号： A61K35/28 , A61K38/18 , A61K38/19 , A61K38/20 , C12N5/0789 , A61K38/22 , A61K48/00 , A61K35/14
摘要： The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an agent for remarkably enhancing the above-described effect for promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO.

8. 发明公开

EP0997150A4 PREVENTIVE AND THERAPEUTIC COMPOSITIONS FOR DRUG INDUCED NEPHROPATHY AND HEPATITIS 失效
标题翻译：预防和治疗组合物反对药物性肝炎病和肾病
公开(公告)号：EP0997150A4
公开(公告)日：2004-06-16
申请号：EP98907207
申请日：1998-03-12
申请人： MURAMATSU TAKASHI
发明人： MURAMATSU TAKASHI , KADOMATSU KENJI , ODA MUNEHIRO , IKEMATSU SHINYA , SAKUMA SADATOSHI
IPC分类号： A61K38/18 , A61K38/17
CPC分类号： A61K38/18
摘要： Novel agents for relieving drug-induced nephropathy and acute hepatitis, containing proteins belonging to the midkine (MK) family, e.g., pleiotrophin (PTN). The proteins belonging to the MK family can inhibit nephropathy induced by antineoplastic agents such as cisplatin or acute hepatitis due to carbon tetrachloride, thus being effective in relieving drug-induced nephropathy or hepatitis.

9. 发明专利

DE60039441D1 未知
公开(公告)号：DE60039441D1
公开(公告)日：2008-08-21
申请号：DE60039441
申请日：2000-09-08
申请人： MURAMATSU TAKASHI
发明人： MURAMATSU TAKASHI , OKAMOTO KOHJI , IKEMATSU SHINYA , ODA MUNEHIRO , KUMAI HIDESHI , SAKUMA SADATOSHI
IPC分类号： G01N33/574
摘要： MK (midkine) was found to rise in the blood or urine of patients with various types of cancers at early stage. Based on this finding, a method for detecting early cancer, comprising the step of measuring MK in blood or urine was completed.

10. 发明专利

DE69836830D1 未知
公开(公告)号：DE69836830D1
公开(公告)日：2007-02-15
申请号：DE69836830
申请日：1998-09-25
申请人： MURAMATSU TAKASHI , YOSHIDA MASAHIRO
发明人： YOSHIDA YOSHIHIRO , IKEMATSU SHINYA , SAKUMA SADATOSHI , ODA MUNEHIRO
IPC分类号： A61K38/17 , A61K38/18 , A61P9/10
摘要： A pharmaceutical composition for treating or preventing cytopathy caused by ischemia, comprising a midkine family protein as an active ingredient, and a pharmaceutical composition for treating or preventing ischemic disorders, comprising a midkine family protein as an active ingredient, are provided. Midkine is efficacious in treating or preventing ischemic disorders and cytopathy caused by ischemia and can remarkably prevent, for example, the development of cerebral infarction, a representative of ischemic brain disorders. The pharmaceutical composition of the present invention is also efficacious against, for example, cerebral ischemic disorders such as cerebrovascular spasm following a subarachnoid hemorrhage, Alzheimer's disease, senile dementia of Alzheimer's type, and cerebrovascular senile dementia, as well as cerebral ischemia, transient cerebral ischemic disease, and head trauma, and other cerebrovascular diseases such as Parkinson's disease, Huntington's chorea, and amyotrophic regressive disorders.

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