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1. 发明专利

DE10081888A5 未知
公开(公告)号：DE10081888A5
公开(公告)日：2007-06-06
申请号：DE10081888
申请日：2000-07-04
申请人： MOORE THOMAS
发明人： MOORE THOMAS , HORN ANTON , KREUSCH STEFAN
IPC分类号： G01N30/02 , G01N33/483 , G01N33/68

2. 发明专利

DE10081888B4 Verfahren zur mehrdimensionalen Analyse eines Proteoms 未知
公开(公告)号：DE10081888B4
公开(公告)日：2014-02-06
申请号：DE10081888
申请日：2000-07-04
申请人： MOORE THOMAS
发明人： MOORE THOMAS , HORN ANTON , KREUSCH STEFAN
IPC分类号： G01N30/02 , G01N33/483 , G01N33/68
摘要： Verfahren zur mehrdimensionalen Analyse eines Proteoms, bei dem das biologische Material mit dem zu analysierenden Proteom aufgeschlossen und die zu dem Proteom gehörenden Proteine getrennt sowie quantitativ bestimmt und identifiziert werden, dadurch gekennzeichnet, – dass die Proteine des Proteoms drei verschiedenen Chromatographieverfahren unter Erhalt der nativen Eigenschaften derart unterworfen werden, dass jeweils jede der in einem Trennschritt erhaltenen flüssigen Fraktionen m1 in einem darauf folgenden Trennschritt m2 flüssige Fraktionen liefert, wobei nach drei Trennschritten m1·m2·m3= M flüssige Fraktionen vorliegen, die mit r verschiedenen Analyseverfahren qualitativ durch an sich bekannte Identifikationsverfahren identifiziert und durch an sich bekannte Quantifikationsverfahren quantitativ bestimmt werden, wobei als Trennverfahren Methoden, die nach Größe der Proteine trennen und/oder Methoden, die nach der Ladung der Proteine trennen und/oder Methoden, die nach der Hydrophobizität der Proteine trennen und/oder Methoden, die nach der Affinität der Proteine hinsichtlich spezifischer Liganden auch zu Antikörpern trennen, ausgewählt werden und wobei als Quantifikationsverfahren quantitative immunologische Methoden und/oder quantitative Bindungsassays ausgewählt werden, so dass nach Zusammenfügen der Analysedaten ein dreidimensionales Abbild des Proteoms, charakterisiert durch Identifikatoren und Quantifikatoren sowie durch die Lage im dreidimensionalen Datenraum, gewonnen wird.

3. 发明专利

AU6555500A Method for the multi-dimensional analysis of a proteome 未知
公开(公告)号：AU6555500A
公开(公告)日：2001-01-22
申请号：AU6555500
申请日：2000-07-04
申请人： MOORE THOMAS
发明人： MOORE THOMAS , HORN ANTON , KREUSCH STEFAN
IPC分类号： G01N33/68 , G01N30/46

4. 发明专利

DE19932270A1 未知
公开(公告)号：DE19932270A1
公开(公告)日：2001-01-11
申请号：DE19932270
申请日：1999-07-05
申请人： UNIV SCHILLER JENA , MOORE THOMAS
发明人： HORN ANTON , KREUSCH STEFAN , MOORE THOMAS
IPC分类号： G01N33/68 , G01N33/48
摘要： The invention relates to a method for the multi-dimensional analysis of a proteome. The method is used in the biochemical, biotechnological and medical fields and in the pharmaceutical industry for diagnostic purposes and for developing biologically active substances. The aim of the invention is to improve, facilitate and for certain proteins first of all to enable the quantification and identification of the proteins of a proteome. According to the invention, the proteins of a proteome are subjected to a large number n of different separation processes under standardised conditions in such a way, that each respective liquid fraction m1, obtained in a separation stage, delivers m2 liquid fractions in a separation stage which immediately follows. After n separation stages, m1* m2* ....mn = M liquid fractions have been produced which are identified qualitatively or quantitatively by known identification methods using o different analysis methods and which are quantitatively determined also by known quantification methods in such a way, that once the analysis data has been unified in a database, an n-dimensional image of the proteome is obtained which is characterised by identifiers and quantifiers and by the position in the n-dimensional network.

5. 发明专利

GB2367894B Method for the multi-dimensional analysis of a proteome 未知
公开(公告)号：GB2367894B
公开(公告)日：2004-05-12
申请号：GB0202280
申请日：2000-07-04
申请人： MOORE THOMAS
发明人： MOORE THOMAS , HORN ANTON , KREUSCH STEFAN
IPC分类号： G01N33/68 , G01N30/46 , G01N33/48

6. 发明专利

GB2367894A Method for the multi-dimensional analysis of a proteome 未知
公开(公告)号：GB2367894A
公开(公告)日：2002-04-17
申请号：GB0202280
申请日：2000-07-04
申请人： MOORE THOMAS
发明人： MOORE THOMAS , HORN ANTON , KREUSCH STEFAN
IPC分类号： G01N33/68 , G01N30/46 , G01N33/48
摘要： The invention relates to a method for the multi-dimensional analysis of a proteome. The method is used in the biochemical, biotechnological and medical fields and in the pharmaceutical industry for diagnostic purposes and for developing biologically active substances. The aim of the invention is to improve, facilitate and for certain proteins first of all to enable the quantification and identification of the proteins of a proteome. According to the invention, the proteins of a proteome are subjected to a large number in of different separation processes under standardised conditions in such a way, that each respective liquid fraction m 1 , obtained in a separation stage, delivers m 2 liquid fractions in a separation stage which immediately follows. After n separation stages, m 1 * m 2 * ....m n = M liquid fractions have been produced which are identified qualitatively or quantitatively by known identification methods using o different analysis methods and which are quantitatively determined also by known quantification methods in such a way, that once the analysis data has been unified in a data-base, an n-dimensional image of the proteome is obtained which is characterised by identifiers and quantifiers and by the position in the n-dimensional network.

7. 发明申请

WO0158591A3 CLOSED MULTI-WELL ANALYTICAL PLATE WITH ANNULAR ADHESIVE PATCHES FOR ANALYTICAL OPTICAL MEASUREMENTS 审中-公开
标题翻译：环形带粘合面CLOSED多井分析板的光学测量
公开(公告)号：WO0158591A3
公开(公告)日：2002-10-31
申请号：PCT/EP0001003
申请日：2000-02-08
申请人： CYBIO INSTR GMBH , HORN ANTON , KREUSCH STEFAN , MOORE THOMAS
发明人： HORN ANTON , KREUSCH STEFAN , MOORE THOMAS
IPC分类号： B01L3/00
CPC分类号： B01L3/50853
摘要： . According to the invention, the collecting-chamber openings of the multi-well analytical plate, generating largely reliable analytical results also at elevated temperatures and over a long period of time, are sealed with an optically clear sealing material, for example, clear plastic film, or a glass sheet. The adhesive for fixing the sealing material which covers the collecting-chamber openings is only applied to the contact area of the sealing material with the multi-well analytical plate and not to the area of the collecting-chamber opening. Neither the sealing material itself, nor the means of fixing to the multi-well analytical plate thereof, in particular, hot-melt adhesives impede the light flux from and to the samples for optical analytical determination.
摘要翻译：根据本发明，多孔板分析，可提供即使在高温下和长时间可靠的结果的收集容器开口，与光学durchlässingen密封材料，例如透明塑料膜或玻璃板上，密封，用粘接剂用于紧固收集容器开口盖只密封材料在多孔分析板中的密封材料的Berährungsstellen，但不是在收集容器开口的区域。既不密封材料本身也没有了它在多孔分析板紧固件，特别是热可释放粘接，损害光辐射和从样品用于光学分析的测量。

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