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1. 发明专利

JPH0710833A PROSTAGLANDIN ANALOGUE, ITS FAT EMULSION AND USE THEREOF 失效
公开(公告)号：JPH0710833A
公开(公告)日：1995-01-13
申请号：JP9669092
申请日：1992-04-16
申请人： MIZUSHIMA YUTAKA , SEIKAGAKU KOGYO CO LTD , ASAHI GLASS CO LTD , TAISHO PHARMA CO LTD , GREEN CROSS CORP
发明人： MIZUSHIMA YUTAKA , IGARASHI TOSHISATO , INOMATA TOSHIHIDE , YASUDA ARATA , ARAKI KUREAKI , IMAGAWA TAKASHI , UCHIDA TAKESHI
IPC分类号： A61K9/107 , A61K31/557 , A61K31/5575 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , C07C405/00
摘要： PURPOSE:To obtain a prostaglandin analogue excellent in stability and useful as a platelet agglutination inhibitor, a blood flow increasing agent and a hypotensive agent, and its fat emulsion. CONSTITUTION:This prostaglandin analogue is butyl-9-butyloxy-11alpha, 15S- dihydroxyprosta-8,13E-diene-1-oate expressed by the formula I. The fat emulsion of a prostaglandin analogue of the formula II (R is acetyl or bytylyl) and a platelet agglutination inhibitor, a blood flow increasing agent and a hypotenisve agent. A hypotensive drug containing a fat emulsion of butyl-9-acetoxy-11alpha,15S- dihydroxy-17S,20-dimethylprosta-8,13E-diene-1-oate of the formula III. These compounds can be obtained by reacting a 1-iodoalkane with an alkyl lithium and then with a trialkylphosphine-copper(I) iodide complex to obtain an orgabolithiocuprate, which is subjected to 1,4 co-addition to a substituted 2- cyclopentene-1-on and quench the carboxylic acid anhydride.

2. 发明专利

CA1239873A PHOSPHOLIPID-EMULSIFIED PROSTAGLANDIN COMPOSITION 未知
公开(公告)号：CA1239873A
公开(公告)日：1988-08-02
申请号：CA471947
申请日：1985-01-11
申请人： TAISHO PHARMA CO LTD , GREEN CROSS CORP
发明人： IMAGAWA TAKASHI , YOKOYAMA KAZUMASA , MIZUSHIMA YUTAKA
IPC分类号： A61K9/10 , A61K9/107 , A61K31/557 , A61P43/00
摘要： M-37-37057C/KT/84. A prostaglandin emulsion composition comprising a prostaglandin emulsified with a phosphatidylethanolamine-free phospholipid, the composition being suitable for intravenous administration.

3. 发明专利

FR2460672A1 PREPARATION DE POUDRE D'ACETYLSALICYLATE POUR INJECTION 未知
公开(公告)号：FR2460672A1
公开(公告)日：1981-01-30
申请号：FR8001989
申请日：1980-01-30
申请人： GREEN CROSS CORP , GREEN CROSS CORP
发明人： IMAGAWA TAKASHI , KAGITANI YOSHIO , YOSHIO KAGITANI TAKASHI IMAGAWA HIROSHISA INAHARA ET RYOZO WATANABE , INAHARA HIROSHISA , WATANABE RYOZO
IPC分类号： A61K9/00 , A61K9/14 , A61K31/60 , A61K9/08 , A61K47/02 , A61K31/615 , A61K47/00
摘要： COMPOSITION PHARMACEUTIQUE INJECTABLE CONTENANT UN ACETYLSALICYLATE D'AMINOACIDE BASIQUE. ELLE EST SOUS FORME SOLIDE ET CONTIENT DU CHLORURE DE CALCIUM ANHYDRE COMME STABILISANT. APPLICATION POUR L'ADMINISTRATION PAR VOIE INTRAVEINEUSE D'ACIDE ACETYLSALICYLATE D'AMINOACIDE.

4. 发明专利

JPH05186372A FAT EMULSION AND CONTRAST MEDIUM FOR MRI DIAGNOSIS 失效
公开(公告)号：JPH05186372A
公开(公告)日：1993-07-27
申请号：JP20039392
申请日：1992-07-03
申请人： GREEN CROSS CORP
发明人： IMAGAWA TAKASHI , MUKAI HIROMICHI , MIYAGI IKUKO , MURAKAMI KAZUKI , NIITOME MASAKAZU , OKANO TADASHI , OHASHI TAKAKO , MORI FUMIO , KIN SHIYOUGEN , MARUKAWA TARO , KOZUKA TAKAHIRO
IPC分类号： A61K49/00 , C07C229/24 , C07F5/00
摘要： PURPOSE:To provide a fat emulsion containing a paramagnetic metal atom and useful for a nuclear magnetic resonance diagnosis method used for clinical diagnosis. CONSTITUTION:The contrast medium for MRI diagnosis contains a compound of the formula (m is 1-3; R1, R2 are H, lower alkyl; R3 to R6 are OH, etc.,) capable of forming a chelate bond with a paramagnetic metal atom (e.g. Gd, Tb, Ho). The preferable composition comprises 0.01-15% of the paramagnetic metal atom, the compound of the formula in a molar rate of approximately 1-5 based on the paramagnetic metal atom, 0.5-50%W/V of a fat or oil (e.g. soybean oil), an emulsifier (e.g. phospholipid, synthetic surfactant) in an amount of 1-100 pts.wt. per 100 pts.wt. of the fat or oil, and a suitable amount of water. When used as a contrast medium for MRI diagnosis, the fat emulsion gives images having excellent contrasts and has an effect to transfer to various organ tissues such as reticuloendothelial system organs, inflammatory sites and arteriosclerotic sites.

5. 发明专利

JPH04154724A FATTY EMULSION CONTAINING ACTIVATION-TYPE VITAMIN D3 COMPOUND 失效
公开(公告)号：JPH04154724A
公开(公告)日：1992-05-27
申请号：JP28128390
申请日：1990-10-18
申请人： GREEN CROSS CORP
发明人： INOUE YOSHIHISA , RI RYOKO , MATSUOKA YASUSHI , IMAGAWA TAKASHI
IPC分类号： A61K31/59 , A61K9/107 , A61P3/00 , A61P3/02 , A61P43/00
摘要： PURPOSE:To obtain the subject formulation, having improved stability and persistency in vivo as well as affinity with bone marrow, enabling intravenous injection, and concentrated to tissue, comprising fatty emulsion containing said activation-type vitamin D3 compound. CONSTITUTION:A small amount, e.g. 0.01-100mug/ml of activation-type vitamin D3 compound such as 1alpha.25-dihydroxycholecalciferol, 1alpha.24- dihydroxycholecalciferol or 1alpha-hydroxycholecalciferol is contained in a fatty emulsion to afford the objective formulation, effective for chronic renal failure, reduction of parathyroidal function, vitamin D-resistant chachitis, osteomalacia or osteoporosis induced by bone metabolic disorder, etc., enabling intravenous injection, efficiently penetrating said compound into tissue and simultaneously exhibiting sufficient pharmacological effect with a small amount of daily dose of about 0.01-10mug in adults due to improved characteristics thereof by emulsifying with fat.

6. 发明专利

JPS58162517A FAT-SOLUBLE VITAMIN-CONTAINING FATTY EMULSION 失效
公开(公告)号：JPS58162517A
公开(公告)日：1983-09-27
申请号：JP4506782
申请日：1982-03-19
申请人： GREEN CROSS CORP
发明人： IMAGAWA TAKASHI , OKAMOTO HIROYUKI , YOKOYAMA KAZUMASA
IPC分类号： A61K31/12 , A61K9/10 , A61K9/107 , A61K31/07 , A61K31/355 , A61K31/59 , A61K45/08 , A61P3/02 , A61P35/00
摘要： PURPOSE:A stable pharmaceutical preparation containing various kinds of fat- soluble vitamins useful for parenteral nutritive therapy, comprising a fatty emulsion containing vitamins A, K, E and D as essential components. CONSTITUTION:A fat-soluble vitamin-containing fatty emulsion containing vitamins A, K, E and D as essential components, preferably (i) effective amount of the fat-soluble vitamins, (ii) 5-50% (w/v) soybean oil, (iii) phospholipid in an amount to give a ratio of phospholipid to soybean oil of (1-50)/100, and (iv) a proper amount of water. The fatty emulsion has longer durability in an organism that a conventional fat-soluble vitamin pharmaceutical preparation, can concentrate specifically in a tissue having a cell of reticuloendothelial system, has improved stability, and can be sterilized. The fatty emulsion can be blended with (v) an isotonic agent, (iv)

7. 发明专利

JPH0899899A GLOBULIN PHARMACEUTICAL PREPARATION FOR INTRAVENOUS INJECTION 失效
公开(公告)号：JPH0899899A
公开(公告)日：1996-04-16
申请号：JP23791794
申请日：1994-09-30
申请人： GREEN CROSS CORP
发明人： HIRAO YUTAKA , OMURA TOMOKO , MITSUNAMI NORIKAZU , IMAGAWA TAKASHI
IPC分类号： A61K9/08 , A61J1/05 , A61K39/395 , A61K47/10
摘要： PURPOSE: To obtain a globulin pharmaceutical preparation for intravenous injection capable of further improving long-term storage stability of γ-globulin liquid composition and consequently being stable and safe. CONSTITUTION: This globulin pharmaceutical preparation for intravenous injection is obtained by putting a globulin liquid composition containing a non- chemically modified perfect molecular type γ-globulin into a plastic vessel. The globulin pharmaceutical preparation is capable of storing for a long period at room temperature. The globulin pharmaceutical preparation for intravenous infection has

8. 发明专利

JPH0543450A LYOPHILIZED PREPARATION 失效
公开(公告)号：JPH0543450A
公开(公告)日：1993-02-23
申请号：JP22479291
申请日：1991-08-09
申请人： GREEN CROSS CORP
发明人： IMAGAWA TAKASHI , SHINTAKU YOSHIHISA
IPC分类号： A61K9/107 , A61K9/14 , A61K47/44
摘要： PURPOSE:To provide the stabilized preparation of a fat emulsion useful as a drug carrier. CONSTITUTION:The subject agent comprises the lyophilized product of a fat emulsion containing a drug, an oil component an emulsifier and water. The lyophilized preparation of the invention has excellent storage stability and exhibits effects different from conventional liquid type fat emulsions, e.g. the preparation can be stored at ordinary temperature.

9. 发明专利

JPS63264517A DRUG COMPOSITION 失效
公开(公告)号：JPS63264517A
公开(公告)日：1988-11-01
申请号：JP9337887
申请日：1987-04-17
申请人： GREEN CROSS CORP
发明人： MOTOYAMA YASUO , IWAI MASAKAZU , IMAGAWA TAKASHI , OKAMOTO HIROYUKI , YOKOYAMA KAZUMASA
IPC分类号： A61K9/127
摘要： PURPOSE:To obtain a novel drug composition effectively making various drugs such as anti-inflammatory drug or carcinostatic drug accumulate and retain at crisis site, having low toxicity and excellent medicinal effects with a small amount of administration, comprising a drug, phospholipid, a glycerylphosphoryl compound and water. CONSTITUTION:A composition comprising a drug, phospholipid, a glycerylphos phoryl compound shown by the formula [R1 is 16C or 18C alkyl; R2 is 1-3C alkyl; R3 is N(CH3)3, N(CH3)2 or NHCH3 or NH2] and water. A fat emulsion or liposome is especially preferable as the form of the drug composition. To be concrete, for example, in the case of the case of the fat emulsion, a fat- soluble drug is preferable as the drug and a vegetable oil, preferably soybean oil is used. First the vegetable oil is blended with the phospholipid, the drug, the compound shown by the formula and optionally an additive, heated homoge nized by a homogenizer to give a water-in-oil type dispersion, which is mixed with water, rehomogenized and converted into an oil-in-water type emulsion to give the aimed composition.

10. 发明专利

JPS62123113A FATTY EMULSION CONTAINING UBIDECARENONE 失效
公开(公告)号：JPS62123113A
公开(公告)日：1987-06-04
申请号：JP26309485
申请日：1985-11-22
申请人： GREEN CROSS CORP
发明人： SUGIO NARUTOSHI , INOUE TADAAKI , IMAGAWA TAKASHI , OKAMOTO HIROYUKI , YOKOYAMA KAZUMASA
IPC分类号： A61K31/12 , A61K9/10 , A61P9/00 , C07C50/28
摘要： PURPOSE:A fatty emulsion, containing ubidecarenone in a fatty emulsion having a specific particle diameter, having rapid migration property in a large amount to the target internal organs and high safety in sterilization and preservation, intravenously administrable and useful for improving cardiac function. CONSTITUTION:A fatty emulsion, containing ubidecarenone as an essential ingredient in a fatty emulsion having 0.4mum average particle diameter. The above-mentioned fatty emulsion is obtained by blending given amounts of an oil ingredient, e.g. soybean oil, with phospholipid, particularly egg yolk lecithin or soybean lecithin, ubidecarenone and, as necessary, an additive, e.g. emulsification adjuvant, stabilizer, isotonizing agent, etc., heating the resultant blend to form a solution, homogenizing the solution with a normally used homogenizer to prepare a water-in-oil type dispersion, adding a required amount of water, rehomogenizing the resultant dispersion and converting the dispersion into an oil-in-water type emulsion. The content of the ubidecarenone is 0.01-50wt/vol%, preferably 0.1-30wt/vol%. The above-mentioned fatty emulsion is preferably subjecteddto sterilizing operation and preservation at 3-8pH, particular 4-7pH.

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