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1. 发明专利

JPS63154618A TRIGLYCERIDE COMPOSITION 失效
公开(公告)号：JPS63154618A
公开(公告)日：1988-06-27
申请号：JP30196186
申请日：1986-12-17
申请人： GREEN CROSS CORP
发明人： INOUE TADAAKI , SUGIO NARUTOSHI , IMAGAWA TAKASHI , OKAMOTO HIROYUKI
IPC分类号： A23L1/30 , A61K31/23 , A61P3/00 , A61P3/06 , A61P3/08 , C11C3/08
摘要： PURPOSE:To obtain a triglyceride composition, having groups respectively derived from a long-chain fatty acid, medium-chain fatty acid and short-chain fatty acid in a specific proportion and effective in enriching nutriments and suppressing decomposition of body proteins as well as treating and preventing hyperlipemia. CONSTITUTION:A triglyceride composition, consisting of two or more kinds of triglycerides expressed by the formula (R1-R3 are acyl derived from 20-22C fatty acid, acyl derived from 14-18C fatty acid or acyl derived from 6-12C fatty acid) and having respective acyl groups, derived from the fatty acids and linked as R1-R3 so as to provide composition ratio of the fatty acids formed in hydrolyzing the total constituent triglyceride as follows. 1-20mol% 20-22C fatty acid, 30-50mol.% 14-18C fatty acid and 40-60mol.% 6-12C fatty acid. The 20-22C fatty acid is preferably eicosapentaenoic acid and the 14-18C fatty acid is preferably linoleic acid. The 6-12C fatty acid is preferably caprylic acid and/or capric acid.

2. 发明专利

JPS62270521A FLURBIPROFEN PREPARATION FOR OPHTHALMIC ADMINISTRATION 失效
公开(公告)号：JPS62270521A
公开(公告)日：1987-11-24
申请号：JP11338386
申请日：1986-05-16
申请人： GREEN CROSS CORP , KAKEN PHARMA CO LTD
发明人： MIZUSHIMA YUTAKA , OKAMOTO HIROYUKI , SUGIO NARUTOSHI , YOKOYAMA KAZUMASA , SUYAMA TADAKAZU , TONO MASAO , OKUMURA MAKOTO , KONISHI YOSHIAKI , ICHIKAWA KIYONOSHIN , UCHIDA KATSUHIRO
IPC分类号： A61K9/00 , A61K9/107 , A61K31/19 , A61K31/22 , A61P27/02 , C07C57/58
摘要： PURPOSE:To obtain a preparation for ophthalmic administration, having high transferability to protomerite and useful for the remedy of inflammation of conjunctiva and ectocornea in ophthalmic field, by adding flurbiprofen (FP) to fat emulsion. CONSTITUTION:Soybean oil is mixed with phospholipid and FP [2-(2-fluoro-4- biphenylyl)propionic acid] or its derivative and, if necessary, with an additive such as emulsifying assistant, stabilizer, etc., at prescribed ratios. The mixture is heated to obtain a solution, homogenized to a W/O-type dispersion with a homogenizer, added with a prescribed amount of water and homogenized again to convert the dispersion to an O/W-type emulsion and obtain an FP- containing fat emulsion having average particle diameter of preferably

3. 发明专利

JPH093097A SACCHARIDE CHAIN ELONGATION PROTEIN DERIVED FROM GENUS PICHIA, DNA CODING THE SAME PROTEIN, MODIFIED DNA AND TRANSFORMANT 失效
公开(公告)号：JPH093097A
公开(公告)日：1997-01-07
申请号：JP15077895
申请日：1995-06-16
申请人： GREEN CROSS CORP
发明人： MURAKAMI KOJI , SUGIO NARUTOSHI
IPC分类号： C12N15/09 , C07K14/39 , C12N1/19 , C12P21/02 , C12R1/84
摘要： PURPOSE: To obtain the subject new protein derived from a yeast belonging to the genus Pichia, having a specific amino acid sequence and a saccharide chain or an analog structural saccharide chain common in a yeast and a mammalian cell, participating to the elongation of a saccharide chain of a glycoprotein useful in terms of a medicine, suitable for studying a saccharide chain mechanism, etc. CONSTITUTION: This new saccharide chain elongation protein is derived from a yeast belonging to the genus Pichia, has an amino acid sequence of the formula in an N end domain and a saccharide chain structure equal to or similar to an ER core saccharide chain common in a yeast and a mammal cell, participates to the elongation of a saccharide chain of a physiologically active glycoprotein useful in terms of a medicine and is suitable for elucidating the bonding/elongation of the saccharide chain of the glycoprotein in a yeast belonging to the genus Pichia. The protein can be produced by culturing a yeast of the genus Pichia according to a conventional method under a condition suitable for breeding of the yeast, extracting the protein from a culture cell and purifying or synthesizing a polypeptide based on the amino acid sequence of the protein or by a conventional recombinant DNA technology based on the base sequence coding the protein.

4. 发明专利

JPS62123113A FATTY EMULSION CONTAINING UBIDECARENONE 失效
公开(公告)号：JPS62123113A
公开(公告)日：1987-06-04
申请号：JP26309485
申请日：1985-11-22
申请人： GREEN CROSS CORP
发明人： SUGIO NARUTOSHI , INOUE TADAAKI , IMAGAWA TAKASHI , OKAMOTO HIROYUKI , YOKOYAMA KAZUMASA
IPC分类号： A61K31/12 , A61K9/10 , A61P9/00 , C07C50/28
摘要： PURPOSE:A fatty emulsion, containing ubidecarenone in a fatty emulsion having a specific particle diameter, having rapid migration property in a large amount to the target internal organs and high safety in sterilization and preservation, intravenously administrable and useful for improving cardiac function. CONSTITUTION:A fatty emulsion, containing ubidecarenone as an essential ingredient in a fatty emulsion having 0.4mum average particle diameter. The above-mentioned fatty emulsion is obtained by blending given amounts of an oil ingredient, e.g. soybean oil, with phospholipid, particularly egg yolk lecithin or soybean lecithin, ubidecarenone and, as necessary, an additive, e.g. emulsification adjuvant, stabilizer, isotonizing agent, etc., heating the resultant blend to form a solution, homogenizing the solution with a normally used homogenizer to prepare a water-in-oil type dispersion, adding a required amount of water, rehomogenizing the resultant dispersion and converting the dispersion into an oil-in-water type emulsion. The content of the ubidecarenone is 0.01-50wt/vol%, preferably 0.1-30wt/vol%. The above-mentioned fatty emulsion is preferably subjecteddto sterilizing operation and preservation at 3-8pH, particular 4-7pH.

5. 发明专利

JPH0832628B2 失效
公开(公告)号：JPH0832628B2
公开(公告)日：1996-03-29
申请号：JP30196186
申请日：1986-12-17
申请人： GREEN CROSS CORP
发明人： INOE TADAAKI , SUGIO NARUTOSHI , IMAGAWA TAKASHI , OKAMOTO HIROYUKI
IPC分类号： A23L1/30 , A61K31/23 , A61P3/00 , A61P3/06 , A61P3/08 , C11C3/08

6. 发明专利

JPH09261A PRODUCTION OF GLYCOPROTEIN 失效
公开(公告)号：JPH09261A
公开(公告)日：1997-01-07
申请号：JP15078095
申请日：1995-06-16
申请人： GREEN CROSS CORP , RA TOMOYASU
发明人： MURAKAMI KOJI , SUGIO NARUTOSHI
IPC分类号： C12N15/09 , C07K14/39 , C07K14/65 , C07K14/735 , C07K19/00 , C12N9/99 , C12P21/02 , C12R1/84
摘要： PURPOSE: To produce a glycoprotein useful for medicines having a saccharide chain in common with a yeast and a mammalian cell by culturing a modified yeast strain of the genus Pichia having the suppressed saccharide chain extending ability as compared with that of a natural type yeast of the genus Pichia as a host and collecting the resultant product from the cultured product. CONSTITUTION: A modified yeast strain of the genus Pichia having the saccharide chain extending ability suppressed as compared with that of a natural type yeast strain of the genus Pichia by possessing a DNA, having an amino acid sequence of the formula in an N-terminal region and a base sequence capable of coding a protein participating in the extension of the saccharide chain in a glycoprotein derived from the yeast of the genus Pichia and partially modified so as to at least suppress the production of a functional product coded with the DNA is cultured to collect a glycoprotein from the cultured product. Thereby, the objective glycoprotein having a saccharide chain structure which is the same or similar to an endoplasmic reticulum(ER) core saccharide chain in common with the yeast and a mammalian cell and medicinally useful physiological activities is obtained.

7. 发明专利

JPH08336387A SUGAR CHAIN-EXTENDED PROTEIN DERIVED FROM PICHIA YEAST AND DNA OF THE PROTEIN 失效
公开(公告)号：JPH08336387A
公开(公告)日：1996-12-24
申请号：JP14500595
申请日：1995-06-12
申请人： GREEN CROSS CORP , RA TOMOYASU
发明人： MURAKAMI KOJI , SUGIO NARUTOSHI , RA TOMOYASU
IPC分类号： C12N15/09 , C07H21/04 , C07K14/37 , C07K14/39 , C07K14/41 , C07K14/705 , C07K19/00 , C12N1/19 , C12N9/10 , C12P21/00 , C12R1/84
摘要： PURPOSE: To obtain a protein manifestation system having proliferative ability equivalent to natural-type Pichia yeast strain but lying declined in or deprived of sugar chain extending ability and useful for producing glycoproteins each having sugar chain structure identical with or similar to that for ER core sugar chain common to yeast and mammal cell. CONSTITUTION: A modified Pichia yeast strain having a base sequence of the formula and also having such a DNA that part thereof coding a protein involving the sugar chain extension of a glycoprotein is modified so as to at least suppress the production of functional products from the DNA is obtained pref. by transformation of a natural-type Pichia yeast by the above-mentioned DNA. The modified sugar chain-extended DNA can be prepared by e.g. transfection of a transformation marker gene into the coding domain for a natural-type sugar chain-extended DNA obtained by amplification by PCR method from the chromosome DNA of a Pichia yeast (e.g. P.pastoris).

8. 发明专利

JPH08231510A NEW OPTICALLY ACTIVE AMINOPYRIDINE DERIVATIVE CRYSTAL, ITS PRODUCTION AND USE THEREOF 失效
公开(公告)号：JPH08231510A
公开(公告)日：1996-09-10
申请号：JP4109995
申请日：1995-02-28
申请人： GREEN CROSS CORP
发明人： SAITO HIROSHI , TSUTSUMIUCHI REIKO , EDA MASAHIRO , SUGIO NARUTOSHI , KONDO NOBUO , UEDA YASUO , NAKAMURA NORIFUMI
IPC分类号： C07D213/75 , A61K31/44 , A61P3/06 , A61P9/00 , A61P9/12 , C07B63/00
摘要： PURPOSE: To obtain the subject crystal in high reproducibility even if mass- synthesized, having new crystal form, and excellent in the stability of the various preparations therefrom because of its stability to heat, light and temperature. CONSTITUTION: This crystal is (+)-N-(6-amino-3-pyridyl)-N''-cyano-N'-[(1S,2R,4 R)-2-norbornyl)guanidine crystal having the following characteristics: in its powder X-ray diffractometry with Cu-Kαwavelength at normal temperatures, there are peaks in the respective diffraction angle 2θ ranges, namely: 5.8-6.2 deg., 8.2-9.0 deg., 14.6-16.2 deg., 17.2-18.2 deg., 19.6-20.3 deg. and 21.4-22.1 deg., but no peak in the ranges, namely: 9.9-10.5 deg. and 13.2-13.7 deg.. This crystal is useful as an agent for circulatory diseases as active ingredient.

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