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1. 发明申请

WO0044485A3 PERFLUORINATED THERMOPLASTIC FILTER CARTRIDGE 审中-公开
标题翻译：全氟化物过滤器盒
公开(公告)号：WO0044485A3
公开(公告)日：2000-12-14
申请号：PCT/US0002423
申请日：2000-01-28
申请人： MILLIPORE CORP , CHENG KWOK SHUN , DOH CHA P , YEN LARRY Y , PATEL RANJIKANT B , GATES T DEAN
发明人： CHENG KWOK-SHUN , DOH CHA P , YEN LARRY Y , PATEL RANJIKANT B , GATES T DEAN
IPC分类号： B01D63/00 , B01D29/11 , B01D35/30 , B01D61/18 , B01D63/02 , B01D63/06 , B01D63/08 , B01D63/10 , B01D71/32 , B01D71/36
CPC分类号： B01D63/067 , B01D29/111 , B01D29/21 , B01D35/30 , B01D63/021 , B01D63/023 , B01D63/025 , B01D63/061 , B01D63/08 , B01D63/10 , B01D2201/0407 , B01D2313/04 , B01D2313/44
摘要： A filtration cartridge having a housing with an inlet and an outlet and a filtration membrane contained within the housing and located between the inlet and the outlet is described. The membrane is sealed in such a manner that all fluid must flow through the membrane between entering the inlet and leaving the outlet of the housing. The entire cartridge, housing, membrane and any other components are all formed of one or more perfluorinated thermoplastic resins. These resins preferably are PFA, MFA, FEP and blends thereof. The membrane may be in the form of hollow fibers, wound fibers such as in a depth filter, or a flat sheet which may be formed into various configurations such as spiral filters, pleated filters, spiral pleated filters, disks and the like. These cartridges provide an inert, high temperature and acid/oxidative chemical resistant filter having properties similar to that of PTFE resins.
摘要翻译：描述了具有壳体的过滤筒，其具有入口和出口以及容纳在壳体内且位于入口和出口之间的过滤膜。膜以这样的方式密封，使得所有流体必须在进入入口并离开壳体的出口之间流过膜。整个墨盒，外壳，膜和任何其他部件都由一种或多种全氟化热塑性树脂形成。这些树脂优选为PFA，MFA，FEP及其共混物。膜可以是中空纤维，诸如深度过滤器中的缠绕纤维或可形成各种构造的扁平片的形式，例如螺旋过滤器，褶皱过滤器，螺旋褶皱过滤器，盘等。这些墨盒提供惰性，高温和耐酸/耐氧化的耐化学性过滤器，其特性与PTFE树脂相似。

2. 发明申请

WO0044482A3 SKINNED HOLLOW FIBER MEMBRANE AND METHOD OF MANUFACTURE 审中-公开
标题翻译：滑动中空纤维膜及其制造方法
公开(公告)号：WO0044482A3
公开(公告)日：2000-12-28
申请号：PCT/US0002194
申请日：2000-01-27
申请人： MILLIPORE CORP , CHENG KWOK SHUN , GATES T DEAN , YEN LARRY Y , PATEL RAJNIKANT B
发明人： CHENG KWOK-SHUN , GATES T DEAN , YEN LARRY Y , PATEL RAJNIKANT B
IPC分类号： B01D61/18 , B01D63/02 , B01D67/00 , B01D69/08 , B01D69/12 , B01D71/32 , B01D71/36 , D01D5/24 , D01F6/12 , D01F6/32
CPC分类号： D01F6/32 , B01D67/003 , B01D69/08 , B01D71/36 , B01D2323/22 , B01D2325/022 , B01D2325/027 , B01D2325/30 , B01D2325/34 , D01D5/24
摘要： Hollow fiber membranes having a skinned surface on one diameter, and a porous surface on the opposite diameter are produced from perfluorinated thermoplastic polymers by extruding a heated solution of the polymer having a lower critical solution temperature directly into a cooling bath to form the porous membrane by liquid-liquid phase separation. Extrusion can be conducted either vertically or horizontally. The hollow fiber membranes are useful as ultrafiltration membranes and as membrane contactors.
摘要翻译：通过将具有较低临界溶解温度的聚合物的加热溶液直接挤出到冷却浴中以形成多孔膜，由全氟化热塑性聚合物制备具有一个直径的表皮表面和相对直径的多孔表面的中空纤维膜，以通过液 - 液相分离。挤出可以垂直或水平进行。中空纤维膜可用作超滤膜和膜接触器。

3. 发明申请

WO0044484A3 MICROPOROUS HOLLOW FIBER MEMBRANES FROM PERFLUORINATED THERMOPLASTIC POLYMERS 审中-公开
标题翻译：全氟热塑性聚合物微孔中空纤维膜
公开(公告)号：WO0044484A3
公开(公告)日：2000-12-21
申请号：PCT/US0002198
申请日：2000-01-27
申请人： MILLIPORE CORP , CHENG KWOK SHUN , PATEL RAJNIKANT B , GATES T DEAN
发明人： CHENG KWOK-SHUN , PATEL RAJNIKANT B , GATES T DEAN
IPC分类号： B01D71/32 , B01D69/08 , D01D5/24 , D01F6/12 , D01F6/32
CPC分类号： D01F6/32 , D01D5/24
摘要： High flux porous hollow fiber membranes are produced from perfluorinated thermoplastic polymers by extruding a heated solution of the polymer having a lower critical solution temperature directly into a cooling bath to form the porous membrane by liquid-liquid phase separation. Extrusion can be conducted either vertically or horizontally.
摘要翻译：高通量多孔中空纤维膜由全氟化热塑性聚合物通过将具有较低临界溶解温度的聚合物的加热溶液直接挤出到冷却浴中以通过液 - 液相分离形成多孔膜来生产。挤出可以垂直或水平进行。

4. 发明申请

WO03029744B1 A THERMOPLASTIC HEAT EXCHANGER AND METHOD OF MAKING THE SAME 审中-公开
标题翻译：一种热塑性热交换器及其制造方法
公开(公告)号：WO03029744B1
公开(公告)日：2004-01-29
申请号：PCT/US0230493
申请日：2002-09-26
申请人： MYKROLIS CORP , DOH CHA P , CHENG KWOK-SHUN , BRIGGS ALICIA
发明人： DOH CHA P , CHENG KWOK-SHUN , BRIGGS ALICIA
IPC分类号： B01D53/22 , B01D61/02 , B01D61/14 , B01D63/00 , B01D63/02 , B01D63/06 , B01D69/08 , B01D71/26 , B01D71/32 , B01D71/36 , B01D71/52 , C02F1/44 , F28D7/02 , F28D7/08 , F28D7/10 , F28D7/16 , F28D9/02 , F28F1/10 , F28F9/18 , F28F21/06
CPC分类号： B01D69/084 , B01D63/02 , B01D63/021 , B01D63/022 , B01D63/06 , B01D63/061 , B01D63/068 , B01D2313/38 , F28D7/08 , F28D7/082 , F28F9/187 , F28F21/062 , Y10S165/905 , Y10T29/4935 , Y10T29/49362 , Y10T29/49373
摘要： A heat exchanger comprising hollow thermoplastic tubes, which are fusion bonded with a thermoplastic resin to form unified terminal end blocks (32, 34), is disclosed. The hollow tubes may be shaped by plaiting or braiding the tubes into cords (70, 72) and then thermally annealing the cords (70, 72) to set the crests and bends of the plait or braid. The cords (70, 72) provide improved flow distribution of fluid about the hollow tubes in the heat exchanger. The heat exchanger is chemically inert and is useful for cross-flow filtration, as well as for heat- and mass-transfer applications in harsh chemical environments.
摘要翻译：公开了一种包括中空热塑性管的热交换器，其与热塑性树脂熔合以形成统一的端部端块（32,34）。中空管可以通过将管子编织或编织成帘线（70,72）而形成，然后对绳索（70,72）进行热退火以设定辫子或编织物的顶部和弯曲部分。帘线（70,72）提供流体在热交换器中围绕中空管的改善的流量分布。热交换器是化学惰性的，可用于交叉流过滤，也可用于恶劣化学环境中的热传质和传质应用。

5. 发明申请

WO03029744A2 EXCHANGE APPARATUS 审中-公开
标题翻译：交换装置
公开(公告)号：WO03029744A2
公开(公告)日：2003-04-10
申请号：PCT/US0230493
申请日：2002-09-26
申请人： MYKROLIS CORP , DOH CHA P , CHENG KWOK-SHUN , BRIGGS ALICIA
发明人： DOH CHA P , CHENG KWOK-SHUN , BRIGGS ALICIA
IPC分类号： B01D53/22 , B01D61/02 , B01D61/14 , B01D63/00 , B01D63/02 , B01D63/06 , B01D69/08 , B01D71/26 , B01D71/32 , B01D71/36 , B01D71/52 , C02F1/44 , F28D7/02 , F28D7/08 , F28D7/10 , F28D7/16 , F28D9/02 , F28F1/10 , F28F9/18 , F28F21/06
CPC分类号： B01D69/084 , B01D63/02 , B01D63/021 , B01D63/022 , B01D63/06 , B01D63/061 , B01D63/068 , B01D2313/38 , F28D7/08 , F28D7/082 , F28F9/187 , F28F21/062 , Y10S165/905 , Y10T29/4935 , Y10T29/49362 , Y10T29/49373
摘要： An exchange apparatus comprised of hollow thermoplastic tubes infusion bonded into a thermoplastic material is disclosed. In a preferred embodiment the hollow tubes are shaped by plaiting the tubes into cords and then thermally annealing the cords to set the crests and bends of the plait. The cords provide improved flow distribution of fluid about the hollow tube tubes in the exchange apparatus. The exchange apparatus is chemically inert and is useful for cross flow filtration, as well as heat and mass transfer in harsh chemical environments.
摘要翻译：公开了一种由中空热塑管组成的交换装置，该热塑性管浸入到热塑性材料中。在一个优选实施例中，中空管通过将管子编织成帘线而成形，然后热退火帘线以设定辫子的顶部和弯曲。帘线在交换装置中提供了围绕中空管管的改善的流体分布。交换装置是化学惰性的，可用于交叉流过滤，以及在恶劣化学环境中的热和质量传递。

6. 发明申请

WO2013009491A3 IMPROVED DEPTH FILTERS FOR DISPOSABLE BIOTECHNOLOGICAL PROCESSES 审中-公开
标题翻译：改进的深度过滤器用于一次性生物技术过程
公开(公告)号：WO2013009491A3
公开(公告)日：2013-05-02
申请号：PCT/US2012044806
申请日：2012-06-29
申请人： SINGH NRIPEN , CHENG KWOK-SHUN
发明人： SINGH NRIPEN , CHENG KWOK-SHUN
IPC分类号： C12M1/12 , B01D29/01 , B01D39/08 , B01D61/00
CPC分类号： B01D15/125 , B01D15/3809 , B01D2239/025 , B01D2239/0428 , B01D2239/065 , C02F1/001 , C02F1/52 , C02F1/56 , C02F2103/343 , C07K1/34
摘要： A process for the primary clarification of feeds, including chemically treated flocculated feeds, containing the target biomolecules of interest such as mAbs, mammalian cell cultures, or bacterial cell cultures, using a primary clarification depth filtration device without the use of a primary clarification centrifugation step or a primary clarification tangential flow microfiltration step. The primary clarification depth filtration device contains a porous depth filter having graded porous layers of varying pore ratings. The primary clarification depth filtration device filters fluid feeds, including chemically treated flocculated feeds containing flocculated cellular debris and colloidal particulates having a particle size distribution of approximately about 0.5 pm to 200 pm, at a flow rate of about 10 litres/m2/hr to about 100 litres/m2/hr. Kits and methods of using and making the same are also provided.
摘要翻译：使用初级澄清深度过滤装置在不使用初级澄清离心步骤的情况下初级澄清饲料（包括化学处理的絮凝饲料），所述饲料包含目的目标生物分子如单克隆抗体，哺乳动物细胞培养物或细菌细胞培养物或初级澄清切向流微滤步骤。初级澄清深度过滤装置包含多孔深度过滤器，其具有不同孔隙率的梯度多孔层。初级澄清深度过滤装置过滤流体进料，包括化学处理的絮凝进料，其包含絮凝的细胞碎片和颗粒大小分布约为0.5pm至200pm的胶体颗粒，流速为约10升/平方米/小时至约 100升/平方米/小时。还提供了使用和制造它们的试剂盒和方法。

7. 发明专利

JP2011128147A Flow through purification process for large biomolecule 审中-公开
标题翻译：通过大生物分子的净化过程流动
公开(公告)号：JP2011128147A
公开(公告)日：2011-06-30
申请号：JP2010263504
申请日：2010-11-26
申请人： Millipore Corp , ミリポア・コーポレイションMillipore Corporation
发明人： IYER GANSPATHYSUBRAMANIAN , RAMASWARMY SENTHIL , CHENG KWOK-SHUN
IPC分类号： G01N30/88 , B01D15/04 , B01D15/08 , C12N1/02 , C12N7/02
CPC分类号： C12N7/00 , C12N2710/10023 , C12N2710/10051 , C12N2760/16123 , C12N2760/16151 , C12N2760/16223 , C12N2760/16251 , C12N2795/12023 , C12N2795/12051
摘要： PROBLEM TO BE SOLVED: To provide novel and improved flow-through purification processes, at least in part, for separating large biomolecules, such as, for example, encapsulated viruses, virus-like particles or conjugate vaccines, from one or more contaminants in a sample.
SOLUTION: The process employs the use of at least one population of a solid porous particle which comprises a minimized external surface area per unit volume of the particles and an internal surface area per unit volume which is not decreased by more than 25% relative to a population of a similar particle which does not have a minimized external surface area.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了提供新颖和改进的流通纯化方法，至少部分地从一个或多个分离大分子分离大分子，例如包封的病毒，病毒样颗粒或缀合疫苗样品中的污染物。解决方案：该方法使用至少一个固体多孔颗粒群，其包括每单位体积的颗粒的最小化外表面积和每单位体积的内表面积，其不降低超过25％相对于不具有最小化的外表面积的类似颗粒的群体。版权所有（C）2011，JPO＆INPIT

8. 发明公开

EP2859084A4 LOW ORGANIC EXTRACTABLE DEPTH FILTER MEDIA PROCESSED WITH SOLVENT EXTRACTION METHOD 审中-公开
标题翻译：在溶剂萃取过程中，处理过的低有机物可渗透深度过滤介质
公开(公告)号：EP2859084A4
公开(公告)日：2015-12-30
申请号：EP13801241
申请日：2013-06-06
申请人： EMD MILLIPORE CORP
发明人： CHENG KWOK-SHUN , SINGH NRIPEN
IPC分类号： C12M1/12 , C07K1/34 , C07K16/00 , C12M1/00 , C12M3/06
CPC分类号： C07K1/34 , C07K16/00 , C12M47/02

9. 发明专利

JP2007077397A Method and apparatus for producing porous agarose bead 有权
标题翻译：用于生产多孔胶珠的方法和装置
公开(公告)号：JP2007077397A
公开(公告)日：2007-03-29
申请号：JP2006246868
申请日：2006-09-12
申请人： Millipore Corp , ミリポア・コーポレイションMillipore Corporation
发明人： CHENG KWOK-SHUN , RAMASWAMY SENTHILKUMAR , BIAN NANYING , GAGNON BRIAN , UMANA JOAQUIN , SOICE NEIL P
IPC分类号： C08J3/16 , B01J2/06 , B01J20/24
CPC分类号： B01J20/24 , B01J13/04 , B01J20/28009 , B01J20/285 , B01J20/286 , B01J20/291 , B01J20/3204 , B01J20/3242 , B01J20/3244 , B01J20/3272 , B01J20/328 , B01J20/3282 , B01J20/3289 , B01J20/3293 , B01J2220/4825
摘要： PROBLEM TO BE SOLVED: To provide a small and inexpensive apparatus for producing porous agarose beads, and a method for producing the beads. SOLUTION: The method for producing the porous agarose bead involves dissolving/gelling agarose 2 in a suitable liquid, mixing the product with a hydrophobic liquid to form an emulsion 10, maintaining the emulsion at a temperature equal to or greater than the gelation point of the agarose, passing the resultant emulsion through a static mixer 12 to create droplets 14 of the agarose, and solidifying the droplets in the second bath 16 of a hydrophobic liquid. The obtained beads are washed and processed to crosslink the agarose, and the resultant beads are treated to add various functionalities on to the agarose. Another method for solidifying the agarose droplets involves continuous cooling. A similar process is used for the cored beads so that the agarose forms a coating on the cores. A similar process with either homogeneous agarose beads or cored agarose beads can be used to add multiple layers of agarose on to the existing beads. An apparatus for running the process is also disclosed. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于生产多孔琼脂糖珠的小型和便宜的装置，以及用于制备珠粒的方法。解决方案：用于制备多孔琼脂糖珠的方法包括将琼脂糖2溶解/胶凝在合适的液体中，将产物与疏水性液体混合以形成乳液10，将乳液保持在等于或大于凝胶化的温度点，使得到的乳液通过静态混合器12产生琼脂糖的液滴14，并使第二槽16中的液滴固化成疏水性液体。将获得的珠子洗涤并加工以使琼脂糖交联，并将所得的珠粒处理以在琼脂糖上添加各种功能。凝固琼脂糖液滴的另一种方法包括连续冷却。核心珠子使用类似的方法，使得琼脂糖在芯上形成涂层。使用均相琼脂糖珠或核心琼脂糖珠的类似方法可用于在现有珠上添加多层琼脂糖。还公开了一种用于运行该过程的装置。版权所有（C）2007，JPO＆INPIT

10. 发明公开

EP2732021A4 IMPROVED DEPTH FILTERS FOR DISPOSABLE BIOTECHNOLOGICAL PROCESSES 有权转让
标题翻译：改进的深度过滤器生物技术一次性程序
公开(公告)号：EP2732021A4
公开(公告)日：2015-05-06
申请号：EP12811005
申请日：2012-06-29
申请人： EMD MILLIPORE CORP
发明人： SINGH NRIPEN , CHENG KWOK-SHUN
IPC分类号： C12M1/12 , B01D29/01 , B01D39/08 , B01D61/00
CPC分类号： B01D15/125 , B01D15/3809 , B01D2239/025 , B01D2239/0428 , B01D2239/065 , C02F1/001 , C02F1/52 , C02F1/56 , C02F2103/343 , C07K1/34
摘要： A process for the primary clarification of feeds, including chemically treated flocculated feeds, containing the target biomolecules of interest such as mAbs, mammalian cell cultures, or bacterial cell cultures, using a primary clarification depth filtration device without the use of a primary clarification centrifugation step or a primary clarification tangential flow microfiltration step. The primary clarification depth filtration device contains a porous depth filter having graded porous layers of varying pore ratings. The primary clarification depth filtration device filters fluid feeds, including chemically treated flocculated feeds containing flocculated cellular debris and colloidal particulates having a particle size distribution of approximately about 0.5 μm to 200 μm, at a flow rate of about 10 litres/m2/hr to about 100 litres/m2/hr. Kits and methods of using and making the same are also provided.

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