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1. 发明申请

WO03033661A8 METHODS OF USING 279, A HUMAN G PROTEIN-COUPLED RECEPTOR 审中-公开
公开(公告)号：WO03033661A8
公开(公告)日：2003-12-24
申请号：PCT/US0232974
申请日：2002-10-16
申请人： MILLENNIUM PHARM INC , LOGAN THOMAS JOSEPH , GALVIN KATHERINE M
发明人： LOGAN THOMAS JOSEPH , GALVIN KATHERINE M
IPC分类号： A61K38/00 , C07K14/705 , C07K14/72 , A61K31/70 , A61K38/16 , A61K38/43 , A61K39/395 , A61K48/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/723
摘要： The invention provides isolated nucleic acids molecules, designated 279 nucleic acid molecules, which encode human G protein-coupled receptor (GPCR) family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 279 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 279 gene bas been introduced or disrupted. The invention still further provides isolated 279 proteins, fusion proteins, antigenic peptides and anti-279 antibodies. Methods utilizing compositions of the invention to treat, prevent or diagnose angiogenic disorders, e.g., cardiovascular and cancerous disorders, are also provided.

2. 发明申请

WO03039341A2 METHODS AND COMPOSITIONS TO TREAT CARDIOVASCULAR DISEASE USING 139, 258, 1261, 1486, 2398, 2414, 7660, 8587, 10183, 10550, 12680, 17921, 32248, 60489 OR 93804 审中-公开
标题翻译：使用139,258,1261,1486,2398,2414,7660,85887,10183,10502,12880,17921,32248,60489或93804治疗心血管疾病的方法和组合物
公开(公告)号：WO03039341A2
公开(公告)日：2003-05-15
申请号：PCT/US0235538
申请日：2002-11-05
申请人： MILLENNIUM PHARM INC , LOGAN THOMAS JOSEPH , CHUN MIYOUNG , GALVIN KATHERINE M
发明人： LOGAN THOMAS JOSEPH , CHUN MIYOUNG , GALVIN KATHERINE M
IPC分类号： A61K45/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/68 , A61B
CPC分类号： G01N33/502 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5067 , G01N33/6893 , G01N2500/00 , G01N2800/32
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 139, 258, 1261, 1486, 2398, 2414, 7660, 8587, 10183, 10550, 12680, 17921, 32248, 60489 or 93804 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
摘要翻译：本发明涉及用于诊断和治疗心血管疾病的方法，包括但不限于动脉粥样硬化，再灌注损伤，高血压，再狭窄，动脉炎症，血栓形成和内皮细胞疾病。具体地，本发明鉴定了心血管疾病状态中的139,258,1261,1486,2388,2414,7660,85887,10183,10550,12680,17721,32248,60489或93804基因的差异表达，相对于其在正常或非心血管疾病状态，和/或响应于与心血管疾病相关的操作。本发明描述了各种心血管疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。本发明还提供了鉴定能调节心血管疾病的化合物的方法。本发明还提供了用于鉴定和治疗化合物作为心血管疾病治疗的方法。

3. 发明申请

WO0202760A3 25869, A HUMAN CARBOXYLESTERASE AND USES THEREOF 审中-公开
标题翻译： 25869，人类羧甲基化酶及其用途
公开(公告)号：WO0202760A3
公开(公告)日：2002-08-15
申请号：PCT/US0120968
申请日：2001-06-29
申请人： MILLENNIUM PHARM INC , CURTIS RORY A J , LOGAN THOMAS JOSEPH
发明人： CURTIS RORY A J , LOGAN THOMAS JOSEPH
IPC分类号： A61K38/00 , C12N9/18 , C12N15/55 , C12N1/21 , C12N5/10 , C12N15/62 , C12Q1/68 , G01N33/53 , G01N33/573
CPC分类号： C12N9/18 , A61K38/00
摘要： The invention provides isolated nucleic acid molecules, designated COE-1 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing COE-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a COE-1 gene has been introduced or disrupted. The invention still further provides isolated COE-1 proteins, fusion proteins, antigenic peptides and anti-COE-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的羧酸酯酶家族成员的分离的核酸分子，命名为COE-1核酸分子。本发明还提供了反义核酸分子，含有COE-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及已引入或破坏了COE-1基因的非人转基因动物。本发明还进一步提供分离的COE-1蛋白，融合蛋白，抗原肽和抗COE-1抗体。还提供了利用本发明组合物的诊断方法。

4. 发明申请

WO0166758A3 25934, A NOVEL FATTY ACID DESATURASE AND USES THEREFOR 审中-公开
标题翻译： 25934，新型脂肪酸去饱和及其用途
公开(公告)号：WO0166758A3
公开(公告)日：2002-04-11
申请号：PCT/US0107309
申请日：2001-03-05
申请人： MILLENNIUM PHARM INC , LOGAN THOMAS JOSEPH , GLUCKSMANN MARIA ALEXANDRA
发明人： LOGAN THOMAS JOSEPH , GLUCKSMANN MARIA ALEXANDRA
IPC分类号： A61K38/00 , C12N9/02 , C12N15/53 , A61K38/44 , C07K16/40 , C12N1/21 , C12N5/10 , C12Q1/26 , C12Q1/68
CPC分类号： C12N9/0071 , A61K38/00 , C12N9/0083
摘要： The invention provides isolated nucleic acids molecules, designated 25934 nucleic acid molecules, which encode a novel desaturase family member. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25934 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25934 gene has been introduced or disrupted. The invention still further provides isolated 25934 proteins, fusion proteins, antigenic peptides and anti-25934 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods for modulating fatty acid metabolism utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing cardiovascular disorders, such atherosclerosis, hypertriglyceridemia, hypercholesterolemia, and hyperlipidemia, are disclosed.
摘要翻译：本发明提供编码新型去饱和酶家族成员的分离的核酸分子，命名为25934核酸分子。本发明还提供了反义核酸分子，含有25934个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已导入或破坏了25934基因的非人转基因动物。本发明还进一步提供了分离的25934蛋白，融合蛋白，抗原肽和抗25934抗体。还提供了利用本发明组合物的诊断方法。本发明还提供了利用本发明组合物调节脂肪酸代谢的方法。因此，公开了治疗，预防和/或诊断心血管疾病，动脉粥样硬化，高甘油三酯血症，高胆固醇血症和高脂血症的方法。

5. 发明申请

WO0216592A3 ATCR-1, A HUMAN ACYLTRANSFERASE AND USES THEREOF 审中-公开
标题翻译： ATCR-1，人类胰蛋白酶及其用途
公开(公告)号：WO0216592A3
公开(公告)日：2003-02-06
申请号：PCT/US0126239
申请日：2001-08-21
申请人： MILLENNIUM PHARM INC , KAPELLER-LIBERMANN ROSANNA , LOGAN THOMAS JOSEPH
发明人： KAPELLER-LIBERMANN ROSANNA , LOGAN THOMAS JOSEPH
IPC分类号： A61K38/00 , C12N9/10 , C12N15/20 , C12N15/00 , C07K14/47 , C12N15/86 , G01N33/00
CPC分类号： C12N9/1029 , A61K38/00 , C12Y203/01015
摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的酰基转移酶家族成员的分离的核酸分子，命名为ACTR-1核酸分子。本发明还提供了反义核酸分子，含有ACTR-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了ACTR-1基因的非人类转基因动物。本发明还进一步提供了分离的ACTR-1蛋白，融合蛋白，抗原肽和抗ACTR-1抗体。还提供了利用本发明组合物的诊断方法。

6. 发明申请

WO0166757A8 25934, A NOVEL FATTY ACID DESATURASE AND USES THEREFOR 审中-公开
标题翻译： 25934，新型脂肪酸去饱和及其用途
公开(公告)号：WO0166757A8
公开(公告)日：2002-03-21
申请号：PCT/US0107229
申请日：2001-03-07
申请人： MILLENNIUM PHARM INC , LOGAN THOMAS JOSEPH , GLUCKSMANN MARIA ALEXANDRA
发明人： LOGAN THOMAS JOSEPH , GLUCKSMANN MARIA ALEXANDRA
IPC分类号： A61K38/00 , C12N9/02 , C12N15/53
CPC分类号： C12N9/0071 , A61K38/00 , C12N9/0083
摘要： L'invention concerne des molécules d'acides nucléiques isolées, appelées molécules d'acides nucléiques 25934, qui codent pour un nouvel élément de la famille de la désaturase. L'invention concerne également des molécules d'acides nucléiques antisens, des vecteurs d'expression de recombinaison contenant des molécules d'acides nucléiques 25934, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits, et des animaux transgéniques non humains dans lesquels un gène 25934 a été introduit ou interrompu. L'invention concerne, en outre, des protéines 25934 isolées, des protéines de fusion, des peptides antigènes, et des anticorps anti-25934. L'invention concerne ensuite des méthodes de diagnostic utilisant les compositions de l'invention, et des méthodes permettant de moduler le métabolisme des acides gras utilisant lesdites compositions. L'invention concerne enfin des méthodes permettant de traiter, de prévenir et/ou de diagnostiquer des troubles cardio-vasculaires, tels que l'athérosclérose, l'hypertriglycéridémie, l'hypercholestérolémie, et l'hyperlipémie.

8. 发明公开

EP1451369A4 METHODS AND COMPOSITIONS TO TREAT CARDIOVASCULAR DISEASE USIN G 1419, 58765 AND 2201 审中-公开
标题翻译：方法和组合物心脏病含电路1419，58765和2201的处理
公开(公告)号：EP1451369A4
公开(公告)日：2006-09-20
申请号：EP02795793
申请日：2002-12-10
申请人： MILLENNIUM PHARM INC
发明人： LOGAN THOMAS JOSEPH , CHUN MIYOUNG
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/06 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/68 , G01N33/53
CPC分类号： G01N33/6887 , C12Q1/6883 , C12Q2600/158 , G01N2500/04 , G01N2800/32

9. 发明专利

AU4730301A 25934, a novel fatty acid desaturase and uses therefor 未知
公开(公告)号：AU4730301A
公开(公告)日：2001-09-17
申请号：AU4730301
申请日：2001-03-07
申请人： MILLENNIUM PHARM INC
发明人： LOGAN THOMAS JOSEPH , GLUCKSMANN MARIA ALEXANDRA
IPC分类号： A61K38/00 , C12N9/02 , C12N15/53 , A61K38/44 , C07K16/40 , C12N1/21 , C12N5/10 , C12Q1/26 , C12Q1/68

10. 发明公开

EP1450666A4 METHODS AND COMPOSITIONS TO TREAT CARDIOVASCULAR DISEASE USING 139,258,1261,1486,2398,2414,7660,8587,10183,10550,12680,17921,32248,60489 OR 93804 审中-公开
标题翻译：用于治疗心血管疾病的方法和组合物使用139,258,1261,1486,2398,2414,7660,8587,10183,10550,12680,17921,32248,60489 OR 93804
公开(公告)号：EP1450666A4
公开(公告)日：2008-11-12
申请号：EP02795592
申请日：2002-11-05
申请人： MILLENNIUM PHARM INC
发明人： LOGAN THOMAS JOSEPH , CHUN MIYOUNG , GALVIN KATHERINE M
IPC分类号： A61K45/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/68
CPC分类号： G01N33/502 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5067 , G01N33/6893 , G01N2500/00 , G01N2800/32

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