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1. 发明申请

WO03033661A8 METHODS OF USING 279, A HUMAN G PROTEIN-COUPLED RECEPTOR 审中-公开
公开(公告)号：WO03033661A8
公开(公告)日：2003-12-24
申请号：PCT/US0232974
申请日：2002-10-16
申请人： MILLENNIUM PHARM INC , LOGAN THOMAS JOSEPH , GALVIN KATHERINE M
发明人： LOGAN THOMAS JOSEPH , GALVIN KATHERINE M
IPC分类号： A61K38/00 , C07K14/705 , C07K14/72 , A61K31/70 , A61K38/16 , A61K38/43 , A61K39/395 , A61K48/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/723
摘要： The invention provides isolated nucleic acids molecules, designated 279 nucleic acid molecules, which encode human G protein-coupled receptor (GPCR) family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 279 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 279 gene bas been introduced or disrupted. The invention still further provides isolated 279 proteins, fusion proteins, antigenic peptides and anti-279 antibodies. Methods utilizing compositions of the invention to treat, prevent or diagnose angiogenic disorders, e.g., cardiovascular and cancerous disorders, are also provided.

2. 发明申请

WO2003065984A2 METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE USING 1682, 6169, 6193, 7771, 14395, 29002, 33216, 43726, 69292, 21656, 32427, 2402, 7747,1720, 9151, 60491, 1371, 7077, 33207, 1419, 18036, 16105, 38650, 14245, 58848, 1870, 25856, 32394, 3484, 345, 9252, 9135, 10532, 18610, 8165,2 审中-公开
标题翻译：使用1682号，6169号，6193号，7771号，14395号，29002号，33216号，43726号，69292号，21656号，第32427号，第2402号，第7747,1720号，第9151号，第60491号，第1371号，第7077号，第33207号，第1419号，第18036号， 16105,38650,14245,5888,1870,25856,332394,38484,345,9252,9135,10532,181010,8165,2
公开(公告)号：WO2003065984A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/002571
申请日：2003-01-29
申请人： MILLENNIUM PHARMACEUTICALS, INC. , LOGAN, Thomas, Joseph , CHUN, Miyoung , GALVIN, Katherine, M. , HEALY, Aileen , ACTON, Susan, L. , DONAGHUE, Mary , STAGLIANO, Nancy , PERODIN, Jacqueline , RODRIGUE-WAY, Amelie
发明人： LOGAN, Thomas, Joseph , CHUN, Miyoung , GALVIN, Katherine, M. , HEALY, Aileen , ACTON, Susan, L. , DONAGHUE, Mary , STAGLIANO, Nancy , PERODIN, Jacqueline , RODRIGUE-WAY, Amelie
IPC分类号： A61K
CPC分类号： G01N33/5067 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5064 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, heart failure, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1682, 6169, 6193, 7771, 14395, 29002, 33216, 43726, 69292, 21656, 32427, 2402, 7747, 1720, 9151, 60491, 1371, 7077, 33207, 1419, 18036, 16105, 38650, 14245, 58848, 1870, 25856, 32394, 3484, 345, 9252, 9135, 10532, 18610, 8165, 2448, 2445, 64624, 84237, 8912, 2868, 283, 2554, 9464, 17799, 26686, 43848, 32135, 12208, 2914, 51130, 19489, 21833, 2917, 59590, 15992, 2094, 2252, 3474, 9792, 15400, 1452 and 6585 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition touch conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
摘要翻译：本发明涉及用于诊断和治疗心血管疾病的方法，包括但不限于动脉粥样硬化，再灌注损伤，高血压，再狭窄，动脉炎症，心力衰竭，血栓形成和内皮细胞疾病。具体而言，本发明鉴定1682,6199,4192,23216,43726,69292,21656,32427,2402,7747,1720,9151,60491,1371,7077,33207,1419的差异表达， 18036,16105,3862,14245,5888,1870,25856,332394,38484,345,9252,9135,1052,38610,8165,2448,2445,64624,84237,8912,2868,283,25454,9644,17999,17167,169,169， 26686,4388,32135,12208,2914,51130,19489,21833,2917,59590,1592,2094，2252,37474,9792,15400,1452和6585基因在心血管疾病状态，相对于它们在正常或非正常的表达，心血管疾病状态，和/或响应与心血管疾病相关的操作。本发明描述了各种心血管疾病的诊断评估和预后的方法，以及用于鉴定表现出倾向性触觉条件的受试者。本发明还提供了鉴定能调节心血管疾病的化合物的方法。本发明还提供了用于鉴定和治疗化合物作为心血管疾病治疗的方法。

3. 发明申请

WO2003050504A2 METHODS AND COMPOSITIONS TO TREAT CARDIOVASCULAR DISEASE USING 1419, 58765 AND 2201 审中-公开
标题翻译：使用G 1419,58765和2201治疗心血管疾病的方法和组合
公开(公告)号：WO2003050504A2
公开(公告)日：2003-06-19
申请号：PCT/US2002/039353
申请日：2002-12-10
申请人： MILLENNIUM PHARMACEUTICALS, INC. , LOGAN, Thomas, Joseph , CHUN, Miyoung
发明人： LOGAN, Thomas, Joseph , CHUN, Miyoung
IPC分类号： G01N
CPC分类号： G01N33/6887 , C12Q1/6883 , C12Q2600/158 , G01N2500/04 , G01N2800/32
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1419, 58765 or 2210 genes in cardiovascular disease states, relative to their expression in normal, or noncardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provide methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
摘要翻译：本发明涉及用于诊断和治疗心血管疾病的方法，包括但不限于动脉粥样硬化，再灌注损伤，高血压，再狭窄，动脉炎症，血栓形成和内皮细胞疾病。具体地，本发明鉴定了心血管疾病状态中1419,58765或2210个基因在正常或非心血管疾病状态下的表达和/或响应于与心血管疾病相关的操作的差异表达。本发明描述了各种心血管疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。本发明还提供了鉴定能调节心血管疾病的化合物的方法。本发明还提供了用于鉴定和治疗化合物作为心血管疾病治疗的方法。

4. 发明申请

WO0166758A3 25934, A NOVEL FATTY ACID DESATURASE AND USES THEREFOR 审中-公开
标题翻译： 25934，新型脂肪酸去饱和及其用途
公开(公告)号：WO0166758A3
公开(公告)日：2002-04-11
申请号：PCT/US0107309
申请日：2001-03-05
申请人： MILLENNIUM PHARM INC , LOGAN THOMAS JOSEPH , GLUCKSMANN MARIA ALEXANDRA
发明人： LOGAN THOMAS JOSEPH , GLUCKSMANN MARIA ALEXANDRA
IPC分类号： A61K38/00 , C12N9/02 , C12N15/53 , A61K38/44 , C07K16/40 , C12N1/21 , C12N5/10 , C12Q1/26 , C12Q1/68
CPC分类号： C12N9/0071 , A61K38/00 , C12N9/0083
摘要： The invention provides isolated nucleic acids molecules, designated 25934 nucleic acid molecules, which encode a novel desaturase family member. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25934 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25934 gene has been introduced or disrupted. The invention still further provides isolated 25934 proteins, fusion proteins, antigenic peptides and anti-25934 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods for modulating fatty acid metabolism utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing cardiovascular disorders, such atherosclerosis, hypertriglyceridemia, hypercholesterolemia, and hyperlipidemia, are disclosed.
摘要翻译：本发明提供编码新型去饱和酶家族成员的分离的核酸分子，命名为25934核酸分子。本发明还提供了反义核酸分子，含有25934个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已导入或破坏了25934基因的非人转基因动物。本发明还进一步提供了分离的25934蛋白，融合蛋白，抗原肽和抗25934抗体。还提供了利用本发明组合物的诊断方法。本发明还提供了利用本发明组合物调节脂肪酸代谢的方法。因此，公开了治疗，预防和/或诊断心血管疾病，动脉粥样硬化，高甘油三酯血症，高胆固醇血症和高脂血症的方法。

5. 发明申请

WO2003050504A3 METHODS AND COMPOSITIONS TO TREAT CARDIOVASCULAR DISEASE USING 1419, 58765 AND 2201 审中-公开
公开(公告)号：WO2003050504A3
公开(公告)日：2003-06-19
申请号：PCT/US2002/039353
申请日：2002-12-10
申请人： MILLENNIUM PHARMACEUTICALS, INC. , LOGAN, Thomas, Joseph , CHUN, Miyoung
发明人： LOGAN, Thomas, Joseph , CHUN, Miyoung
IPC分类号： C12Q1/68
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1419, 58765 or 2210 genes in cardiovascular disease states, relative to their expression in normal, or noncardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provide methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

6. 发明申请

WO2003025199A2 MID 4460, A HUMAN TYROSINE PHOSPHATASE FAMILY MEMBER AND USES THEREFOR 审中-公开
标题翻译： MID 4460，一种人类酪氨酸磷酸酯酶家族成员并用于此目的
公开(公告)号：WO2003025199A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/029353
申请日：2002-09-17
申请人： MILLENNIUM PHARMACEUTICALS, INC. , LOGAN, Thomas, Joseph
发明人： LOGAN, Thomas, Joseph
IPC分类号： C12Q
CPC分类号： C12N9/16 , C12Q1/42 , G01N33/573
摘要： The invention provides isolated nucleic acids molecules, designated MID 4460 nucleic acid molecules, which encode novel tyrosine phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MID 4460 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a MID 4460 gene has been introduced or disrupted. The invention still further provides isolated MID 4460 proteins, fusion proteins, antigenic peptides and anti-MID 4460 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的核酸分子，命名为MID 4460核酸分子，其编码新的酪氨酸磷酸酶家族成员。本发明还提供了反义核酸分子，含有MID 4460核酸分子的重组表达载体，导入了表达载体的宿主细胞以及导入或破坏了MID 4460基因的非人转基因动物。本发明还提供了分离的MID 4460蛋白，融合蛋白，抗原肽和抗MID 4460抗体。还提供了利用本发明组合物的诊断和治疗方法。

7. 发明申请

WO2003065984A3 METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE 审中-公开
公开(公告)号：WO2003065984A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/002571
申请日：2003-01-29
申请人： MILLENNIUM PHARMACEUTICALS, INC. , LOGAN, Thomas, Joseph , CHUN, Miyoung , GALVIN, Katherine, M. , HEALY, Aileen , ACTON, Susan, L. , DONAGHUE, Mary , STAGLIANO, Nancy , PERODIN, Jacqueline , RODRIGUE-WAY, Amelie
发明人： LOGAN, Thomas, Joseph , CHUN, Miyoung , GALVIN, Katherine, M. , HEALY, Aileen , ACTON, Susan, L. , DONAGHUE, Mary , STAGLIANO, Nancy , PERODIN, Jacqueline , RODRIGUE-WAY, Amelie
IPC分类号： C12Q1/00
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, heart failure, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1682, 6169, 6193, 7771, 14395, 29002, 33216, 43726, 69292, 21656, 32427, 2402, 7747, 1720, 9151, 60491, 1371, 7077, 33207, 1419, 18036, 16105, 38650, 14245, 58848, 1870, 25856, 32394, 3484, 345, 9252, 9135, 10532, 18610, 8165, 2448, 2445, 64624, 84237, 8912, 2868, 283, 2554, 9464, 17799, 26686, 43848, 32135, 12208, 2914, 51130, 19489, 21833, 2917, 59590, 15992, 2094, 2252, 3474, 9792, 15400, 1452 and 6585 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition touch conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

8. 发明申请

WO2003039341A3 METHODS AND COMPOSITIONS TO TREAT CARDIOVASCULAR DISEASE USING 139, 258, 1261, 1486, 2398, 2414, 7660, 8587, 10183, 10550, 12680, 17921, 32248, 60489 OR 93804 审中-公开
公开(公告)号：WO2003039341A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/035538
申请日：2002-11-05
申请人： MILLENNIUM PHARMACEUTICALS, INC. , LOGAN, Thomas, Joseph , CHUN, Miyoung , GALVIN, Katherine, M.
发明人： LOGAN, Thomas, Joseph , CHUN, Miyoung , GALVIN, Katherine, M.
IPC分类号： A61K69/00
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 139, 258, 1261, 1486, 2398, 2414, 7660, 8587, 10183, 10550, 12680, 17921, 32248, 60489 or 93804 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

9. 发明申请

WO03039341A2 METHODS AND COMPOSITIONS TO TREAT CARDIOVASCULAR DISEASE USING 139, 258, 1261, 1486, 2398, 2414, 7660, 8587, 10183, 10550, 12680, 17921, 32248, 60489 OR 93804 审中-公开
标题翻译：使用139,258,1261,1486,2398,2414,7660,85887,10183,10502,12880,17921,32248,60489或93804治疗心血管疾病的方法和组合物
公开(公告)号：WO03039341A2
公开(公告)日：2003-05-15
申请号：PCT/US0235538
申请日：2002-11-05
申请人： MILLENNIUM PHARM INC , LOGAN THOMAS JOSEPH , CHUN MIYOUNG , GALVIN KATHERINE M
发明人： LOGAN THOMAS JOSEPH , CHUN MIYOUNG , GALVIN KATHERINE M
IPC分类号： A61K45/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/68 , A61B
CPC分类号： G01N33/502 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5067 , G01N33/6893 , G01N2500/00 , G01N2800/32
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 139, 258, 1261, 1486, 2398, 2414, 7660, 8587, 10183, 10550, 12680, 17921, 32248, 60489 or 93804 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
摘要翻译：本发明涉及用于诊断和治疗心血管疾病的方法，包括但不限于动脉粥样硬化，再灌注损伤，高血压，再狭窄，动脉炎症，血栓形成和内皮细胞疾病。具体地，本发明鉴定了心血管疾病状态中的139,258,1261,1486,2388,2414,7660,85887,10183,10550,12680,17721,32248,60489或93804基因的差异表达，相对于其在正常或非心血管疾病状态，和/或响应于与心血管疾病相关的操作。本发明描述了各种心血管疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。本发明还提供了鉴定能调节心血管疾病的化合物的方法。本发明还提供了用于鉴定和治疗化合物作为心血管疾病治疗的方法。

10. 发明申请

WO2003033661A2 METHODS OF USING 279, A HUMAN G PROTEIN-COUPLED PROTEIN RECEPTOR 审中-公开
标题翻译：使用279的人G蛋白偶联受体的方法
公开(公告)号：WO2003033661A2
公开(公告)日：2003-04-24
申请号：PCT/US2002/032974
申请日：2002-10-16
申请人： MILLENNIUM PHARMACEUTICALS, INC. , LOGAN, Thomas, Joseph , GALVIN, Katherine, M.
发明人： LOGAN, Thomas, Joseph , GALVIN, Katherine, M.
IPC分类号： C12N
CPC分类号： C07K14/705 , A61K38/00 , C07K14/723
摘要： The invention provides isolated nucleic acids molecules, designated 279 nucleic acid molecules, which encode human G protein-coupled receptor (GPCR) family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 279 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 279 gene bas been introduced or disrupted. The invention still further provides isolated 279 proteins, fusion proteins, antigenic peptides and anti-279 antibodies. Methods utilizing compositions of the invention to treat, prevent or diagnose angiogenic disorders, e.g., cardiovascular and cancerous disorders, are also provided.
摘要翻译：本发明提供编码人G蛋白偶联受体（GPCR）家族成员的分离的核酸分子，命名为279个核酸分子。本发明还提供反义核酸分子，含有279个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了279个基因的非人类转基因动物。本发明还进一步提供了分离的279蛋白，融合蛋白，抗原肽和抗-279抗体。还提供了利用本发明组合物治疗，预防或诊断血管生成障碍（例如心血管和癌症）的方法。

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