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1. 发明申请

WO2004106381A1 PHARMACEUTICAL COMPOSITIONS COMPRISING BISPECIFIC ANTI-CD3, ANTI-CD19 ANTIBODY CONSTRUCTS FOR THE TREATMENT OF B-CELL RELATED DISORDERS 审中-公开
标题翻译：包含BISPECIFIC抗CD3，抗CD19抗体构建物的治疗B细胞相关疾病的药物组合物
公开(公告)号：WO2004106381A1
公开(公告)日：2004-12-09
申请号：PCT/EP2004/005685
申请日：2004-05-26
申请人： MICROMET AG , KUFER, Peter , LUTTERBÜSE, Ralf , KOHLEISEN, Birgit , ZEMAN, Steven , BÄUERLE, Patrick
发明人： KUFER, Peter , LUTTERBÜSE, Ralf , KOHLEISEN, Birgit , ZEMAN, Steven , BÄUERLE, Patrick
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K2317/31 , C07K2317/34 , C07K2317/622
摘要： The present invention relates to a pharmaceutical composition comprising a bispecific single chain antibody construct, said bispecific single chain antibody construct comprising binding domains specific for human CD3 and human CD19, wherein the corresponding variable heavy chain regions (V H ) and the corresponding variable light chain regions (V L ) regions are arranged, from N-terminus to C-terminus, in the order, V H (CD19)-V L (CD19)-V H (CD3)-V L (CD3), V H (CD3)-V L -(CD3)-V H (CD19)-V L (CD19) or V H (CD3)-V L (CD3)-V L (CD19)-V H (CD19). Furthermore, processes for the production of said pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CD19 antigen are disclosed.
摘要翻译：本发明涉及包含双特异性单链抗体构建体的药物组合物，所述双特异性单链抗体构建体包含对人CD3和人CD19特异的结合结构域，其中相应的可变重链区（VH）和相应的可变轻链区（CD19）-VL（CD3）-VH（CD3）-VL（CD3）-VL（CD3）-VL（CD3）-VL（CD3）-VL -VH（CD19）-VL（CD19）或VH（CD3）-VL（CD3）-VL（CD19）-VH（CD19）。此外，公开了用于生产所述药物组合物的方法以及对于人CD3抗原和人CD19抗原具有特异性的特异性双特异性单链抗体分子的医学/药物用途。

2. 发明申请

WO2004106380A3 HUMAN-ANTI-HUMAN CD3 BINDING MOLECULES 审中-公开
公开(公告)号：WO2004106380A3
公开(公告)日：2004-12-09
申请号：PCT/EP2004/005684
申请日：2004-05-26
申请人： MICROMET AG , KUFER, Peter , RAUM, Tobias , BERRY, Meera , KISCHEL, Roman , MANGOLD, Susanne , KRINNER, Eva , KOHLEISEN, Birgit , ZEMAN, Steven , ITIN, Christian , BÄUERLE, Patrick
发明人： KUFER, Peter , RAUM, Tobias , BERRY, Meera , KISCHEL, Roman , MANGOLD, Susanne , KRINNER, Eva , KOHLEISEN, Birgit , ZEMAN, Steven , ITIN, Christian , BÄUERLE, Patrick
IPC分类号： C07K16/28
摘要： The present invention provides a method for the preparation of a human binding molecule, fragment or derivative thereof which specifically binds to the human CD3 complex. Furthermore, the invention provides a human binding molecules specifically binding to the human CD3 complex and means comprising said human binding molecules.

3. 发明申请

WO2005077982A1 LESS IMMUNOGENIC BINDING MOLECULES 审中-公开
标题翻译：无细胞结合分子
公开(公告)号：WO2005077982A1
公开(公告)日：2005-08-25
申请号：PCT/EP2005/001573
申请日：2005-02-16
申请人： MICROMET AG , KUFER, Peter , LENKKERI-SCHÜTZ, Ulla , LUTTERBÜSE, Ralf , KOHLEISEN, Birgit
发明人： KUFER, Peter , LENKKERI-SCHÜTZ, Ulla , LUTTERBÜSE, Ralf , KOHLEISEN, Birgit
IPC分类号： C07K16/28
CPC分类号： C07K16/2809 , C07K16/2803 , C07K16/30 , C07K2317/31 , C07K2317/34 , C07K2317/622
摘要： The present invention provides a bispecific binding molecule, wherein said molecule comprises or consists of at least two domains whereby one of said at least two domains specifically binds to/interacts with the human CD3 complex and said domain comprises an amino acid sequence of an antibody derived light chain, wherein said amino acid sequence is a particularly identified amino acid sequence comprising specific amino acid substitutions, and a second domain is or contains at least one further antigen-interaction-site and/or at least one further effector domain. The invention further provides nucleic acid molecules encoding the bispecific binding molecules of the invention, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors. Moreover, the invention concerns a method for the production of bispecific binding molecules of the invention and compositions comprising the bispecific binding molecules of the invention, the nucleic acid molecules of the invention or the host cells of the invention.
摘要翻译：本发明提供双特异性结合分子，其中所述分子包含至少两个结构域或由至少两个结构域组成，其中所述至少两个结构域之一与人CD3复合物特异性结合/相互作用，并且所述结构域包含抗体衍生的氨基酸序列轻链，其中所述氨基酸序列是特别鉴定的包含特异性氨基酸取代的氨基酸序列，第二结构域是或含有至少一个其它抗原相互作用位点和/或至少一个其它效应子结构域。本发明还提供了编码本发明的双特异性结合分子的核酸分子，包含所述核酸分子的载体和用所述载体转化或转染的宿主细胞。此外，本发明涉及制备本发明的双特异性结合分子的方法和包含本发明的双特异性结合分子，本发明的核酸分子或本发明的宿主细胞的组合物。

4. 发明申请

WO2004106383A1 PHARMACEUTICAL COMPOSITION COMPRISING A BISPECIFIC ANTIBODY FOR EPCAM 审中-公开
标题翻译：包含EPCAM的双重抗体的药物组合物
公开(公告)号：WO2004106383A1
公开(公告)日：2004-12-09
申请号：PCT/EP2004/005687
申请日：2004-05-26
申请人： MICROMET AG , KUFER, Peter , BERRY, Meera , OFFNER, Sonja , BRISCHWEIN, Klaus , WOLF, Andreas , RAUM, Tobias , KOHLEISEN, Birgit , LENKKERI-SCHÜTZ, Ulla , BÄUERLE, Patrick
发明人： KUFER, Peter , BERRY, Meera , OFFNER, Sonja , BRISCHWEIN, Klaus , WOLF, Andreas , RAUM, Tobias , KOHLEISEN, Birgit , LENKKERI-SCHÜTZ, Ulla , BÄUERLE, Patrick
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2809 , C07K16/3076 , C07K2317/31 , C07K2317/622 , C07K2317/92 , C07K2319/00 , Y10S435/81 , Y10S435/975
摘要： The present invention provides a pharmaceutical composition comprising a bispecific single chain antibody construct. Said bispecific single chain antibody construct is characterized to comprise or consist of at least two domains, whereby one of said at least two domains specifically binds to human EpCAM and comprises at least one CDR-H3 region comprising the amino acid sequence NXID antigen and a second domain binds to human CD3 antigen. The invention further provides a process for the production of the pharmaceutical composition of the invention, a method for the prevention, treatment or amelioration of a tumorous disease and the use of the disclosed bispecific single chain antibody construct and corresponding means in the prevention, treatment or amelioration of a tumorous disease.
摘要翻译：本发明提供包含双特异性单链抗体构建体的药物组合物。所述双特异性单链抗体构建体的特征在于包含至少两个结构域或由至少两个结构域组成，其中所述至少两个结构域之一特异性结合人EpCAM并且包含至少一个CDR-H3区，其包含氨基酸序列NXID抗原和第二结构域结合人CD3抗原。本发明进一步提供了制备本发明的药物组合物的方法，一种预防，治疗或改善肿瘤疾病的方法，以及所公开的双特异性单链抗体构建体的用途和相应的手段，用于预防，治疗或改善肿瘤疾病

5. 发明申请

WO2005040220A1 MULTISPECIFIC DEIMMUNIZED CD3-BINDERS 审中-公开
标题翻译：多重免疫的CD3-结合蛋白
公开(公告)号：WO2005040220A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011646
申请日：2004-10-15
申请人： MICROMET AG , HOFMEISTER, Robert , KOHLEISEN, Birgit , LENKKERI-SCHÜTZ, Ulla , ITIN, Christian , BÄUERLE, Patrick , CARR, Francis, J. , HAMILTON, Anita, A. , WILLIAMS, Stephen
发明人： HOFMEISTER, Robert , KOHLEISEN, Birgit , LENKKERI-SCHÜTZ, Ulla , ITIN, Christian , BÄUERLE, Patrick , CARR, Francis, J. , HAMILTON, Anita, A. , WILLIAMS, Stephen
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/567
摘要： The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.
摘要翻译：本发明提供了细胞毒活性CD3特异性结合构建体，其包含与人CD3特异性结合的第一结构域和来自Ig的第二结合结构域。此外，提供了编码本发明的CD3特异性结合构建体的核酸序列。本发明的其它方面是包含所述核酸序列的载体和宿主细胞，用于生产本发明构建体的方法和包含所述构建体的组合物。本发明还提供所述构建体用于制备用于治疗特定疾病的药物组合物，用于治疗特定疾病的方法和包含本发明的结合构建体的试剂盒的用途。

6. 发明授权

EP1673398B1 MULTISPECIFIC DEIMMUNIZED CD3-BINDERS 有权转让
标题翻译：多特异性结合分子DEIMMUNISIERTE CD3
公开(公告)号：EP1673398B1
公开(公告)日：2010-12-29
申请号：EP04790488.3
申请日：2004-10-15
申请人： Micromet AG
发明人： HOFMEISTER, Robert , KOHLEISEN, Birgit , LENKKERI-SCHÜTZ, Ulla , ITIN, Christian , BÄUERLE, Patrick , CARR, Francis, J. , HAMILTON, Anita, A. , WILLIAMS, Stephen
IPC分类号： C07K16/28 , A61K39/395 , C12N15/13
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/567
摘要： The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.

7. 发明公开

EP1716178A1 LESS IMMUNOGENIC BINDING MOLECULES 无效转让
标题翻译：较小的免疫原性结合分子
公开(公告)号：EP1716178A1
公开(公告)日：2006-11-02
申请号：EP05715354.6
申请日：2005-02-16
申请人： Micromet AG
发明人： KUFER, Peter , LENKKERI-SCHÜTZ, Ulla , LUTTERBÜSE, Ralf , KOHLEISEN, Birgit
IPC分类号： C07K16/28 , C07K16/30 , C07K16/46 , A61K39/395 , A61P31/00 , A61P33/00 , A61P35/00 , A61P37/00
CPC分类号： C07K16/2809 , C07K16/2803 , C07K16/30 , C07K2317/31 , C07K2317/34 , C07K2317/622
摘要： The present invention provides a bispecific binding molecule, wherein said molecule comprises or consists of at least two domains whereby one of said at least two domains specifically binds to/interacts with the human CD3 complex and said domain comprises an amino acid sequence of an antibody derived light chain, wherein said amino acid sequence is a particularly identified amino acid sequence comprising specific amino acid substitutions, and a second domain is or contains at least one further antigen-interaction-site and/or at least one further effector domain. The invention further provides nucleic acid molecules encoding the bispecific binding molecules of the invention, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors. Moreover, the invention concerns a method for the production of bispecific binding molecules of the invention and compositions comprising the bispecific binding molecules of the invention, the nucleic acid molecules of the invention or the host cells of the invention.

8. 发明授权

EP1629011B1 HUMAN ANTI-HUMAN CD3 BINDING MOLECULES 有权转让
标题翻译：人抗人CD3结合分子
公开(公告)号：EP1629011B1
公开(公告)日：2010-01-13
申请号：EP04739377.2
申请日：2004-05-26
申请人： Micromet AG
发明人： KUFER, Peter , RAUM, Tobias , BERRY, Meera , KISCHEL, Roman , MANGOLD, Susanne , KRINNER, Eva , KOHLEISEN, Birgit , ZEMAN, Steven , ITIN, Christian , BÄUERLE, Patrick
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K2317/21 , C07K2317/31 , C07K2317/34
摘要： The present invention provides a method for the preparation of a human binding molecule, fragment or derivative thereof which specifically binds to the human CD3 complex. Furthermore, the invention provides a human binding molecules specifically binding to the human CD3 complex and means comprising said human binding molecules.

9. 发明公开

EP1673398A1 MULTISPECIFIC DEIMMUNIZED CD3-BINDERS 有权转让
标题翻译：多特异性结合分子DEIMMUNISIERTE CD3
公开(公告)号：EP1673398A1
公开(公告)日：2006-06-28
申请号：EP04790488.3
申请日：2004-10-15
申请人： Micromet AG
发明人： HOFMEISTER, Robert , KOHLEISEN, Birgit , LENKKERI-SCHÜTZ, Ulla , ITIN, Christian , BÄUERLE, Patrick , CARR, Francis, J. , HAMILTON, Anita, A. , WILLIAMS, Stephen
IPC分类号： C07K16/28 , A61K39/395 , C12N15/13
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/567
摘要： The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.

10. 发明授权

EP1716178B1 LESS IMMUNOGENIC BINDING MOLECULES 无效转让
标题翻译：较小的免疫原性结合分子
公开(公告)号：EP1716178B1
公开(公告)日：2010-08-11
申请号：EP05715354.6
申请日：2005-02-16
申请人： Micromet AG
发明人： KUFER, Peter , LENKKERI-SCHÜTZ, Ulla , LUTTERBÜSE, Ralf , KOHLEISEN, Birgit
IPC分类号： C07K16/28 , C07K16/30 , C07K16/46 , A61K39/395 , A61P31/00 , A61P33/00 , A61P35/00 , A61P37/00
CPC分类号： C07K16/2809 , C07K16/2803 , C07K16/30 , C07K2317/31 , C07K2317/34 , C07K2317/622
摘要： The present invention provides a bispecific binding molecule, wherein said molecule comprises or consists of at least two domains whereby one of said at least two domains specifically binds to/interacts with the human CD3 complex and said domain comprises an amino acid sequence of an antibody derived light chain, wherein said amino acid sequence is a particularly identified amino acid sequence comprising specific amino acid substitutions, and a second domain is or contains at least one further antigen-interaction-site and/or at least one further effector domain. The invention further provides nucleic acid molecules encoding the bispecific binding molecules of the invention, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors. Moreover, the invention concerns a method for the production of bispecific binding molecules of the invention and compositions comprising the bispecific binding molecules of the invention, the nucleic acid molecules of the invention or the host cells of the invention.

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