专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013005061A2 PHOTO-DISSOCIATION OF PROTEINS AND PEPTIDES IN A MASS SPECTROMETER 审中-公开
标题翻译：质谱仪中蛋白质和肽的光解离
公开(公告)号：WO2013005061A2
公开(公告)日：2013-01-10
申请号：PCT/GB2012/051610
申请日：2012-07-06
申请人： MICROMASS UK LIMITED , BROWN, Jeffery Mark , GILES, Kevin , KENNY, Daniel James , MURRAY, Paul , RICHARDSON, Keith
发明人： BROWN, Jeffery Mark , GILES, Kevin , KENNY, Daniel James , MURRAY, Paul , RICHARDSON, Keith
IPC分类号： H01J49/00
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.
摘要翻译：公开了一种质谱法，其包括将来自激光器的第一光子引导到位于2D或线性离子引导器或离子阱内的离子。扫描第一光子的频率并检测由离子发射的第一光子和/或第二光子。然后使用飞行时间质量分析仪对离子进行质量分析。

2. 发明申请

WO2013005060A2 PHOTO-DISSOCIATION OF PROTEINS AND PEPTIDES IN A MASS SPECTROMETER 审中-公开
标题翻译：蛋白质和肽在大量光谱仪中的照片分离
公开(公告)号：WO2013005060A2
公开(公告)日：2013-01-10
申请号：PCT/GB2012/051609
申请日：2012-07-06
申请人： MICROMASS UK LIMITED , KENNY, Daniel James , MURRAY, Paul , RICHARDSON, Keith , GILES, Kevin , BROWN, Jeffery Mark
发明人： KENNY, Daniel James , MURRAY, Paul , RICHARDSON, Keith , GILES, Kevin , BROWN, Jeffery Mark
IPC分类号： H01J49/00
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.
摘要翻译：公开了一种自动重复执行多个操作循环的质谱方法，其中操作循环包括以下步骤：（i）质量分析第一离子; （ii）将第一离子暴露于第一光离解装置以形成多个第二离子并大量分析第二离子; 和（iii）将第一离子暴露于第一光解离装置以形成多个第二离子，使第二离子碎裂以形成多个第三离子并质量分析第三离子。

3. 发明申请

WO2012066329A1 CONTROLLING HYDROGEN-DEUTERIUM EXCHANGE ON A SPECTRUM BY SPECTRUM BASIS 审中-公开
标题翻译：通过光谱基础控制光谱上的氢代谢物交换
公开(公告)号：WO2012066329A1
公开(公告)日：2012-05-24
申请号：PCT/GB2011/052237
申请日：2011-11-16
申请人： MICROMASS UK LIMITED , BROWN, Jeffery Mark , PRINGLE, Steven Derek , RICHARDSON, Keith
发明人： BROWN, Jeffery Mark , PRINGLE, Steven Derek , RICHARDSON, Keith
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/0077 , H01J49/00 , H01J49/0031 , H01J49/0036 , H01J49/0054 , H01J49/0072 , H01J49/06 , H01J49/065 , H01J49/26
摘要： A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.
摘要翻译：公开了一种质谱仪，其包括用于分离离子的液相色谱装置。气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，至少一些母体或前体离子在反应中发生反应器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。

4. 发明申请

WO2011092515A1 FRAGMENTATION REAGENTS FOR MASS SPECTROMETRY 审中-公开
标题翻译：大分子量分散试剂
公开(公告)号：WO2011092515A1
公开(公告)日：2011-08-04
申请号：PCT/GB2011/050155
申请日：2011-01-31
申请人： MICROMASS UK LIMITED , BROWN, Jeffery Mark , CAMPUZANO, Iain , BROUSMICHE, Darryl W. , DORSCHEL, Craig , WILLIAMS, Jonathan Paul , PRINGLE, Steven Derek , RICHARDSON, Keith
发明人： BROWN, Jeffery Mark , CAMPUZANO, Iain , BROUSMICHE, Darryl W. , DORSCHEL, Craig , WILLIAMS, Jonathan Paul , PRINGLE, Steven Derek , RICHARDSON, Keith
IPC分类号： H01J49/00
CPC分类号： G01N33/6848 , C07C47/54 , C07C47/55 , C07C205/06 , C07C205/44 , C07C255/51 , H01J49/0045 , H01J49/0072 , Y10T436/24
摘要： A mass spectrometry electron transfer dissociation reagent comprising an unsaturated compound having a Frank Condon factor between 0.1 and 1.0 and an electron affinity having a positive value between 0.1 to 150 kJ/mol.
摘要翻译：一种质谱电子转移离解试剂，其包含Frank Condon因子在0.1至1.0之间的不饱和化合物和具有0.1至150kJ / mol的正值的电子亲和力。

5. 发明申请

WO2012095647A2 METHOD OF PROCESSING MULTIDIMENSIONAL MASS SPECTROMETRY DATA 审中-公开
标题翻译：处理多尺度质谱数据的方法
公开(公告)号：WO2012095647A2
公开(公告)日：2012-07-19
申请号：PCT/GB2012/050022
申请日：2012-01-06
申请人： MICROMASS UK LIMITED , RICHARDSON, Keith , DENNY, Richard
发明人： RICHARDSON, Keith , DENNY, Richard
CPC分类号： H01J49/0036
摘要： A method of processing multidimensional data acquired from analytical equipment, which method comprises the steps of providing raw multidimensional data that includes mass spectrometric analytical data obtained from a sample, conducting a first processing step of identifying regions of interest within the raw multidimensional data and conducting a second processing step of refining the raw multidimensional data associated with the one or more regions of interest using peak detection of the mass spectrometric analytical data, wherein the first processing step is conducted using a first processing means and/or a first software program and the second processing step is conducted using a second processing means and/or a second software program, whereby the first and second processing steps are capable of independent implementation.
摘要翻译：一种处理从分析设备获得的多维数据的方法，该方法包括以下步骤：提供原始多维数据，其包括从样本获得的质谱分析数据，进行识别原始多维数据内的感兴趣区域的第一处理步骤，第二处理步骤，使用所述质谱分析数据的峰值检测来精炼与所述一个或多个感兴趣区域相关联的原始多维数据，其中所述第一处理步骤使用第一处理装置和/或第一软件程序进行，所述第二处理步骤处理步骤使用第二处理装置和/或第二软件程序进行，由此第一和第二处理步骤能够独立实现。

6. 发明申请

WO2012123754A1 M/Z TARGETED ATTENUATION ON TIME OF FLIGHT INSTRUMENTS 审中-公开
标题翻译：飞行器具时间M / Z目标衰减
公开(公告)号：WO2012123754A1
公开(公告)日：2012-09-20
申请号：PCT/GB2012/050576
申请日：2012-03-15
申请人： MICROMASS UK LIMITED , RICHARDSON, Keith
发明人： RICHARDSON, Keith
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/401 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/40
摘要： A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a Time of Flight mass analyser are controlled by attenuating ions which would otherwise be transmitted to the Time of Flight mass analyser and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity.
摘要翻译：公开了一种质谱法，其包括根据一种或多种物理化学性质分离离子。向上传播到飞行时间质量分析器的离子通过衰减离子来控制，否则离子将否则将被传输到飞行时间质量分析器并引起离子检测器的饱和，并且已被确定或预测具有相对较高的强度。

7. 发明申请

WO2011098834A1 METHOD OF MASS SPECTROMETRY AND MASS SPECTROMETER USING PEAK DECONVOLUTION 审中-公开
标题翻译：使用峰值解卷积的质谱方法和质谱仪
公开(公告)号：WO2011098834A1
公开(公告)日：2011-08-18
申请号：PCT/GB2011/050274
申请日：2011-02-14
申请人： MICROMASS UK LIMITED , DENNY, Richard , RICHARDSON, Keith , GREEN, Martin, Raymond , PRINGLE, Steven Derek , GILBERT, Anthony James , SKILLING, John , WILDGOOSE, Jason Lee
发明人： DENNY, Richard , RICHARDSON, Keith , GREEN, Martin, Raymond , PRINGLE, Steven Derek , GILBERT, Anthony James , SKILLING, John , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed wherein a signal output from an ion detector is digitised by an Analogue to Digital Converter and is then deconvoluted to determine one or more ion arrival times and one more ion arrival intensities. The process of deconvoluting the ion signal involves determining a point spread function characteristic of an ion arriving at and being detected by the ion detector. A distribution of ion arrival times which produces a best fit to the digitised signal is then determined given that each ion arrival is assumed to produce a response given by the point spread function. A plurality of ion arrival times are then combined to produce a composite ion arrival time-intensity spectrum.
摘要翻译：公开了一种质谱法，其中从离子检测器输出的信号被模拟数字转换器数字化，然后进行解卷积，以确定一个或多个离子到达时间和一个离子到达强度。去卷积离子信号的过程涉及确定到达并被离子检测器检测的离子的点扩散函数特征。因此，假设每个离子到达产生由点扩散函数给出的响应，则确定产生与数字化信号最佳拟合的离子到达时间的分布。然后将多个离子到达时间组合以产生复合离子到达时间强度谱。

8. 发明申请

WO2005106920A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2005106920A2
公开(公告)日：2005-11-10
申请号：PCT/GB2005/001674
申请日：2005-05-03
申请人： MICROMASS UK LIMITED , DENNY, Richard , RICHARDSON, Keith
发明人： DENNY, Richard , RICHARDSON, Keith
IPC分类号： H01J49/00
CPC分类号： G01N30/8682 , G01N30/7233 , H01J49/0036
摘要： A mass spectrometer and a method of spectrometry are disclosed wherein liquid chromatography mass spectral data are probabilistically clustered on the basis of mass to charge ratio and retention time.
摘要翻译：公开了一种质谱仪和光谱测定方法，其中液相色谱质谱数据基于质荷比和保留时间概率聚类。

9. 发明申请

WO2012095655A1 A METHOD OF CORRECTION OF DATA IMPAIRED BY HARDWARE LIMITATIONS IN MASS SPECTROMETRY 审中-公开
标题翻译：一种校正数据在质谱中受五维限制所限制的数据的方法
公开(公告)号：WO2012095655A1
公开(公告)日：2012-07-19
申请号：PCT/GB2012/050036
申请日：2012-01-09
申请人： MICROMASS UK LIMITED , RICHARDSON, Keith , DENNY, Richard , GREEN, Martin , WILDGOOSE, Jason Lee
发明人： RICHARDSON, Keith , DENNY, Richard , GREEN, Martin , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00
CPC分类号： H01J49/0036
摘要： A method of improving the fidelity of m/z dependent and/or intensity measurements for a species of interest in an analyte to correct for hardware limitations within a mass spectrometer, which method comprises the steps of acquiring raw data produced by a mass spectrometer, identifying a region within the raw data that relates to the species of interest, forming a mathematical model to calculate the joint probability distribution of the parameters effecting the m/z dependent and/or intensity measurements, analytically obtaining samples from the joint probability distribution to produce corrected or refined m/z dependent and/or intensity measurements with associated uncertainties.
摘要翻译：一种提高分析物感兴趣的物种的m / z依赖和/或强度测量的保真度以校正质谱仪内的硬件限制的方法，该方法包括以下步骤：获取由质谱仪产生的原始数据，识别原始数据中与感兴趣物种相关的区域，形成数学模型以计算影响m / z依赖和/或强度测量的参数的联合概率分布，从联合概率分布中分析获取样本以产生校正的或精确的m / z依赖和/或强度测量与相关的不确定性。

10. 发明申请

WO2010089611A1 METHOD OF MASS SPECTROMETRY 审中-公开
标题翻译：质谱法
公开(公告)号：WO2010089611A1
公开(公告)日：2010-08-12
申请号：PCT/GB2010/050194
申请日：2010-02-08
申请人： MICROMASS UK LIMITED , CLAUDE, Emmanuel , VISSERS, Johannes, Petrus, Cornelis , RICHARDSON, Keith
发明人： MICROMASS UK LIMITED , CLAUDE, Emmanuel , VISSERS, Johannes, Petrus, Cornelis , RICHARDSON, Keith
IPC分类号： H01J49/00 , G01N33/68
CPC分类号： G01N33/6848 , H01J49/0004 , H01J49/0027
摘要： This invention comprises a method of imaging of a substrate in which a sample of interest is first ionized at multiple known positions whereafter a mass spectrum of the ionized sample at each of the multiple known positions is produced using a Mass Spectrometer. An overall spectrum for the whole sample is then created, and a number of peaks within the overall spectrum is selected. A scan distribution for at least some of the selected peaks is created, and the scan distributions are compared to identify correlations between different analytes within the sample.
摘要翻译：本发明包括一种基底成像方法，其中感兴趣的样品首先在多个已知位置离子化，之后使用质谱仪产生多个已知位置的每一个的离子化样品的质谱。然后创建整个样品的总谱，并选择整个谱中的数个峰。创建至少一些所选峰的扫描分布，并比较扫描分布以识别样品中不同分析物之间的相关性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式