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1. 发明申请

WO2008139193A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2008139193A2
公开(公告)日：2008-11-20
申请号：PCT/GB2008/001663
申请日：2008-05-14
申请人： MICROMASS UK LIMITED , GILBERT, Anthony, James , GREEN, Martin
发明人： GILBERT, Anthony, James , GREEN, Martin
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , G06K9/0051 , H01J49/00
摘要： A mass spectrometer is disclosed wherein a signal output from an ion detector is digitised using an Analogue to Digital Converter. A background or baseline level is dynamically subtracted from the digitised signal whilst the time of flight data is still being acquired. A threshold is also applied dynamically to the digitised signal in order to reduce electronic noise.
摘要翻译：公开了一种质谱仪，其中从离子检测器输出的信号使用模数转换器进行数字化。从数字化信号中动态减去背景或基线水平，同时仍然获取飞行时间数据。阈值也被动态地应用于数字化信号，以减少电子噪声。

2. 发明申请

WO2007138338A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007138338A2
公开(公告)日：2007-12-06
申请号：PCT/GB2007/002044
申请日：2007-06-01
申请人： MICROMASS UK LIMITED , BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee , GILBERT, Anthony, James , PRINGLE, Steven, Derek
发明人： BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee , GILBERT, Anthony, James , PRINGLE, Steven, Derek
IPC分类号： H01J49/02
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T 0 and intensity S 0 of each ion arrival event is converted into two separate intensities S (n) ,S (n+i) which are stored in neighbouring time bins T (n) , T (n+1) .
摘要翻译：公开了一种质谱仪，其包括飞行时间质量分析器，其包括离子检测器，该离子检测器包括模数转换器。从模拟到数字转换器的信号被数字化，并确定离子的到达时间和强度。每个离子到达事件的到达时间T 0 0和强度S 0 被转换成两个分开的强度S（N），S （n + 1）存储在相邻的时间段T（n），T（n + 1）中。

3. 发明申请

WO2007138337A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2007138337A3
公开(公告)日：2007-12-06
申请号：PCT/GB2007/002043
申请日：2007-06-01
申请人： MICROMASS UK LIMITED , BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee , GILBERT, Anthony, James , PRINGLE, Steven, Derek
发明人： BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee , GILBERT, Anthony, James , PRINGLE, Steven, Derek
IPC分类号： H01J49/02
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.

4. 发明申请

WO2006129094A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006129094A2
公开(公告)日：2006-12-07
申请号：PCT/GB2006/001996
申请日：2006-06-01
申请人： MICROMASS UK LIMITED , BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee
发明人： BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee
IPC分类号： H01J49/02
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

5. 发明申请

WO2008047101A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2008047101A3
公开(公告)日：2008-04-24
申请号：PCT/GB2007/003937
申请日：2007-10-16
申请人： MICROMASS UK LIMITED , KENNY, Daniel, James , BATEMAN, Robert, Harold , GREEN, Martin , WILDGOOSE, Jason, Lee , PRINGLE, Steven, Derek
发明人： KENNY, Daniel, James , BATEMAN, Robert, Harold , GREEN, Martin , WILDGOOSE, Jason, Lee , PRINGLE, Steven, Derek
IPC分类号： H01J49/42
摘要： A collision or fragmentation cell (4) is disclosed comprising a plurality of electrodes wherein a first RF voltage (7a) is applied to an upstream group of electrodes and a second different RF voltage (7b) is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell (4) is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell (4) is optimised by the second different RF voltage applied to the downstream group of electrodes.

6. 发明申请

WO2006075182A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2006075182A3
公开(公告)日：2006-07-20
申请号：PCT/GB2006/000138
申请日：2006-01-17
申请人： MICROMASS UK LIMITED , GILES, Kevin , GREEN, Martin , WILDGOOSE, Jason, Lee
发明人： GILES, Kevin , GREEN, Martin , WILDGOOSE, Jason, Lee
IPC分类号： H01J49/42 , H01J49/04
摘要： An ion guide or ion trap (1) is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap (1) by the application of an AC or RF voltage to the electrodes. A static potential well is maintained along at least a portion of the axial length of the ion guide or ion trap (1). A time varying homogeneous electric field is applied along at least a portion of the axial length of the ion guide or ion trap (1). The combination of the static axial potential well and the time varying axial homogeneous electric field causes ions to be ejected from the ion guide or ion trap (1) in a substantially non-resonant manner.

7. 发明申请

WO2006008537A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006008537A2
公开(公告)日：2006-01-26
申请号：PCT/GB2005/002874
申请日：2005-07-21
申请人： MICROMASS UK LIMITED , BATEMAN, Robert, Harold , BROWN, Jeffery , GREEN, Martin
发明人： BATEMAN, Robert, Harold , BROWN, Jeffery , GREEN, Martin
IPC分类号： H01J49/04
CPC分类号： H01J49/062 , H01J49/027 , H01J49/422 , H01J49/4245
摘要： A mass spectrometer is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap by the application of an AC or RF voltage to the electrodes forming the ion guide or ion trap. A quadratic DC potential is applied along the axial length of the ion guide or ion trap in order to cause trapped ions to perform simple harmonic motion within the ion guide or ion trap. The frequency of the oscillations of the ions is detected using one or more inductive detectors. The mass to charge ratio of the ions can then be determined from the determined frequency of oscillations.
摘要翻译：公开了一种质谱仪，其包括分段线性离子导向器或离子阱。通过对形成离子导向器或离子阱的电极施加AC或RF电压，离子导向器或离子阱中的离子被径向限制。沿着离子导向器或离子阱的轴向长度施加二次直流电位，以使被捕获的离子在离子导向器或离子阱内进行简单的谐波运动。使用一个或多个感应检测器检测离子振荡的频率。然后可以从确定的振荡频率确定离子的质荷比。

8. 发明申请

WO2012095655A1 A METHOD OF CORRECTION OF DATA IMPAIRED BY HARDWARE LIMITATIONS IN MASS SPECTROMETRY 审中-公开
标题翻译：一种校正数据在质谱中受五维限制所限制的数据的方法
公开(公告)号：WO2012095655A1
公开(公告)日：2012-07-19
申请号：PCT/GB2012/050036
申请日：2012-01-09
申请人： MICROMASS UK LIMITED , RICHARDSON, Keith , DENNY, Richard , GREEN, Martin , WILDGOOSE, Jason Lee
发明人： RICHARDSON, Keith , DENNY, Richard , GREEN, Martin , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00
CPC分类号： H01J49/0036
摘要： A method of improving the fidelity of m/z dependent and/or intensity measurements for a species of interest in an analyte to correct for hardware limitations within a mass spectrometer, which method comprises the steps of acquiring raw data produced by a mass spectrometer, identifying a region within the raw data that relates to the species of interest, forming a mathematical model to calculate the joint probability distribution of the parameters effecting the m/z dependent and/or intensity measurements, analytically obtaining samples from the joint probability distribution to produce corrected or refined m/z dependent and/or intensity measurements with associated uncertainties.
摘要翻译：一种提高分析物感兴趣的物种的m / z依赖和/或强度测量的保真度以校正质谱仪内的硬件限制的方法，该方法包括以下步骤：获取由质谱仪产生的原始数据，识别原始数据中与感兴趣物种相关的区域，形成数学模型以计算影响m / z依赖和/或强度测量的参数的联合概率分布，从联合概率分布中分析获取样本以产生校正的或精确的m / z依赖和/或强度测量与相关的不确定性。

9. 发明申请

WO2007072038A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007072038A2
公开(公告)日：2007-06-28
申请号：PCT/GB2006/004892
申请日：2006-12-21
申请人： MICROMASS UK LIMITED , GREEN, Martin
发明人： GREEN, Martin
IPC分类号： H01J49/42
CPC分类号： H01J49/4235 , H01J49/427
摘要： An ion trap mass analyser (1) is disclosed comprising a segmented rod set. Ions are trapped radially within the mass analyser by a radial pseudo-potential well. The ions are also confined axially within the ion trap by an axial electric field. The axial electric field is substantially linear across the central section of the iøn trap, but the electric field is distorted across both ends of the ion trap. A supplemental AC voltage or potential is applied to the electrodes comprising the ion trap mass analyser (1) in order to excite resonantly ions within the ion trap (1). The distortions in the electric field at the ends of the ion trap cause the resonant frequency of ions within the ion trap to shift to either a higher or lower frequency. If the frequency of the supplemental AC voltage or potential is scanned appropriately then ions are ejected from the ion trap in a shorter period of time leading to an improvement in mass resolution.
摘要翻译：公开了一种离子阱质量分析器（1），其包括分段杆组。离子通过径向假电位阱在质量分析器内径向捕获。离子也通过轴向电场轴向限定在离子阱内。轴向电场横跨i阱陷阱的中心部分基本上是线性的，但电场在离子阱的两端变形。为了激发离子阱（1）内的共振离子，对包括离子阱质量分析器（1）的电极施加补充AC电压或电位。离子阱末端的电场畸变导致离子阱内的离子的共振频率向更高或更低的频率移动。如果适当地扫描补充AC电压或电位的频率，则离子在较短时间内从离子阱排出，导致质量分辨率的提高。

10. 发明申请

WO2005104178A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2005104178A2
公开(公告)日：2005-11-03
申请号：PCT/GB2005/001585
申请日：2005-04-26
申请人： MICROMASS UK LIMITED , GREEN, Martin , BATEMAN, Robert, Harold
发明人： GREEN, Martin , BATEMAN, Robert, Harold
IPC分类号： H01J49/02
CPC分类号： H01J43/246 , H01J49/025
摘要： An ion detector for a mass spectrometer is provided wherein a mask (10) is provided between a first microchannel plate (2a) and a second microchannel plate (2b). The mask (10) prevents ion arrival events causing a cloud of secondary electrons to be from the second microchannel plate (2b) which would illuminate two collection anodes (5,6) at substantially the same time. The mask (10) also prevents electron clouds emitted which would otherwise vary significantly in intensity.
摘要翻译：提供了一种用于质谱仪的离子检测器，其中在第一微通道板（2a）和第二微通道板（2b）之间设置有掩模（10）。掩模（10）防止导致二次电子云的离子到达事件来自第二微通道板（2b），其将基本上同时照射两个收集阳极（5,6）。掩模（10）还防止了否则在强度上会显着变化的电子云。

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