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1. 发明申请

WO2006129094A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006129094A2
公开(公告)日：2006-12-07
申请号：PCT/GB2006/001996
申请日：2006-06-01
申请人： MICROMASS UK LIMITED , BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee
发明人： BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee
IPC分类号： H01J49/02
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

2. 发明申请

WO2007138338A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007138338A2
公开(公告)日：2007-12-06
申请号：PCT/GB2007/002044
申请日：2007-06-01
申请人： MICROMASS UK LIMITED , BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee , GILBERT, Anthony, James , PRINGLE, Steven, Derek
发明人： BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee , GILBERT, Anthony, James , PRINGLE, Steven, Derek
IPC分类号： H01J49/02
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T 0 and intensity S 0 of each ion arrival event is converted into two separate intensities S (n) ,S (n+i) which are stored in neighbouring time bins T (n) , T (n+1) .
摘要翻译：公开了一种质谱仪，其包括飞行时间质量分析器，其包括离子检测器，该离子检测器包括模数转换器。从模拟到数字转换器的信号被数字化，并确定离子的到达时间和强度。每个离子到达事件的到达时间T 0 0和强度S 0 被转换成两个分开的强度S（N），S （n + 1）存储在相邻的时间段T（n），T（n + 1）中。

3. 发明申请

WO2007138337A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2007138337A3
公开(公告)日：2007-12-06
申请号：PCT/GB2007/002043
申请日：2007-06-01
申请人： MICROMASS UK LIMITED , BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee , GILBERT, Anthony, James , PRINGLE, Steven, Derek
发明人： BATEMAN, Robert, Harold , BROWN, Jeffery, Mark , GREEN, Martin , WILDGOOSE, Jason, Lee , GILBERT, Anthony, James , PRINGLE, Steven, Derek
IPC分类号： H01J49/02
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.

4. 发明申请

WO2008047101A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2008047101A3
公开(公告)日：2008-04-24
申请号：PCT/GB2007/003937
申请日：2007-10-16
申请人： MICROMASS UK LIMITED , KENNY, Daniel, James , BATEMAN, Robert, Harold , GREEN, Martin , WILDGOOSE, Jason, Lee , PRINGLE, Steven, Derek
发明人： KENNY, Daniel, James , BATEMAN, Robert, Harold , GREEN, Martin , WILDGOOSE, Jason, Lee , PRINGLE, Steven, Derek
IPC分类号： H01J49/42
摘要： A collision or fragmentation cell (4) is disclosed comprising a plurality of electrodes wherein a first RF voltage (7a) is applied to an upstream group of electrodes and a second different RF voltage (7b) is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell (4) is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell (4) is optimised by the second different RF voltage applied to the downstream group of electrodes.

5. 发明申请

WO2008102155A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2008102155A2
公开(公告)日：2008-08-28
申请号：PCT/GB2008/000617
申请日：2008-02-21
申请人： MICROMASS UK LIMITED , BATEMAN, Robert, Harold , GREEN, Martin , WILDGOOSE, Jason, Lee
发明人： BATEMAN, Robert, Harold , GREEN, Martin , WILDGOOSE, Jason, Lee
IPC分类号： H01J49/42
CPC分类号： H01J49/0095 , H01J49/423 , H01J49/424
摘要： A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods 1 to allow ions to be ejected radially from the ion trap. The 3D ion trap comprises a central ring electrode which is radially segmented and wherein a slot is provided in each radial segment to allow ions to be ejected radially from the ion trap. Ions having different mass to charge ratios and/or opposite polarities may be simultaneously ejected from the ion trap via different exit pathways.
摘要翻译：公开了包括2D或3D离子阱的质谱仪。 2D离子阱包括四极棒组离子阱，其中在每个棒1中设置槽，以允许离子从离子阱径向喷射。 3D离子阱包括径向分段的中心环电极，并且其中在每个径向段中设置狭槽以允许离子从离子阱径向喷射。具有不同质荷比和/或相反极性的离子可以通过不同的出口通道从离子阱同时喷出。

6. 发明申请

WO2008117040A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱分析仪
公开(公告)号：WO2008117040A3
公开(公告)日：2008-10-02
申请号：PCT/GB2008/001028
申请日：2008-03-26
申请人： MICROMASS UK LIMITED , GREEN, Martin , WILDGOOSE, Jason, Lee , BROWN, Jeffery, Mark
发明人： GREEN, Martin , WILDGOOSE, Jason, Lee , BROWN, Jeffery, Mark
IPC分类号： H01J49/00
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority. of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了包括电子转移解离单元（1）的质谱仪。与单电荷负试剂离子碰撞时，阳性分析物离子碎裂成碎片离子（1）。该电池包括形成球形俘获体积的多个环形电极（1）。大多数离子经历的RF加热可以忽略不计。的捕获体积，其使得分析物和试剂离子的动能降低到正好高于热温度。由此提供具有增强的灵敏度的电子转移解离电池（1）。在电池（1）内产生的碎片离子可以被冷却并且可以向前传输到正交加速度飞行时间质量分析仪，使得能够显着提高质量分析仪的分辨率。

7. 发明申请

WO2006075182A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2006075182A3
公开(公告)日：2006-07-20
申请号：PCT/GB2006/000138
申请日：2006-01-17
申请人： MICROMASS UK LIMITED , GILES, Kevin , GREEN, Martin , WILDGOOSE, Jason, Lee
发明人： GILES, Kevin , GREEN, Martin , WILDGOOSE, Jason, Lee
IPC分类号： H01J49/42 , H01J49/04
摘要： An ion guide or ion trap (1) is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap (1) by the application of an AC or RF voltage to the electrodes. A static potential well is maintained along at least a portion of the axial length of the ion guide or ion trap (1). A time varying homogeneous electric field is applied along at least a portion of the axial length of the ion guide or ion trap (1). The combination of the static axial potential well and the time varying axial homogeneous electric field causes ions to be ejected from the ion guide or ion trap (1) in a substantially non-resonant manner.

8. 发明申请

WO2009007739A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2009007739A3
公开(公告)日：2009-01-15
申请号：PCT/GB2008/002402
申请日：2008-07-14
申请人： MICROMASS UK LIMITED , GREEN, Martin , KENNY, Daniel, James , LANGRIDGE, David , WILDGOOSE, Jason, Lee
发明人： GREEN, Martin , KENNY, Daniel, James , LANGRIDGE, David , WILDGOOSE, Jason, Lee
IPC分类号： H01J49/42
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion trap (2, 3) wherein a potential field is created at the exit of the ion trap (4, 5) which decreases with increasing radius in one radial direction. Ions within the ion trap (2, 3) are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap (2, 3).

9. 发明申请

WO2007125354A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2007125354A3
公开(公告)日：2007-11-08
申请号：PCT/GB2007/001589
申请日：2007-04-30
申请人： MICROMASS UK LIMITED , GREEN, Martin , WILDGOOSE, Jason, Lee , PRINGLE, Steven, Derek , KENNY, Daniel, James
发明人： GREEN, Martin , WILDGOOSE, Jason, Lee , PRINGLE, Steven, Derek , KENNY, Daniel, James
IPC分类号： H01J49/32
摘要： An ion guide or mass analyser (2) is disclosed comprising a plurality of electrodes (2a) having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser (2). The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages (4) are applied to the electrodes (2a) of the ion guide or mass analyser (2) in order to urge ions along the length of the ion guides or mass analyser (2). The amplitude of the transient DC voltage (4) applied to the electrode (2a) may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser (2) in reverse order of their mass to charge ratio.

10. 发明申请

WO2006075189A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006075189A2
公开(公告)日：2006-07-20
申请号：PCT/GB2006/000155
申请日：2006-01-17
申请人： MICROMASS UK LIMITED , GILES, Kevin , GREEN, Martin , WILDGOOSE, Jason, Lee
发明人： GILES, Kevin , GREEN, Martin , WILDGOOSE, Jason, Lee
IPC分类号： H01J49/04 , H01J49/40
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap 1 is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap 1 by the application of an AC or RF voltage to the electrodes. Ions are trapped within an axial quadratic potential well which is oscillated or modulated axially so as to cause ions to be ejected from the ion guide or ion trap 1 in a substantially non-resonant manner.
摘要翻译：公开了一种离子导向器或离子阱1，其包括分段线性离子导向器或离子阱。通过向电极施加AC或RF电压，离子限制在离子导向器或离子阱1的径向内。离子被捕获在轴向二次势阱内，其轴向振荡或调制，从而使离子以基本上非共振的方式从离子导向器或离子阱1喷出。

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