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1. 发明申请

WO2009007739A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱分析仪
公开(公告)号：WO2009007739A2
公开(公告)日：2009-01-15
申请号：PCT/GB2008002402
申请日：2008-07-14
申请人： MICROMASS LTD , GREEN MARTIN , KENNY DANIEL JAMES , LANGRIDGE DAVID , WILDGOOSE JASON LEE
发明人： GREEN MARTIN , KENNY DANIEL JAMES , LANGRIDGE DAVID , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： H01J49/4205 , H01J49/02 , H01J49/4225
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion trap (2, 3) wherein a potential field is created at the exit of the ion trap (4, 5) which decreases with increasing radius in one radial direction. Ions within the ion trap (2, 3) are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap (2, 3).
摘要翻译：公开了一种包括四极杆组离子阱（2,3）的质谱仪，其中在离子阱（4,5）的出口处产生势能场，其在一个径向方向上随半径增加而减小。离子阱（2,3）内的离子在径向方向上被质量选择性地激发。已经在径向激发的离子经历势场，该势场不再将离子轴向限制在离子阱内，而是用于提取离子并因此导致离子从离子阱（2,3）轴向射出，。

2. 发明申请

WO2008047101A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2008047101A2
公开(公告)日：2008-04-24
申请号：PCT/GB2007003937
申请日：2007-10-16
申请人： MICROMASS LTD , KENNY DANIEL JAMES , BATEMAN ROBERT HAROLD , GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK
发明人： KENNY DANIEL JAMES , BATEMAN ROBERT HAROLD , GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK
CPC分类号： H01J49/005 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/065 , H01J49/34 , H01J49/4235
摘要： A collision or fragmentation cell (4) is disclosed comprising a plurality of electrodes wherein a first RF voltage (7a) is applied to an upstream group of electrodes and a second different RF voltage (7b) is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell (4) is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell (4) is optimised by the second different RF voltage applied to the downstream group of electrodes.
摘要翻译：公开了一种碰撞或分裂单元（4），其包括多个电极，其中将第一RF电压（7a）施加到上游电极组，并且将第二不同RF电压（7b）施加到下游组电极。通过施加到上游电极组的第一RF电压来优化进入碰撞或破碎电池（4）的母体离子的径向约束，并且优化在碰撞或断裂电池（4）内产生的子或碎片离子的径向约束通过施加到下游组电极的第二不同RF电压。

3. 发明申请

WO2008071993A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2008071993A3
公开(公告)日：2009-04-02
申请号：PCT/GB2007004820
申请日：2007-12-14
申请人： MICROMASS LTD , KENNY DANIEL JAMES , WILDGOOSE JASON LEE , GREEN MARTIN
发明人： KENNY DANIEL JAMES , WILDGOOSE JASON LEE , GREEN MARTIN
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap (7) or alternatively from a travelling wave ion guide arranged upstream of an orthogonal acceleration electrode (2) which forms part of the Time of Flight mass analyser. Ions in the pulse or packet of ions which is released become temporally dispersed and the orthogonal acceleration electrode (2) is energised multiple times prior the release of a subsequent pulse or packet of ions.
摘要翻译：公开了一种质谱仪，其包括正交加速时间飞行质量分析器。从离子阱（7）或替代地从布置在作为飞行时间质量分析器的一部分的正交加速电极（2）的上游的行波离子导向器释放脉冲或包离子。释放的脉冲或离子束中的离子变得暂时分散，并且在随后的脉冲或包离子的释放之前，正交加速电极（2）被多次通电。

4. 发明申请

WO2007125354A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007125354A2
公开(公告)日：2007-11-08
申请号：PCT/GB2007001589
申请日：2007-04-30
申请人： MICROMASS LTD , GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK , KENNY DANIEL JAMES
发明人： GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK , KENNY DANIEL JAMES
CPC分类号： H01J49/4235 , H01J49/065
摘要： An ion guide or mass analyser (2) is disclosed comprising a plurality of electrodes (2a) having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser (2). The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages (4) are applied to the electrodes (2a) of the ion guide or mass analyser (2) in order to urge ions along the length of the ion guides or mass analyser (2). The amplitude of the transient DC voltage (4) applied to the electrode (2a) may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser (2) in reverse order of their mass to charge ratio.
摘要翻译：公开了一种离子导向器或质量分析器（2），其包括具有孔的多个电极（2a），在使用中通过该孔具有离子。在离子导向器或质量分析器（2）的出口处产生伪势垒。伪势垒的幅度或深度与离子的质荷比成反比。一个或多个瞬态DC电压（4）被施加到离子导向器或质量分析器（2）的电极（2a），以促使沿着离子导向器或质量分析器（2）的长度的离子。施加到电极（2a）的瞬态直流电压（4）的振幅可以随时间增加，使得离子以其质荷比相反的顺序从离子导向器或质量分析器（2）发射。

5. 发明申请

WO2007138338A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007138338A3
公开(公告)日：2008-12-31
申请号：PCT/GB2007002044
申请日：2007-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
IPC分类号： H01J49/02
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+i) which are stored in neighbouring time bins T(n), T(n+1).
摘要翻译：公开了一种质谱仪，其包括飞行时间质量分析器，其包括离子检测器，该离子检测器包括模数转换器。从模拟到数字转换器的信号被数字化，并确定离子的到达时间和强度。每个离子到达事件的到达时间T0和强度S0被转换成存储在相邻时间段T（n），T（n + 1）中的两个分开的强度S（n），S（n + i）。

6. 发明申请

WO2007138337A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007138337A2
公开(公告)日：2007-12-06
申请号：PCT/GB2007002043
申请日：2007-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
IPC分类号： H01J49/02
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译：公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。如果从两个信号确定的到达时间落入相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。

7. 发明申请

WO2006129106A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006129106A3
公开(公告)日：2007-11-15
申请号：PCT/GB2006002024
申请日：2006-06-05
申请人： MICROMASS LTD , GILES KEVIN , GREEN MARTIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
发明人： GILES KEVIN , GREEN MARTIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
IPC分类号： H01J49/42 , H01J49/40
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap (1) is disclosed having an entrance electrode (2) and an exit electrode (3). The potential of the exit electrode (3) is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap (1) via an aperture in the exit electrode (3). The period of time that the potential of the exit electrode (3) is dropped for is progressively increased and ions emerge from the ion guide or ion trap (1) in a mass to charge ratio dependent manner. The ion guide or ion trap (1) may be operated as a mass separator or low resolution mass analyser.
摘要翻译：公开了一种具有入口电极（2）和出口电极（3）的离子导向器或离子阱（1）。出口电极（3）的电位周期性地下降相当短的时间段，允许一些离子通过出射电极（3）中的孔从离子导向器或离子阱（1）逸出。退出电极（3）的电位下降的时间段逐渐增加，并且离子导向器或离子阱（1）以质荷比依赖的方式出现离子。离子导向器或离子阱（1）可以作为质量分离器或低分辨率质量分析器来操作。

8. 发明申请

WO2006075189A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006075189A3
公开(公告)日：2007-05-18
申请号：PCT/GB2006000155
申请日：2006-01-17
申请人： MICROMASS LTD , GILES KEVIN , GREEN MARTIN , WILDGOOSE JASON LEE
发明人： GILES KEVIN , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/04 , H01J49/42
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap 1 is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap 1 by the application of an AC or RF voltage to the electrodes. Ions are trapped within an axial quadratic potential well which is oscillated or modulated axially so as to cause ions to be ejected from the ion guide or ion trap 1 in a substantially non-resonant manner.
摘要翻译：公开了一种离子导向器或离子阱1，其包括分段线性离子导向器或离子阱。通过向电极施加AC或RF电压，离子限制在离子导向器或离子阱1的径向内。离子被捕获在轴向二次势阱内，其轴向振荡或调制，以使离子以基本上非共振的方式从离子导向器或离子阱1喷出。

9. 发明申请

WO2006129094A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006129094A3
公开(公告)日：2008-03-06
申请号：PCT/GB2006001996
申请日：2006-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/02 , G06F19/00 , H01J49/00
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

10. 发明申请

WO2005098899A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2005098899A3
公开(公告)日：2006-12-28
申请号：PCT/GB2005001290
申请日：2005-04-04
申请人： MICROMASS LTD , GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK , GILES KEVIN
发明人： GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK , GILES KEVIN
IPC分类号： H01J49/04 , G01T1/36 , H01J49/06 , H01J49/16 , H01J49/26 , H01J49/40
CPC分类号： H01J49/06 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an ion beam attenuator which attenuates an ion beam repeatedly switching between a zero transmission mode of operation during a time period ?T1 and a non-zero transmission mode of operation during a time period ?T 2 . The degree of attenuation of the ion beam can be varied by varying the mark space ratio ?T 2 /?T 1 . The ion beam attenuator may release ions in packets or pulses but the packets or pulses of ions may be converted into a continuous ion beam by a relatively high pressure ion guide or gas collision cell arranged downstream of the ion beam attenuator.
摘要翻译：公开了一种质谱仪，其包括离子束衰减器，该离子束衰减器在时间段ΔT1期间衰减离子束在时间段ΔT1内的零传输模式和非零传输模式之间重复切换， / SUB>。离子束的衰减程度可以通过改变标记空间比ΔT2 /βT 1 1来改变。离子束衰减器可以以分组或脉冲的形式释放离子，但是离子束或脉冲可以通过布置在离子束衰减器下游的相对高压的离子导向器或气体碰撞元件转换为连续的离子束。

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