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1. 发明申请

WO2007138338A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007138338A3
公开(公告)日：2008-12-31
申请号：PCT/GB2007002044
申请日：2007-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
IPC分类号： H01J49/02
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+i) which are stored in neighbouring time bins T(n), T(n+1).
摘要翻译：公开了一种质谱仪，其包括飞行时间质量分析器，其包括离子检测器，该离子检测器包括模数转换器。从模拟到数字转换器的信号被数字化，并确定离子的到达时间和强度。每个离子到达事件的到达时间T0和强度S0被转换成存储在相邻时间段T（n），T（n + 1）中的两个分开的强度S（n），S（n + i）。

2. 发明申请

WO2007138337A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007138337A2
公开(公告)日：2007-12-06
申请号：PCT/GB2007002043
申请日：2007-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
IPC分类号： H01J49/02
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译：公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。如果从两个信号确定的到达时间落入相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。

3. 发明申请

WO2006129094A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006129094A3
公开(公告)日：2008-03-06
申请号：PCT/GB2006001996
申请日：2006-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/02 , G06F19/00 , H01J49/00
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

4. 发明申请

WO2008117040A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2008117040A2
公开(公告)日：2008-10-02
申请号：PCT/GB2008001028
申请日：2008-03-26
申请人： MICROMASS LTD , GREEN MARTIN , WILDGOOSE JASON LEE , BROWN JEFFERY MARK
发明人： GREEN MARTIN , WILDGOOSE JASON LEE , BROWN JEFFERY MARK
IPC分类号： H01J49/06
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority. of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了包含电子转移离解电池（1）的质谱仪。当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子（1）。电池包括形成球形捕获体积的多个环形电极（1）。在多数情况下，离子经验可以忽略不计。的捕获体积，其使分析物和试剂离子的动能降低到恰好高于热温度。由此提供了具有增强的灵敏度的电子转移解离单元（1）。在细胞（1）内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，使得可以获得质量分析仪的分辨率的显着提高。

5. 发明申请

WO2010012987A8 GLOW DISCHARGE ION SOURCE 审中-公开
标题翻译： GLOW放射源
公开(公告)号：WO2010012987A8
公开(公告)日：2011-02-17
申请号：PCT/GB2009001842
申请日：2009-07-27
申请人： MICROMAS UK LTD , BROWN JEFFERY MARK , GREEN MARTIN RAYMOND , PRINGLE STEVEN DEREK
发明人： BROWN JEFFERY MARK , GREEN MARTIN RAYMOND , PRINGLE STEVEN DEREK
IPC分类号： H01J49/00 , H01J49/10 , H01J49/16
CPC分类号： H01J49/12 , G01N24/00 , H01J49/0009 , H01J49/0072 , H01J49/0495 , H01J49/107 , H01J49/165 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode (14) which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
摘要翻译：公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。辉光放电装置可以包括设置在真空室中的隔离阀（15）内的管状电极（14）。可以通过管状电极（14）提供试剂蒸气，然后其随后通过辉光放电电离。所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。考虑其他实施例，其中由辉光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。

6. 发明申请

WO2009066087A3 ION- ION REACTION DEVICE 审中-公开
标题翻译：离子反应装置
公开(公告)号：WO2009066087A3
公开(公告)日：2009-11-26
申请号：PCT/GB2008003916
申请日：2008-11-24
申请人： MICROMASS LTD , BROWN JEFFERY MARK , GREEN MARTIN RAYMOND
发明人： BROWN JEFFERY MARK , GREEN MARTIN RAYMOND
IPC分类号： H01J49/00
CPC分类号： H01J49/065 , H01J49/0072
摘要： An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide ()2. A transient DC voltage wave is applied to the electrodes (2) in order to load reagent anions into the ion guide (2). Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.
摘要翻译：提供了包括形成离子导向器（）2的多个电极（1）的离子 - 离子反应池。将瞬态直流电压波施加到电极（2）上以将试剂阴离子加载到离子导向器（2）中。随后分析物阳离子通过随后的瞬态DC电压波传输通过离子 - 离子反应池。离子布置成在反应池内进行离子 - 离子反应，然后通过瞬态直流电压波将在反应池内形成的碎片离子随后转移出反应池。

7. 发明申请

WO2009127808A8 ELECTRON TRANSFER DISSOCIATION DEVICE 审中-公开
标题翻译：电子传输解调装置
公开(公告)号：WO2009127808A8
公开(公告)日：2011-04-28
申请号：PCT/GB2009000902
申请日：2009-04-03
申请人： MICROMASS LTD , BROWN JEFFERY MARK , GREEN MARTIN RAYMOND
发明人： BROWN JEFFERY MARK , GREEN MARTIN RAYMOND
IPC分类号： H01J49/06 , H01J49/00
CPC分类号： H01J49/28 , H01J49/0072 , H01J49/065
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
摘要翻译：公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。

8. 发明申请

WO2009066089A3 ION- ION REACTION DEVICE 审中-公开
标题翻译：离子反应装置
公开(公告)号：WO2009066089A3
公开(公告)日：2009-11-26
申请号：PCT/GB2008003918
申请日：2008-11-24
申请人： MICROMASS LTD , BROWN JEFFERY MARK , GREEN MARTIN RAYMOND
发明人： BROWN JEFFERY MARK , GREEN MARTIN RAYMOND
IPC分类号： H01J49/00
CPC分类号： H01J49/065 , H01J49/0072
摘要： An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). One or more transient DC voltage waves (8, 9) are applied to the electrodes (2). Reagent anions and analyte cations are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of one or more transient DC voltage waves (8, 9).
摘要翻译：提供离子离子反应池，其包括形成离子导向器（2）的多个电极（1）。一个或多个瞬态DC电压波（8,9）被施加到电极（2）。试剂阴离子和分析物阳离子排列成在反应池内进行离子 - 离子反应，然后在反应池内形成的所得碎片离子随后通过一个或多个瞬态直流电压波（8 ，9）。

9. 发明申请

WO2013005061A3 PHOTO-DISSOCIATION OF PROTEINS AND PEPTIDES IN A MASS SPECTROMETER 审中-公开
标题翻译：蛋白质和蛋白质在质谱仪中的照片分离
公开(公告)号：WO2013005061A3
公开(公告)日：2013-06-27
申请号：PCT/GB2012051610
申请日：2012-07-06
申请人： MICROMASS LTD , BROWN JEFFERY MARK , GILES KEVIN , KENNY DANIEL JAMES , MURRAY PAUL , RICHARDSON KEITH
发明人： BROWN JEFFERY MARK , GILES KEVIN , KENNY DANIEL JAMES , MURRAY PAUL , RICHARDSON KEITH
IPC分类号： H01J49/00
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.
摘要翻译：公开了一种质谱法，其包括将来自激光器的第一光子引导到位于2D或线性离子导向器或离子阱内的离子上。扫描第一光子的频率，并检测由离子发射的第一光子和/或第二光子。然后使用飞行时间质量分析仪对离子进行质量分析。

10. 发明申请

WO2007104992A8 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007104992A8
公开(公告)日：2013-03-14
申请号：PCT/GB2007000905
申请日：2007-03-14
申请人： MICROMASS LTD , BROWN JEFFERY MARK
发明人： BROWN JEFFERY MARK
IPC分类号： H01J49/40
CPC分类号： H01J49/408
摘要： A multi-turn Time of Flight mass analyser is disclosed comprising a first electric sector (5) and a second electric sector (8). The second electric sector (8) is arranged orthogonal to the first electric sector (5). Ions may make multiple loops or circuits of the mass analyser before being detected and mass analysed enabling a high resolution mass analyser to be provided. According to another embodiment the mass analyser may have an open-loop geometry wherein the first electric sector is elongated and further electric sectors are arranged in a staggered manner along the length of the first electric sector. The first and second electric sectors (5,8) may be sub-divided into a plurality of electric sector segments.
摘要翻译：公开了一种多转飞行时间质量分析器，其包括第一电扇区（5）和第二电扇区（8）。第二电扇区（8）布置成与第一电扇区（5）正交。在检测到质子分析仪之前，离子可能会产生多个回路或质量分析器，并进行质量分析，以提供高分辨率质量分析仪。根据另一个实施例，质量分析器可以具有开环几何形状，其中第一电气部分是细长的，并且进一步的电扇区沿着第一电气部分的长度以交错的方式布置。第一和第二电扇区（5,8）可以被细分成多个电扇区段。

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