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1. 发明申请

WO2012085594A2 IMPROVED SPACE FOCUS TIME OF FLIGHT MASS SPECTROMETER 审中-公开
标题翻译：改进飞行质谱仪空间聚焦时间
公开(公告)号：WO2012085594A2
公开(公告)日：2012-06-28
申请号：PCT/GB2011052576
申请日：2011-12-22
申请人： MICROMASS LTD , HOYES JOHN BRIAN , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
发明人： HOYES JOHN BRIAN , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/0027 , H01J49/401
摘要： A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyser is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ?T of ions arriving at the ion detector.
摘要翻译：公开了一种飞行时间质谱仪，其中提供了五阶空间聚焦装置。可以包括飞行时间质量分析器的源区域中的附加阶段的装置被布置为引入非零五阶空间聚焦项，使得第一，第三和第五阶空间聚焦项的组合效果导致a 减少离子到达离子检测器的离子到达时间ΔT的扩散。

2. 发明申请

WO2012123730A3 ION MOBILITY SPECTROMETER WITH VARIABLE EFFECTIVE DRIFT LENGTH 审中-公开
标题翻译：离子移动光谱仪具有可变的有效载流子长度
公开(公告)号：WO2012123730A3
公开(公告)日：2012-12-06
申请号：PCT/GB2012050545
申请日：2012-03-13
申请人： MICROMASS LTD , GREEN MARTIN RAYMOND , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
发明人： GREEN MARTIN RAYMOND , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
IPC分类号： H01J49/40 , G01N27/62 , H01J49/42
CPC分类号： H01J49/36 , G01N27/624 , H01J49/06 , H01J49/42 , H01J49/426
摘要： An ion mobility separator or spectrometer is disclosed comprising an inner cylinder (2) and an outer cylinder (1). The inner cylinder (2) and the outer cylinder (1) define an annular volume (3) through which ions are transmitted. One or more spiral electrodes a-f are arranged on a surface of the inner cylinder (2) and/or on a surface of the outer cylinder (1). A first device is arranged and adapted to maintain a DC electric field and/or a pseudo- potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply one or more transient DC voltages to the one or more spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator.
摘要翻译：公开了一种离子迁移率分离器或光谱仪，其包括内筒（2）和外筒（1）。内筒（2）和外筒（1）限定了一个环形体积（3），离子通过该环体积传递。一个或多个螺旋形电极a-f布置在内筒（2）的表面和/或外筒（1）的表面上。第一装置被布置并适于维持DC电场和/或伪电势力，其作用是将离子从离子迁移率分离器或光谱仪的第一端促进到离子迁移率分离器或光谱仪的第二端。第二装置被布置并适于将一个或多个瞬态DC电压施加到所述一个或多个螺旋电极，以促使离子朝向离子迁移率分离器或光谱仪的第一端。净效应是延长离子迁移率分离器的有效路径长度。

3. 发明申请

WO03050843A2 METHOD OF MASS SPECTROMETRY 审中-公开
标题翻译：质谱法
公开(公告)号：WO03050843A2
公开(公告)日：2003-06-19
申请号：PCT/GB0205628
申请日：2002-12-12
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , HOYES JOHN BRIAN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES
发明人： BATEMAN ROBERT HAROLD , HOYES JOHN BRIAN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/062
摘要： A method of mass spectrometry is disclosed wherein ions are trapped for a period of time T within an AC or RF ion guide maintained at a pressure P wherein the product P x T is at least 1 mbar-ms. The effect of trapping the ions according to a preferred embodiment is that singly charged ions which may, for example, comprise unwanted background ions are substantially lost from the trap whereas multiply charged analyte ions are maintained within the ion trap and can then be released for subsequent mass analysis.
摘要翻译：公开了一种质谱法，其中将离子俘获在维持在压力P的AC或RF离子导向器内的一段时间T内，其中产物P x T至少为1毫巴。捕获根据优选实施方案的离子的效果是，可以例如包含不想要的背景离子的单电荷离子从捕获阱基本上丢失，而多电荷分析物离子保持在离子阱内，然后可以释放以用于随后的质量分析。

4. 发明申请

WO2013027054A2 ION TRAP WITH SPATIALLY EXTENDED ION TRAPPING REGION 审中-公开
标题翻译：离子阱与空间扩展的离子俘获区域
公开(公告)号：WO2013027054A2
公开(公告)日：2013-02-28
申请号：PCT/GB2012052053
申请日：2012-08-22
申请人： MICROMASS LTD , GILES KEVIN , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
发明人： GILES KEVIN , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/421 , H01J49/422 , H01J49/4285
摘要： A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction.
摘要翻译：公开的具有增加的电荷存储容量的质量或质荷比选择离子阱。 RF电压用于在离子阱内的第一（y）方向上限制离子。直流电压和/或RF电压用于在离子阱内的第二（x）方向上限制离子。二次直流势阱用于在离子阱内的第三（z）方向上限制离子。离子在第三（z）方向上被激发，并且导致质量或质荷比选择性地在第三（z）方向上喷射。

5. 发明申请

WO2012123729A2 ION GUIDE WITH ORTHOGONAL SAMPLING 审中-公开
标题翻译：离子指南与正交采样
公开(公告)号：WO2012123729A2
公开(公告)日：2012-09-20
申请号：PCT/GB2012050544
申请日：2012-03-13
申请人： MICROMASS LTD , GREEN MARTIN RAYMOND , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
发明人： GREEN MARTIN RAYMOND , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
IPC分类号： H01J49/06 , G01N27/62
CPC分类号： H01J49/065 , G01N27/622 , H01J49/0031 , H01J49/022 , H01J49/062 , H01J49/063 , H01J49/36
摘要： A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001 -0.001 mbar; (ii) 0.001 -0.01 mbar; (iii) 0.01 -0.1 mbar; (iv) 0.1 -1 mbar; (v) 1 -10 mbar; (vi) 10-100 mbar; and (vii) > 100 mbar.
摘要翻译：公开了一种质谱仪，其包括RF离子导向器，其中在操作模式中，连续的，准连续的或脉冲的离子束从离子导向器正交地采样，并且其中连续的，准连续的或脉冲的离子束不轴向被捕获或以其它方式轴向限制在RF离子导向器内。离子导向器在使用中以选自以下的压力保持：（i）0.0001 -0.001毫巴; （ii）0.001 -0.01毫巴; （iii）0.01 -0.1毫巴; （iv）0.1-1毫巴; （v）1 -10 mbar; （vi）10-100毫巴; 和（vii）> 100mbar。

6. 发明申请

WO2012085595A2 FAST PUSHING TIME OF FLIGHT MASS SPECTROMETER COMBINED WITH RESTRICTED MASS TO CHARGE RATIO RANGE DELIVERY 审中-公开
标题翻译：与限制质量组合的飞行质谱仪的快速推送时间以充电比例范围传送
公开(公告)号：WO2012085595A2
公开(公告)日：2012-06-28
申请号：PCT/GB2011052577
申请日：2011-12-22
申请人： MICROMASS LTD , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , WILDGOOSE JASON LEE
发明人： GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , WILDGOOSE JASON LEE
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0086
摘要： Ions having a restricted range of mass to charge ratios are transmitted to the acceleration region of a Time of Flight mass analyser. A control system applies a first extraction pulse to an acceleration electrode in order to accelerate a first group of ions into the time of flight region at a first time T1, wherein tons having the lowest mass to charge ratio in the first group of ions have a time of flight ?T1min through the time of flight region and ions having the highest mass to charge ratio in the first group of ions have a time of flight ?T1max through the time of flight region. The control system applies a second extraction pulse to the acceleration electrode at a subsequent second time T2, wherein ?T1max- ?T1min = T2-T1 max.
摘要翻译：具有有限范围的质荷比的离子被传送到飞行时间质量分析器的加速区域。控制系统将第一提取脉冲施加到加速电极，以便在第一时间T1将第一组离子加速到飞行时间区域，其中在第一组离子中具有最低质荷比的吨具有飞行时间T1min通过飞行时间段，第一组离子中质荷比最高的离子在飞行时间段内具有飞行时间T1max。控制系统在随后的第二时间T2向加速电极施加第二提取脉冲，其中ΔT1max-ΔT1min= T2-T1max。

7. 发明申请

WO2007138338A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007138338A3
公开(公告)日：2008-12-31
申请号：PCT/GB2007002044
申请日：2007-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
IPC分类号： H01J49/02
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+i) which are stored in neighbouring time bins T(n), T(n+1).
摘要翻译：公开了一种质谱仪，其包括飞行时间质量分析器，其包括离子检测器，该离子检测器包括模数转换器。从模拟到数字转换器的信号被数字化，并确定离子的到达时间和强度。每个离子到达事件的到达时间T0和强度S0被转换成存储在相邻时间段T（n），T（n + 1）中的两个分开的强度S（n），S（n + i）。

8. 发明申请

WO2006061625A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006061625A3
公开(公告)日：2007-06-14
申请号：PCT/GB2005004724
申请日：2005-12-08
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE , BROWN JEFFREY MARK
发明人： BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE , BROWN JEFFREY MARK
IPC分类号： H01J49/04 , H01J49/42
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyser (4) arranged upstream of an ion guide (6). Ions are scanned out of the mass selective ion trap or mass analyser (4) and are received in one or more axial potential wells created or formed within the ion guide (6). One or more transient DC voltages or potentials are preferably applied to the ion guide (6) in order to create a plurality of axial potential wells which are translated along the length of the ion guide (6). Ions are released in packets from the exit of the ion guide (6) and are orthogonally accelerated into a drift or flight region of an orthogonal acceleration Time of Flight mass analyser (13) with a relatively high duty cycle.
摘要翻译：公开了一种质谱仪，其包括布置在离子导向器（6）上游的质量选择性离子阱或质量分析器（4）。从质量选择性离子阱或质量分析器（4）中扫描离子，并将其接收在离子导向器（6）内产生或形成的一个或多个轴向势阱中。优选地将一个或多个瞬态DC电压或电位施加到离子导向器（6），以便产生沿离子导向件（6）的长度平移的多个轴向势阱。从离子导向器（6）的出口以分组的形式释放离子，并以相对较高的占空比正交加速到正交加速时间飞行质量分析器（13）的漂移或飞行区域。

9. 发明申请

WO2006054101A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006054101A3
公开(公告)日：2007-01-18
申请号：PCT/GB2005004457
申请日：2005-11-18
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
发明人： BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
IPC分类号： H01J49/42 , H01J49/16
CPC分类号： H01J49/4215 , H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).
摘要翻译：公开了一种质谱仪，其包括四极棒离子导向器或质量过滤装置（6）。具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。缺口宽带频率信号（10）使离子引导（6）共振地排出不想要的离子。缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。离子导向器或质量过滤器装置（6）使得能够通过离子导向器或质量过滤器装置（6）同时传输具有不同质荷比的多个所需离子，而其它离子从离子导向器或质量过滤器装置（6）。

10. 发明申请

WO2008090365A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2008090365A3
公开(公告)日：2009-07-02
申请号：PCT/GB2008000275
申请日：2008-01-25
申请人： MICROMASS LTD , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
发明人： PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
IPC分类号： H01J49/00
CPC分类号： H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.
摘要翻译：公开了一种质谱仪，其包括四极杆组离子导向器或质量过滤装置。具有多个频率切口（16a; 16b; 16c）的宽带频率信号（13,14,15）依次施加到四极杆组的杆上。缺口宽带频率信号（16a，16b，16c）使离子引导不需要的离子共振或参数地喷出。所得到的离子信号被去卷积以提供质谱。

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