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1. 发明申请

WO2007138338A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007138338A3
公开(公告)日：2008-12-31
申请号：PCT/GB2007002044
申请日：2007-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
IPC分类号： H01J49/02
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+i) which are stored in neighbouring time bins T(n), T(n+1).
摘要翻译：公开了一种质谱仪，其包括飞行时间质量分析器，其包括离子检测器，该离子检测器包括模数转换器。从模拟到数字转换器的信号被数字化，并确定离子的到达时间和强度。每个离子到达事件的到达时间T0和强度S0被转换成存储在相邻时间段T（n），T（n + 1）中的两个分开的强度S（n），S（n + i）。

2. 发明申请

WO2009007739A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱分析仪
公开(公告)号：WO2009007739A2
公开(公告)日：2009-01-15
申请号：PCT/GB2008002402
申请日：2008-07-14
申请人： MICROMASS LTD , GREEN MARTIN , KENNY DANIEL JAMES , LANGRIDGE DAVID , WILDGOOSE JASON LEE
发明人： GREEN MARTIN , KENNY DANIEL JAMES , LANGRIDGE DAVID , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： H01J49/4205 , H01J49/02 , H01J49/4225
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion trap (2, 3) wherein a potential field is created at the exit of the ion trap (4, 5) which decreases with increasing radius in one radial direction. Ions within the ion trap (2, 3) are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap (2, 3).
摘要翻译：公开了一种包括四极杆组离子阱（2,3）的质谱仪，其中在离子阱（4,5）的出口处产生势能场，其在一个径向方向上随半径增加而减小。离子阱（2,3）内的离子在径向方向上被质量选择性地激发。已经在径向激发的离子经历势场，该势场不再将离子轴向限制在离子阱内，而是用于提取离子并因此导致离子从离子阱（2,3）轴向射出，。

3. 发明申请

WO2007138337A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007138337A2
公开(公告)日：2007-12-06
申请号：PCT/GB2007002043
申请日：2007-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
IPC分类号： H01J49/02
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译：公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。如果从两个信号确定的到达时间落入相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。

4. 发明申请

WO2006129106A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006129106A3
公开(公告)日：2007-11-15
申请号：PCT/GB2006002024
申请日：2006-06-05
申请人： MICROMASS LTD , GILES KEVIN , GREEN MARTIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
发明人： GILES KEVIN , GREEN MARTIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
IPC分类号： H01J49/42 , H01J49/40
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap (1) is disclosed having an entrance electrode (2) and an exit electrode (3). The potential of the exit electrode (3) is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap (1) via an aperture in the exit electrode (3). The period of time that the potential of the exit electrode (3) is dropped for is progressively increased and ions emerge from the ion guide or ion trap (1) in a mass to charge ratio dependent manner. The ion guide or ion trap (1) may be operated as a mass separator or low resolution mass analyser.
摘要翻译：公开了一种具有入口电极（2）和出口电极（3）的离子导向器或离子阱（1）。出口电极（3）的电位周期性地下降相当短的时间段，允许一些离子通过出射电极（3）中的孔从离子导向器或离子阱（1）逸出。退出电极（3）的电位下降的时间段逐渐增加，并且离子导向器或离子阱（1）以质荷比依赖的方式出现离子。离子导向器或离子阱（1）可以作为质量分离器或低分辨率质量分析器来操作。

5. 发明申请

WO2007060436A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007060436A2
公开(公告)日：2007-05-31
申请号：PCT/GB2006004385
申请日：2006-11-23
申请人： MICROMASS LTD , GREEN MARTIN
发明人： GREEN MARTIN
IPC分类号： H01J49/42
CPC分类号： H01J49/4235 , H01J49/427
摘要： An ion trap mass analyser (1) is disclosed comprising a segmented rod set. Ions are trapped radially within the mass analyser by a radial pseudo-potential well. The ions are also confined axially within a quadratic axial potential well. A supplemental AC voltage or potential is applied to the electrodes comprising the ion trap mass analyser (1) in order to excite parametrically ions within the ion trap (1).
摘要翻译：公开了一种离子阱质量分析器（1），其包括分段杆组。离子通过径向伪势阱在径向上被捕获在质量分析器内。离子也在二次轴向势阱内轴向限制。对包括离子阱质量分析器（1）的电极施加补充AC电压或电位，以激发离子阱（1）内的参数离子。

6. 发明申请

WO2008047101A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2008047101A2
公开(公告)日：2008-04-24
申请号：PCT/GB2007003937
申请日：2007-10-16
申请人： MICROMASS LTD , KENNY DANIEL JAMES , BATEMAN ROBERT HAROLD , GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK
发明人： KENNY DANIEL JAMES , BATEMAN ROBERT HAROLD , GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK
CPC分类号： H01J49/005 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/065 , H01J49/34 , H01J49/4235
摘要： A collision or fragmentation cell (4) is disclosed comprising a plurality of electrodes wherein a first RF voltage (7a) is applied to an upstream group of electrodes and a second different RF voltage (7b) is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell (4) is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell (4) is optimised by the second different RF voltage applied to the downstream group of electrodes.
摘要翻译：公开了一种碰撞或分裂单元（4），其包括多个电极，其中将第一RF电压（7a）施加到上游电极组，并且将第二不同RF电压（7b）施加到下游组电极。通过施加到上游电极组的第一RF电压来优化进入碰撞或破碎电池（4）的母体离子的径向约束，并且优化在碰撞或断裂电池（4）内产生的子或碎片离子的径向约束通过施加到下游组电极的第二不同RF电压。

7. 发明申请

WO2007072038A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007072038A3
公开(公告)日：2008-03-27
申请号：PCT/GB2006004892
申请日：2006-12-21
申请人： MICROMASS LTD , GREEN MARTIN
发明人： GREEN MARTIN
IPC分类号： H01J49/42
CPC分类号： H01J49/4235 , H01J49/427
摘要： An ion trap mass analyser (1) is disclosed comprising a segmented rod set. Ions are trapped radially within the mass analyser by a radial pseudo-potential well. The ions are also confined axially within the ion trap by an axial electric field. The axial electric field is substantially linear across the central section of the iøn trap, but the electric field is distorted across both ends of the ion trap. A supplemental AC voltage or potential is applied to the electrodes comprising the ion trap mass analyser (1) in order to excite resonantly ions within the ion trap (1). The distortions in the electric field at the ends of the ion trap cause the resonant frequency of ions within the ion trap to shift to either a higher or lower frequency. If the frequency of the supplemental AC voltage or potential is scanned appropriately then ions are ejected from the ion trap in a shorter period of time leading to an improvement in mass resolution.
摘要翻译：公开了一种离子阱质量分析器（1），其包括分段杆组。离子通过径向假电位阱在质量分析器内径向捕获。离子也通过轴向电场轴向限定在离子阱内。轴向电场横跨i阱陷阱的中心部分基本上是线性的，但电场在离子阱的两端变形。为了激发离子阱（1）内的共振离子，对包括离子阱质量分析器（1）的电极施加补充AC电压或电位。离子阱末端的电场畸变导致离子阱内的离子的共振频率向更高或更低的频率移动。如果适当地扫描补充AC电压或电位的频率，则离子在较短时间内从离子阱排出，导致质量分辨率的提高。

8. 发明申请

WO2006075189A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006075189A3
公开(公告)日：2007-05-18
申请号：PCT/GB2006000155
申请日：2006-01-17
申请人： MICROMASS LTD , GILES KEVIN , GREEN MARTIN , WILDGOOSE JASON LEE
发明人： GILES KEVIN , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/04 , H01J49/42
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap 1 is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap 1 by the application of an AC or RF voltage to the electrodes. Ions are trapped within an axial quadratic potential well which is oscillated or modulated axially so as to cause ions to be ejected from the ion guide or ion trap 1 in a substantially non-resonant manner.
摘要翻译：公开了一种离子导向器或离子阱1，其包括分段线性离子导向器或离子阱。通过向电极施加AC或RF电压，离子限制在离子导向器或离子阱1的径向内。离子被捕获在轴向二次势阱内，其轴向振荡或调制，以使离子以基本上非共振的方式从离子导向器或离子阱1喷出。

9. 发明申请

WO2008139193A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2008139193A3
公开(公告)日：2009-08-13
申请号：PCT/GB2008001663
申请日：2008-05-14
申请人： MICROMASS LTD , GILBERT ANTHONY JAMES , GREEN MARTIN
发明人： GILBERT ANTHONY JAMES , GREEN MARTIN
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , G06K9/0051 , H01J49/00
摘要： A mass spectrometer is disclosed wherein a signal output from an ion detector is digitised using an Analogue to Digital Converter. A background or baseline level is dynamically subtracted from the digitised signal whilst the time of flight data is still being acquired. A threshold is also applied dynamically to the digitised signal in order to reduce electronic noise.
摘要翻译：公开了一种质谱仪，其中从离子检测器输出的信号使用模数转换器进行数字化。从数字化信号中动态减去背景或基线水平，同时仍然获取飞行时间数据。阈值也被动态地应用于数字化信号，以减少电子噪声。

10. 发明申请

WO2006129094A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006129094A3
公开(公告)日：2008-03-06
申请号：PCT/GB2006001996
申请日：2006-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/02 , G06F19/00 , H01J49/00
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

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