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1. 发明申请

WO2013049779A1 DELIVERY DEVICES AND METHODS FOR GASTROINTESTINAL IMPLANTS 审中-公开
标题翻译：输送装置和气体植入物的方法
公开(公告)号：WO2013049779A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/058202
申请日：2012-09-30
申请人： METAMODIX, INC. , BELHE, Kedar, R. , THOMPSON, Paul, J. , GRAFOV, Alexander, D. , SCHWARZ, Werner
发明人： BELHE, Kedar, R. , THOMPSON, Paul, J. , GRAFOV, Alexander, D. , SCHWARZ, Werner
IPC分类号： A61M5/00
CPC分类号： A61F5/0076 , A61F2/04 , A61F5/0079 , A61F5/0089 , A61F2002/044 , A61F2002/045 , A61F2220/0008 , A61F2230/0065 , A61M39/0208 , A61M2039/0223 , A61M2210/1042 , F04C2270/041
摘要： Several gastrointestinal surgery procedures are effective as treatments for metabolic disorders such as obesity and diabetes. Minimally invasive procedures including intra-luminal gastrointestinal implants have been proposed to mimic the anatomical, physiological and metabolic changes achieved by these procedures. Many of these designs include long sleeve like elements that prevent contact of food with the walls of the small intestine. It is desirable to have simple delivery systems that can place these implants under endoscopic guidance. However, in order to anchor these sleeve elements safely and reliably, the inventors have previously disclosed anchoring means that anchor the sleeves at the junctions of the stomach and the intestine or the stomach and esophagus.
摘要翻译：几种胃肠手术方法作为代谢紊乱如肥胖和糖尿病的治疗是有效的。已经提出微创手术，包括腔内胃肠植入物，以模拟通过这些程序实现的解剖，生理和代谢变化。这些设计中的许多包括防止食物与小肠壁接触的长袖状元件。希望具有能够将这些植入物置于内窥镜引导下的简单输送系统。然而，为了安全可靠地锚定这些套筒元件，本发明人先前已经公开了将套筒锚定在胃和肠或胃和食道的接合处的锚固装置。

2. 发明申请

WO2022232409A1 SYSTEMS AND METHOD FOR STABILIZING ANTI-MIGRATION ANCHOR SYSTEM 审中-公开
公开(公告)号：WO2022232409A1
公开(公告)日：2022-11-03
申请号：PCT/US2022/026756
申请日：2022-04-28
申请人： METAMODIX, INC.
发明人： BELHE, Kedar R. , SCHWARZ, Werner , HAGEN, Parker , STANGENES, Todd , MATTISON, Richard
IPC分类号： A61F5/00 , A61F2/04 , A61F2/82 , A61F2/95
摘要： A system for delivering an anti-migration anchor to an implantable device includes a locator system having a head portion adapted to mate with the neck portion of the device, a locator capsule coupled to the head portion, and a plurality of arms coupled to the head portion and the locator capsule, the arms having a collapsed and an extended configuration. The system includes a catheter having a distal portion coupled to and extending from the head portion. The system includes a handle coupled to a portion of the catheter, the handle having a mechanism to effect relative motion between an inner and an outer member of the catheter to cause the arms to transition from the collapsed to the extended configuration. The system includes a plurality of elongate elements having a distal end coupled to the arm and configured to facilitate the delivery of an anti-migration anchor to the arm.

3. 发明公开

EP3973929A1 PYLORIC ANCHORS AND METHODS FOR INTESTINAL BYPASS SLEEVES 审中-公开
公开(公告)号：EP3973929A1
公开(公告)日：2022-03-30
申请号：EP21183837.0
申请日：2017-03-02
申请人： Metamodix, Inc.
发明人： STANGENES, Todd , SCHWARZ, Werner , BELHE, Kedar R. , ZIEBOL, Mathew , ANDERSON, Edward
IPC分类号： A61F5/00
摘要： A gastrointestinal device for implanting within a patient's gastrointestinal tract, the device having a central axis and a first expandable portion comprising a hollow tubular braided structure of wire and having a first cylinder extending parallel to the central axis, the first cylinder having a length and a first face; a neck portion extending from the first face of the first expandable portion parallel to the central axis, the neck portion having a first end, a second end, a wall extending between the first end and second end, and a diameter sized to fit within a pylorus; and a second expandable portion comprising a hollow tubular braided structure of wire and having a second cylinder extending parallel to the central axis, the second cylinder having a second face located at the proximal end of the second cylinder and oriented transverse to the central axis.

4. 发明申请

WO2017201424A1 PYLORIC ANCHOR RETRIEVAL TOOLS AND METHODS 审中-公开
公开(公告)号：WO2017201424A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/033573
申请日：2017-05-19
申请人： METAMODIX, INC.
发明人： STANGENES, Todd , SCHWARZ, Werner , BELHE, Kedar, R. , ZIEBOL, Mathew , ANDERSON, Edward
IPC分类号： A61F5/00
摘要： A retrieval device comprising a hook assembly and a capsule assembly. The hook assembly has an attachment feature at a first end. The capsule assembly includes a capsule, a capsule shaft, and a handle connected in series and defining an inner bore. The capsule has a first end defining an opening. The inner bore of the capsule assembly is configured to slidably receive the hook assembly. The handle has a central portion, a first extension portion attached to the capsule shaft, and a second extension portion with a hook assembly lock at a second end. The hook assembly lock is configured to lock the hook assembly to the second extension portion. The second extension portion is configured to pull the hook assembly relative to the capsule shaft, and the first extension portion is configured to push the capsule shaft relative to the hook assembly along the central longitudinal axis.
摘要翻译：包括钩组件和胶囊组件的取出装置。钩组件在第一端处具有附接特征。胶囊组件包括胶囊，胶囊轴和串联连接并限定内孔的手柄。胶囊具有限定开口的第一端。胶囊组件的内孔构造成可滑动地接收钩组件。手柄具有中心部分，连接到胶囊轴的第一延伸部分，以及在第二端具有钩组件锁的第二延伸部。挂钩组件锁构造成将挂钩组件锁定到第二延伸部分。第二延伸部分构造成相对于胶囊轴拉动挂钩组件，并且第一延伸部分构造成沿中心纵向轴线相对于挂钩组件推动胶囊轴。

5. 发明申请

WO2021080640A1 SYSTEMS AND METHODS FOR ANCHORING AND RESTRAINING GASTROINTESTINAL PROSTHESES 审中-公开
公开(公告)号：WO2021080640A1
公开(公告)日：2021-04-29
申请号：PCT/US2020/021765
申请日：2020-03-09
申请人： METAMODIX, INC.
发明人： BELHE, Kedar , SCHWARZ, Werner , STANGENES, Todd , HAGEN, Parker
IPC分类号： A61F5/00
摘要： Systems and methods for anchoring and restraining gastrointestinal prostheses are disclosed. In various examples, the systems and methods include securing a gastrointestinal device within a patient's anatomy by extending an anti-migration anchor through a plurality of portions of the gastrointestinal device to couple together the plurality of portions of the gastrointestinal device. In some examples, the anti-migration anchor extends through tissue situated between the plurality of portions of the gastrointestinal device.

6. 发明申请

WO2019191652A1 SYSTEMS AND METHODS FOR ANCHORING AND RESTRAINING GASTROINTESTINAL PROSTHESES 审中-公开
公开(公告)号：WO2019191652A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/024950
申请日：2019-03-29
申请人： METAMODIX, INC.
发明人： BELHE, Kedar, R. , SCHWARZ, Werner , STANGENES, Todd
IPC分类号： A61B17/00 , A61F5/00
摘要： Systems and methods for anchoring and restraining gastrointestinal prostheses are disclosed. In various examples, the systems and methods include securing a gastrointestinal device within a patient's anatomy by extending an anti-migration anchor through a plurality of portions of the gastrointestinal device to couple together the plurality of portions of the gastrointestinal device. In some examples, the anti-migration anchor extends through tissue situated between the plurality of portions of the gastrointestinal device.

7. 发明申请

WO2005047979A2 OPTICAL SYSTEM 审中-公开
标题翻译：光学系统
公开(公告)号：WO2005047979A2
公开(公告)日：2005-05-26
申请号：PCT/EP2004/012113
申请日：2004-10-27
申请人： CARL ZEISS SMT AG , SOHMEN, Erik , KAUFMANN, Paul , SCHWARZ, Werner
发明人： SOHMEN, Erik , KAUFMANN, Paul , SCHWARZ, Werner
IPC分类号： G03F7/20
CPC分类号： G03F7/70825 , G03F7/70833
摘要： An optical signal, in particular for projection microlithography, having optical elements, in particular mirrors and/or lenses, in a sealed sheath in which there is an inert gas or vacuum, and having a bearing with a bearing gap. The bearing is a fluid bearing and the bearing gap has restriction stages and is pumped differentially in two or more stages.
摘要翻译：特别是用于投影微光刻的光学信号，在具有惰性气体或真空的密封护套中具有光学元件，特别是反射镜和/或透镜，并且具有轴承间隙的轴承。轴承是流体轴承，轴承间隙具有限制级，并且在两个或多个阶段中差分泵送。

8. 发明申请

WO2017151951A1 PYLORIC ANCHORS AND METHODS FOR INTESTINAL BYPASS SLEEVES 审中-公开
标题翻译：用于肠道旁路套管的PYLORIC锚杆和方法
公开(公告)号：WO2017151951A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020494
申请日：2017-03-02
申请人： METAMODIX, INC.
发明人： STANGENES, Todd , SCHWARZ, Werner , BELHE, Kedar, R. , ZIEBOL, Mathew , ANDERSON, Edward
IPC分类号： A61M5/00
摘要： A gastrointestinal device for implanting within a patient's gastrointestinal tract, the device having a central axis and a first expandable portion comprising a hollow tubular braided structure of wire and having a first cylinder extending parallel to the central axis, the first cylinder having a length and a first face; a neck portion extending from the first face of the first expandable portion parallel to the central axis, the neck portion having a first end, a second end, a wall extending between the first end and second end, and a diameter sized to fit within a pylorus; and a second expandable portion comprising a hollow tubular braided structure of wire and having a second cylinder extending parallel to the central axis, the second cylinder having a second face located at the proximal end of the second cylinder and oriented transverse to the central axis.
摘要翻译：一种用于植入患者胃肠道内的胃肠装置，所述装置具有中心轴线和第一可膨胀部分，所述第一可膨胀部分包括金属丝的中空管状编织结构并且具有平行于所述中心轴线延伸的第一圆柱体，所述第一圆筒具有长度和第一面; 从所述第一可膨胀部分的所述第一面平行于所述中心轴线延伸的颈部，所述颈部具有第一端，第二端，在所述第一端和所述第二端之间延伸的壁，以及直径，幽门; 以及第二可膨胀部分，所述第二可膨胀部分包括金属丝的中空管状编织结构并且具有平行于所述中心轴线延伸的第二圆柱体，所述第二圆柱体具有位于所述第二圆柱体的近端处且横向于所述中心轴线定向的第二面。 / p>

9. 发明申请

WO2015138465A1 EXTERNAL ANCHORING CONFIGURATIONS FOR MODULAR GASTROINTESTINAL PROSTHESES 审中-公开
标题翻译：用于模块化气体放置的外部锚固配置
公开(公告)号：WO2015138465A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/019730
申请日：2015-03-10
申请人： METAMODIX, INC.
发明人： BELHE, Kedar , THOMPSON, Paul , GARFOV, Alexander , SCHWARZ, Werner
IPC分类号： A61F2/00
CPC分类号： A61F5/0079 , A61F5/0013 , A61F5/0076 , A61F5/0089
摘要： Components may be used separately or in combination to create anchoring systems for intra-luminal implants for the treatment of metabolic disorders such as obesity and diabetes. Various systems include an external component adapted for deployment around a portion of the gastrointestinal tract (e.g., the duodenum) and an internal component adapted for implantation within the gastrointestinal tract. Various systems use anchoring means that are based on mechanical interference, elasticity, spring force, shape memory transformation, magnetic attraction, repulsion and/or levitation. Various embodiments rely on longitudinal anchoring of the implants with minimal force against tissue.
摘要翻译：组分可以单独使用或组合使用以产生腔内植入物用于治疗代谢紊乱如肥胖症和糖尿病的锚定系统。各种系统包括适于部署在胃肠道的一部分（例如，十二指肠）周围的外部部件和适于植入胃肠道内部的内部部件。各种系统使用基于机械干涉，弹性，弹簧力，形状记忆变换，磁吸引，排斥和/或悬浮的锚固装置。各种实施例依赖于对组织的最小力的植入物的纵向锚固。

10. 发明申请

WO2016116093A1 VORRICHTUNG ZUM FESTKLEMMEN EINES MEDIZINISCHEN FÜHRUNGSDRAHTES 审中-公开
标题翻译：装置用于夹持医用导丝
公开(公告)号：WO2016116093A1
公开(公告)日：2016-07-28
申请号：PCT/DE2016/000020
申请日：2016-01-20
申请人： UROTECH GMBH , SCHWARZ, Werner
发明人： SCHWARZ, Werner
IPC分类号： A61B17/00 , A61M25/09
CPC分类号： A61B17/00 , A61B2017/00469 , A61M25/09041 , A61M2025/09116 , A61M2025/09125
摘要： Zum Festklemmen eines in einer Längsöffnung (3) eines Aufnahmekörpers (1) verschiebbaren und verdrehbaren medizinischen Führungsdrahtes (2) ist entweder nur an einem Ende der Längsöffnung (3) oder an jedem Ende der Längsöffnung (3) ein Klemmmechanismus (5, 8; 5') vorhanden, der einen quer zu der Längsöffnung (3) verlaufenden erweiterten Öffnungsbereich (4) und eine mit dem Aufnahmekörper (1) elastisch ausbiegbar verbundene Klemmgliedanordnung (5, 8; 5') mit einem in dem Öffnungsbereich (4) liegenden Kantenteil (7; 7') aufweist, an dem der Führungsdraht (2) nach seinem Verschwenken aus der Längsöffnung (3) an dem betreffenden Ende des Aufnahmekörpers (1) und an der Klemmgliedanordnung (5, 8; 5') unter Blockierung seiner Verschieb- und/oder Verdrehbarkeit in Anlage bringbar ist.
摘要翻译：在纵向开口的仅一个端部中的接收体（1）可移动的和可扭转医疗引导线（2）是或者的纵向开口（3）夹紧（3），或在纵向开口的每个端部（3）的夹紧机构（5,8; 5 “）存在，则延伸的横向（与纵向开口3）延伸的开口面积（4）和一个（与连接在女性身体1）夹紧构件组件可弹性偏转的（5,8; 5”）位于与一个（在开口部分4）边缘部（ 7; 7“），在其上导引钢丝（2）其枢转出在接收体的有关端部的纵向开口（3）的（1）之后和在所述夹紧部件组件（5,8; 5”）通过阻断其可移动性和 /或可转动地接触。

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