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1. 发明申请

WO2012103531A2 ANCHORS AND METHODS FOR INTESTINAL BYPASS SLEEVES 审中-公开
标题翻译：专用旁路系统的锚杆和方法
公开(公告)号：WO2012103531A2
公开(公告)日：2012-08-02
申请号：PCT/US2012/023048
申请日：2012-01-28
申请人： METAMODIX, INC. , THOMPSON, Paul J. , BELHE, Kedar R. , GRAFOV, Alexander D.
发明人： THOMPSON, Paul J. , BELHE, Kedar R. , GRAFOV, Alexander D.
IPC分类号： A61M5/00
CPC分类号： A61F5/0076 , A61B17/064 , A61B17/0643 , A61B17/12036 , A61B17/1204 , A61B17/122 , A61B17/1227 , A61B2017/00818 , A61B2017/00986 , A61B2017/0641 , A61B2017/0647
摘要： A gastrointestinal device for implanting within a pylorus, a duodenal bulb, and a duodenum of a patient's gastrointestinal tract includes an expandable structure includes a proximal portion having a plurality of spring arms and a distal portion having a plurality of spring arms, the proximal and distal portions coupled by a rigid central cylinder having a diameter capable of fitting within the pylorus and having a length greater than a width of the pylorus. A membrane is coupled to and covering at least a portion of one of the proximal portion and the distal portion of the expandable structure. An intestinal bypass sleeve is coupled to at least one of the proximal and distal portions of the expandable structure and having a length sufficient to extend at least partially into the duodenum. In the expanded configuration, the proximal portion has a diameter larger than a maximum opening diameter of the pylorus and further wherein, in the expanded configuration, the distal portion has a diameter larger than a maximum opening diameter of the pylorus.
摘要翻译：用于植入在幽门，十二指肠球和患者胃肠道十二指肠内的胃肠装置包括可扩张结构，其包括具有多个弹簧臂的近端部分和具有多个弹簧臂的远侧部分，近端和远端部分通过刚性中心圆柱体联接，所述刚性中心圆柱体具有能够配置在幽门内并且具有大于幽门宽度的长度的直径。膜连接到并覆盖可扩张结构的近端部分和远端部分中的一个的至少一部分。肠旁路套管联接到可扩张结构的近端部分和远端部分中的至少一个，并且具有足以至少部分延伸到十二指肠的长度。在扩张构造中，近侧部分具有大于幽门的最大开口直径的直径，此外，在扩张构造中，远侧部分具有大于幽门的最大开口直径的直径。

2. 发明申请

WO2013049779A1 DELIVERY DEVICES AND METHODS FOR GASTROINTESTINAL IMPLANTS 审中-公开
标题翻译：输送装置和气体植入物的方法
公开(公告)号：WO2013049779A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/058202
申请日：2012-09-30
申请人： METAMODIX, INC. , BELHE, Kedar, R. , THOMPSON, Paul, J. , GRAFOV, Alexander, D. , SCHWARZ, Werner
发明人： BELHE, Kedar, R. , THOMPSON, Paul, J. , GRAFOV, Alexander, D. , SCHWARZ, Werner
IPC分类号： A61M5/00
CPC分类号： A61F5/0076 , A61F2/04 , A61F5/0079 , A61F5/0089 , A61F2002/044 , A61F2002/045 , A61F2220/0008 , A61F2230/0065 , A61M39/0208 , A61M2039/0223 , A61M2210/1042 , F04C2270/041
摘要： Several gastrointestinal surgery procedures are effective as treatments for metabolic disorders such as obesity and diabetes. Minimally invasive procedures including intra-luminal gastrointestinal implants have been proposed to mimic the anatomical, physiological and metabolic changes achieved by these procedures. Many of these designs include long sleeve like elements that prevent contact of food with the walls of the small intestine. It is desirable to have simple delivery systems that can place these implants under endoscopic guidance. However, in order to anchor these sleeve elements safely and reliably, the inventors have previously disclosed anchoring means that anchor the sleeves at the junctions of the stomach and the intestine or the stomach and esophagus.
摘要翻译：几种胃肠手术方法作为代谢紊乱如肥胖和糖尿病的治疗是有效的。已经提出微创手术，包括腔内胃肠植入物，以模拟通过这些程序实现的解剖，生理和代谢变化。这些设计中的许多包括防止食物与小肠壁接触的长袖状元件。希望具有能够将这些植入物置于内窥镜引导下的简单输送系统。然而，为了安全可靠地锚定这些套筒元件，本发明人先前已经公开了将套筒锚定在胃和肠或胃和食道的接合处的锚固装置。

3. 发明申请

WO2014040231A1 CONNECTORS AND METHODS FOR MANUFACTURING CONNECTORS 审中-公开
标题翻译：用于制造连接器的连接器和方法
公开(公告)号：WO2014040231A1
公开(公告)日：2014-03-20
申请号：PCT/CN2012/081257
申请日：2012-09-11
申请人： APPLE INC. , JOL, Eric S. , SPRAGGS, Ian , GOLKO, Albert J. , THOMPSON, Paul J. , SCHMIDT, Mathias W.
发明人： JOL, Eric S. , SPRAGGS, Ian , GOLKO, Albert J. , THOMPSON, Paul J. , SCHMIDT, Mathias W.
IPC分类号： H01R13/648
CPC分类号： H01R43/18 , B22F3/225 , B22F5/10 , B22F2998/10 , H01R13/659 , H01R24/60 , H01R43/16 , B22F3/1021 , B22F3/10 , B22F3/162
摘要： Frames for plug connectorscapable of being a reduced size may include features to support contacts, house circuitry for coupling with the contacts, facilitate the flow of molten material during the molding of the frame, and allow for ease of insertion and removal of the plug connector to and from a corresponding receptacle connector. For example, a frame may include ledges, interlocks and rounded and tapered openings. Methods for manufacturing the frame are also provided.
摘要翻译：能够缩小尺寸的插头连接器的框架可以包括用于支撑触点的特征，用于与触点耦合的住宅电路，在框架的模制期间促进熔融材料的流动，并且允许容易地插入和移除插头连接器和相应的插座连接器。例如，框架可以包括凸缘，互锁和圆形和锥形开口。还提供了制造框架的方法。

4. 发明申请

WO2012103531A3 ANCHORS AND METHODS FOR INTESTINAL BYPASS SLEEVES 审中-公开
标题翻译：专用旁路系统的锚杆和方法
公开(公告)号：WO2012103531A3
公开(公告)日：2013-10-24
申请号：PCT/US2012023048
申请日：2012-01-28
申请人： METAMODIX INC , THOMPSON PAUL J , BELHE KEDAR R , GRAFOV ALEXANDER D
发明人： THOMPSON PAUL J , BELHE KEDAR R , GRAFOV ALEXANDER D
IPC分类号： A61M5/00
CPC分类号： A61F5/0076 , A61B17/064 , A61B17/0643 , A61B17/12036 , A61B17/1204 , A61B17/122 , A61B17/1227 , A61B2017/00818 , A61B2017/00986 , A61B2017/0641 , A61B2017/0647
摘要： A gastrointestinal device for implanting within a pylorus, a duodenal bulb, and a duodenum of a patient's gastrointestinal tract includes an expandable structure includes a proximal and distal portion having a plurality of spring arms, the proximal and distal portions coupled by a central cylinder having a diameter capable of fitting within the pylorus and having a length greater than a width of the pylorus. A membrane is coupled to and covering at least a portion of one of the proximal and distal portion of the expandable structure. An intestinal bypass sleeve is coupled to at least one of the proximal and distal portions of the expandable structure and having a length sufficient to extend at least partially into the duodenum. In the expanded configuration, the proximal and distal portions have a diameter larger than a maximum opening diameter of the pylorus.
摘要翻译：用于植入在幽门，十二指肠球囊和患者胃肠道十二指肠内的胃肠装置包括可扩张结构，其包括具有多个弹簧臂的近端部分和远端部分，近端部分和远端部分由具有直径能够安装在幽门内并且具有大于幽门宽度的长度。膜连接到并覆盖可扩张结构的近端部分和远端部分之一的至少一部分。肠旁路套管联接到可扩张结构的近端部分和远端部分中的至少一个，并且具有足以至少部分延伸到十二指肠的长度。在扩张构型中，近端部分和远端部分的直径大于幽门的最大开口直径。

5. 发明申请

WO2012068377A1 EXPANDABLE PYLORIC ANCHORS 审中-公开
标题翻译：可扩展的PYLORIC锚杆
公开(公告)号：WO2012068377A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/061193
申请日：2011-11-17
申请人： METAMODIX, INC. , THOMPSON, Paul, J. , BELHE, Kedar, R. , GRAFOV, Alex
发明人： THOMPSON, Paul, J. , BELHE, Kedar, R. , GRAFOV, Alex
IPC分类号： A61F5/00
CPC分类号： A61F5/0079
摘要： A gastrointestinal device for implanting within a patient's gastrointestinal tract includes first and second expandable anchoring rings configured to be disposed on either side of a patient's pylorus (106). The first expandable anchoring ring (120) has a collapsed configuration and an expanded configuration, wherein in the expanded configuration the first expandable anchoring ring has a diameter larger than a maximum opening diameter of the pylorus. The second expandable anchoring ring also has a collapsed configuration and an expanded configuration, wherein in the expanded configuration the second expandable anchoring ring has a diameter larger than a maximum opening diameter of the pylorus. An intestinal bypass sleeve (132) couples the first expandable anchoring ring and the second expandable anchoring ring, so as to allow a distance between the anchoring rings to exceed a width of the pylorus.
摘要翻译：用于植入患者胃肠道内的胃肠装置包括被配置为设置在患者幽门（106）的任一侧上的第一和第二可扩张锚定环。第一可膨胀锚定环（120）具有收缩构型和膨胀构型，其中在膨胀构型中，第一可膨胀锚定环的直径大于幽门的最大开口直径。第二可膨胀锚固环还具有收缩构型和膨胀构型，其中在膨胀构型中，第二可膨胀锚固环的直径大于幽门的最大开口直径。肠旁路套管（132）联接第一可膨胀锚定环和第二可膨胀锚固环，以便允许锚定环之间的距离超过幽门的宽度。

6. 发明申请

WO2011006098A2 EXTERNAL ANCHORING CONFIGURATIONS FOR MODULAR GASTROINTESTINAL PROSTHESES 审中-公开
标题翻译：用于模块化气体放置的外部锚固配置
公开(公告)号：WO2011006098A2
公开(公告)日：2011-01-13
申请号：PCT/US2010041574
申请日：2010-07-09
申请人： METAMODIX INC , BELHE KEDAR R , THOMPSON PAUL J
发明人： BELHE KEDAR R , THOMPSON PAUL J
IPC分类号： A61F2/04
CPC分类号： A61F5/0076 , A61F5/003
摘要： Components may be used separately or in combination to create anchoring systems for intra-luminal implants for the treatment of metabolic disorders such as obesity and diabetes. Various systems include an external component adapted for deployment around a portion of the gastrointestinal tract (e.g., the duodenum) and an internal component adapted for implantation within the gastrointestinal tract. Various systems use anchoring means that are based on mechanical interference, elasticity, spring force, shape memory transformation, magnetic attraction, repulsion and/or levitation. Various embodiments rely on longitudinal anchoring of the implants with minimal force against tissue.
摘要翻译：组分可以单独使用或组合使用以产生腔内植入物用于治疗代谢紊乱如肥胖症和糖尿病的锚定系统。各种系统包括适于部署在胃肠道的一部分（例如，十二指肠）周围的外部部件和适于植入胃肠道内部的内部部件。各种系统使用基于机械干涉，弹性，弹簧力，形状记忆变换，磁吸引，排斥和/或悬浮的锚固装置。各种实施例依赖于对组织的最小力的植入物的纵向锚固。

7. 发明申请

WO2010115011A1 MODULAR GASTROINTESTINAL PROSTHESES 审中-公开
标题翻译：模块化胃肠疾病
公开(公告)号：WO2010115011A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029648
申请日：2010-04-01
申请人： METAMODIX, INC. , BELHE, Kedar R., Dr. , THOMPSON, Paul J.
发明人： BELHE, Kedar R., Dr. , THOMPSON, Paul J.
IPC分类号： A61F5/00 , A61F2/86
CPC分类号： A61F5/0076 , A61F5/0079 , A61F2002/044 , A61F2002/045
摘要： A modular system for therapy within a gastrointestinal system. The system includes anchoring or attachment functionality (110) embodied in a low-profile implant technology (111) and removable therapy components, which can be reversibly attached to these low-profile implants to accomplish various therapies. This modular design allows the physician to tailor the therapy to the patient's needs. The modular system has the potential to create conduits for diversion and/or restriction of food and organ secretions and to facilitate the treatment of metabolic disorders such as obesity and T2DM.
摘要翻译：用于胃肠系统内治疗的模块化系统。该系统包括体现在低轮廓植入技术（111）中的锚定或附接功能（110）和可移除的治疗部件，其可逆地附接到这些低轮廓植入物以完成各种治疗。这种模块化设计允许医师根据患者的需要定制治疗。模块化系统有可能为食物和器官分泌物的转移和/或限制创建导管，并有助于治疗代谢性疾病如肥胖和T2DM。

8. 发明申请

WO2011085234A1 GASTROINTESTINAL PROSTHESES HAVING PARTIAL BYPASS CONFIGURATIONS 审中-公开
标题翻译：具有部分旁路配置的气体发生器
公开(公告)号：WO2011085234A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020560
申请日：2011-01-07
申请人： METAMODIX, INC. , BELHE, Kedar R. , THOMPSON, Paul J.
发明人： BELHE, Kedar R. , THOMPSON, Paul J.
IPC分类号： A61F2/04
CPC分类号： A61F5/0076 , A61F5/005 , A61F2002/045
摘要： A system of components may be used separately or in combination to create partial bypass of food, stomach and intestinal secretions and digestive enzymes. The systems are designed to be modular so as to allow the physicians to quickly replace certain elements to tailor the amount of material bypassed, the restriction applied to food passage, and the origin and destination of bypass according to the patient's individualized clinical needs.
摘要翻译：组分体系可以单独使用或组合使用以产生食物，胃和肠分泌物和消化酶的部分旁路。这些系统被设计为模块化的，以便允许医生根据患者的个性化临床需要，迅速地替换某些元件以调整旁路材料的量，应用于食物通过的限制以及旁路的起点和目的地。

9. 发明申请

WO2011006098A3 EXTERNAL ANCHORING CONFIGURATIONS FOR MODULAR GASTROINTESTINAL PROSTHESES 审中-公开
公开(公告)号：WO2011006098A3
公开(公告)日：2011-01-13
申请号：PCT/US2010/041574
申请日：2010-07-09
申请人： METAMODIX, INC. , BELHE, Kedar R. , THOMPSON, Paul J.
发明人： BELHE, Kedar R. , THOMPSON, Paul J.
IPC分类号： A61F5/00
摘要： Components may be used separately or in combination to create anchoring systems for intra-luminal implants for the treatment of metabolic disorders such as obesity and diabetes. Various systems include an external component adapted for deployment around a portion of the gastrointestinal tract (e.g., the duodenum) and an internal component adapted for implantation within the gastrointestinal tract. Various systems use anchoring means that are based on mechanical interference, elasticity, spring force, shape memory transformation, magnetic attraction, repulsion and/or levitation. Various embodiments rely on longitudinal anchoring of the implants with minimal force against tissue.

10. 发明授权

US2814242A Hot air diffuser or distributor of the type known as a hot air mopboard or baseboard 失效
标题翻译：称为热风摩托车或踢脚板的热风扩散器或分配器
公开(公告)号：US2814242A
公开(公告)日：1957-11-26
申请号：US31119652
申请日：1952-09-24
申请人： MARINI THOMAS O , THOMPSON PAUL J
发明人： MARINI THOMAS O , THOMPSON PAUL J
IPC分类号： F24F13/12
CPC分类号： F24F13/12

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