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1. 发明申请

WO2009157771A3 ANTIBODY PRODUCING NON-HUMAN MAMMALS 审中-公开
标题翻译：抗生素生产非人类哺乳动物
公开(公告)号：WO2009157771A3
公开(公告)日：2010-02-18
申请号：PCT/NL2009050381
申请日：2009-06-29
申请人： MERUS B V , HOUTZAGER ERWIN , PINTO RUI DANIEL , LOGTENBERG TON , THROSBY MARK , KRAMER ROBERT ARJEN , DE KRUIF CORNELIS ADRIAAN
发明人： HOUTZAGER ERWIN , PINTO RUI DANIEL , LOGTENBERG TON , THROSBY MARK , KRAMER ROBERT ARJEN , DE KRUIF CORNELIS ADRIAAN
IPC分类号： A01K67/027 , C07K16/00 , C12N5/10 , C12N15/85
CPC分类号： A01K67/0276 , A01K67/0275 , A01K2217/052 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K2317/21 , C07K2317/24 , C12N15/8509 , C12N2800/30
摘要： The invention provides transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. The invention further provides methods for producing an immunoglobulin from the transgenic, non-human animal.
摘要翻译：本发明提供了包含编码免疫球蛋白轻链的核酸的转基因非人动物，其中免疫球蛋白轻链是人类，人类样或人源化的。为核酸提供了使其对DNA重排和/或体细胞超突变有抗性的手段。在一个实施方案中，所述核酸包含用于在发育成熟B细胞的细胞的某一发育阶段期间在细胞中表达所需分子的表达盒。本发明还提供从转基因非人动物中产生免疫球蛋白的方法。

2. 发明申请

WO2005068622A3 MIXTURES OF BINDING PROTEINS 审中-公开
标题翻译：结合蛋白的混合物
公开(公告)号：WO2005068622A3
公开(公告)日：2006-03-02
申请号：PCT/NL2005000036
申请日：2005-01-19
申请人： MERUS B V , LOGTENBERG TON , HOOGENBOOM HENDRICUS RENERUS J
发明人： LOGTENBERG TON , HOOGENBOOM HENDRICUS RENERUS J
IPC分类号： C12P21/08 , C07K16/00 , C12N5/10 , C12P21/02
CPC分类号： C12N15/1086 , C07K16/10 , C07K16/20 , C07K16/40 , C07K2317/22 , C07K2317/569 , C07K2318/20 , C12N15/1082
摘要： The invention provides methods for the production of libraries of cells expressing at least two separate single polypeptide chain binding proteins, in which the binding proteins have different target epitopes. Such libraries are made by integration of the nucleic acid sequences encoding the polypeptide chains into the genome of the host cell, and selecting for cells that have successfully integrated these nucleic acids. The selected cells are preferably subjected to a cloning step. Mixtures of binding proteins are produced without having to individually produce each of the components of the mixture. A library of cells wherein essentially each cell encodes at least two single polypeptide chain binding proteins having different target epitopes is also herewith provided, as well as methods for producing a composition comprising at least two separate single polypeptide chain binding proteins having different target epitopes.
摘要翻译：本发明提供了产生表达至少两种分开的单个多肽链结合蛋白的细胞文库的方法，其中结合蛋白具有不同的靶表位。通过将编码多肽链的核酸序列整合到宿主细胞的基因组中并选择成功整合这些核酸的细胞来制备此类文库。所选择的细胞优选进行克隆步骤。产生结合蛋白的混合物，而不必单独产生混合物的每种组分。还提供了其中基本上每个细胞编码至少两种具有不同靶表位的单个多肽链结合蛋白的细胞库，以及用于产生包含至少两种具有不同靶表位的单独多肽链结合蛋白的组合物的方法。

3. 发明专利

ZA201407835B METHODS AN MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES 未知
公开(公告)号：ZA201407835B
公开(公告)日：2015-12-23
申请号：ZA201407835
申请日：2014-10-27
申请人： MERUS B V
发明人： HENDRIKS LINDA JOHANNA ALEIDA , LOGTENBERG TON , DE KRUIF CORNELIS ADRIAAN
摘要： The invention provides means and methods for producing one or more Ig-like molecules in a single host cell. Novel CH3 mutations enabling the production of monospecific and/or bispecific Ig-like molecules of interest are also provided.

4. 发明专利

MX2015003885A ANTICUERPOS IGG BIESPECIFICOS, ACOPLADORES DE LINFOCITOS T. 未知
公开(公告)号：MX2015003885A
公开(公告)日：2015-07-06
申请号：MX2015003885
申请日：2013-09-27
申请人： MERUS B V
发明人： LOGTENBERG TON , BAKKER ALEXANDER BERTHOLD HENDRIK , LOO PIETER FOKKO VAN
IPC分类号： C07K16/28
摘要： La presente invención proporciona anticuerpos biespecíficos IgG humanos, en donde un brazo del anticuerpo que une un epítopo sobre células efectoras inmunitarias mientras que el otro brazo se dirige a CLEC12A o un equivalente funcional del mismo. También se proporcionan usos farmacéuticos de estos anticuerpos contra cánceres malignos tales como MDS, CML o AML.

5. 发明专利

SG10201408500RA ANTIBODY PRODUCING NON-HUMAN MAMMALS 未知
公开(公告)号：SG10201408500RA
公开(公告)日：2015-01-29
申请号：SG10201408500R
申请日：2009-06-29
申请人： MERUS B V
发明人： HOUTZAGER ERWIN , PINTO RUI DANIEL , LOGTENBERG TON , THROSBY MARK , KRAMER ROBERT ARJEN , DE KRUIF CORNELIS ADRIAAN
摘要： 94 Title: Antibody producing non-human 5 The invention provides transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression 10 cassette for the expression of a desired molecule in cells during a certain stage of development cells in developing into mature B cells. The invention further provides methods for producing an immunoglobulin from the transgenic, non-human animal. (No suitable figure)

6. 发明专利

RS53146B ANTIBODY PRODUCING NON-HUMAN MAMMALS 未知
公开(公告)号：RS53146B
公开(公告)日：2014-06-30
申请号：RSP20140063
申请日：2009-06-29
申请人： MERUS B V
发明人： HOUTZAGER ERWIN , PINTO RUI DANIEL , LOGTENBERG TON , THROSBY MARK
IPC分类号： A01K67/027 , C07K16/00 , C12N5/10 , C12N15/85
摘要： The invention provides transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. The invention further provides methods for producing an immunoglobulin from the transgenic, non-human animal.

7. 发明专利

CA2889681A1 BISPECIFIC IGG ANTIBODIES AS T CELL ENGAGERS 未知
公开(公告)号：CA2889681A1
公开(公告)日：2014-04-03
申请号：CA2889681
申请日：2013-09-27
申请人： MERUS B V
发明人： BAKKER ALEXANDER BERTHOLD HENDRIK , VAN LOO PIETER FOKKO , LOGTENBERG TON
IPC分类号： C07K16/28
摘要： The present invention provides human IgG bispecific antibodies, wherein one arm of the antibody binds an epitope on immune effector cells, whilst the other arm targets CLEC12A or a functional equivalent thereof. Pharmaceutical uses of these antibodies against malignancies such as MDS, CML or AML are also provided.

8. 发明专利

HRP20140139T1 PROTUTIJELA KOJA PROIZVODE NEHUMANI SISAVCI 未知
公开(公告)号：HRP20140139T1
公开(公告)日：2014-03-14
申请号：HRP20140139
申请日：2014-02-13
申请人： MERUS B V
发明人： HOUTZAGER ERWIN , PINTO RUI DANIEL , LOGTENBERG TON , THROSBY MARK
IPC分类号： A01K67/027 , C07K16/00 , C12N5/10 , C12N15/85

9. 发明专利

SI2147594T1 Protitelo proizvajajoči ne-humani sesalci 未知
公开(公告)号：SI2147594T1
公开(公告)日：2014-02-28
申请号：SI200930829
申请日：2009-06-29
申请人： MERUS B V
发明人： HOUTZAGER ERWIN , PINTO RUI DANIEL , LOGTENBERG TON , THROSBY MARK
IPC分类号： A01K67/00 , C07K16/00 , C12N5/00 , C12N15/00

10. 发明专利

CA2791109A1 GENERATION OF BINDING MOLECULES 未知
公开(公告)号：CA2791109A1
公开(公告)日：2013-03-26
申请号：CA2791109
申请日：2012-09-25
申请人： MERUS B V
发明人： THROSBY MARK , DE KRUIF CORNELIS ADRIAAN , LOGTENBERG TON
IPC分类号： C40B50/06 , A61K39/395 , C07K16/00 , C12N15/00 , C12N15/13 , C12P21/08 , C12Q1/68 , C40B30/04 , G01N33/577
摘要： A method is described for generating binding molecules. A defined population of binding molecules is produced using at least the following steps: (a) providing a population of B cells expressing a limited VL repertoire wherein essentially all B cells carry at least one VL; (b) obtaining nucleic acids from said B cells; (c) optionally, amplifying nucleic acids encoding immunoglobulin heavy chain variable regions in said sample; (d) at least partial sequencing of essentially all obtained nucleic acids of step (b) or amplification products of step (c); (e) performing frequency analysis of sequences from step (d); (f) selecting desired VH sequences; (g) providing a host cell with at least one vector comprising at least one of said desired VH sequences and/or at least one VL sequence of said limited VL repertoire; (h) culturing host cells and allowing for expression of VH or VL polypeptides; and (i) obtaining said binding molecules.

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