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1. 发明申请

WO2022173714A2 ANTIBODIES THAT BIND METAPNEUMOVIRUS, ANTIGENIC METAPNEUMOVIRUS PROTEINS, AND USES THEREOF 审中-公开
公开(公告)号：WO2022173714A2
公开(公告)日：2022-08-18
申请号：PCT/US2022/015565
申请日：2022-02-08
申请人： MERCK SHARP & DOHME LLC , CHEN, Zhifeng , COX, Kara, S. , FRIDMAN, Arthur , GALLI, Jennifer Dawn , SU, Hua-Poo , TANG, Aimin , VORA, Kalpit , WEN, Zhiyun , XIAO, Xiao , ZHANG, Lan
发明人： CHEN, Zhifeng , COX, Kara, S. , FRIDMAN, Arthur , GALLI, Jennifer Dawn , SU, Hua-Poo , TANG, Aimin , VORA, Kalpit , WEN, Zhiyun , XIAO, Xiao , ZHANG, Lan
IPC分类号： A61K39/395 , C07K16/1018 , C07K16/1027 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to anti-human metapneumovirus (hMPV) antibodies, as well as use of such antibodies in the treatment of viral infections. The invention also includes antigenic hMPV proteins and immunogenic compositions comprising such antigenic hMPV proteins, and the use of such antigenic hMPV proteins and related compositions for preventing or treating viral infection in a subject.

2. 发明申请

WO2017075124A1 ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：抗体中和人呼吸道合胞病毒
公开(公告)号：WO2017075124A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/058975
申请日：2016-10-27
申请人： MERCK SHARP & DOHME CORP. , VORA, Kalpit, A. , COX, Kara, S. , TANG, Aimin , CHEN, Zhifeng , DISTEFANO, Daniel , ZHANG, Lan , SU, Hua-Poo
发明人： VORA, Kalpit, A. , COX, Kara, S. , TANG, Aimin , CHEN, Zhifeng , DISTEFANO, Daniel , ZHANG, Lan , SU, Hua-Poo
IPC分类号： C07K16/10 , A61P31/14
CPC分类号： C07K16/1027 , A61K39/42 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
摘要翻译：本发明涉及具有高抗RSV中和滴度的单克隆抗体。本发明进一步提供了编码本发明抗体的分离的核酸和用其转化的宿主细胞。本发明进一步提供了采用本发明的抗体和核酸的诊断，预防和治疗方法，特别是作为婴幼儿和老年人的被动免疫治疗剂。

3. 发明申请

WO2020123268A1 METHOD FOR IDENTIFYING HIGH AFFINITY MONOCLONAL ANTIBODY HEAVY AND LIGHT CHAIN PAIRS FROM HIGH THROUGHPUT SCREENS OF B-CELL AND HYBRIDOMA LIBRARIES 审中-公开
公开(公告)号：WO2020123268A1
公开(公告)日：2020-06-18
申请号：PCT/US2019/064813
申请日：2019-12-06
申请人： MERCK SHARP & DOHME CORP. , DURR, Eberhard , LIU, Yaping , CHEN, Zhifeng , FRIDMAN, Arthur
发明人： DURR, Eberhard , LIU, Yaping , CHEN, Zhifeng , FRIDMAN, Arthur
IPC分类号： G01N33/68 , C07K16/00
摘要： A method is described for identifying high affinity monoclonal antibody heavy and light chain pairs from high throughput screens of antibody producing cell libraries such as B-cell and hybridoma libraries. Specifically, the method relates to application of reversed immunocapture and high resolution tandem mass spectrometry for the identification of heavy and light chain pairs of binding antibodies obtained from high throughput screens of antibody producing cell libraries.

4. 发明公开

EP4291232A2 ANTIBODIES THAT BIND METAPNEUMOVIRUS, ANTIGENIC METAPNEUMOVIRUS PROTEINS, AND USES THEREOF 审中-公开
公开(公告)号：EP4291232A2
公开(公告)日：2023-12-20
申请号：EP22753192.8
申请日：2022-02-08
申请人： Merck Sharp & Dohme LLC
发明人： CHEN, Zhifeng , COX, Kara, S. , FRIDMAN, Arthur , GALLI, Jennifer Dawn , SU, Hua-Poo , TANG, Aimin , VORA, Kalpit , WEN, Zhiyun , XIAO, Xiao , ZHANG, Lan
IPC分类号： A61K39/395

5. 发明申请

WO2012061258A2 PARAMETRIC BIT RATE MODEL FOR FRAME-LEVEL RATE CONTROL IN VIDEO CODING 审中-公开
标题翻译：视频编码中帧率控制的参数比特率模型
公开(公告)号：WO2012061258A2
公开(公告)日：2012-05-10
申请号：PCT/US2011/058480
申请日：2011-10-28
申请人： VID SCALE, INC. , CHEN, Zhifeng , DOKEN, Serhad
发明人： CHEN, Zhifeng , DOKEN, Serhad
IPC分类号： G06T7/20
CPC分类号： H04N19/19 , H04N19/124 , H04N19/142 , H04N19/147
摘要： Methods, systems and apparatuses for performing frame-level rate control in video coding are provided. Included among such methods, systems and apparatuses is a method that includes obtaining an estimated average variance associated with video residual data, and obtaining a target bit rate. The method may also include using the target bit rate, the estimated average variance and an entropy estimation based on non-identically distributed coefficients, to determine a quantization parameter for transform coefficients of the video residual data. The method may further include calculating quantized transform coefficients using the quantization parameter.
摘要翻译：提供了用于在视频编码中执行帧级速率控制的方法，系统和装置。在这些方法中，系统和装置包括获得与视频残差数据相关联的估计平均方差，以及获得目标比特率的方法。该方法还可以包括使用目标比特率，估计的平均方差和基于非相同分布系数的熵估计来确定用于视频残差数据的变换系数的量化参数。该方法还可以包括使用量化参数来计算量化的变换系数。

6. 发明申请

WO2010033229A2 METHODS AND VECTORS FOR DISPLAY OF MOLECULES AND DISPLAYED MOLECULES AND COLLECTIONS 审中-公开
标题翻译：显示分子和显示分子和收集的方法和矢量
公开(公告)号：WO2010033229A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/005221
申请日：2009-09-18
申请人： CALMUNE CORPORATION , WILLIAMSON, Robert, Anthony , WADIA, Jehangir , MARUYAMA, Toshiaki , CHEN, Zhifeng , NELSON, Joshua
发明人： WILLIAMSON, Robert, Anthony , WADIA, Jehangir , MARUYAMA, Toshiaki , CHEN, Zhifeng , NELSON, Joshua
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , C07K2317/54 , C07K2317/622 , C07K2317/624 , C12N15/1037
摘要： Provided herein are methods for generating diverse polypeptide and nucleic acid molecule libraries and collections, and the collections and libraries; methods for selecting variant polypeptides and nucleic acid molecules from the libraries; and molecules selected from the libraries. Exemplary of the polypeptides and nucleic acid molecules are antibodies and nucleic acids encoding the antibodies (including antibody fragments and domain exchanged antibodies). Also provided herein are methods of displaying polypeptides such as antibodies, for example on the surface of genetic packages, such as phage; and libraries and collections of the displayed polypeptides and vectors for producing the displayed polypeptides, libraries and collections. Exemplary of the displayed antibodies are domain exchanged antibodies.
摘要翻译：本文提供了用于产生不同多肽和核酸分子文库和集合的方法，以及收集和文库; 从文库中选择变体多肽和核酸分子的方法; 和选自图书馆的分子。多肽和核酸分子的示例是编码抗体的抗体和核酸（包括抗体片段和结构域交换的抗体）。本文还提供了显示多肽例如抗体的方法，例如在遗传包装的表面上，例如噬菌体; 以及用于产生所显示的多肽，文库和集合的显示的多肽和载体的文库和集合。显示的抗体的示例是域交换的抗体。

7. 发明申请

WO2007071557A2 MANAGEMENT OF STORAGE RESOURCE CAPACITY 审中-公开
标题翻译：存储资源管理能力
公开(公告)号：WO2007071557A2
公开(公告)日：2007-06-28
申请号：PCT/EP2006/069343
申请日：2006-12-05
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , CHEN, Zhifeng , GONZALES, Cesar , IYER, Balakrishna, Raghavendra , POFF, Dan , ROBINSON, John, Timothy
发明人： CHEN, Zhifeng , GONZALES, Cesar , IYER, Balakrishna, Raghavendra , POFF, Dan , ROBINSON, John, Timothy
IPC分类号： G06F3/06
CPC分类号： G06F3/0644 , G06F3/0608 , G06F3/0674
摘要： A method for increasing virtual storage capacity in on-demand storage systems utilizes data compression to selectively compress data stored in a storage resource to reduce the utilization of physical storage space whenever such physical resources have been over committed and the demand for physical storage exceeds its availability. In one exemplary embodiment, the utilization of the capacity of a shared storage resource is monitored and data is selected for compression based on the utilization. The compression of the selected data is triggered in response to the monitoring results. In addition, policies and rules are defined that determine which data is selected for compression. For example, the selection of data may be based on one or more of the following: a degree of utilization of said capacity of said shared storage resource, a volume size of said data, an indicator of compressibility of said data, a frequency of use of said data, a manual selection of said data, and a predefined priority of said data. The disclosed methods improve the operation of virtual allocation by further enhancing the availability of physical space through data compression. Virtual allocation and block-based data compression techniques are utilized to improve storage efficiency with a minimal risk to system availability and reliability and with a minimal impact to access time and latency.
摘要翻译：在按需存储系统中增加虚拟存储容量的方法利用数据压缩来选择性地压缩存储在存储资源中的数据，以减少物理存储空间的利用，只要这些物理资源已经过度承诺并且对物理存储的需求超过其可用性。在一个示例性实施例中，监视共享存储资源的容量的利用，并且基于利用率选择数据进行压缩。响应于监视结果触发所选数据的压缩。另外，定义了决定哪些数据被选择用于压缩的策略和规则。例如，数据的选择可以基于以下中的一个或多个：所述共享存储资源的所述容量的利用程度，所述数据的卷大小，所述数据的可压缩性的指标，使用频率所述数据的手动选择，以及所述数据的预定优先级。所公开的方法通过进一步增强通过数据压缩的物理空间的可用性来改进虚拟分配的操作。利用虚拟分配和基于块的数据压缩技术来提高存储效率，同时对系统可用性和可靠性的风险最小，对访问时间和延迟的影响最小。

8. 发明申请

WO2010033237A2 METHODS FOR CREATING DIVERSITY IN LIBRARIES AND LIBRARIES, DISPLAY VECTORS AND METHODS, AND DISPLAYED MOLECULES 审中-公开
标题翻译：用于在图书馆和图书馆中创建多样性的方法，显示载体和方法以及显示的分子
公开(公告)号：WO2010033237A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/005230
申请日：2009-09-18
申请人： CALMUNE CORPORATION , WILLIAMSON, Robert, Anthony , WADIA, Jehangir , MARUYAMA, Toshiaki , CHEN, Zhifeng , NELSON, Joshua
发明人： WILLIAMSON, Robert, Anthony , WADIA, Jehangir , MARUYAMA, Toshiaki , CHEN, Zhifeng , NELSON, Joshua
IPC分类号： C12N15/09
CPC分类号： C12N15/1027 , C07K16/005 , C07K16/087 , C07K16/1063 , C07K2317/565 , C12N15/1037 , C40B40/08 , C40B50/06
摘要： Provided herein are methods for generating diverse polypeptide and nucleic acid molecule libraries and collections, and the collections and libraries; methods for selecting variant polypeptides and nucleic acid molecules from the libraries; and molecules selected from the libraries. Exemplary of the polypeptides and nucleic acid molecules are antibodies and nucleic acids encoding the antibodies (including antibody fragments and domain exchanged antibodies). Also provided herein are methods of displaying polypeptides such as antibodies, for example on the surface of genetic packages, such as phage; and libraries and collections of the displayed polypeptides and vectors for producing the displayed polypeptides, libraries and collections. Exemplary of the displayed antibodies are domain exchanged antibodies.
摘要翻译：本文提供了用于产生不同的多肽和核酸分子文库和集合以及集合和文库的方法; 从文库中选择变体多肽和核酸分子的方法; 和选自文库的分子。多肽和核酸分子的例子是抗体和编码抗体的核酸（包括抗体片段和结构域交换的抗体）。本文还提供了展示多肽例如抗体的方法，例如在遗传包装例如噬菌体的表面上; 以及展示的多肽和载体的文库和集合，用于产生展示的多肽，文库和收藏品。展示的抗体的例子是结构域交换的抗体。

9. 发明申请

WO2013025534A1 METHODS AND SYSTEMS FOR PACKET DIFFERENTIATION 审中-公开
标题翻译：分组差异的方法和系统
公开(公告)号：WO2013025534A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/050405
申请日：2012-08-10
申请人： VID SCALE, INC. , MA, Liangping , ZIERA, Ariela , SHAHEEN, Kamel, M. , LIU, Hang , DENG, Zhuorong , LIU, Weimin , WALLACE, Chris , RAPAPORT, Avi , CHEN, Zhifeng , HEPLER, Edward, L. , MILLER, James, M. , PRAGADA, Ravikumar, V. , RYU, Eun
发明人： MA, Liangping , ZIERA, Ariela , SHAHEEN, Kamel, M. , LIU, Hang , DENG, Zhuorong , LIU, Weimin , WALLACE, Chris , RAPAPORT, Avi , CHEN, Zhifeng , HEPLER, Edward, L. , MILLER, James, M. , PRAGADA, Ravikumar, V. , RYU, Eun
IPC分类号： H04L12/56
CPC分类号： H04N19/66 , H04L47/20 , H04L47/2408 , H04L47/34 , H04L47/624 , H04L49/3009 , H04L65/4053 , H04L65/602 , H04L65/80 , H04W4/18 , H04W28/065
摘要： Methods and systems are disclosed facilitate differentiated QoS service for packets within a single packet stream. For example, extended QCI values may be used to differentiate service of video packets associated with different priorities. A flexible representation of QoS requirements/parameters is disclosed where QoS may be defined as a hyperspace that is a function of base QoS parameters. A WTRU may explicitly specify and/or request desired QoS parameters. A WTRU may be configured to perform one or more of video packet separation into a plurality of video packet sub-streams, merging of the video packet sub-streams, and/or reordering of the packets included in the video packet sub-streams. Techniques may be utilized to exposing more information to a data transmission network regarding the type of video packets (and/or other packets) being transmitted.
摘要翻译：公开的方法和系统有助于在单个分组流内的分组的差分QoS服务。例如，可以使用扩展QCI值来区分与不同优先级相关联的视频分组的服务。公开了QoS要求/参数的灵活表示，其中QoS可以被定义为作为基本QoS参数的函数的超空间。 WTRU可以明确地指定和/或请求所需的QoS参数。 WTRU可以被配置为执行视频分组分离成多个视频分组子流中的一个或多个，视频分组子流的合并和/或包括在视频分组子流中的分组的重新排序。可以使用技术来向数据传输网络发送关于正被发送的视频分组（和/或其他分组）的类型的更多信息。

10. 发明申请

WO2012058394A1 SYSTEMS AND METHODS FOR ADAPTIVE VIDEO CODING 审中-公开
标题翻译：用于自适应视频编码的系统和方法
公开(公告)号：WO2012058394A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/058027
申请日：2011-10-27
申请人： VID SCALE, INC. , DOKEN, Serhad , CHEN, Zhifeng , DONG, Jie , YE, Yan
发明人： DOKEN, Serhad , CHEN, Zhifeng , DONG, Jie , YE, Yan
IPC分类号： H04N7/26 , H04N7/30 , H04N7/46
CPC分类号： H04N19/59 , H04N19/117 , H04N19/146 , H04N19/147 , H04N19/172 , H04N19/189 , H04N19/196 , H04N19/587 , H04N19/60 , H04N19/85
摘要： Systems and methods are described for determining an optimised sampling ratio for coding video data that reduces overall distortion introduced by the coding process. It seeks to balance the information loss introduced during downsampling and the information loss introduced during coding. The sampling ratio is generally determined by reducing, or in some cases minimizing, the overall error introduced through the downsampling process and the coding process, and may be adaptive based on the content of the video data being processed and a target bit rate. Computation power can be saved by coding a downsampled video. The process derives a plurality of downsampling ratios, and selects a downsampling ratio that reduces the total amount of distortion introduced during the down - sampling and coding stages. The down - sampling ratio may be selected given the available data transmission capacity, input video signal statistics, and/or other operational parameters, and may optimally reduce the overall distortion.
摘要翻译：描述了用于确定用于编码视频数据的优化采样率的系统和方法，其减少由编码过程引入的整体失真。它寻求平衡在下采样期间引入的信息丢失和编码期间引入的信息丢失。采样率通常通过减小或在一些情况下最小化通过下采样处理和编码处理引入的总体误差来确定，并且可以基于正在处理的视频数据的内容和目标比特率来自适应。可以通过对下采样视频进行编码来节省计算功率。该过程导出多个下采样比，并且选择降低在下采样和编码阶段期间引入的失真总量的下采样比。给定可用数据传输容量，输入视频信号统计和/或其他操作参数可以选择下采样比，并且可以最佳地降低整体失真。

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