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1. 发明专利

AR122007A1 INHIBIDORES DE IL4I1 Y MÉTODOS DE USO 未知
公开(公告)号：AR122007A1
公开(公告)日：2022-08-03
申请号：ARP210101215
申请日：2021-05-04
申请人： MERCK SHARP & DOHME
发明人： CASH BRANDON D , FU WENLANG , GIAMBASU GEORGE MADALIN , HAIDLE ANDREW M , HOPKINS BRETT A , LARSEN MATTHEW A , LESBURG CHARLES A , LIU PING , MGOWAN MEREDETH A , PU QINGLIN , SANYAL SULAGNA , SILIPHAIVANH PHIENG , WHITE CATHERINE M , YAN XIN
IPC分类号： C07D403/10 , A61K31/4184 , A61P35/00 , C07D235/26 , C07D401/06 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/10 , C07D419/10
摘要： En el presente documento, se describen compuestos de fórmula (1) o una sal farmacéuticamente aceptable del mismo. Los compuestos de fórmula (1) actúan como inhibidores de IL4I1, y pueden ser útiles en la prevención, el tratamiento o la actuación como agente curativo de enfermedades relacionadas con IL4I1. Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo, en donde: X es CH o S, en donde, cuando X es S, Z es CH; Y es CH o un enlace; Z es CH o S, en donde, cuando Z es S, X es CH; A es arilo, cicloalquilo C₃₋₁₀, heteroarilo o cicloheteroalquilo; L es un alquilenilo (C₁₋₅) lineal o ramificado, en donde uno o más grupos -CH₂- de L se reemplazan opcional e independientemente con un resto seleccionado del grupo que consiste en O y NH; R¹ es halógeno, alquilo C₁₋₆ o cicloheteroalquilo; cada aparición de R² se selecciona independientemente entre -alquil C₁₋₆-NR⁴CO-cicloalquilo C₃₋₆, -alquil C₁₋₆-NR⁴CO-alquilo C₁₋₆, -alquil C₁₋₆-CONR⁴-alquilo C₁₋₆, halógeno, alcoxi, -alquil C₁₋₆-cicloheteroalquilo, -alquil C₁₋₆-CONR⁴-arilo, alquilo C₁₋₆, -alquil C₁₋₆-CO-cicloheteroalquilo, -alquil C₁₋₆-CONR⁴-heteroarilo, -alquil C₁₋₆-NR⁴SO₂-alquilo C₁₋₆, -alquil C₁₋₆-NR⁴SO₂-cicloalquilo C₃₋₆, cicloalquilo C₃₋₆, -alquil C₁₋₆-CONR⁴-cicloalquilo C₃₋₆, cicloheteroalquilo, haloalquilo C₁₋₆, -CONR⁴-haloalquilo, -CO-cicloheteroalquilo, CN, -CONR⁴-alquilo C₁₋₆, -CONR⁴-cicloalquilo C₃₋₆, heteroarilo, arilo, haloalcoxi, -alquil C₁₋₆-cicloalquilo C₃₋₁₀, oxo, -alquil C₁₋₆-heteroarilo, -NR⁴CO-alquilo C₁₋₆, en donde el -alquil C₁₋₆-NR⁴CO-cicloalquilo C₃₋₆, -alquil C₁₋₆-CONR⁴-cicloalquilo C₃₋₆, -alquil C₁₋₆-CONR⁴-arilo, alquil C₁₋₆-cicloheteroalquilo, -alquil C₁₋₆-CO-cicloheteroalquilo, cicloalquilo C₃₋₆, cicloheteroalquilo, heteroarilo, -alquil C₁₋₆-cicloalquilo C₃₋₁₀, está sin sustituir o sustituido con 1 a 3 sustituyentes seleccionados del grupo que consiste en alcoxi, CN, -alquil C₁₋₆-OH, halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, oxo, OH, CN, -alquil C₁₋₆-CN, -CO-alquilo C₁₋₆ y cicloalquilo C₃₋₆; R³ es hidrógeno, alquilo C₁₋₆ o halo-alquilo C₁₋₆; R⁴ es alquilo C₁₋₆ o hidrógeno; m es 0, 1 ó 2; y n es 0, 1, 2 ó 3.

2. 发明专利

AU2021268614A1 IL4I1 inhibitors and methods of use 未知
公开(公告)号：AU2021268614A1
公开(公告)日：2022-12-08
申请号：AU2021268614
申请日：2021-05-04
申请人： MERCK SHARP & DOHME LLC
发明人： CASH BRANDON D , FU WENLANG , GIAMBASU GEORGE MADALIN , HAIDLE ANDREW M , HOPKINS BRETT A , LARSEN MATTHEW A , LESBURG CHARLES A , LIU PING , MCGOWAN MEREDETH A , PU QINGLIN , SANYAL SULAGNA , SILIPHAIVANH PHIENG , WHITE CATHERINE M , YAN XIN
IPC分类号： C07D403/10 , A61K31/4184 , A61P35/00 , C07D235/26 , C07D401/06 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/10 , C07D417/10 , C07D419/10 , C07D495/04
摘要： Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases.

4. 发明专利

AU2018368332B2 Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors 未知
公开(公告)号：AU2018368332B2
公开(公告)日：2022-05-12
申请号：AU2018368332
申请日：2018-11-12
申请人： MERCK SHARP & DOHME
发明人： HAN YONGXIN , ACHAB ABDELGHANI , DENG YONGQI , FRADERA XAVIER , GIBEAU CRAIG , HOPKINS BRETT A , LI DERUN , LIU KUN , MCGOWAN MEREDETH A , SCIAMMETTA NUNZIO , SLOMAN DAVID , WHITE CATHERINE , ZHANG HONGJUN , ZHOU HUA
IPC分类号： C07D405/14 , A61K31/337 , A61K31/437 , A61K31/443 , A61K31/444 , A61P31/00 , A61P35/00 , A61P37/00 , C07D209/46 , C07D213/56 , C07D231/12 , C07D241/12 , C07D263/32 , C07D305/08 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

5. 发明专利

AU2018368332A1 Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors 未知
公开(公告)号：AU2018368332A1
公开(公告)日：2020-04-23
申请号：AU2018368332
申请日：2018-11-12
申请人： MERCK SHARP & DOHME
发明人： HAN YONGXIN , ACHAB ABDELGHANI , DENG YONGQI , FRADERA XAVIER , GIBEAU CRAIG , HOPKINS BRETT A , LI DERUN , LIU KUN , MCGOWAN MEREDETH A , SCIAMMETTA NUNZIO , SLOMAN DAVID , WHITE CATHERINE , ZHANG HONGJUN , ZHOU HUA
IPC分类号： C07D405/14 , A61K31/337 , A61K31/437 , A61K31/443 , A61K31/444 , A61P31/00 , A61P35/00 , A61P37/00 , C07D209/46 , C07D213/56 , C07D231/12 , C07D241/12 , C07D263/32 , C07D305/08 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

6. 发明专利

CA3082108A1 NOVEL SUBSTITUTED BIARYL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS 未知
公开(公告)号：CA3082108A1
公开(公告)日：2019-05-23
申请号：CA3082108
申请日：2018-11-12
申请人： MERCK SHARP & DOHME
发明人： HAN YONGXIN , ACHAB ABDELGHANI , DENG YONGQI , FRADERA XAVIER , GIBEAU CRAIG , HOPKINS BRETT A , LI DERUN , LIU KUN , MCGOWAN MEREDETH A , SCIAMMETTA NUNZIO , SLOMAN DAVID , WHITE CATHERINE , ZHANG HONGJUN , ZHOU HUA
IPC分类号： C07D405/14 , A61K31/337 , A61K31/437 , A61K31/443 , A61K31/444 , A61P31/00 , A61P35/00 , A61P37/00 , C07D209/46 , C07D213/56 , C07D231/12 , C07D241/12 , C07D263/32 , C07D305/08 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

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