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1. 发明专利

IL251441D0 Imidazo pyridine derivatives and pharmaceutical compositions containing them 未知
公开(公告)号：IL251441D0
公开(公告)日：2017-05-29
申请号：IL25144117
申请日：2017-03-29
申请人： MERCK PATENT GMBH , GAILLARD PASCALE , SEENISAMY JEYAPRAKASHNARAYANAN , LIU BUJALSKI LESLEY , POTNICK JUSTIN , CALDWELL RICHARD D , QIU HUI , NEAGU CONSTANTIN , JONES REINALDO , WON ANNIE CHO , GOUTOPOULOS ANDREAS , SHERER BRIAN , JOHNSON THERESA L , GARDBERG ANNA
发明人： GAILLARD PASCALE , SEENISAMY JEYAPRAKASHNARAYANAN , LIU-BUJALSKI LESLEY , POTNICK JUSTIN , CALDWELL RICHARD D , QIU HUI , NEAGU CONSTANTIN , JONES REINALDO , WON ANNIE CHO , GOUTOPOULOS ANDREAS , SHERER BRIAN , JOHNSON THERESA L , GARDBERG ANNA
IPC分类号： C07D20060101
摘要： Imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof are useful as BTK inhibitors.

2. 发明专利

IL251441A Imidazo pyridine derivatives and pharmaceutical compositions containing them 未知
公开(公告)号：IL251441A
公开(公告)日：2020-06-30
申请号：IL25144117
申请日：2017-03-29
申请人： MERCK PATENT GMBH , GAILLARD PASCALE , SEENISAMY JEYAPRAKASHNARAYANAN , LIU BUJALSKI LESLEY , POTNICK JUSTIN , CALDWELL RICHARD D , QIU HUI , NEAGU CONSTANTIN , JONES REINALDO , WON ANNIE CHO , GOUTOPOULOS ANDREAS , SHERER BRIAN , JOHNSON THERESA L , GARDBERG ANNA
发明人： GAILLARD PASCALE , SEENISAMY JEYAPRAKASHNARAYANAN , LIU-BUJALSKI LESLEY , POTNICK JUSTIN , CALDWELL RICHARD D , QIU HUI , NEAGU CONSTANTIN , JONES REINALDO , WON ANNIE CHO , GOUTOPOULOS ANDREAS , SHERER BRIAN , JOHNSON THERESA L , GARDBERG ANNA
IPC分类号： A61K31/553 , A61K31/437 , A61P29/00 , A61P37/00
摘要： Imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof are useful as BTK inhibitors.

3. 发明专利

IL252346A Heteroaryl compounds, their preparation and use 未知
公开(公告)号：IL252346A
公开(公告)日：2019-09-26
申请号：IL25234617
申请日：2017-05-17
申请人： JORAND LEBRUN CATHERINE , JONES REINALDO , MERCK PATENT GMBH , WON ANNIE CHO , JOHNSON THERESA L , NGUYEN NGAN , DESELM LIZBETH CELESTE , PANDA KAUSIK
发明人： JORAND-LEBRUN CATHERINE , JONES REINALDO , WON ANNIE CHO , JOHNSON THERESA L , NGUYEN NGAN , DESELM LIZBETH CELESTE , PANDA KAUSIK
摘要： The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.

4. 发明专利

IL252346D0 Heteroaryl compounds, their preparation and use 未知
公开(公告)号：IL252346D0
公开(公告)日：2017-07-31
申请号：IL25234617
申请日：2017-05-17
申请人： JORAND LEBRUN CATHERINE , JONES REINALDO , MERCK PATENT GMBH , WON ANNIE CHO , JOHNSON THERESA L , NGUYEN NGAN , DESELM LIZBETH CELESTE , PANDA KAUSIK
发明人： JORAND-LEBRUN CATHERINE , JONES REINALDO , WON ANNIE CHO , JOHNSON THERESA L , NGUYEN NGAN , DESELM LIZBETH CELESTE , PANDA KAUSIK
IPC分类号： C07D20060101
摘要： The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.

5. 发明专利

ES2772133T3 Compuestos heteroarilo como inhibidores de IRAK y sus usos 未知
公开(公告)号：ES2772133T3
公开(公告)日：2020-07-07
申请号：ES15801650
申请日：2015-11-19
申请人： MERCK PATENT GMBH
发明人： JORAND-LEBRUN CATHERINE , JONES REINALDO , WON ANNIE CHO , NGUYEN NGAN , JOHNSON THERESA L , DESELM LIZBETH CELESTE , PANDA KAUSIK
IPC分类号： C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P13/02 , A61P19/02 , A61P43/00 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/14 , C07D487/04
摘要： Un compuesto de formula I, **(Ver fórmula)** o una sal farmaceuticamente aceptable del mismo, donde: X es CR o N; A es O, S, SO2, SO, -NRC(O), -NRSO2 o N(R); o A esta ausente; R3 es H, C1-6 alifatico, arilo C3-10, un anillo carbociclico de 3-8 atomos saturado o parcialmente insaturado, o un anillo heterociclico de 3-7 atomos con 1-4 heteroatomos seleccionados independientemente entre nitrogeno, oxigeno o azufre; cada uno de los cuales esta opcionalmente sustituido; o R3 es halogeno, - haloalquilo, -OR, -SR, -CN, -NO2, -SO2R, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)N(R)2, - NRSO2R o -N(R)2; o donde A es -NRC(O), -NRSO2 o N(R); entonces R y R3, junto con los atomos a los que cada uno esta unido, pueden formar un anillo heterociclico de 3-7 atomos que tiene 1-4 heteroatomos seleccionados independientemente entre nitrogeno, oxigeno o azufre, o un anillo heteroarilo monociclico de 5-6 atomos que tiene 1-4 heteroatomos seleccionados independientemente entre nitrogeno, oxigeno o azufre, cada uno de ellos opcionalmente sustituido; X' es CR o N; El anillo Z es un anillo heterociclico de 3-7 atomos que tiene 1-4 heteroatomos seleccionados independientemente entre nitrogeno, oxigeno o azufre, o un anillo heteroarilo monociclico de 5-6 atomos que tiene 1-4 heteroatomos seleccionados independientemente entre nitrogeno, oxigeno o azufre, cada uno de ellos opcionalmente sustituido; R1 es -R, halogeno, -haloalquilo, -OR, - SR, -CN, -NO2, -SO2R, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, - NRC(O)R, -NRC(O)N(R)2, -NRSO2R o -N(R)2; Ra esta ausente o es -R, halogeno, -haloalquilo, -OR, -SR, -CN, -NO2, -SO2R, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)N(R)2, -NRSO2R o -N(R)2; El anillo Y es un piridilo, pirazol o tiadiazol opcionalmente sustituido; R2 es -R, halogeno, -haloalquilo, -OR, - SR, -CN, -NO2, -SO2R, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, - NRC(O)R, -NRC(O)N(R)2, -NRSO2R o -N(R)2; Rb esta ausente o es -R, halogeno, -haloalquilo, -OR, -SR, -CN, -NO2, -SO2R, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)N(R)2, -NRSO2R o -N(R)2; cada R es independientemente hidrogeno, alifatico C1-6, arilo C3-10, un anillo carbociclico de 3-8 atomos saturado o parcialmente insaturado, un anillo heterociclico de 3-7 atomos que tiene 1-4 heteroatomos seleccionados independientemente entre nitrogeno, oxigeno o azufre, o un anillo heteroarilo monociclico de 5-6 atomos que tiene 1-4 heteroatomos seleccionados independientemente entre nitrogeno, oxigeno o azufre, cada uno de ellos opcionalmente sustituido; o se toman dos grupos R del mismo atomo junto con el atomo al que estan unidos para formar un arilo C3-10, un anillo carbociclico de 3-8 atomos saturado o parcialmente insaturado, un anillo heterociclico de 3-7 atomos que tiene 1-4 heteroatomos seleccionados independientemente entre nitrogeno, oxigeno o azufre, o un anillo heteroarilo monociclico de 5-6 atomos que tiene 1-4 heteroatomos, seleccionados independientemente entre nitrogeno, oxigeno o azufre, cada uno de ellos opcionalmente sustituido; donde cuando X es N y A esta ausente, entonces R3 no es H.

6. 发明专利

RS59974B1 HETEROARIL JEDINJENJA KAO IRAK INHIBITORI I NJIHOVA UPOTREBA 未知
公开(公告)号：RS59974B1
公开(公告)日：2020-03-31
申请号：RSP20200153
申请日：2015-11-19
申请人： MERCK PATENT GMBH
发明人： JORAND-LEBRUN CATHERINE , JONES REINALDO , WON ANNIE CHO , NGUYEN NGAN , JOHNSON THERESA L , DESELM LIZBETH CELESTE , PANDA KAUSIK
IPC分类号： C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P13/02 , A61P19/02 , A61P43/00 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/14 , C07D487/04

7. 发明专利

PH12017500408B1 HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF 未知
公开(公告)号：PH12017500408B1
公开(公告)日：2017-07-17
申请号：PH12017500408
申请日：2017-03-03
申请人： MERCK PATENT GMBH
发明人： GAILLARD PASCALE , SEENISAMY JEYAPRAKASHNARAYANAN , LIU-BUJALSKI LESLEY , POTNICK JUSTIN , CALDWELL RICHARD D , QIU HUI , NEAGU CONSTANTIN , JONES REINALDO , WON ANNIE CHO , GOUTOPOULOS ANDREAS , SHERER BRIAN A , JOHNSON THERESA L , GARDBERG ANNA
IPC分类号： A61K31/437 , A61K31/553 , A61P29/00 , A61P37/00 , C07D471/04 , C07D519/00
摘要： The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.

8. 发明专利

SG11201701573QA HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF 未知
公开(公告)号：SG11201701573QA
公开(公告)日：2017-03-30
申请号：SG11201701573Q
申请日：2015-10-06
申请人： MERCK PATENT GMBH
发明人： GAILLARD PASCALE , SEENISAMY JEYAPRAKASHNARAYANAN , LIU-BUJALSKI LESLEY , POTNICK JUSTIN , CALDWELL RICHARD D , QIU HUI , NEAGU CONSTANTIN , JONES REINALDO , WON ANNIE CHO , GOUTOPOULOS ANDREAS , SHERER BRIAN A , JOHNSON THERESA L , GARDBERG ANNA
IPC分类号： A61K31/437 , C07D471/04 , A61K31/553 , A61P29/00 , A61P37/00 , C07D519/00
摘要： Imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof are useful as BTK inhibitors.

9. 发明专利

CA2964982A1 HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF 未知
公开(公告)号：CA2964982A1
公开(公告)日：2016-05-26
申请号：CA2964982
申请日：2015-11-19
申请人： MERCK PATENT GMBH
发明人： JORAND-LEBRUN CATHERINE , JONES REINALDO , WON ANNIE CHO , NGUYEN NGAN , JOHNSON THERESA L , DESELM LIZBETH CELESTE , PANDA KAUSIK
IPC分类号： C07D403/10 , A61K31/4439 , A61K31/4545 , A61K31/506 , A61K31/55 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/18
摘要： The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, useful as IRAK inhibitors.

10. 发明专利

CA2964982C HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF 未知
公开(公告)号：CA2964982C
公开(公告)日：2022-07-05
申请号：CA2964982
申请日：2015-11-19
申请人： MERCK PATENT GMBH
发明人： JORAND-LEBRUN CATHERINE , JONES REINALDO , WON ANNIE CHO , NGUYEN NGAN , JOHNSON THERESA L , DESELM LIZBETH CELESTE , PANDA KAUSIK
IPC分类号： C07D403/10 , A61K31/4439 , A61K31/4545 , A61K31/506 , A61K31/55 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/18
摘要： The present invention relates to compounds of Formula I and pharmaceutically acceptable salts thereof. The present application further provides phamiaceutical compositions comprising compounds of Fommla I, or phamiaceutically acceptable salts thereof, and uses of the compounds of Fonnula I, or pharmaceutically acceptable salts thereof, in the treatment of IRAK-mediated disorders or IRAK-mediated canc er.

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