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1. 发明申请

WO2009100318A1 1B20 PCSK9 ANTAGONISTS 审中-公开
公开(公告)号：WO2009100318A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033369
申请日：2009-02-06
申请人： MERCK & CO., INC. , CONDRA, Jon, H. , CUBBON, Rose, M. , HAMMOND, Holly, A. , MCCABE, Timothy , PANDIT, Shilpa , PETERSON, Laurence, B. , SANTORO, Joseph, C. , SITLANI, Ayesha , WOOD, Dana, D. , MACH, Henryk , YODER, Heidi , GREGORY, Sonia, M. , BLUE, Jeffrey, T. , WANG, Kevin , LUO, Peter , NAWROCKI, Denise, K. , ZHONG, Pingyu , DONG, Feng , LI, Yan
发明人： CONDRA, Jon, H. , CUBBON, Rose, M. , HAMMOND, Holly, A. , MCCABE, Timothy , PANDIT, Shilpa , PETERSON, Laurence, B. , SANTORO, Joseph, C. , SITLANI, Ayesha , WOOD, Dana, D. , MACH, Henryk , YODER, Heidi , GREGORY, Sonia, M. , BLUE, Jeffrey, T. , WANG, Kevin , LUO, Peter , NAWROCKI, Denise, K. , ZHONG, Pingyu , DONG, Feng , LI, Yan
IPC分类号： C07K16/40 , C12N9/64 , A61K39/395 , C12N15/13 , A61P3/06
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 ('PCSK9') are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（'PCSK9'）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并且形成了本公开的重要的附加方面。

2. 发明申请

WO2009100297A1 1D05 PCSK9 ANTAGONISTS 审中-公开
公开(公告)号：WO2009100297A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033341
申请日：2009-02-06
申请人： MERCK & CO., INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE S.P.A. , CONDRA, Jon, H. , CUBBON, Rose, M. , HAMMOND, Holly, A. , ORSATTI, Laura , PANDIT, Shilpa , PETERSON, Laurence, B. , SANTORO, Joseph, C. , SITLANI, Ayesha , WOOD, Dana, D. , MACH, Henryk , YODER, Heidi , GREGORY, Sonia, M. , BLUE, Jeffrey, T. , WANG, Kevin , LUO, Peter , NAWROCKI, Denise, K. , ZHONG, Pingyu , DONG, Feng , LI, Yan
发明人： CONDRA, Jon, H. , CUBBON, Rose, M. , HAMMOND, Holly, A. , ORSATTI, Laura , PANDIT, Shilpa , PETERSON, Laurence, B. , SANTORO, Joseph, C. , SITLANI, Ayesha , WOOD, Dana, D. , MACH, Henryk , YODER, Heidi , GREGORY, Sonia, M. , BLUE, Jeffrey, T. , WANG, Kevin , LUO, Peter , NAWROCKI, Denise, K. , ZHONG, Pingyu , DONG, Feng , LI, Yan
IPC分类号： C07K16/40 , C12N9/64 , A61K39/395 , C12N15/13 , A61P3/06
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 ('PCSK9') are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（'PCSK9'）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并且形成了本公开的重要的附加方面。

3. 发明申请

WO2017147777A1 SYSTEMS AND METHODS FOR CABIN AIR QUALITY CONTROL 审中-公开
标题翻译：用于舱室空气质量控制的系统和方法
公开(公告)号：WO2017147777A1
公开(公告)日：2017-09-08
申请号：PCT/CN2016/075142
申请日：2016-03-01
申请人： GM GLOBAL TECHNOLOGY OPERATIONS LLC , LI, Yan
发明人： LI, Yan , WANG, Kevin , ZHU, Xiaolin , ZHANG, Jing
IPC分类号： B60H1/00 , B60H3/06
CPC分类号： B60H1/008 , B60H1/00842 , B60H1/00978 , B60H1/00985 , B60H1/242 , B60H1/248 , B60H3/06 , B60H2003/0683
摘要： Methods and apparatus are provided for controlling an air quality within a passenger cabin (38). The method includes outputting one or more control signals, by a processor (20), to activate a motor (32) to generate an airflow stream for observation by a fine particulate matter sensor (36), the fine particulate matter sensor (36) generating sensor signals based on the observation; determining a concentration level of fine particulate matter in the airflow based on the sensor signals; and outputting one or more control signals to an air quality system (16) associated with the passenger cabin (38) to generate an airflow into the passenger cabin (38) based on the determined concentration level, the airflow into the passenger cabin (38) flowing through a fine particulate matter filter (50).
摘要翻译：提供了用于控制客舱（38）内的空气质量的方法和设备。该方法包括由处理器（20）输出一个或多个控制信号以激活马达（32）以产生气流以供细颗粒物质传感器（36）观察，细颗粒物质传感器（36）产生基于观察的传感器信号; 基于传感器信号确定气流中的细颗粒物质的浓度水平; 和输出一个或多个控制信号到与客舱（38）相关的空气质量系统（16），以基于确定的浓度水平，进入客舱（38）的气流产生进入客舱（38）的气流，流过细颗粒物质过滤器（50）。

4. 发明申请

WO2009117282A2 METHODS AND SYSTEMS FOR NETWORK CHANNEL CAPACITY PLANNING, MEASURING AND ANALYZING OF WLAN NETWORKS 审中-公开
标题翻译： WLAN网络网络通道容量规划，测量与分析的方法与系统
公开(公告)号：WO2009117282A2
公开(公告)日：2009-09-24
申请号：PCT/US2009/036688
申请日：2009-03-10
申请人： AIRMAGNET, INC. , BLACKWELL, Warren , WANG, Kevin , KUAN, Chia-chee
发明人： BLACKWELL, Warren , WANG, Kevin , KUAN, Chia-chee
IPC分类号： H04L12/28
CPC分类号： H04W24/08 , H04W84/12
摘要： An apparatus and method for network channel capacity planning, measuring, and analyzing of WLAN networks are presented. In one embodiment, the method includes importing network and node configuration of an existing physical wireless local area network (WLAN) deployment from WLAN surveying system that captures and analyzes WLAN traffic in order to define a configuration of the existing physical WLAN, simulating a virtual WLAN using the imported network and node configuration as parameters of the simulated WLAN and applying various other configurations not present in the imported network and node configuration as parameters of the simulated WLAN, and analyzing the simulated WLAN to produce throughput statistics of network and nodes of the simulated WLAN.
摘要翻译：介绍了WLAN网络的网络通道容量规划，测量和分析方法。在一个实施例中，该方法包括从WLAN测量系统导入现有物理无线局域网（WLAN）部署的网络和节点配置，其捕获和分析WLAN业务，以定义现有物理WLAN的配置，模拟虚拟WLAN 使用导入的网络和节点配置作为模拟WLAN的参数，并应用导入的网络和节点配置中不存在的各种其他配置作为模拟WLAN的参数，并分析模拟的WLAN以产生模拟的网络和节点的吞吐量统计 WLAN。

5. 发明申请

WO2012045197A1 TRIM ELEMENT FOR MOTOR VEHICLE ADAPTED TO OPTIMUM DEPLOYMENT OF INFLATABLE BAG DEVICE 审中-公开
标题翻译：适用于最佳部署可充气袋装置的电机车辆元件
公开(公告)号：WO2012045197A1
公开(公告)日：2012-04-12
申请号：PCT/CN2010/001580
申请日：2010-10-09
申请人： FAURECIA INTERIEUR INDUSTRIE , WANG, Kevin , MEZIERE, Jérôme , MUNCH, Thierry
发明人： WANG, Kevin , MEZIERE, Jérôme , MUNCH, Thierry
IPC分类号： B60R21/205
CPC分类号： B60R21/205 , B60R13/0206 , B60R21/2165 , B60R2021/21652
摘要： The object of the invention is a trim element (10) for a motor vehicle comprising a rigid supporting member (12), a flexible covering member (14) covering the supporting member (12), and a rigid frame (16). The covering member (14) comprises a skin (26) intended to be visible by an occupant of the passenger compartment of the motor vehicle, and the supporting member (12) comprises at least one aperture (22) allowing deployment of an inflatable bag device outwards from the trimming member (10). The frame (16) is attached to the supporting member (12) on the periphery of said aperture (22) through several attachment means (20). A flap (18) covers the aperture (22) while being jointed with said frame (16). The frame (16) comprises a continuous rib (34) extending from the frame (16) into the covering member. The rib (34) extends along at least one portion of the frame (16) and includes one portion above at least one portion of the attachment means (20).
摘要翻译：本发明的目的是用于机动车辆的装饰元件（10），其包括刚性支撑构件（12），覆盖支撑构件（12）的柔性覆盖构件（14）和刚性框架（16）。覆盖构件（14）包括旨在由机动车辆的乘客舱的乘客可见的皮肤（26），并且支撑构件（12）包括至少一个孔（22），允许展开可充气袋装置从修剪构件（10）向外。框架（16）通过几个附接装置（20）附接到所述孔（22）的周边上的支撑构件（12）上。翼片（18）在与所述框架（16）接合的同时覆盖所述孔（22）。框架（16）包括从框架（16）延伸到覆盖构件中的连续肋（34）。肋（34）沿着框架（16）的至少一部分延伸并且包括在附接装置（20）的至少一部分上方的一个部分。

6. 发明申请

WO2006047417A2 DETECTION OF CANNABINOID RECEPTOR BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：检测CANNABINOID受体生物标志物及其用途
公开(公告)号：WO2006047417A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/038185
申请日：2005-10-21
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , SVETLOV, Stanislav , HAYES, Ronald, L. , WANG, Kevin
发明人： SVETLOV, Stanislav , HAYES, Ronald, L. , WANG, Kevin
IPC分类号： C12Q1/68
CPC分类号： G01N33/6896 , C07K16/28 , G01N33/948 , G01N2500/00 , G01N2800/28
摘要： Traumatic insult to the brain leads to a degradation of low molecular weight of CB1 receptor and generation of high molecular weight complexes in cortex and hippocampus, as assessed by both N-terminal and C-terminal specific antibody. The formation and release of CB1 oligomers was dramatically increased into CSF within 1 hour following traumatic brain insult. Novel CB1 receptor-based, prognostic markers of traumatic brain injury, subarachnoid hemorrhage, epilepsy, stroke, alcohol or substance/chemical-induced brain injury and other forms of brain injury, in addition to targeting CB1 receptor for therapeutic neuroprotection in TB1 are disclosed.
摘要翻译：如通过N末端和C末端特异性抗体评估的，对脑的创伤性侮辱导致低分子量CB1受体的降解和皮层和海马中高分子量复合物的产生。创伤性脑损伤后1小时内，CB1寡聚体的形成和释放显着增加到CSF中。公开了除了靶向TB1治疗性神经保护作用的CB1受体之外，基于CB1受体的新型创伤性脑损伤预后标志物，蛛网膜下腔出血，癫痫，中风，酒精或物质/化学诱导的脑损伤和其他形式的脑损伤。

7. 发明申请

WO2009100131A2 PROCESS TO DIAGNOSE OR TREAT BRAIN INJURY 审中-公开
标题翻译：诊断或治疗脑损伤的过程
公开(公告)号：WO2009100131A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/033080
申请日：2009-02-04
申请人： BANYAN BIOMARKERS, INC. , WANG, Kevin , HAYES, Ronald, L.
发明人： WANG, Kevin , HAYES, Ronald, L.
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/914 , G01N2800/28 , G01N2800/2871
摘要： A process for diagnosing and treating a neurological condition in a subject is provided that includes assaying a biological sample of a subject for the presence of one or more biomarkers; diagnosing a neurological condition based on a ratio of one or more of the biomarkers in the sample; and administering a therapeutic to the subject to alter the ratio of one or more biomarkers. The diagnosis numerous neurological conditions such as brain injury, or multiple organ injury is provided.
摘要翻译：提供了用于诊断和治疗受试者中的神经病症的方法，其包括测定受试者的生物样品中是否存在一种或多种生物标志物; 基于样品中的一种或多种生物标志物的比率诊断神经病症; 并且向受试者施用治疗剂以改变一种或多种生物标志物的比例。诊断提供许多神经系统疾病，如脑损伤或多器官损伤。

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