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1. 发明专利

AU4650799A Remedies for apoptosis-associated diseases 未知
公开(公告)号：AU4650799A
公开(公告)日：2000-02-01
申请号：AU4650799
申请日：1999-07-09
申请人： MEIJI MILK PROD CO LTD , TAKASHI MURAMATSU
发明人： MURAMATSU TAKASHI , IKEMATSU SHINYA , YOSHIDA YOSHIHIRO , KADOMATSU KENJI , ODA MUNEHIRO , SAKUMA SADATOSHI , ASHIDA KIN-YA , KINO KOHSUKE
IPC分类号： A61K38/18
摘要： Proteins belonging to the MK family can suppress apoptosis induced by various stimuli such as carcinostatics, ultraviolet light and radiation, ischemic stresses, etc. Based on this finding, the invention provides novel agents for treating or preventing various diseases attributed to apoptosis such as cerebropathy, cardiopathy, nephropathy, neuropathy, or hepatopathy, etc., comprising proteins belonging to the MK family as an effective ingredient.

2. 发明专利

AU5305599A Preventives/remedies for arteriosclerosis and post-ptca reangiostenosis 未知
公开(公告)号：AU5305599A
公开(公告)日：2000-03-14
申请号：AU5305599
申请日：1999-08-24
申请人： MEIJI MILK PROD CO LTD , TAKASHI MURAMATSU
发明人： MURAMATSU TAKASHI , KADOMATSU KENJI , HORIBA MITSURU , IKEMATSU SHINYA , SAKUMA SADATOSHI
IPC分类号： C12N15/113 , C12N15/19
摘要： The present invention provides a pharmaceutical composition for the prevention or treatment of angiostenosis, comprising a compound inhibiting the function of midkine (MK) in blood vessel tissues as an effective ingredient. The present invention is useful for the prevention or treatment of angiostenosis attributed to arteriosclerosis or restenosis after percutaneous transluminal coronary angioplasty (PTCA). As compounds inhibiting the function of MK, antisense oligonucleotides that bind to a segment of a single-stranded mRNA transcribed from the MK gene to inhibit the synthesis of MK protein in cells, antibodies against the MK protein, and such can be used.

3. 发明申请

WO0002578A8 REMEDIES FOR APOPTOSIS-ASSOCIATED DISEASES 审中-公开
标题翻译：用于治疗相关疾病的补救措施
公开(公告)号：WO0002578A8
公开(公告)日：2001-03-15
申请号：PCT/JP9903740
申请日：1999-07-09
申请人： MEIJI MILK PROD CO LTD , MURAMATSU TAKASHI , IKEMATSU SHINYA , YOSHIDA YOSHIHIRO , KADOMATSU KENJI , ODA MUNEHIRO , SAKUMA SADATOSHI , ASHIDA KIN YA , KINO KOHSUKE
发明人： MURAMATSU TAKASHI , IKEMATSU SHINYA , YOSHIDA YOSHIHIRO , KADOMATSU KENJI , ODA MUNEHIRO , SAKUMA SADATOSHI , ASHIDA KIN-YA , KINO KOHSUKE
IPC分类号： A61K38/18 , A61K38/17
CPC分类号： A61K38/18
摘要： It is found out that a protein belonging to the midkine (MK) family inhibits the induction of apoptosis caused by anticancer agents, ultraviolet irradiation and ischemic stress. This finding makes it possible to provide novel drugs containing the protein belonging to the MK family as the active ingredient for treating and preventing any diseases caused by apoptosis, for example, heart diseases, renal diseases, nervous diseases or liver diseases.
摘要翻译：发现属于中期因子（MK）家族的蛋白质抑制由抗癌剂引起的凋亡诱导，紫外线照射和缺血应激。该发现使得可以提供含有属于MK家族的蛋白质的新药物作为治疗和预防由凋亡引起的任何疾病，例如心脏病，肾脏疾病，神经疾病或肝脏疾病的活性成分。

4. 发明专利

JP2000072799A RECEPTOR-LIKE TYROSINE-RICH PROTEIN 失效
公开(公告)号：JP2000072799A
公开(公告)日：2000-03-07
申请号：JP23785498
申请日：1998-08-24
申请人： MEIJI MILK PROD CO LTD , MURAMATSU TAKASHI
发明人： MURAMATSU TOSHIKO , MURAMATSU TAKASHI , IKEMATSU SHINYA , SAKUMA SADATOSHI
IPC分类号： G01N33/566 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To obtain a new protein including a specific amino acid sequence, having avidity to midkine, having a region rich in tyrosine and a transmembrane-like sequence and is useful for screening candidate compounds as medicament. SOLUTION: This protein includes an amino acid sequence of the formula, or may include alterations selected from the group consisting of at least one amino acid substitution, deletion, insertion and/or addition and has avidity to midkine. It is pref. to produce the protein by culturing a transformant holding a vector having DNA encoding the protein. Moreover it is pref. to screen a compound inhibiting the avidity to midkine by contacting the protein (or its partial peptide) with midkine in the presence of a detecting compound to detect the avidity and by comparing it with the avidity detected in the absence of the detecting compound.

5. 发明专利

JPH0995454A ANTIULCERATIVE COMPOSITION 失效
公开(公告)号：JPH0995454A
公开(公告)日：1997-04-08
申请号：JP25535495
申请日：1995-10-02
申请人： MEIJI MILK PROD CO LTD
发明人： UCHIDA KATSUYUKI , IKEMATSU SHINYA , YOKOYAMA MINEHIKO , YAMASHITA AKIO , KUMAI HIDESHI , ODA MUNEHIRO , KATO NAOKI , SAKUMA SADATOSHI , MURAMATSU TAKASHI
IPC分类号： A61K38/00 , A61K38/18 , A61P1/04 , C07K14/47 , C07K14/52
摘要： PROBLEM TO BE SOLVED: To obtain an antiulcerative composition which has a new action mechanism similar to natural healing and is useful in therapy for gastric ulcer by formulating MK-protein, its derivative holding the biological activity of the protein or a part of them as an active ingredient. SOLUTION: MK protein, a growth and differentiation factor represented by either one of formulas I-III, its derivative which holds the biological activity of this protein, or at least one of their parts holding the biological activity of the protein is used as an active ingredient and mixed with a pharmaceutically permissible excipient, a binder, a disintegrator, a lubricant, a usually used carrier such as a solubilizer or the like, and diluent to prepare an oral medicine such as tablets, granules, capsules, syrup or troche or parenteral preparation such as injection solution, transrectal agent, eye drop or pereuteneous medicine. This medicine can be expected to have an antiulcerative effect by a new action mechanism similar to natural healing, for example, for ulcerative diseases in digestive organs such as gastric ulcer.

6. 发明专利

JPH10160735A SANDWICH MEASURING METHOD 失效
公开(公告)号：JPH10160735A
公开(公告)日：1998-06-19
申请号：JP1774997
申请日：1997-01-16
申请人： MEIJI MILK PROD CO LTD
发明人： YANO AKIRA , YOKOYAMA MINEHIKO , IKEMATSU SHINYA , ODA MUNEHIRO , MURAMATSU TAKASHI , MURAMATSU TOSHIKO
IPC分类号： G01N33/53 , G01N33/531 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To obtain a sandwich measuring method in which a high-sensitivity measuring system can be constructed by a method wherein two kinds of polychlonal antibodies are used as a first antibody and a second antibody for a sandwich method. SOLUTION: A sandwich method is constructed in such a way that human MK is used as an antigen and that a rabbit and a chicken are used an immune animals. When epitopes on MK molecules recognized by two kinds of polyclonal antibodies derived from the rabbit and the chicken are compared, the two kinds of polyclonal antibodies recognize respectively different epitope groups on identical antigen molecules. When the polyclonal antibodies are used as a first antibody and a second antibody for the sandwich method, it is possible to establish the sandwich method similar to that of monoclonal antibodies. In addition, an antigen is a protein which is originally owened by an animal species, different animal species are immunized, and polyclonal antibodies are obtained from them. In addition, two kinds of animal species which are immunized are not limited to the rabbit and the chicken, and a combination of animal species in which epitopes are not overlapped can be used arbitrarily.

7. 发明专利

JP2002085058A MONOCLONAL ANTIBODY AGAINST HUMAN MK 失效
公开(公告)号：JP2002085058A
公开(公告)日：2002-03-26
申请号：JP2000272199
申请日：2000-09-07
申请人： MEIJI MILK PROD CO LTD , MURAMATSU TAKASHI
发明人： KADOMATSU KENJI , MURAMATSU TOSHIKO , MURAMATSU TAKASHI , IKEMATSU SHINYA , ODA MUNEHIRO , SAKUMA SADATOSHI
IPC分类号： C12N15/02 , C07K16/24 , C12N5/10 , C12P21/08 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To provide a monoclonal antibody that specifically recognizes the human MK. SOLUTION: As a result that the MK gene knock-out mouse is used as an immune animal, an antimouse human MK monoclonal antibody could be created.

8. 发明专利

JP2001064196A COMPOSITION FOR PROMOTING THERAPY OF WOUND 失效
公开(公告)号：JP2001064196A
公开(公告)日：2001-03-13
申请号：JP23676299
申请日：1999-08-24
申请人： MEIJI MILK PROD CO LTD , MURAMATSU TAKASHI
发明人： WASHIMI YUKIO , HATAKE KENICHIRO , UEDA MINORU , MURAMATSU TAKASHI , MURAMATSU TOSHIKO , IKEMATSU SHINYA , ODA MUNEHIRO , SAKUMA SADATOSHI
IPC分类号： A61K38/00 , A61P17/02 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain a composition capable of promoting the gel shrinkage in its initial stages in a three-dimensional collagen shrinkage system, having wound-closing activities at the early time in the wound-curing stage, and useful for promoting the cure of the wound in the wound-curing process by a new mechanism of action by making the composition include a specific polypeptide. SOLUTION: This composition contains a polypeptide belonging to a midkine(MK) family, preferably a midkine protein as an active ingredient. For example, the polypeptide can be prepared by formulating the polypeptide with a general vehicle, diluent or carrier to provide a preparation such as a tablet and a capsule. The preparation can includes at least one non-fibrotic growth factor or the like. An effective daily oral dose is about 0.1-1,000 mg and the dose is administered once or by dividing the dose up to about three times.

9. 发明专利

JP2000354487A MIDKINE RECEPTOR 失效
公开(公告)号：JP2000354487A
公开(公告)日：2000-12-26
申请号：JP16854999
申请日：1999-06-15
申请人： MURAMATSU TAKASHI , MEIJI MILK PROD CO LTD
发明人： KADOMATSU KENJI , MURAMATSU TAKASHI , IKEMATSU SHINYA , ODA MUNEHIRO , SAKUMA SADATOSHI
IPC分类号： C12N15/09 , A61K31/00 , A61K45/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/705 , C07K16/30 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , G01N33/15 , G01N33/50 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To obtain a new midkine receptor which binds to midkine and pleiotrophin, whose binding with midkine is inhibited by heparin, whose complex with midkine is slowly degraded in a cell, and is useful for developing a therapeutic agent for cancer, etc. SOLUTION: This is a new midkine receptor which binds to midkine and pleiotrophin, whose binding with midkine is inhibited in the presence of heparin, which is incorporated into a cell as a complex with midkine after binding with midkine, which is slowly degraded in the cell, is used for screening antibody, agonist, and antagonist against midkine receptor, etc., and is capable of developing a therapeutic agent for cancer and for a prophylactic for cancer metastasis, an antiinflammatory agent, a therapeutic agent for treating Alzheimer's disease, etc. This receptor is obtained by screening a cDNA library produced from a brain of mouse fetus with a probe coding for a partial amino acid sequence of midkine receptor, followed by integrating the obtained gene into an expression vector to express in a host cell.

10. 发明专利

CA2260014A1 NOVEL USE OF MK FAMILY AS HEMATOPOIETIC FACTOR 未知
公开(公告)号：CA2260014A1
公开(公告)日：1998-01-15
申请号：CA2260014
申请日：1997-07-10
申请人： MEIJI MILK PROD CO LTD
发明人： KIKUCHI MAKOTO , IKEMATSU SHINYA , SAKUMA SADATOSHI , ODA MUNEHIRO , MURAMATSU TAKASHI
IPC分类号： A61K35/28 , A61K38/18 , A61K38/19 , A61K38/20 , C12N5/0789 , A61K35/14
摘要： A novel use of the MK family alone as a proliferation promoter for hematopoietic stem cells and prodromal hematopoietic cells. Potentiators having remarkably improved effects of promoting the proliferation of hematopoietic stem cells and prodromal hematopoietic cells by the combined use of the MK family with existing hematopoietic factors such as IL-3, IL-6, GCSF, GM-CSF, M-CSF, SCF and EPO.

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