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1. 发明专利

JP2001037455A PRODUCTION OF BEVERAGE OF NUTRITIOUS FOOD 失效
公开(公告)号：JP2001037455A
公开(公告)日：2001-02-13
申请号：JP21097699
申请日：1999-07-26
申请人： MEIJI MILK PROD CO LTD
发明人： INAGAKI HIROKI , NAKATSUBO TADASHI , SUMIO HAJIME , TAKETOMO TADAO , KENJO HISAYOSHI
IPC分类号： A23L2/38 , A23L2/52 , A61K36/25 , A61K36/896
摘要： PROBLEM TO BE SOLVED: To obtain a beverage of nutritious foods, which is excellent in flavor and can be used for producing, e.g. health and refreshing beverages directly (i.e., without processing them by powdering or the like), by uniformly dispersing the nutritious food stocks by the aid of a thickening polysaccharide to have the extracts of these nutritious food stocks. SOLUTION: This method produces a beverage of nutritious foods by uniformly dispersing the nutritious food stocks, e.g. Korean carrot and garlic, by the aid of at least one thickening polysaccharide selected from the group consisting of gelangum, pectin and carageenan, containing preferably 0.02 to 0.1 wt.% based on the beverage. It is preferable to produce the beverage by incorporating the nutritious foods after sterilizing and crushing or milling them into the puree- like state. It is also preferable to have the uniform puree by stirring the puree and thickening polysaccharide added to the solution which dissolves the calcium compound inonized therein, such as calcium lactate or gluconate.

2. 发明专利

JPH08217620A MELANOGENESIS INHIBITOR AND SKIN COSMETIC 失效
公开(公告)号：JPH08217620A
公开(公告)日：1996-08-27
申请号：JP2671895
申请日：1995-02-15
申请人： MEIJI MILK PROD CO LTD
发明人： KAMIYAMA TOMOTAKA , SAWAI YASUKO , TAKETOMO TADAO , YOSHIYAMA YOSHIHIRO
IPC分类号： A61K8/30 , A61K8/00 , A61K8/49 , A61K38/00 , A61K38/55 , A61P17/00 , A61P43/00 , A61Q19/02 , C07K5/117 , C07K14/195 , C07K14/41 , C07K14/81 , A61K7/00
摘要： PURPOSE: To obtain a melanogenesis inhibitor containing, as active ingredient, echinomycin. CONSTITUTION: This melanogenesis inhibitor contains, as active ingredient, echinomycin, a kind of quinoxaline-based antibiotic. This inhibitor is prepared by conventional method after addition of desired ingredients other than the echinomycin. The other objective skin cosmetic intended for skin whitening effect can be prepared by incorporating a cosmetic base with 10 -10 wt.% of echinomycin. The echinomycin has been discovered from Streptomyces echinatus, and can be obtained by purification and isolation from a culture extract of Actinomyces with the melanogenesis inhibitory activity in B16 mouse melanoma cells serving as indicator; or the echinomycin to be used may be commercially available. This skin cosmetic can be prepared in the form of cream, milky lotion, face lotion, foundation, pack, lotion, get, solution, stick, etc.

3. 发明专利

JPH0328175B2 失效
公开(公告)号：JPH0328175B2
公开(公告)日：1991-04-18
申请号：JP12349583
申请日：1983-07-08
申请人： MEIJI MILK PROD CO LTD
发明人： UEDA KAZUSA , KANBE MICHIO , TAKETOMO TADAO , KOBAYASHI TOSHITAKA , SAKAI RYOICHI , YAMAMOTO YOSHIRO
IPC分类号： A61K35/20 , A23C9/13 , A23L29/20 , A23L29/231 , A23L29/256 , A23L29/275 , A23L35/00 , A61K35/64 , A61K35/644 , A61P3/00

4. 发明专利

JPS60188060A LIVE MOLD POWDER OF BACTERIUM BELONGING TO GENUS BIFIDOBACTERIUM, HAVING HIGH RESISTANCE TO ACID IN STOMACH, AND ITS PREPARATION 失效
公开(公告)号：JPS60188060A
公开(公告)日：1985-09-25
申请号：JP4298284
申请日：1984-03-08
申请人： MEIJI MILK PROD CO LTD
发明人： KANEKO TSUTOMU , TAKETOMO TADAO , IWANA HIROKAZU , TAKAHASHI TSUYOSHI
IPC分类号： A23C9/123 , A23L35/00 , C12N1/20 , C12R1/01
摘要： PURPOSE:To prepare live mold powder of bacterium belonging to the genus Bifidobacterium having a great number of molds showing no reduction in numbers of live molds even in preservation at room temperature, by cultivating a bacterium belonging to genus Bifidobacterium in a medium with specific components. CONSTITUTION:A bacterium belonging to the genus Bifidobacterium is inoculated into a medium containing an edible emulsifying agent comprising a hydrolyzate of milk protein, a saccharide, a yeast extract, and oleic acid as main components, and cultivated anaerobically in a pH range of about 6.8 - about 4.7 while keeping the pH almost constant. The prepared solution containing molds is blended with defatted powdered milk, starch hydrolyzate, sodium glutamate, sodium ascorbate, and a magnesium salt, and lyophilized.

5. 发明专利

JP2001153868A IMMUNOASSAY OF ASSAYING CASEIN PHOSPHOPETIDE(CPP) 失效
公开(公告)号：JP2001153868A
公开(公告)日：2001-06-08
申请号：JP33646099
申请日：1999-11-26
申请人： MEIJI MILK PROD CO LTD
发明人： IKEGAMI HIDEJI , TAKETOMO TADAO , SAWAI YASUKO
IPC分类号： G01N33/53 , C07K16/18 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To easily and precisely assay a CPP in food. SOLUTION: The CPP in the food is assayed easily and precisely by an immunoassay using an anti-CPP antibody.

6. 发明专利

JPH07188286A CYCLIC DEPSIPEPTIDE AND CARDIOTONIC AGENT CONTAINING THE SAME 失效
公开(公告)号：JPH07188286A
公开(公告)日：1995-07-25
申请号：JP22917994
申请日：1994-09-26
申请人： MEIJI MILK PROD CO LTD
发明人： SUMIO AKINOBU , TAKETOMO TADAO , YOSHIYAMA YOSHIHIRO , SATO YOSHIRO , AJISAKA KATSUMI , KAMIJO MASAYUKI
IPC分类号： C12P21/02 , A61K38/00 , A61P9/04 , C07K11/02 , C07K14/37 , C07K14/41 , C12R1/645
摘要： PURPOSE:To obtain a new depsipeptide useful as a cardiotonic agent, etc., without any side effects such as arrhythmia. CONSTITUTION:This compound is expressed by the formula and has the following physical properties: appearance: colorless needlelike crystal; molecular weight: 607;molecular formula: C31H53N5O7; high-resolution mass spectrometry: 607.3964 ; specific rotatory power: [alpha] D-206.4 (c =1.00, methanol); ultraviolet absorption spectrum: max (methanol) nm (epsilon): 208 (1200); melting point: 200-205 deg.C; solubility; soluble in methanol, ethanol, ethyl acetate, benzene and chloroform and sparingly soluble in water and X-ray analysis: the rhombic system. Furthermore, the compound expressed by the formula is obtained by culturing a sporogenous imperfect fungus TT03 strain (FERM P-13868) and isolating and purifying the compound from the resultant culture.

7. 发明专利

JPH06116257A BENZOFURAN DERIVATIVE AND ITS USE 失效
公开(公告)号：JPH06116257A
公开(公告)日：1994-04-26
申请号：JP26739192
申请日：1992-10-06
申请人： MEIJI MILK PROD CO LTD
发明人： FUJIMOTO YASUO , MIYAKE MUNEHARU , TAKETOMO TADAO , SATO YOSHIRO , YOKOTA ITSURO , YOSHIYAMA YOSHIHIRO
IPC分类号： A61K31/34 , A61K31/343 , A61P29/00 , A61P37/08 , A61P43/00 , C07D307/79
摘要： PURPOSE:To obtain a new compound, having inhibitory action on the lipoxygenase activity, excellent in safety and useful as a preventing and a therapeutic agents for allergic and rheumatic diseases, psoriasis, etc. CONSTITUTION:The objective compound of formula I (R is H or hydroxyl group), e.g. 2-(1, 3-pentadienyl)-5-hydroxy-2,3-dihydroxybenzo[b]furan. Furthermore, this compound of formula I is obtained by using, e.g. a compound of formula II as a starting raw material and hydrolyzing the resultant compound of formula III.

8. 发明专利

JPH04360855A CATECHOL DERIVATIVE, PRODUCTION THEREOF AND USE THEREOF 失效
公开(公告)号：JPH04360855A
公开(公告)日：1992-12-14
申请号：JP13279491
申请日：1991-06-04
申请人： MEIJI MILK PROD CO LTD
发明人： SATO YOSHIRO , TAKETOMO TADAO , YOSHIYAMA YOSHIHIRO , YOKOTA ITSURO
IPC分类号： A61K31/05 , A61P11/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C205/17 , C12N1/20 , C12N9/99 , C12P13/00 , C12R1/465
摘要： PURPOSE:To provide a highly safe 4-(2-nitroethyl)-1,2-benzenediol having an excellent 5-lipoxygenase-inhibiting activity. CONSTITUTION:4-(2-Nitroethyl)-1,2-benzenediol of the formula. The compound of the formula is produced by culturing a bacterium producing the compound of the formula and belonging to the genus Streptomyces, e.g. Streptomyces SP-MA-1189 (FERM 12273) and subsequently separating the compound from the cultured product. The compound of the formula has a 5-lipoxygenase- inhibiting activity and is effective for treating and preventing allergic diseases such as bronchial asthma and various inflammations.

9. 发明专利

JPS58219121A Preparation of nutrimental composition for patient with advanced disease 失效
标题翻译：具有先进疾病患者的营养成分的制备
公开(公告)号：JPS58219121A
公开(公告)日：1983-12-20
申请号：JP10133882
申请日：1982-06-15
申请人： Meiji Milk Prod Co Ltd
发明人： UEDA KAZUSUKE , KANBE MICHIO , ODA MUNEHIRO , TAKETOMO TADAO
IPC分类号： A61K35/20 , A23C9/137 , A23L35/00 , A61K35/64 , A61K35/74
摘要： PURPOSE: To obtain the titled composition, storable at room temperature for a long term, and orally or parenterally administrable, by incorporating a fermented a fermented milk with honey and a specific stabilizer, homogenizing the resultant mixture, and instantaneously pasteurizing the resultant homogenized mixture at an ultrahigh temperature.
CONSTITUTION: A nutrimental composition prepared by incorporating 100pts.wt. fermented milk with 18W22pts.wt. honey and further ultrahigh methoxypectin (UHM pectin) and propylene glycol ester (PGA) of alginic acid as a stabilizer without causing the separation and settling of the contents even on the instantaneous pasteurization at an ultrahigh temperature. Preferably, the above-mentioned UHM pectin is added in an amount of 0.1W1.0%, and the PGA is added in an amount of 0.05W0.5%. The above-mentioned fermented milk is obtained by adding skimmilk powder, water and if necessary a fat or oil to a cow's milk, and inoculating the prepared milk with a lactic acid bacterial starter, and cultivating the bacterial starter at 3.5W4.5pH.
COPYRIGHT: (C)1983,JPO&Japio
摘要翻译：目的：为了获得长期储存的口服或肠胃外给药的标题化合物，通过将发酵的发酵乳与蜂蜜和特定稳定剂混合，使所得混合物均化，并将所得均匀混合物瞬间巴氏杀菌超高温。构成：通过加入100pts.wt。发酵乳与18-22pts.wt。蜂蜜和进一步的超高甲氧基蛋白（UHM果胶）和丙二醇酯（PGA）作为稳定剂，即使在超高温下即时进行巴氏消毒也不会引起内容物的分离和沉降。优选上述UHM果胶的添加量为0.1〜1.0％，PGA的添加量为0.05〜0.5％。上述发酵乳是通过将牛奶粉，水，如果需要的话，向牛奶中加入脂肪或油，并用乳酸菌发酵剂接种制备的乳，并以3.5-4.5pH培养细菌起始物获得的。

10. 发明专利

JPS58204001A Macromolecular polysaccharide substance mps-83 and its use 失效
标题翻译：大分子多糖物质MPS-83及其用途
公开(公告)号：JPS58204001A
公开(公告)日：1983-11-28
申请号：JP8659382
申请日：1982-05-24
申请人： Meiji Milk Prod Co Ltd
发明人： OZAKI MICHIO , OBARA NAOHIRO , TSUCHIYA FUMIYASU , KANEKO SHIYOUHEI , KANBE MICHIO , ODA MUNEHIRO , TAKETOMO TADAO , OOYAMA YOSHIO
IPC分类号： C08B37/00 , A61K31/715 , A61K35/74 , A61P35/00 , C12P19/04 , C12R1/225
摘要： PURPOSE: To obtain an excellent immunity-activating agent, antitumoric agent or thickneing agent, by using a novel macromolecular polysaccharide substance MPS-83 which is produced from macromolecular polysaccharide substance MPS- 83-producing bacteria belonging to genus Lactobacillus as an effective component.
CONSTITUTION: Macromolecular polysaccharide substance MPS-83 is obtained by culturing macromolecular polysaccharide substance MPS-83-producing bacteria (e.g., Lactobacillus S-10-LR, FERM BP-127, which are bacteria separated from a dairy product and deposited with the Fermentation Research Institute) and then separating and recovering the substance from the liquid and bacterial fractins of the culture. As a culture medium, a lactic acid bacteria-culturing medium containing skim milk, whey or the like is preferred. The culturing is performed satisfactorily under conditions including, for example, 20W45°C, CO
2 atmosphere and stationary culture.
COPYRIGHT: (C)1983,JPO&Japio
摘要翻译：目的：通过使用由属于乳杆菌属的MPS-83生产菌的大分子多糖物质产生的新型大分子多糖物质MPS-83作为有效成分，获得优异的免疫活性剂，抗肿瘤剂或增稠剂。构成：大分子多糖物质MPS-83是通过培养大分子多糖物质MPS-83生产菌（例如，乳杆菌S-10-LR，FERM BP-127，它们是从乳制品中分离的细菌并保藏在发酵研究中研究所），然后从培养物的液体和细菌分裂物中分离和回收物质。作为培养基，优选含有脱脂乳，乳清等的乳酸菌培养基。在包括例如20-45℃，二氧化碳气氛和静止培养的条件下令人满意地进行培养。

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