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1. 发明申请

WO2010059391A1 LARGE ANIMAL MODEL FOR HUMAN-LIKE ADVANCED ATHEROSCLEROTIC PLAQUE 审中-公开
标题翻译：人类先进的人体动物模型大动物模型
公开(公告)号：WO2010059391A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/062624
申请日：2009-10-29
申请人： MEDTRONIC VASCULAR INC. , TUNEV, Stefan , SHAH, Ankit , CACERES, Alejandra , GUO, Ya , TRUDEL, Julie , HIM, Phean , HEZI-YAMIT, Ayala
发明人： TUNEV, Stefan , SHAH, Ankit , CACERES, Alejandra , GUO, Ya , TRUDEL, Julie , HIM, Phean , HEZI-YAMIT, Ayala
IPC分类号： A01K67/027 , A01K49/00
CPC分类号： A01K67/027 , A01K2217/00 , A01K2227/108 , A01K2267/03 , A01K2267/0375
摘要： An animal model for cardiovascular disease comprising one or more vascular plaque lesions formed at selected sites within a vascular segment of a nonhuman mammal. The vascular plaque lesion is formed by administering a hypercholesterolemic diet to the nonhuman mammal, inflicting an injury to the vascular wall at the selected site after a predetermined exposure to the hypercholesterolemic diet, and applying a hydrogel to the injured vascular wall. Another aspect of the invention provides a method for evaluating a test compound for an effect on atherosclerotic lesion formation comprising administering to a nonhuman mammal a hypercholesterolemic diet, and, after a defined period of time, isolating a segment of a blood vessel using a balloon catheter, inflicting an injury to the vascular wall within the isolated segment, and applying a hydrogel within the vascular segment. The method further comprises forming a vascular plaque lesion on the vascular wall at the site of the injury, delivering the test compound to the nonhuman mammal, and monitoring atherosclerotic lesion size and composition at the injured site after a defined period of exposure to the test compound.
摘要翻译：一种用于心血管疾病的动物模型，其包含在非人哺乳动物的血管片段内的选定位置处形成的一个或多个血管斑块损伤。通过向非人哺乳动物施用高胆固醇血症饮食来形成血管斑块损伤，在预先暴露于高胆固醇血症饮食之后对选定部位的血管壁施加损伤，并将水凝胶施加到损伤的血管壁。本发明的另一方面提供了一种用于评估对动脉粥样硬化病变形成的影响的测试化合物的方法，包括向非人类哺乳动物施用高胆固醇血症饮食，并且在限定的时间段之后，使用气囊导管分离血管的一段对隔离区段内的血管壁造成损伤，并在血管段内施用水凝胶。该方法还包括在损伤部位的血管壁上形成血管斑块损伤，将测试化合物递送至非人类哺乳动物，并在暴露于测试化合物的确定的时间段后监测受伤部位的动脉粥样硬化病变大小和组成。

2. 发明申请

WO2013134469A1 SELECTIVE MODULATION OF RENAL NERVES 审中-公开
标题翻译：选择性调节肾脏神经
公开(公告)号：WO2013134469A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/029526
申请日：2013-03-07
申请人： MEDTRONIC ARDIAN LUXEMBOURG SARL , TUNEV, Stefan
发明人： TUNEV, Stefan , TRUDEL, Julie
IPC分类号： A61N1/32 , A61N1/36
CPC分类号： A61B18/04 , A61B18/02 , A61B18/1492 , A61B18/1815 , A61B2018/00434 , A61B2018/046 , A61M25/0084 , A61M2025/0089 , A61M2202/048 , A61M2202/049 , A61N1/0551 , A61N1/327 , A61N1/3605 , A61N7/00 , A61N2007/003
摘要： Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including selectively neuromodulating afferent or efferent renal nerves. One or more measurable physiological parameters corresponding to systemic sympathetic overactivity or hyperactivity in the patient can thereby be reduced. Selectively neuromodulating afferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a renal pelvis. This can include, for example, neuromodulating via fluid within the renal pelvis. Selectively neuromodulating efferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a portion of a renal artery or a renal branch artery proximate a renal parenchyma. This can include, for example, neuromodulating via a therapeutic element within the portion of the renal artery or the renal branch artery.
摘要翻译：本文公开了使用治疗性肾神经调节和相关联的装置，系统和方法治疗患者的方法。本技术的一个方面涉及包括选择性神经调节传入或传出肾神经的方法。因此可以减少对应于患者的全身交感神经过度活动或多动症的一个或多个可测量的生理参数。选择性神经调节传入肾神经可以包括抑制邻近肾盂的神经中的交感神经活动。这可以包括例如通过肾盂内的流体进行神经调节。选择性神经调节传出肾神经可以包括抑制邻近肾动脉的一部分或靠近肾实质的肾分支动脉的神经中的交感神经活动。这可以包括例如通过肾动脉或肾分支动脉部分内的治疗元件神经调节。

3. 发明申请

WO2018089705A1 DRUG-FILLED STENTS TO PREVENT VESSEL MICRO-INJURIES AND METHODS OF MANUFACTURE THEREOF 审中-公开
标题翻译：药物填充支架以防止血管微创伤及其制造方法
公开(公告)号：WO2018089705A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060958
申请日：2017-11-09
申请人： MEDTRONIC VASCULAR INC.
发明人： TUNEV, Stefan , BIENVENU, Ryan , PETERSON, Justin , SULLIVAN, Carol , STORMENT, Christopher , HARMS, Michael
IPC分类号： A61F2/88 , A61F2/915
摘要： A stent includes a hollow wire formed into a stent pattern. The hollow wire includes an outer member, a lumen extending longitudinally within the hollow wire, at least one opening extending from an outer surface of the outer member to the lumen, and a surface area component within the hollow wire. The surface area component increases the amount of surface area available for tissue in-growth within the hollow wire. More than one surface area component may be utilized. Each surface area component may be disposed within the lumen or the at least one opening of the hollow wire. A pharmacologically or biologically active agent may be disposed within the lumen.
摘要翻译：支架包括形成为支架图案的中空丝。中空线包括外部构件，在中空线内纵向延伸的内腔，从外部构件的外表面延伸至内腔的至少一个开口以及中空线内的表面区域组件。表面积组分增加了空心丝内组织向内生长的表面积。可以使用多于一个的表面区域组件。每个表面区域组件可以布置在内腔或中空线的至少一个开口内。药理学或生物活性剂可置于腔内。

4. 发明申请

WO2018089696A1 DRUG-FILLED STENT WITH FILAMENTS FOR INCREASED LUMEN SURFACE AREA AND METHOD OF MANUFACTURE THEREOF 审中-公开
标题翻译：含药物的药物支架用于增加液体表面积及其制造方法
公开(公告)号：WO2018089696A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060947
申请日：2017-11-09
申请人： MEDTRONIC VASCULAR INC.
发明人： BIENVENU, Ryan , PETERSON, Justin , TUNEV, Stefan , HARMS, Michael
IPC分类号： A61F2/88 , A61F2/915
摘要： A stent including a hollow wire formed into a stent pattern. The hollow wire includes an outer member having an outer surface and an inner surface, a lumen extending longitudinally within the hollow wire, at least one opening extending from the outer surface of the outer member to the lumen, and a plurality of filaments extending longitudinally within the lumen. The plurality of filaments increases the amount of surface area available for tissue in-growth within the lumen. Each filament of the plurality of filaments is spaced from adjacent filaments of the plurality of filaments, and the spacing between adjacent filaments of the plurality of filaments is configured to permit tissue in-growth between the adjacent filaments.
摘要翻译：包括形成支架图案的中空丝的支架。中空线包括具有外表面和内表面的外部构件，在中空线内纵向延伸的内腔，从外部构件的外表面延伸到内腔的至少一个开口以及多个纵向延伸的细丝流明。多根细丝增加了可用于组织在内腔内生长的表面积的量。多根长丝中的每根长丝与多根长丝中的相邻长丝间隔开，并且多根长丝中相邻长丝之间的间隔被配置成允许组织在相邻长丝之间的内生长。

5. 发明申请

WO2018089697A1 STENTS FORMED FROM DISSIMILAR METALS FOR TISSUE GROWTH CONTROL 审中-公开
标题翻译：从异种金属形成的支架用于组织生长控制
公开(公告)号：WO2018089697A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060948
申请日：2017-11-09
申请人： MEDTRONIC VASCULAR INC.
发明人： PETERSON, Justin , BIENVENU, Ryan , TUNEV, Stefan , HARMS, Michael
IPC分类号： A61F2/90 , A61F2/915
摘要： Stents formed from dissimilar materials configured to control tissue growth. A stent may be formed from a composite wire helically wound into a stent having a tubular configuration. The composite wire includes a first wire and a second wire coupled together, the first and second wires being formed from dissimilar metals such that a potential difference is formed when the dissimilar metals are exposed to bodily fluids. The potential difference is configured to inhibit cell proliferation and thereby control tissue growth around the stent after implantation. A stent may be formed from a hollow composite wire including an inner member that includes first and second longitudinal strips formed from dissimilar metals. A stent may be formed from a composite wire having a plurality of windows along a length of the composite wire. An insert formed from a dissimilar metal is disposed within each window of the plurality of windows.
摘要翻译：由配置成控制组织生长的不同材料形成的支架。支架可以由螺旋缠绕成具有管状构造的支架的复合线形成。复合导线包括连接在一起的第一导线和第二导线，第一导线和第二导线由不同金属形成，使得当异种金属暴露于体液时形成电位差。电位差配置成抑制细胞增殖并由此控制植入后支架周围的组织生长。支架可以由包括内部构件的中空复合金属丝形成，所述内部构件包括由不同金属形成的第一和第二纵向条。支架可由具有沿着复合线材的长度的多个窗口的复合线材形成。由不同种金属形成的插入件设置在多个窗口的每个窗口内。

6. 发明公开

EP2355654A1 LARGE ANIMAL MODEL FOR HUMAN-LIKE ADVANCED ATHEROSCLEROTIC PLAQUE 审中-公开
标题翻译：大型动物模型的人喜欢，先进的粥样硬化斑块
公开(公告)号：EP2355654A1
公开(公告)日：2011-08-17
申请号：EP09747980.2
申请日：2009-10-29
申请人： Medtronic Vascular Inc.
发明人： TUNEV, Stefan , SHAH, Ankit , CACERES, Alejandra , GUO, Ya , TRUDEL, Julie , HIM, Phean , HEZI-YAMIT, Ayala
IPC分类号： A01K67/027 , A01K49/00
CPC分类号： A01K67/027 , A01K2217/00 , A01K2227/108 , A01K2267/03 , A01K2267/0375
摘要： An animal model for cardiovascular disease comprising one or more vascular plaque lesions formed at selected sites within a vascular segment of a nonhuman mammal. The vascular plaque lesion is formed by administering a hypercholesterolemic diet to the nonhuman mammal, inflicting an injury to the vascular wall at the selected site after a predetermined exposure to the hypercholesterolemic diet, and applying a hydrogel to the injured vascular wall. Another aspect of the invention provides a method for evaluating a test compound for an effect on atherosclerotic lesion formation comprising administering to a nonhuman mammal a hypercholesterolemic diet, and, after a defined period of time, isolating a segment of a blood vessel using a balloon catheter, inflicting an injury to the vascular wall within the isolated segment, and applying a hydrogel within the vascular segment. The method further comprises forming a vascular plaque lesion on the vascular wall at the site of the injury, delivering the test compound to the nonhuman mammal, and monitoring atherosclerotic lesion size and composition at the injured site after a defined period of exposure to the test compound.

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