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1. 发明申请

WO2010117537A3 IMPLANTABLE MEDICAL DEVICES HAVING BIOABSORBABLE PRIMER POLYMER COATINGS 审中-公开
标题翻译：可生物降解的聚合物涂料的可植入医疗器械
公开(公告)号：WO2010117537A3
公开(公告)日：2011-03-10
申请号：PCT/US2010026869
申请日：2010-03-10
申请人： MEDTRONIC VASCULAR INC , UDIPI KISHORE , GUO YA
发明人： UDIPI KISHORE , GUO YA
IPC分类号： A61L31/02 , A61L31/10
CPC分类号： A61L31/022 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： The present disclosure generally relates to implantable medical devices having a metallic surface coated with a bioabsorbable primer polymer layer under a bioabsorbable drug polymer layer. Thus, in addition to the degradation of the drug polymer layer, there is degradation of the primer layer. The underlying metallic framework may or may not degrade depending on whether bioabsorbable or biostable metals are chosen.
摘要翻译：本公开总体上涉及具有在生物可吸收的药物聚合物层下面具有生物可吸收底漆聚合物层的金属表面的可植入医疗装置。因此，除了药物聚合物层的降解之外，还有底漆层的降解。根据是否选择生物可吸收或生物稳定金属，底层金属框架可能降解或不会降解。

2. 发明申请

WO2013059715A2 IRON BASED ALLOYS FOR BIOABSORBABLE STENT 审中-公开
标题翻译：用于生物可吸收支架的铁基合金
公开(公告)号：WO2013059715A2
公开(公告)日：2013-04-25
申请号：PCT/US2012/061183
申请日：2012-10-19
申请人： MEDTRONIC VASCULAR INC. , GUO, Ya , BERGLUND, Joseph , STORMENT, Christopher W. , WRIGHT, James A.
发明人： GUO, Ya , BERGLUND, Joseph , STORMENT, Christopher W. , WRIGHT, James A.
IPC分类号： H01L23/053 , H01L23/055 , H01L23/057 , H01L23/08 , H01L23/10 , H01L23/15 , H01L25/065 , H01L25/10 , H01L27/146 , H01L31/048 , H05K3/42 , B81C1/00
CPC分类号： A61L31/022 , A61L31/148
摘要： A stent includes an iron-based alloy that consists essentially of: Fe-X-Y, wherein X is at least one austenite stabilizing element selected from the group consisting of Co, Ni, Mn, Cu, Re, Rh, Ru, Ir, Pt, Pd, C, and N, and wherein Y is at least one corrosion-activator species selected from the group consisting of Au, and Pd.
摘要翻译：支架包括基本上由以下组成的铁基合金：Fe-XY，其中X是至少一种选自Co，Ni，Mn，Cu，Re的奥氏体稳定元素， Rh，Ru，Ir，Pt，Pd，C和N，并且其中Y是选自由Au和Pd组成的组中的至少一种腐蚀 - 活化剂物质。

3. 发明申请

WO2010068381A3 IMPLANTABLE MEDICAL DEVICES HAVING MULTIBLOCK COPOLYMERS 审中-公开
公开(公告)号：WO2010068381A3
公开(公告)日：2010-06-17
申请号：PCT/US2009/064930
申请日：2009-11-18
申请人： MEDTRONIC VASCULAR INC. , GUO, Ya , UDIPI, Kishore
发明人： GUO, Ya , UDIPI, Kishore
IPC分类号： A61L31/06 , A61L31/10 , A61L31/16 , A61L31/14
摘要： Provided herein are implantable medical devices comprising a biodegradable multiblock copolymer comprising at least three blocks; wherein the at least three blocks includes at least one inner block and two end blocks; further wherein each of the at least one inner block comprises monomers selected from the group consisting of e-caprolactone, r-butylactone, trimethylene carbonate, caprolactone derivatives, P-Dioxanone, and combinations thereof; and further wherein each of the end blocks comprises monomers selected from the group consisting of I-lactide, D-lactide, glycolide, L,D-lactide, and combinations thereof.

4. 发明申请

WO2010059479A2 BRAIDED STENT WITH A SHORTENABLE TETHER 审中-公开
标题翻译： BRAIDED STENT WITH SHORTENABLE TETHER
公开(公告)号：WO2010059479A2
公开(公告)日：2010-05-27
申请号：PCT/US2009/064053
申请日：2009-11-11
申请人： MEDTRONIC VASCULAR INC. , KALSTAD, Megan , GUO, Ya
发明人： KALSTAD, Megan , GUO, Ya
IPC分类号： A61F2/90 , A61M25/00 , A61L27/58 , A61F2/06 , A61L27/14
CPC分类号： A61F2/90 , A61F2/95 , A61F2002/825
摘要： The braided stent with a shortenable tether of the present invention includes a stent for use in a vessel having a vessel wall including a braided stent framework having a first framework end and a second framework end; and a plurality of shortenable tethers, each of the plurality of shortenable tethers having a first tether end and a second tether end, the plurality of shortenable tethers being disposed along a length of the braided stent framework and fixed to the braided stent framework at the first tether end and the second tether end. The plurality of shortenable tethers shorten in response to vessel conditions to urge the first framework end and the second framework end toward each other when the stent is deployed in the vessel to urge a circumference of the braided stent framework toward the vessel wall.
摘要翻译：具有本发明的可缩短系绳的编织支架包括用于容器中的支架，所述支架具有容器壁，所述容器壁包括具有第一框架端和第二框架端的编织支架框架; 所述多个可缩短的系绳中的每一个具有第一系绳端和第二系绳端，所述多个可缩短系绳沿所述编织支架框架的长度设置并且在所述第一系绳的第一位置处固定到所述编织支架框架系绳端和第二系绳端。当支架部署在容器中以促使编织支架框架的周边朝向血管壁时，多个可缩短的系绳响应于血管状况而缩短以将第一框架端和第二框架端朝向彼此推动。

5. 发明申请

WO2010059391A1 LARGE ANIMAL MODEL FOR HUMAN-LIKE ADVANCED ATHEROSCLEROTIC PLAQUE 审中-公开
标题翻译：人类先进的人体动物模型大动物模型
公开(公告)号：WO2010059391A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/062624
申请日：2009-10-29
申请人： MEDTRONIC VASCULAR INC. , TUNEV, Stefan , SHAH, Ankit , CACERES, Alejandra , GUO, Ya , TRUDEL, Julie , HIM, Phean , HEZI-YAMIT, Ayala
发明人： TUNEV, Stefan , SHAH, Ankit , CACERES, Alejandra , GUO, Ya , TRUDEL, Julie , HIM, Phean , HEZI-YAMIT, Ayala
IPC分类号： A01K67/027 , A01K49/00
CPC分类号： A01K67/027 , A01K2217/00 , A01K2227/108 , A01K2267/03 , A01K2267/0375
摘要： An animal model for cardiovascular disease comprising one or more vascular plaque lesions formed at selected sites within a vascular segment of a nonhuman mammal. The vascular plaque lesion is formed by administering a hypercholesterolemic diet to the nonhuman mammal, inflicting an injury to the vascular wall at the selected site after a predetermined exposure to the hypercholesterolemic diet, and applying a hydrogel to the injured vascular wall. Another aspect of the invention provides a method for evaluating a test compound for an effect on atherosclerotic lesion formation comprising administering to a nonhuman mammal a hypercholesterolemic diet, and, after a defined period of time, isolating a segment of a blood vessel using a balloon catheter, inflicting an injury to the vascular wall within the isolated segment, and applying a hydrogel within the vascular segment. The method further comprises forming a vascular plaque lesion on the vascular wall at the site of the injury, delivering the test compound to the nonhuman mammal, and monitoring atherosclerotic lesion size and composition at the injured site after a defined period of exposure to the test compound.
摘要翻译：一种用于心血管疾病的动物模型，其包含在非人哺乳动物的血管片段内的选定位置处形成的一个或多个血管斑块损伤。通过向非人哺乳动物施用高胆固醇血症饮食来形成血管斑块损伤，在预先暴露于高胆固醇血症饮食之后对选定部位的血管壁施加损伤，并将水凝胶施加到损伤的血管壁。本发明的另一方面提供了一种用于评估对动脉粥样硬化病变形成的影响的测试化合物的方法，包括向非人类哺乳动物施用高胆固醇血症饮食，并且在限定的时间段之后，使用气囊导管分离血管的一段对隔离区段内的血管壁造成损伤，并在血管段内施用水凝胶。该方法还包括在损伤部位的血管壁上形成血管斑块损伤，将测试化合物递送至非人类哺乳动物，并在暴露于测试化合物的确定的时间段后监测受伤部位的动脉粥样硬化病变大小和组成。

6. 发明申请

WO2009117185A2 NONDEGRADABLE HYDROGELS FOR MEDICAL DEVICE APPLICATION 审中-公开
标题翻译：医疗器械应用的非可控水压
公开(公告)号：WO2009117185A2
公开(公告)日：2009-09-24
申请号：PCT/US2009/033337
申请日：2009-02-06
申请人： MEDTRONIC VASCULAR INC. , UDIPI, Kishore , TRUDEL, Julie , GUO, Ya
发明人： UDIPI, Kishore , TRUDEL, Julie , GUO, Ya
IPC分类号： A61L31/04 , A61L31/10 , A61L31/16
CPC分类号： A61L29/085 , A61L27/18 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , C08L71/02
摘要： Disclosed are nondegradable hydrogels used to coat or form at least a portion of a medical device. The hydrogels may be formed from functionalized PEG based macromers. These hydrogels are easy to sterilize, transport and store. Methods of forming these hydrogels as described herein are included.
摘要翻译：公开了用于涂覆或形成医疗装置的至少一部分的不可降解水凝胶。水凝胶可以由官能化的基于PEG的大分子单体形成。这些水凝胶易于消毒，运输和储存。包括如本文所述形成这些水凝胶的方法。

7. 发明申请

WO2008127889A3 DEGRADABLE POLYMERS INCORPORATING GAMMA- BUTYROLACTONE 审中-公开
标题翻译：加入甘油 - 丁基酮的可降解聚合物
公开(公告)号：WO2008127889A3
公开(公告)日：2009-09-24
申请号：PCT/US2008059361
申请日：2008-04-04
申请人： MEDTRONIC VASCULAR INC , CHEN MINGFEI , CHENG PEIWEN , GUO YA , UDIPI KISHORE
发明人： CHEN MINGFEI , CHENG PEIWEN , GUO YA , UDIPI KISHORE
IPC分类号： A61L31/06 , A61L31/10 , A61L31/16 , C08G63/02 , C08L67/04
CPC分类号： A61L31/148 , A61F2210/0004 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/402 , A61L2300/414 , A61L2300/432 , C08G63/08 , C08G63/823 , C09D167/04 , C08L67/04
摘要： Disclosed herein are implantable medical devices having controlled release biodegradable polymer coatings thereon wherein the polymer comprises a monomer formed from ring opening of ?-butyrolactone and at least one additional monomer selected from the group consisting of trimethylene carbonate, lactide, polyethylene glycol, glycolide, the monomers formed from ring opening of e-caprolactone, 4-tert- butyl caprolactone, and N-acetyl caprolactone, and combinations thereof, and at least one drug releasable from the biodegradable polymer. Also disclosed are implantable medical devices form of the biodegradable polymers and processes for forming the polymers.
摘要翻译：本文公开了具有其上具有控制释放的可生物降解的聚合物涂层的可植入医疗装置，其中所述聚合物包含由γ-丁内酯的开环形成的单体和至少一种选自三亚甲基碳酸酯，丙交酯，聚乙二醇，乙交酯，由ε-己内酯，4-叔丁基己内酯和N-乙酰己内酯的开环形成的单体及其组合，以及可从可生物降解的聚合物中释放的至少一种药物。还公开了可生物降解聚合物的可植入医疗装置形式和形成聚合物的方法。

8. 发明申请

WO2007133924A2 BIODEGRADABLE MODIFIED CAPROLACTONE POLYMERS FOR FABRICATING AND COATING MEDICAL DEVICES 审中-公开
标题翻译：生物可修饰的改性聚酰胺聚合物，用于制作和涂布医疗器械
公开(公告)号：WO2007133924A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/067781
申请日：2007-04-30
申请人： MEDTRONIC VASCULAR, INC. , CHENG, Mingfei , CHEN, Peiwen , GUO, Ya , UDIPI, Kishore
发明人： CHENG, Mingfei , CHEN, Peiwen , GUO, Ya , UDIPI, Kishore
CPC分类号： C08G63/664 , A61L27/34 , A61L27/58 , A61L29/085 , A61L29/148 , A61L31/10 , A61L31/148 , C08G63/08 , C09D167/04 , C08L67/04
摘要： Disclosed herein are biodegradable modified caprolactone polymers for coating and forming medical devices. The properties of the polymers are fine tuned for optimal performance depending on the medical purpose. Moreover, the polymers are suitable for the controlled in situ release of drugs at the treatment site.
摘要翻译：本文公开了用于涂覆和形成医疗装置的可生物降解的改性己内酯聚合物。根据医疗目的，聚合物的性质被微调以获得最佳性能。此外，聚合物适合于在治疗部位的药物的受控原位释放。

9. 发明申请

WO2010059479A3 BRAIDED STENT WITH A SHORTENABLE TETHER 审中-公开
标题翻译：带有可缩短的TETHER的编织托架
公开(公告)号：WO2010059479A3
公开(公告)日：2010-09-30
申请号：PCT/US2009064053
申请日：2009-11-11
申请人： MEDTRONIC VASCULAR INC , KALSTAD MEGAN , GUO YA
发明人： KALSTAD MEGAN , GUO YA
IPC分类号： A61F2/82 , A61F2/90 , A61L27/14 , A61L27/58 , A61M25/00
CPC分类号： A61F2/90 , A61F2/95 , A61F2002/825
摘要： The braided stent with a shortenable tether of the present invention includes a stent for use in a vessel having a vessel wall including a braided stent framework having a first framework end and a second framework end; and a plurality of shortenable tethers, each of the plurality of shortenable tethers having a first tether end and a second tether end, the plurality of shortenable tethers being disposed along a length of the braided stent framework and fixed to the braided stent framework at the first tether end and the second tether end. The plurality of shortenable tethers shorten in response to vessel conditions to urge the first framework end and the second framework end toward each other when the stent is deployed in the vessel to urge a circumference of the braided stent framework toward the vessel wall.
摘要翻译：本发明的具有可缩短系绳的编织支架包括用于具有血管壁的血管的支架，所述血管壁包括具有第一框架端部和第二框架端部的编织支架框架; 以及多个可缩短绳索，所述多个可缩短绳索中的每一个具有第一绳索端部和第二绳索端部，所述多个可缩短绳索沿着编织支架框架的长度布置并且在第一端部处固定到编织支架框架系绳端和第二系绳端。当支架被部署在血管中以促使编织的支架框架的周边朝向血管壁时，多个可缩短的系绳响应于血管状况而缩短以促使第一框架端部和第二框架端部朝向彼此。

10. 发明申请

WO2010068381A2 IMPLANTABLE MEDICAL DEVICES HAVING MULTIBLOCK COPOLYMERS 审中-公开
标题翻译：具有多片共聚物的可植入医疗器械
公开(公告)号：WO2010068381A2
公开(公告)日：2010-06-17
申请号：PCT/US2009064930
申请日：2009-11-18
申请人： MEDTRONIC VASCULAR INC , GUO YA , UDIPI KISHORE
发明人： GUO YA , UDIPI KISHORE
IPC分类号： A61L31/06 , A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61L31/06 , A61L31/10 , A61L2300/416 , C08L67/04
摘要： Provided herein are implantable medical devices comprising a biodegradable multiblock copolymer comprising at least three blocks; wherein the at least three blocks includes at least one inner block and two end blocks; further wherein each of the at least one inner block comprises monomers selected from the group consisting of e-caprolactone, r-butylactone, trimethylene carbonate, caprolactone derivatives, P-Dioxanone, and combinations thereof; and further wherein each of the end blocks comprises monomers selected from the group consisting of I-lactide, D-lactide, glycolide, L,D-lactide, and combinations thereof.
摘要翻译：本文提供了可植入医疗装置，其包含至少三个块的可生物降解的多嵌段共聚物; 其中所述至少三个块包括至少一个内部块和两个端块; 进一步其中所述至少一个内部块中的每一个包含选自由ε-己内酯，γ-丁内酯，三亚甲基碳酸酯，己内酯衍生物，对二恶烷酮及其组合组成的组的单体; 并且其中每个末端嵌段包含选自1-丙交酯，D-丙交酯，乙交酯，L，D-丙交酯及其组合的单体。

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