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1. 发明申请

WO2009085331A1 DEVICES. FOR INJECTION OF MULTIPLE-COMPONENT THERAPIES 审中-公开
标题翻译：设备。注射多组分治疗
公开(公告)号：WO2009085331A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/056072
申请日：2008-03-06
申请人： MEDTRONIC VASCULAR INC. , NAYAK, Asha , MACIEL, Mario
发明人： NAYAK, Asha , MACIEL, Mario
IPC分类号： A61M5/19 , A61B17/00
CPC分类号： A61M5/19 , A61B17/3478 , A61B2017/00247 , A61B2017/00495 , A61B2018/00392 , A61M5/1782 , A61M5/204 , A61M5/284 , A61M5/3137 , A61M5/32 , A61M5/3294 , A61M5/3295 , A61M5/44 , A61M5/445 , A61M5/46 , A61M2005/3128 , A61M2005/3201 , A61M2205/3606 , A61M2205/3626 , A61M2205/3633 , A61M2205/3646
摘要： Devices and methods for injecting or otherwise delivering multiple-component therapies to human or animal subjects. Devices having injectors (e.g., syringes (16, 18)) attached to biaxial or coaxial injection cannula(s) (14) are used to deliver multiple components of a particular therapy such that those components become combined shortly before or upon exiting the injection cannula (s). In some embodiments, the injector devices of the present invention may include a first set of finger grips (24a) at a first location and a second set of finger grips (24b) at a second location. Also, in some embodiments, the injector devices of the present invention may include depth stops (15) for controlling the depth within tissue at which the therapeutic substance is delivered. Also, in some embodiments, the injector devices of the' present invention may include refill manifolds (42a, 42b) with attached syringes or other reservoirs containing the component substances to facilitate refilling of the inj ectors.
摘要翻译：用于将人体或动物受试者注射或以其他方式递送多组分疗法的装置和方法。连接到双轴或同轴注射套管（14）的具有注射器（例如，注射器（16,18））的装置被用于递送特定疗法的多个部件，使得那些部件在离开注射套管之前或之后不久就组合（S）。在一些实施例中，本发明的注射器装置可以包括在第一位置处的第一组手指夹（24a）和在第二位置处的第二组手指夹（24b）。而且，在一些实施例中，本发明的注射器装置可以包括用于控制组织内深度的深度限制（15），治疗物质在其内被输送。此外，在一些实施例中，本发明的注射器装置可以包括具有连接的注射器的补充歧管（42a，42b）或其他含有组分物质的储存器，以便于重新注射注射器。

2. 发明申请

WO2007121139A2 IN VIVO LOCALIZATION AND TRACKING OF TISSUE PENETRATING CATHETERS USING MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：使用磁共振成像的组织穿刺导管的体内定位和跟踪
公开(公告)号：WO2007121139A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/066242
申请日：2007-04-09
申请人： MEDTRONIC VASCULAR, INC. , MACAULAY, Patrick , NAYAK, Asha
发明人： MACAULAY, Patrick , NAYAK, Asha
CPC分类号： G01R33/287 , A61B5/02007 , A61B5/055 , A61B5/064 , A61B5/416 , A61B5/4839 , A61B5/6852 , A61B34/20 , A61B2034/107 , A61B2034/2051 , A61B2090/374 , A61M25/0029 , A61M25/007 , A61M25/0127 , A61M2025/0037 , A61M2025/0096
摘要： Magnetic resonance image (MRI) guided tissue penetrating catheters and their methods of use. One or more MRI apparatus (e.g., one or more coils) are positioned on or in a catheter device that includes a tissue penetrator that may be used to form a penetration tract from a body lumen in which the catheter is positioned to a target location outside of that body lumen. The MRI apparatus (e.g., coil(s)) is/are used in conjunction with an MRI imaging system to indicate the position and/or rotational orientation of the penetrating catheter within the subject's body.
摘要翻译：磁共振图像（MRI）引导组织穿透导管及其使用方法。一个或多个MRI装置（例如，一个或多个线圈）被定位在导管装置上或导管装置中，该导管装置包括组织穿透器，所述组织穿透器可用于形成来自体腔的穿透管，其中导管定位在外部的目标位置的体腔。 MRI装置（例如，线圈）与MRI成像系统结合使用以指示穿透导管在受检者体内的位置和/或旋转取向。

3. 发明申请

WO2009131774A2 DEVICES AND METHODS FOR CONTROLLED-DEPTH INJECTION 审中-公开
标题翻译：控制深度注射的装置和方法
公开(公告)号：WO2009131774A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/037573
申请日：2009-03-18
申请人： MEDTRONIC VASCULAR INC. , MACAULAY, Patrick , NAYAK, Asha , THOMPSON, Dustin
发明人： MACAULAY, Patrick , NAYAK, Asha , THOMPSON, Dustin
IPC分类号： A61M5/315 , A61M5/178 , A61M5/32
CPC分类号： A61B17/3478 , A61B2017/00247 , A61B2018/00392 , A61B2090/034 , A61M5/46
摘要： Devices and methods for limiting the depth to which a penetrator is advanced into an organ or mass of tissue. The device generally comprises a first member and a second member. The penetrator is attached to and extends from a second member. The first member has a penetrator shroud and a hollow bore extending therethrough. The second member is engageable with the first member such that a distal portion of the penetrator extends through the penetrator shroud. The distance to which the penetrator protrudes out of and beyond the distal end of the penetrator shroud is adjustable in accordance with the desired depth of penetration. The penetrator may then be advanced into the organ or tissue mass until the distal end of the shroud abuts against the organ or tissue mass, thereby stopping further advancement of the penetrator. The penetrator may have one or more lumen(s) for aspirating or infusing substances.
摘要翻译：用于限制穿透器进入器官或组织块的深度的装置和方法。该装置通常包括第一构件和第二构件。穿透器附接到第二构件并从第二构件延伸。第一构件具有穿透器护罩和延伸穿过其中的中空孔。第二构件可与第一构件接合，使得穿透器的远端部分延伸穿过穿透器护罩。穿透器突出到穿透器护罩的远端之外的距离可以根据期望的穿透深度进行调节。然后穿透器可以推进到器官或组织块中，直到护罩的远端抵靠器官或组织块，从而停止穿透器的进一步前进。穿透器可以具有用于吸入或输注物质的一个或多个内腔。

4. 发明申请

WO2007002554A2 METHODS AND SYSTEMS FOR TREATING INJURED CARDIAC TISSUE 审中-公开
标题翻译：用于治疗受损的心脏组织的方法和系统
公开(公告)号：WO2007002554A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024731
申请日：2006-06-23
申请人： MEDTRONIC VASCULAR, INC. , NAYAK, Asha , KEOGH, James
发明人： NAYAK, Asha , KEOGH, James
CPC分类号： A61L27/52 , A61B17/3478 , A61B2017/00247 , A61B2017/00495 , A61B2017/0243 , A61B2017/306 , A61B2017/308 , A61B2018/00392 , A61L2400/16 , A61L2430/20 , A61M5/19 , A61N1/306 , A61N1/36017 , A61N1/362
摘要： Methods and systems are disclosed for treating injury to cardiac tissue by delivering a composition which provides structural support to the cardiac tissue. The composition helps to prevent chamber remodeling by providing structural reinforcement of the tissue or structural reinforcement of the tissue combined with biological therapy. The structurally reinforcing composition can thicken the wall of a heart, or act to prevent further thinning and thereby provide resistance against further remodeling. A number of compositions are disclosed, including multi-component substances such as autologous platelet gel, and other substances. The compositions disclosed can contain additives to augment/enhance the desired effects of the injection.
摘要翻译：公开了用于通过递送向心脏组织提供结构支撑的组合物来治疗对心脏组织的损伤的方法和系统。该组合物通过提供组织的结构增强或与生物疗法相结合的组织的结构增强来帮助防止腔室重塑。结构增强组合物可以增厚心脏的壁，或用于防止进一步变薄，从而提供抵抗进一步重塑的抵抗力。公开了许多组合物，包括多组分物质如自体血小板凝胶和其他物质。所公开的组合物可含有添加剂以增强/增强注射的所需效果。

5. 发明申请

WO2007112135A3 METHODS AND SYSTEMS FOR TREATING INJURED CARDIAC TISSUE 审中-公开
公开(公告)号：WO2007112135A3
公开(公告)日：2007-10-04
申请号：PCT/US2007/060059
申请日：2007-01-03
申请人： MEDTRONIC VASCULAR, INC. , NAYAK, Asha
发明人： NAYAK, Asha
IPC分类号： A61K35/14 , A61M25/00 , A61L26/00 , A61L24/00 , A61P9/10
摘要： Methods and systems are disclosed for treating cardiac tissue by delivering a platelet composition which induces neovascularization in the cardiac tissue. The platelet composition can additionally contain structural materials and/or bioactive agents.

6. 发明申请

WO2007098354A1 APPARATUS AND METHODS FOR CREATING AN OPENING IN A TISSUE MEMRBRANE 审中-公开
标题翻译：用于在组织中形成开放的装置和方法
公开(公告)号：WO2007098354A1
公开(公告)日：2007-08-30
申请号：PCT/US2007/062183
申请日：2007-02-15
申请人： MEDTRONIC VASCULAR, INC. , NAYAK, Asha
发明人： NAYAK, Asha
IPC分类号： A61B17/32
CPC分类号： A61B17/32053 , A61B10/0283 , A61B10/04 , A61B17/32075 , A61B2017/00867
摘要： The current invention discloses an apparatus for creating openings in tissue membranes and methods for using the apparatus. The apparatus comprises a cutting device that can include a cutting element and a resisting element located on the ends of elongate members. The cutting device can be manipulated so that the cutting element and resisting element are on opposite sides of the target tissue membrane. The cutting device is delivered to a tissue membrane using an elongate delivery device that can be routed through a working lumen in an endoscopic probe. The delivery device can also access the tissue membrane via means other than an endoscopic probe. Embodiments of the invention can include a vacuum lumen in the delivery device and a vacuum source for stabilizing the tissue membrane relative to the apparatus or for securing sections of tissue that are removed from the membrane.
摘要翻译：本发明公开了一种用于在组织膜中产生开口的装置以及使用该装置的方法。该装置包括切割装置，其可以包括切割元件和位于细长构件的端部上的抵抗元件。可以操纵切割装置，使得切割元件和抵抗元件位于目标组织膜的相对侧上。切割装置使用细长的输送装置输送到组织膜，细长的输送装置可以穿过内窥镜探针中的工作腔。递送装置还可以经由除了内窥镜探针之外的装置访问组织膜。本发明的实施例可以包括输送装置中的真空腔和用于相对于装置稳定组织膜的真空源或用于固定从膜去除的组织部分。

7. 发明申请

WO2007112136A2 METHODS AND SYSTEMS FOR TREATING INJURED CARDIAC TISSUE 审中-公开
标题翻译：用于治疗受损的心脏组织的方法和系统
公开(公告)号：WO2007112136A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/060060
申请日：2007-01-03
申请人： MEDTRONIC VASCULAR, INC. , NAYAK, Asha
发明人： NAYAK, Asha
IPC分类号： A61K35/16 , A61K35/19
CPC分类号： A61K35/16 , A61K35/19 , A61K38/4833 , A61M5/19 , A61N1/306 , A61N1/325 , A61K2300/00
摘要： Methods and systems are disclosed for treating cardiac tissue by delivering a platelet composition which induces neovascularization in the cardiac tissue followed by a cell preparation which induces regeneration in the re-vascularized tissue. The platelet composition can additionally contain structural materials and/or bioactive agents.
摘要翻译：公开了用于治疗心脏组织的方法和系统，其通过递送在心脏组织中诱导新血管形成的血小板组合物，接着诱导再血管化组织中的再生的细胞制备物。血小板组合物可另外含有结构材料和/或生物活性剂。

8. 发明公开

EP2274031A2 DEVICES AND METHODS FOR CONTROLLED-DEPTH INJECTION 审中-公开
标题翻译：用于控制深度注射的装置和方法
公开(公告)号：EP2274031A2
公开(公告)日：2011-01-19
申请号：EP09734601.9
申请日：2009-03-18
申请人： Medtronic Vascular Inc.
发明人： MACAULAY, Patrick , NAYAK, Asha , THOMPSON, Dustin
IPC分类号： A61M5/315 , A61M5/178 , A61M5/32
CPC分类号： A61B17/3478 , A61B2017/00247 , A61B2018/00392 , A61B2090/034 , A61M5/46
摘要： Devices and methods for limiting the depth to which a penetrator is advanced into an organ or mass of tissue. The device generally comprises a first member and a second member. The penetrator is attached to and extends from a second member. The first member has a penetrator shroud and a hollow bore extending therethrough. The second member is engageable with the first member such that a distal portion of the penetrator extends through the penetrator shroud. The distance to which the penetrator protrudes out of and beyond the distal end of the penetrator shroud is adjustable in accordance with the desired depth of penetration. The penetrator may then be advanced into the organ or tissue mass until the distal end of the shroud abuts against the organ or tissue mass, thereby stopping further advancement of the penetrator. The penetrator may have one or more lumen(s) for aspirating or infusing substances.
摘要翻译：用于限制穿透器进入器官或组织块的深度的装置和方法。该装置通常包括第一构件和第二构件。穿透器附接到第二构件并从第二构件延伸。第一构件具有穿透器护罩和贯穿其中的中空孔。第二构件可与第一构件接合，使得穿透器的远侧部分延伸穿过穿透器护罩。穿透器伸出并穿过穿透器护罩的远端的距离可根据所需的穿透深度进行调节。然后可以将穿透器推进到器官或组织块中，直到护罩的远端抵靠器官或组织块，由此停止穿透器的进一步推进。穿透器可具有一个或多个用于抽吸或注入物质的内腔。

9. 发明公开

EP2247326A1 DEVICES FOR INJECTION OF MULTIPLE-COMPONENT THERAPIES 有权
标题翻译：设备注射多个组件疗法
公开(公告)号：EP2247326A1
公开(公告)日：2010-11-10
申请号：EP08731561.0
申请日：2008-03-06
申请人： Medtronic Vascular Inc.
发明人： NAYAK, Asha , MACIEL, Mario
IPC分类号： A61M5/19 , A61B17/00
CPC分类号： A61M5/19 , A61B17/3478 , A61B2017/00247 , A61B2017/00495 , A61B2018/00392 , A61M5/1782 , A61M5/204 , A61M5/284 , A61M5/3137 , A61M5/32 , A61M5/3294 , A61M5/3295 , A61M5/44 , A61M5/445 , A61M5/46 , A61M2005/3128 , A61M2005/3201 , A61M2205/3606 , A61M2205/3626 , A61M2205/3633 , A61M2205/3646
摘要： Devices and methods for injecting or otherwise delivering multiple-component therapies to human or animal subjects. Devices having injectors (e.g., syringes (16, 18)) attached to biaxial or coaxial injection cannula(s) (14) are used to deliver multiple components of a particular therapy such that those components become combined shortly before or upon exiting the injection cannula (s). In some embodiments, the injector devices of the present invention may include a first set of finger grips (24a) at a first location and a second set of finger grips (24b) at a second location. Also, in some embodiments, the injector devices of the present invention may include depth stops (15) for controlling the depth within tissue at which the therapeutic substance is delivered. Also, in some embodiments, the injector devices of the' present invention may include refill manifolds (42a, 42b) with attached syringes or other reservoirs containing the component substances to facilitate refilling of the inj ectors.

10. 发明公开

EP2012666A2 IN VIVO LOCALIZATION AND TRACKING OF TISSUE PENETRATING CATHETERS USING MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：体内检测和组织的调查尿急导管磁成像手段
公开(公告)号：EP2012666A2
公开(公告)日：2009-01-14
申请号：EP07760326.4
申请日：2007-04-09
申请人： Medtronic Vascular, Inc.
发明人： MACAULAY, Patrick , NAYAK, Asha
IPC分类号： A61B5/06 , A61M25/00 , A61B5/055 , A61M25/01 , G01R33/28
CPC分类号： G01R33/287 , A61B5/02007 , A61B5/055 , A61B5/064 , A61B5/416 , A61B5/4839 , A61B5/6852 , A61B34/20 , A61B2034/107 , A61B2034/2051 , A61B2090/374 , A61M25/0029 , A61M25/007 , A61M25/0127 , A61M2025/0037 , A61M2025/0096
摘要： Magnetic resonance image (MRI) guided tissue penetrating catheters (10). One or more MRI apparatus (34,35,46) (e.g., one or more coils) are positioned on or in a catheter device that includes a tissue penetrator (30) that may be used to form a penetration tract from a body lumen in which the catheter is positioned to a target location outside of that body lumen. The MRI apparatus (e.g., coil(s) ) is/are used in conjunction with an MRI imaging system to indicate the position and/or rotational orientation of the penetrating catheter within the subject's body.

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