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1. 发明申请

WO2007001701A1 CATHETER-BASED, DUAL BALLOON PHOTOPOLYMERIZATION SYSTEM 审中-公开
标题翻译：基于CATHETER的双壁光电聚合体系
公开(公告)号：WO2007001701A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/020197
申请日：2006-05-24
申请人： MEDTRONIC VASCULAR, INC. , DOTY, David , OZDIL, Feridun , WILCOX, Josiah , MURRAY, Robert , KILARI, Prasad
发明人： DOTY, David , OZDIL, Feridun , WILCOX, Josiah , MURRAY, Robert , KILARI, Prasad
IPC分类号： A61M25/10 , A61B18/24 , A61N5/06
CPC分类号： A61B17/12136 , A61B17/12045 , A61B17/12109 , A61B2017/12127 , A61B2017/22085 , A61M25/1011 , A61M2025/09008 , A61M2025/1052 , A61N5/0601 , A61N5/062
摘要： A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter (110) having a first inflatable member and a guidewire (140) having a second inflatable member. The catheter has an extended tip (112) distal to the first inflatable member that includes multiple perfusion ports (115) . A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel . The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil .
摘要翻译：通过光聚合将聚合物（水凝胶）施加到容器的内表面的系统包括具有第一可膨胀构件的导管（110）和具有第二可充气构件的导丝（140）。导管具有远离第一可充气构件的延伸尖端（112），其包括多个灌注端口（115）。发光线圈设置在延伸尖端上，其中单个线圈环与灌注端口间隔开。在一种方法中，导丝被输送到血管内的治疗部位。导管通过导丝输送到治疗部位。充气构件被充气以在容器内形成封闭的处理空间。光引发剂被输送到封闭的处理空间。过量的光引发剂从处理空间冲洗，并且预聚物被输送。预聚物由发光线圈输送的光固化。

2. 发明申请

WO2009046206A1 SCORING CATHETER WITH DRUG DELIVERY MEMBRANE 审中-公开
标题翻译：具有药物输送膜的分拣管
公开(公告)号：WO2009046206A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/078607
申请日：2008-10-02
申请人： ANGIOSCORE, INC. , OZDIL, Feridun , DOTY, David , RAFFIN, Tom, A.
发明人： OZDIL, Feridun , DOTY, David , RAFFIN, Tom, A.
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61B17/320725 , A61B2017/22061 , A61M2025/105 , A61M2025/1081 , A61M2025/1086
摘要： Angioplasty and other dilatation devices are provided with scoring elements. The device additionally incorporates a separate drug application membrane which is used to deliver drugs and other active substances to a body lumen, typically a blood vessel. The device functions to release drug into a region of the luminal wall as the scoring structure is radially expanded into the lumen wall.
摘要翻译：血管成形术和其他扩张装置具有评分要素。该装置还包括单独的药物施用膜，其用于将药物和其它活性物质递送至体腔，通常为血管。当评分结构径向扩张到管腔壁中时，该装置用于将药物释放到腔壁的区域中。

3. 发明申请

WO2007027384A1 INTRAVASCULAR THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：血管内皮细胞治疗
公开(公告)号：WO2007027384A1
公开(公告)日：2007-03-08
申请号：PCT/US2006/030951
申请日：2006-08-09
申请人： MEDTRONIC VASCULAR, INC. , DOTY, David
发明人： DOTY, David
IPC分类号： A61M25/10 , A61M29/02
CPC分类号： A61M25/10 , A61M2025/105 , A61M2025/1093
摘要： Intravascular devices of delivering at least one therapeutic agent. The device includes an elongate element with proximal and distal portions and at least first and second lumens provided therein. The first lumen is adapted for delivering at least one therapeutic agent. The second lumen is adapted for allowing fluid therethrough. An expandable member is disposed adjacent to the distal portion of the elongate element. At least one tip cut is provided in a distal tip portion of the elongate element. The at least one tip cut is adapted for providing flexibility to the elongate element. The method includes providing an elongate element. Spacing of at least one tip cut is varied during positioning of the elongate element within a vessel. The vessel is occluded with the elongate element. The at least one therapeutic agent is delivered to tissue adjacent the occluded vessel.
摘要翻译：递送至少一种治疗剂的血管内装置。该装置包括具有近端部分和远端部分的细长元件以及设置在其中的至少第一和第二内腔。第一管腔适于递送至少一种治疗剂。第二腔适于允许流体通过其中。可扩张构件设置成与细长元件的远侧部分相邻。至少一个尖端切口设置在细长元件的远侧末端部分中。至少一个尖端切口适于为细长元件提供柔性。该方法包括提供细长元件。在细长元件在容器内的定位期间，至少一个尖端切割的间距是不同的。容器用细长元件封闭。将至少一种治疗剂递送至邻近闭塞血管的组织。

4. 发明申请

WO2008118606A2 BIODEGRADABLE METAL BARRIER LAYER FOR A DRUG-ELUTING STENT 审中-公开
标题翻译：可生物降解的金属阻隔层用于药物洗脱支架
公开(公告)号：WO2008118606A2
公开(公告)日：2008-10-02
申请号：PCT/US2008/055314
申请日：2008-02-28
申请人： MEDTRONIC VASCULAR INC. , DOTY, David , KRIVORUCHKO, Michael
发明人： DOTY, David , KRIVORUCHKO, Michael
IPC分类号： A61L31/08 , A61L31/12 , A61L31/14 , A61L31/16
CPC分类号： A61L31/082 , A61L27/30 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/43 , A61L2300/44 , A61L2300/64
摘要： An implantable medical device includes a substrate, a drug-impregnated layer deposited over the substrate, and a barrier layer at least partially covering the drug-impregnated layer. The barrier layer may be a biodegradable metal, biodegradable metal oxide, or biodegradable metal alloy, such as, magnesium, a magnesium oxide or a magnesium alloy. The drug-impregnated layer includes a therapeutic substance, such as, antineoplastic, anti-inflammatory, antiplatelet, anticoagulant, fibrinolytic, thrombin inhibitor, antimitotic, antiallergic, and antiproliferative substances.
摘要翻译：可植入医疗装置包括基底，沉积在基底上的药物浸渍层和至少部分覆盖药物浸渍层的阻挡层。阻挡层可以是可生物降解的金属，可生物降解的金属氧化物或可生物降解的金属合金，例如镁，氧化镁或镁合金。药物浸渍层包括治疗物质，例如抗肿瘤，抗炎，抗血小板，抗凝血，纤维蛋白溶解，凝血酶抑制剂，抗有丝分裂，抗过敏和抗增生物质。

5. 发明申请

WO2007112159A2 STENT, INTRALUMINAL STENT DELIVERY SYSTEM, AND METHOD OF TREATING A VASCULAR CONDITION 审中-公开
标题翻译： STENT，INTRALUMINAL STENT DELIVERY SYSTEM，AND METHOD OF TRANTING A VASCULAR CONDITION
公开(公告)号：WO2007112159A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/062226
申请日：2007-02-15
申请人： MEDTRONIC VASCULAR, INC. , DOTY, David
发明人： DOTY, David
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/148 , A61L31/16 , A61L2300/00
摘要： A stent, a stent delivery system, and a method of treating a vascular condition. The system includes a catheter, an inflatable member operably attached to the catheter, and a biodegradable stent disposed on the inflatable member. The stent includes a biodegradable flexible elongate member including an elongate member wall surrounding a cavity. A biodegradable reinforcing member is positioned within or adjacent the elongate member wall to support the biodegradable sleeve. A biodegradable photo-curable polymer positioned within the cavity. The method includes delivering a biodegradable stent having a cavity filled with a pre-polymer to a treatment site. A balloon is expanded to position the stent at the treatment site. The pre-polymer positioned within the stent cavity is photopolymerized. The deployed stent is supported in a radial direction with a biodegradable reinforcing member.
摘要翻译：支架，支架输送系统和治疗血管病症的方法。该系统包括导管，可操作地附接到导管的可充气构件和设置在可膨胀构件上的可生物降解的支架。支架包括可生物降解的柔性细长构件，其包括围绕空腔的细长构件壁。可生物降解的加强构件定位在细长构件壁内或邻近细长构件壁以支撑可生物降解的套筒。位于腔内的可生物降解的可光固化聚合物。该方法包括将具有填充有预聚物的腔的可生物降解的支架递送至治疗部位。扩张气囊以将支架定位在治疗部位。位于支架腔内的预聚物被光聚合。部署的支架在径向方向上具有可生物降解的加强构件。

6. 发明申请

WO2007136969A3 BIOABSORBABLE MAGNESIUM-REINFORCED POLYMER STENTS 审中-公开
公开(公告)号：WO2007136969A3
公开(公告)日：2007-11-29
申请号：PCT/US2007/067881
申请日：2007-05-01
申请人： MEDTRONIC VASCULAR, INC. , DOTY, David
发明人： DOTY, David
IPC分类号： A61L31/12 , A61L31/14
摘要： Bioabsorbable magnesium-reinforced polymer stents are disclosed. Additionally, bioabsorbable magnesium-reinforced polymer stents are disclosed which elute therapeutic agents.

7. 发明申请

WO2006104649A1 CATHETER-BASED, DUAL COIL PHOTOPOLYMERIZATION SYSTEM 审中-公开
标题翻译：基于CATHETER的双线圈光电聚合系统
公开(公告)号：WO2006104649A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/008128
申请日：2006-03-07
申请人： MEDTRONIC VASCULAR, INC. , DOTY, David
发明人： DOTY, David
IPC分类号： A61M25/00
CPC分类号： A61L31/10 , A61L24/0031 , A61L27/34 , A61L29/085 , A61M25/0029 , A61M25/0045 , A61M31/00 , A61M2025/0034 , A61M2025/0037 , Y10T29/49826
摘要： A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes an inner catheter received (110) within an outer catheter (120) and a fluid channeling structure (130) mounted on the catheters with its proximal end attached to the outer catheter and its distal end attached to the inner catheter. The fluid channeling structure includes an elastomeric sleeve (134) sandwiched between an inner elastic coil (132) and an outer light emission coil (136). Light emission coil loops are interspaced with elastic coil loops. The light emission coil has a smaller diameter than the elastic coil, drawing the elastomeric sleeve down between loops of the elastic coil to form a helical channel. The coils and sleeve are stretched to provide a narrowed crossing profile for delivery, and are contracted at a treatment site to form a helical cavity between the sleeve and the vessel wall within which to perform interfacial photopolymerization.
摘要翻译：通过光聚合将聚合物（水凝胶）施加到容器的内表面的系统包括在外导管（120）内容纳（110）的内导管和安装在导管上的流体通道结构（130），其近端附接到外导管并且其远端附接到内导管。流体通道结构包括夹在内部弹性线圈（132）和外部发光线圈（136）之间的弹性体套筒（134）。发光线圈环与弹性线圈环相互间隔。发光线圈具有比弹性线圈更小的直径，将弹性体套筒向下拉动在弹性线圈的环之间以形成螺旋通道。线圈和套筒被拉伸以提供用于输送的变窄的交叉轮廓，并且在处理部位收缩以在套筒和容器壁之间形成螺旋空腔，在其内进行界面光聚合。

8. 发明公开

EP2004253A2 STENT, INTRALUMINAL STENT DELIVERY SYSTEM, AND METHOD OF TREATING A VASCULAR CONDITION 有权
标题翻译：覆膜支架腔内STENTABGAGESYSTEM和方法治疗血管疾病的
公开(公告)号：EP2004253A2
公开(公告)日：2008-12-24
申请号：EP07710486.7
申请日：2007-02-15
申请人： Medtronic Vascular, Inc.
发明人： DOTY, David
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/148 , A61L31/16 , A61L2300/00
摘要： A stent, a stent delivery system, and a method of treating a vascular condition. The system includes a catheter, an inflatable member operably attached to the catheter, and a biodegradable stent disposed on the inflatable member. The stent includes a biodegradable flexible elongate member including an elongate member wall surrounding a cavity. A biodegradable reinforcing member is positioned within or adjacent the elongate member wall to support the biodegradable sleeve. A biodegradable photo-curable polymer positioned within the cavity. The method includes delivering a biodegradable stent having a cavity filled with a pre-polymer to a treatment site. A balloon is expanded to position the stent at the treatment site. The pre-polymer positioned within the stent cavity is photopolymerized. The deployed stent is supported in a radial direction with a biodegradable reinforcing member.

9. 发明授权

EP1904138B1 Catheter-based, dual balloon photopolymerization system 有权
标题翻译：光聚合基于导管的两个气球
公开(公告)号：EP1904138B1
公开(公告)日：2011-03-02
申请号：EP06760370.4
申请日：2006-05-24
申请人： Medtronic Vascular, Inc.
发明人： DOTY, David , OZDIL, Feridun , WILCOX, Josiah , MURRAY, Robert , KILARI, Prasad
IPC分类号： A61M25/10 , A61B18/24 , A61N5/06
CPC分类号： A61B17/12136 , A61B17/12045 , A61B17/12109 , A61B2017/12127 , A61B2017/22085 , A61M25/1011 , A61M2025/09008 , A61M2025/1052 , A61N5/0601 , A61N5/062
摘要： A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter (110) having a first inflatable member and a guidewire (140) having a second inflatable member. The catheter has an extended tip (112) distal to the first inflatable member that includes multiple perfusion ports (115) . A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel . The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil .

10. 发明公开

EP1569579A1 BALLOON CATHETER FOR STENT DELIVERY WITH RETENTION MEANS ON BALLOON 审中-公开
标题翻译：球囊导管球囊GIVEN支架ON附筹集资金
公开(公告)号：EP1569579A1
公开(公告)日：2005-09-07
申请号：EP03781801.0
申请日：2003-11-07
申请人： Medtronic Vascular, Inc.
发明人： DOTY, David
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2002/9583
摘要： A stent delivery system (20) comprises an inner member and an expandable balloon (34) mounted thereon in a collapsed state. A compressible stent (22), having a proximal edge and a distal edge, is mounted around the expandable balloon. At least first and second retention bumps (36) are respectively affixed adjacent to the proximal and distal edges of the stent in order to reduce the longitudinal displacement of the compressible stent during insertion and/or retraction of the balloon/stent assembly.

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