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1. 发明申请

WO2008118606A2 BIODEGRADABLE METAL BARRIER LAYER FOR A DRUG-ELUTING STENT 审中-公开
标题翻译：可生物降解的金属阻隔层用于药物洗脱支架
公开(公告)号：WO2008118606A2
公开(公告)日：2008-10-02
申请号：PCT/US2008/055314
申请日：2008-02-28
申请人： MEDTRONIC VASCULAR INC. , DOTY, David , KRIVORUCHKO, Michael
发明人： DOTY, David , KRIVORUCHKO, Michael
IPC分类号： A61L31/08 , A61L31/12 , A61L31/14 , A61L31/16
CPC分类号： A61L31/082 , A61L27/30 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/43 , A61L2300/44 , A61L2300/64
摘要： An implantable medical device includes a substrate, a drug-impregnated layer deposited over the substrate, and a barrier layer at least partially covering the drug-impregnated layer. The barrier layer may be a biodegradable metal, biodegradable metal oxide, or biodegradable metal alloy, such as, magnesium, a magnesium oxide or a magnesium alloy. The drug-impregnated layer includes a therapeutic substance, such as, antineoplastic, anti-inflammatory, antiplatelet, anticoagulant, fibrinolytic, thrombin inhibitor, antimitotic, antiallergic, and antiproliferative substances.
摘要翻译：可植入医疗装置包括基底，沉积在基底上的药物浸渍层和至少部分覆盖药物浸渍层的阻挡层。阻挡层可以是可生物降解的金属，可生物降解的金属氧化物或可生物降解的金属合金，例如镁，氧化镁或镁合金。药物浸渍层包括治疗物质，例如抗肿瘤，抗炎，抗血小板，抗凝血，纤维蛋白溶解，凝血酶抑制剂，抗有丝分裂，抗过敏和抗增生物质。

2. 发明申请

WO2009061625A1 STENT WITH IMPROVED MECHANICAL PROPERTIES 审中-公开
标题翻译：具有改进的机械性能的STENT
公开(公告)号：WO2009061625A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/081184
申请日：2008-10-24
申请人： MEDTRONIC VASCULAR INC. , KRIVORUCHKO, Michael , BIRDSALL, Matthew , PELLEGRINI, Gianfranco , GOSHGARIAN, Justin , ALLEN, Jeffrey
发明人： KRIVORUCHKO, Michael , BIRDSALL, Matthew , PELLEGRINI, Gianfranco , GOSHGARIAN, Justin , ALLEN, Jeffrey
IPC分类号： A61F2/90 , A61F2/88
CPC分类号： A61F2/88 , A61F2/915 , A61F2002/91508 , A61F2002/91558 , A61F2220/0058 , A61F2250/0036
摘要： A stent (10) includes a central portion (12) having a first waveform. The first waveform is wrapped around a longitudinal axis of the stent at a pitch to define a plurality of helical turns. The stent also includes an end segment (14) connected to one end of the central portion. The end segment has a second waveform that includes a plurality of struts and a plurality of crowns. Each of the plurality of struts has a different length so that peaks of the crowns that define an end of the stent lie within a plane that is substantially perpendicular to the longitudinal axis. Cross-sectional areas of the struts having different lengths vary so that the struts move substantially uniformly during radial contraction and/or radial expansion of the stent.
摘要翻译：支架（10）包括具有第一波形的中心部分（12）。第一波形以间距缠绕在支架的纵向轴线上以限定多个螺旋形匝。支架还包括连接到中心部分的一端的端部段（14）。端部段具有包括多个支柱和多个冠部的第二波形。多个支柱中的每一个具有不同的长度，使得限定支架的端部的冠部的顶点位于基本上垂直于纵向轴线的平面内。具有不同长度的支柱的横截面积变化，使得支柱在支架的径向收缩和/或径向膨胀期间基本均匀地移动。

3. 发明申请

WO2007127541A1 LAMINATED IMPLANTABLE MEDICAL DEVICE HAVING A METALLIC COATING 审中-公开
标题翻译：具有金属涂层的层压可植入医疗装置
公开(公告)号：WO2007127541A1
公开(公告)日：2007-11-08
申请号：PCT/US2007/064318
申请日：2007-03-19
申请人： MEDTRONIC VASCULAR, INC. , KRIVORUCHKO, Michael , BIRDSALL, Matthew
发明人： KRIVORUCHKO, Michael , BIRDSALL, Matthew
IPC分类号： A61L31/08 , A61L31/12
CPC分类号： A61L31/082
摘要： A laminated stent encapsulated with a metal coating is provided. The metal coating may be a very thin metal coating. Portions of the metal coating may be removed such that the metal coating covers voids in the laminate, particularly in the area where the different layers of the laminated stent come together. The metal coating for the laminated stent may be provided by sputtering, such as vacuum deposition or ion beam sputtering, spraying, dipping, or other known methods.
摘要翻译：提供了用金属涂层包封的层压支架。金属涂层可以是非常薄的金属涂层。可以去除金属涂层的一部分，使得金属涂层覆盖层压体中的空隙，特别是在层压支架的不同层聚集在一起的区域中。用于层压支架的金属涂层可以通过诸如真空沉积或离子束溅射，喷涂，浸渍或其它已知方法的溅射来提供。

4. 发明申请

WO2008076582A3 BIORESORBABLE STENT 审中-公开
公开(公告)号：WO2008076582A3
公开(公告)日：2008-06-26
申请号：PCT/US2007/085112
申请日：2007-11-19
申请人： MEDTRONIC VASCULAR INC. , KRIVORUCHKO, Michael , ALLEN, Jeffrey , BIRDSALL, Matthew
发明人： KRIVORUCHKO, Michael , ALLEN, Jeffrey , BIRDSALL, Matthew
IPC分类号： A61L31/02 , A61L31/12 , A61L31/14
摘要： A bioresorbable endoluminal prosthesis for placement in a body lumen having a stent substrate of a first metallic material that has a lower electrical potential than a standard reference electrode. The stent substrate is coated with a biodegradable polymer having a second metallic material dispersed therein, wherein the second metallic material has a higher electrical potential than the standard reference electrode. After implantation of the stent within the body lumen, the second metallic material is present in the polymeric coating in a sufficient concentration to cause galvanic corrosion of the first metallic material such that over time the stent substrate is bioresorbed.

5. 发明申请

WO2008124308A2 CATHETER BALLOON HAVING IMPROVED FLEXIBILITY AND METHODS FOR MAKING SAME 审中-公开
标题翻译：具有改进的灵活性的导管气泡和制造它们的方法
公开(公告)号：WO2008124308A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/058291
申请日：2008-03-26
申请人： MEDTRONIC VASCULAR INC. , KRIVORUCHKO, Michael
发明人： KRIVORUCHKO, Michael
IPC分类号： A61L29/14 , A61L29/04
CPC分类号： A61L29/146 , A61L29/041 , A61L29/06 , C08L23/06 , C08L67/00 , C08L77/00 , C08L67/02
摘要： A method for manufacturing a balloon catheter assembly includes forming a balloon from a polymer selected from the group consisting of polyamide, polyether block amide, and polyethylene terephthalate, forming a plurality of pores in the polymer, and mounting the balloon onto a catheter shaft. The shaft is configured to supply a fluid to the balloon to inflate the balloon, and the pores are configured to prevent the fluid from passing through the balloon.
摘要翻译：一种气囊导管组件的制造方法，其特征在于，由聚酰胺，聚醚嵌段酰胺，聚对苯二甲酸乙二醇酯等聚合物形成气囊，在聚合物中形成多个孔，将该气囊安装在导管轴上。轴构造成向球囊供应流体以使气囊膨胀，并且孔构造成防止流体通过气囊。

6. 发明申请

WO2007114981A1 CUSTOMIZED ALLOYS FOR STENTS 审中-公开
标题翻译：定制的合金合金
公开(公告)号：WO2007114981A1
公开(公告)日：2007-10-11
申请号：PCT/US2007/062390
申请日：2007-02-19
申请人： MEDTRONIC VASCULAR, INC. , KRIVORUCHKO, Michael , LESSAR, Joseph , FRANCIS, Richard , BIRDSALL, Matthew , UNTEREKER, Darrel , ALLEN, Jeffrey
发明人： KRIVORUCHKO, Michael , LESSAR, Joseph , FRANCIS, Richard , BIRDSALL, Matthew , UNTEREKER, Darrel , ALLEN, Jeffrey
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91516 , A61F2002/91541 , A61F2002/91558 , A61F2230/0013 , A61L31/022
摘要： A balloon-expandable stent formed from a customized alloy formulation. The stent alloy has a either a high, variable or no work hardening rate, very high modulus of elasticity (Young's modulus), and a low yield point. A stent constructed of a material with this combination of properties undergoes significant plastic deformation upon deployment in vivo to its implantation diameter and exhibits minimum recoil for better sizing. The plastic deformation also raises the subsequent yield point of the stent material resulting in a stronger stent upon implantation that is more resistant to vascular loading.
摘要翻译：由定制的合金制剂形成的球囊扩张支架。支架合金具有高的，可变的或没有加工硬化速率，非常高的弹性模量（杨氏模量）和低屈服点。由具有这种性质组合的材料构成的支架在体内部署到其植入直径时经历显着的塑性变形，并且表现出最小的后坐力以获得更好的尺寸。塑性变形也提高了支架材料的随后屈服点，从而在植入时产生更强的支架，其更能抵抗血管负荷。

7. 发明申请

WO2009002642A1 VASCULAR STENT AND METHOD OF MAKING VASCULAR STENT 审中-公开
标题翻译：血管支架及其制造方法
公开(公告)号：WO2009002642A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/064472
申请日：2008-05-22
申请人： MEDTRONIC VASCULAR INC. , CRAVEN, Michael , KRIVORUCHKO, Michael , PELLIGRINI, Gianfranco , BALDWIN, Matthew
发明人： CRAVEN, Michael , KRIVORUCHKO, Michael , PELLIGRINI, Gianfranco , BALDWIN, Matthew
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2/88 , A61F2/915 , A61F2002/91525
摘要： A stent and method of forming a stent include a wire bent into a waveform spirally wrapped into a hollow cylindrical shape. The waveform includes a first end portion, a middle portion, and a second end portion. The middle portion of the waveform includes a first amplitude and a first period. The first end portion of the waveform includes a first plurality of amplitudes and a first plurality of periods, wherein the first plurality of amplitudes decrease from adjacent the middle portion to a first end of the wire and first plurality of frequencies increase from adjacent the middle portion to the first end of the wire. The waveform may also include a second end portion with a second plurality of amplitudes and a second plurality of periods, wherein the second plurality of amplitudes decrease from adjacent the middle portion to a second end of the wire and the second plurality of frequencies increase from adjacent the middle portion to the second end of the wire.
摘要翻译：支架和形成支架的方法包括弯曲成螺旋地卷绕成中空圆柱形状的波形的线。波形包括第一端部，中间部分和第二端部。波形的中间部分包括第一幅度和第一周期。波形的第一端部包括第一多个幅度和第一多个周期，其中第一多个振幅从相邻的中间部分延伸到线的第一端，并且第一多个频率从相邻的中间部分增加到电线的第一端。波形还可以包括具有第二多个幅度和第二多个周期的第二端部分，其中第二多个幅度从相邻的中间部分到第二端减小，并且第二多个频率从相邻的线的中间部分到第二端。

8. 发明申请

WO2008106311A1 ION BEAM ETCHING A SURFACE OF AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：离子束蚀刻可植入医疗器械的表面
公开(公告)号：WO2008106311A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/053748
申请日：2008-02-12
申请人： MEDTRONIC VASCULAR INC. , KRIVORUCHKO, Michael
发明人： KRIVORUCHKO, Michael
IPC分类号： A61F2/90
CPC分类号： A61F2/82 , A61F2/0077 , A61F2/91 , A61F2230/0013 , A61F2250/0025
摘要： An implantable medical device capable of delivering therapeutic substances includes a roughened surface formed by ion beam etching. Ionized gas particles are shot at the medical device at high velocity to ablate portions of the surface of the medical device. The medical device, or a portion thereof, can be coated with a coating containing a therapeutic substance or substances, a polymer, or a combination of therapeutic substances and polymer. The coating can be made of one or more layers and the various layers can include different therapeutic substances, polymers, or combinations of therapeutic substances and polymers. The roughened surface has a greater surface area than a smooth surface, providing a better mechanical hold for the coating, thereby improving coating retention or therapeutic substance elution.
摘要翻译：能够递送治疗物质的可植入医疗装置包括通过离子束蚀刻形成的粗糙表面。电离气体颗粒以高速度在医疗装置上射击以烧蚀医疗装置的表面的部分。医疗装置或其一部分可以涂覆有包含治疗物质或物质，聚合物或治疗物质和聚合物的组合的涂层。涂层可以由一层或多层制成，各层可以包括不同的治疗物质，聚合物或治疗物质和聚合物的组合。粗糙表面具有比光滑表面更大的表面积，为涂层提供更好的机械保持，从而改善涂层保留或治疗物质洗脱。

9. 发明申请

WO2008106309A1 STENT HAVING CONTROLLED POROSITY FOR IMPROVED DUCTILITY. 审中-公开
标题翻译：具有改进的保护性的控制孔隙度的控制。
公开(公告)号：WO2008106309A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/053690
申请日：2008-02-12
申请人： MEDTRONIC VASCULAR INC. , KRIVORUCHKO, Michael , ALLEN, Jeffrey , BIRDSALL, Matthew
发明人： KRIVORUCHKO, Michael , ALLEN, Jeffrey , BIRDSALL, Matthew
IPC分类号： A61F2/82
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2230/0013 , A61F2250/0023 , A61L31/146
摘要： An endoluminal prosthesis for placement in a body lumen of a metallic material having controlled porosity for improved ductility. The metallic material may be formed into a stent structure or a wire or sheet, which may then be formed into the stent structure. The porous network of the stent includes pores that range from nanometer scale to micron scale. The controlled porosity accommodates volume changes as well as provides a barrier to crack propagation to allow alloy steels and amorphous metal materials, which would otherwise be considered too brittle for the demands of intraventional use, to be utilized in a stent.
摘要翻译：用于放置在具有受控孔隙度的金属材料的体腔中用于改善延展性的腔内假体。金属材料可以形成为可以形成支架结构的支架结构或线或片。支架的多孔网络包括范围从纳米级到微米级的孔。受控的孔隙率适应体积变化，并且提供裂纹扩展的障碍，以允许在支架中使用合金钢和非晶态金属材料，否则其将被认为对于常规使用的要求太脆。

10. 发明申请

WO2008089134A2 STENT WITH IMPROVED FLEXIBILITY AND METHOD FOR MAKING SAME 审中-公开
标题翻译：具有改进的柔性的支架和用于制造该支架的方法
公开(公告)号：WO2008089134A2
公开(公告)日：2008-07-24
申请号：PCT/US2008/050993
申请日：2008-01-14
申请人： MEDTRONIC VASCULAR, INC. , KRIVORUCHKO, Michael , LESSAR, Joseph
发明人： KRIVORUCHKO, Michael , LESSAR, Joseph
IPC分类号： A61F2/90 , B23K33/00 , C21D7/04
CPC分类号： B21F99/00 , A61F2/90 , A61F2230/0054 , A61F2250/0029 , C21D7/04 , C21D2201/01 , Y10T29/49
摘要： A stent and a method for manufacturing a stent are provided. The stent includes a first ring having a plurality of peaks and a plurality of valleys, a second ring having a plurality of peaks and a plurality of valleys, and a connector that connects one of the peaks of the first ring to one of the valleys of the second ring. The connected peak of the first ring includes a deformed portion that extends towards the connected valley of the second ring. The method includes forming a first ring having a plurality of peaks and a plurality of valleys, forming a second ring having a plurality of peaks and a plurality of valleys, deforming a portion of at least one of the peaks of the first ring, and connecting the deformed portion of the peak of the first ring to one of the valleys of the second ring.
摘要翻译：提供了一种用于制造支架的支架和方法。支架包括具有多个峰和多个谷的第一环，具有多个峰和多个谷的第二环以及将第一环的一个峰连接到第一环的一个谷的连接器，第二个戒指。第一环的连接峰包括朝向第二环的连接谷延伸的变形部分。该方法包括形成具有多个峰和多个谷的第一环，形成具有多个峰和多个谷的第二环，使第一环的至少一个峰的一部分变形，并且连接第一个环的峰的变形部分到第二个环的一个谷。

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