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1. 发明申请

WO2011163303A3 SENSOR SYSTEMS HAVING MULTIPLE PROBES AND ELECTRODE ARRAYS 审中-公开
标题翻译：具有多个探头和电极阵列的传感器系统
公开(公告)号：WO2011163303A3
公开(公告)日：2012-03-22
申请号：PCT/US2011041357
申请日：2011-06-22
申请人： MEDTRONIC MINIMED INC , GOTTLIEB REBECCA K , CHIU CHIA-HUNG , RAMACHANDRAN MEENA , DANGUI-PATEL NANDITA , ROSE JEFFERSON , RAO ASHWIN K , WANG HSIFU , LUO YING
发明人： GOTTLIEB REBECCA K , CHIU CHIA-HUNG , RAMACHANDRAN MEENA , DANGUI-PATEL NANDITA , ROSE JEFFERSON , RAO ASHWIN K , WANG HSIFU , LUO YING
IPC分类号： C12Q1/00 , A61B5/145 , A61B5/1486 , A61B5/1495
CPC分类号： A61B5/1486 , A61B5/0017 , A61B5/14503 , A61B5/14532 , A61B5/726 , C12Q1/001 , G01N27/307
摘要： Embodiments of the invention provide amperometric analyte sensors having multiple related structural elements (e.g. sensor arrays comprising a working, counter and reference electrode) and algorithms designed for use with such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本发明的实施方案提供了具有多个相关结构元件（例如包括工作，计数器和参考电极的传感器阵列）和设计用于与这种传感器一起使用的算法的电流分析物传感器。虽然本发明的实施方案可以在各种情况下使用，但是本发明的典型实施方案包括用于糖尿病管理的葡萄糖传感器。

2. 发明申请

WO2012006208A3 METHOD AND/OR SYSTEM FOR DETERMINING BLOOD GLUCOSE REFERENCE SAMPLE TIMES 审中-公开
标题翻译：用于确定血糖参考样本时间的方法和/或系统
公开(公告)号：WO2012006208A3
公开(公告)日：2012-05-24
申请号：PCT/US2011042560
申请日：2011-06-30
申请人： MEDTRONIC MINIMED INC , GOTTLIEB REBECCA K , RAMACHANDRAN MEENA
发明人： GOTTLIEB REBECCA K , RAMACHANDRAN MEENA
IPC分类号： A61B5/145 , A61M5/142
CPC分类号： A61B5/14532 , A61B5/14503 , A61B5/4839 , A61B5/6832 , A61B5/6849 , A61B5/7221 , A61B5/742 , A61M5/14244 , A61M5/1723 , A61M2005/14208 , A61M2205/18 , A61M2205/50 , A61M2230/201
摘要： Subject matter disclosed herein relates to monitoring and/or controlling blood glucose levels in patients. In particular, times for obtaining metered blood glucose samples of a patient may be altered based, at least in part, on a blood glucose level of said patient observed from a blood glucose sensor.
摘要翻译：本文公开的主题涉及监测和/或控制患者的血糖水平。具体而言，用于获得患者的计量血糖样品的时间可以至少部分地基于从血糖传感器观察到的所述患者的血糖水平来改变。

3. 发明申请

WO2010014959A3 ANALYTE SENSOR APPARATUSES HAVING IMPROVED ELECTRODE CONFIGURATIONS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：具有改进的电极配置的分析仪传感器设备及其制造和使用它们的方法
公开(公告)号：WO2010014959A3
公开(公告)日：2010-03-25
申请号：PCT/US2009052497
申请日：2009-07-31
申请人： MEDTRONIC MINIMED INC , GOTTLIEB REBECCA K , SHAH RAJIV , WOLFE KATHERINE T , SOUNDARARAJAN GOPIKRISHNAN , COOPER KENNETH W , VEJELLA RATNAKER , JIN ENJOO , KANNARD BRIAN T , MASTROTOTARO JOHN J
发明人： GOTTLIEB REBECCA K , SHAH RAJIV , WOLFE KATHERINE T , SOUNDARARAJAN GOPIKRISHNAN , COOPER KENNETH W , VEJELLA RATNAKER , JIN ENJOO , KANNARD BRIAN T , MASTROTOTARO JOHN J
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/6848 , A61B5/6849
摘要： Glucose sensor for implantation within a mammal, the analyte sensor comprising a flexible substrate, a conductive layer disposed on the substrate and comprising a reference electrode, a working electrode and a counter electrode. The sensor further comprises an analyte sensing layer, an analyte modulating layer and a cover layer disposed on the analyte sensor apparatus, wherein the cover layer comprises an aperture positioned on the cover layer so as to facilitate an analyte present in the mammal contacting and diffusing through the analyte modulating layer and contacting the analyte sensing layer. The device further comprises a processor for noise reduction and data processing A fuse element for avoiding overuse, circuitry for generating a pulsed sensing current and means for sensing if the sensor is sufficiently hydrated. Typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：用于在哺乳动物内植入的葡萄糖传感器，所述分析物传感器包括柔性基底，设置在所述基底上并包括参比电极，工作电极和对电极的导电层。传感器还包括分析物感测层，分析物调节层和设置在分析物传感器设备上的覆盖层，其中覆盖层包括定位在覆盖层上的孔，以便于存在于哺乳动物中的分析物接触并扩散通过分析物转化层并接触分析物感测层。该装置还包括用于降噪和数据处理的处理器用于避免过度使用的熔丝元件，用于产生脉冲感测电流的电路和用于感测传感器是否充分水合的装置。本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

4. 发明申请

WO2009154675A3 NEEDLE PROTECTIVE DEVICE FOR SUBCUTANEOUS SENSORS 审中-公开
标题翻译：用于传感器的针头保护装置
公开(公告)号：WO2009154675A3
公开(公告)日：2010-03-04
申请号：PCT/US2009002945
申请日：2009-05-12
申请人： MEDTRONIC MINIMED INC , GOTTLIEB REBECCA K , SHAH RAJIV , WOLFE KATHERINE T , LARSON ERIC ALLAN
发明人： GOTTLIEB REBECCA K , SHAH RAJIV , WOLFE KATHERINE T , LARSON ERIC ALLAN
IPC分类号： A61M5/32 , A61M25/06 , A61M37/00
CPC分类号： A61B5/14532 , A61B5/1473 , A61B5/6849 , A61B17/3496 , A61M5/158 , A61M5/3243 , A61M25/0612 , A61M37/0069 , A61M2005/1585 , A61M2005/3247
摘要： An introducer is provided for introducing a sensor into the body of a patient. The introducer connects to a sensor hub. When the sensor hub and introducer are connected, the introducer needle is exposed. When the sensor hub and introducer are disconnected, a needle cover and the needle move with respect to each other so that the needle cover substantially covers the needle, protecting a user from being injured by the needle.
摘要翻译：提供导引器用于将传感器引入患者体内。导引器连接到传感器集线器。当传感器轮毂和导引器连接时，导引针被暴露。当传感器毂和导引器断开时，针盖和针相对于彼此移动，使得针盖基本上覆盖针，保护使用者免受针受伤。

5. 发明申请

WO2007114943A3 METHODS AND MATERIALS FOR CONTROLLING THE ELECTROCHEMISTRY OF ANALYTE SENSORS 审中-公开
标题翻译：用于控制分析仪传感器电化学的方法和材料
公开(公告)号：WO2007114943A3
公开(公告)日：2008-03-06
申请号：PCT/US2007008491
申请日：2007-04-04
申请人： MEDTRONIC MINIMED INC , SHAH RAJIV , HOSS UDO , GOTTLIEB REBECCA K , SOUNDARARAJAN GOPIKRISHNAN , HOLKER JAMES D
发明人： SHAH RAJIV , HOSS UDO , GOTTLIEB REBECCA K , SOUNDARARAJAN GOPIKRISHNAN , HOLKER JAMES D
IPC分类号： G01N33/487 , A61B5/00 , G01N27/30 , G01N27/327
CPC分类号： G01N27/327 , A61B5/1486 , C25D1/10 , C25D5/10 , G01N27/307 , Y10T428/12389 , Y10T428/12479 , Y10T428/12493 , Y10T428/12875 , Y10T428/12889
摘要： Methods and sensors for detecting an analyte in a fluid, wherein the sensors comprises at least one electorde disposed upon a base substrate, the base substrate includes a geometric feature selected to increase the surface area of an electrochemically reactive surface on the electrode disposed thereon.
摘要翻译：用于检测流体中的分析物的方法和传感器，其中所述传感器包括设置在基底基板上的至少一个电极，所述基底基板包括几何特征，所述几何特征被选择以增加其上设置的电极上的电化学反应性表面的表面积。

6. 发明申请

WO2011063259A3 MULTI-CONDUCTOR LEAD CONFIGURATIONS USEFUL WITH MEDICAL DEVICE SYSTEMS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：具有医疗装置系统的多导体引线配置及其制造和使用方法
公开(公告)号：WO2011063259A3
公开(公告)日：2011-08-04
申请号：PCT/US2010057474
申请日：2010-11-19
申请人： MEDTRONIC MINIMED INC , SHAH RAJIV , GOTTLIEB REBECCA K , WOLFE KATHERINE T
发明人： SHAH RAJIV , GOTTLIEB REBECCA K , WOLFE KATHERINE T
IPC分类号： A61B5/145 , H01B7/08
CPC分类号： A61B5/14503 , A61B5/14532 , A61B2562/222 , A61N1/05 , A61N1/08 , Y10T29/49204
摘要： A multiple-conductor electrical lead for use with medical device systems and a method of manufacture is disclosed. The multiple-conductor electrical lead comprises a central core and has at least one conductor, typically in the form of a ribbon cable, coiled around it along its length. Typically one or more ribbon cables coiled around a central core each comprise a plurality of separate electrical conductors both coupled together along their lengths in series and electrically insulated from one another with an insulating material. The material of the central core, e.g. polyester, stainless steel, nickel titanium, and the structural configuration, e.g. wrapping pitch of the ribbon cable around the central core and number of ribbon cables, are selected based on desired mechanical characteristics. Such multiple-conductor electrical leads are useful, for example, with analyte sensor systems such as amperometric glucose sensor systems used in the management of diabetes.
摘要翻译：公开了与医疗装置系统一起使用的多导体电引线和制造方法。多导体电引线包括中心芯，并且具有至少一个通常为带状电缆形式的导体，其沿着其长度卷绕在其周围。典型地，一个或多个缠绕在中心芯上的带状电缆每个都包括多个分开的电导体，这两个电导体都沿着它们的长度串联连接在一起并且用绝缘材料彼此电绝缘。中央核心的材料，例如聚酯，不锈钢，镍钛和结构构造，例如，根据所需的机械特性来选择将带状电缆的节距缠绕在中央芯部和带状电缆的数量上。这种多导体电导线可用于例如分析物传感器系统，例如用于管理糖尿病的安培葡萄糖传感器系统。

7. 发明申请

WO2010014964A3 ANALYTE SENSOR APPARATUSES COMPRISING MULTIPLE IMPLANTABLE SENSOR ELEMENTS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：包含多个可植入传感器元件的分析传感器装置及其制造和使用方法
公开(公告)号：WO2010014964A3
公开(公告)日：2010-04-01
申请号：PCT/US2009052506
申请日：2009-07-31
申请人： MEDTRONIC MINIMED INC , GOTTLIEB REBECCA K , SHAH RAJIV , LARSON ERIC A , CHIU CHIA
发明人： GOTTLIEB REBECCA K , SHAH RAJIV , LARSON ERIC A , CHIU CHIA
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1473 , A61B5/14865 , A61B5/6848 , A61B5/6849 , C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes. One embodiment provides an apparatus for monitoring an analyte in a patient, the apparatus comprising a base element adapted to secure the apparatus to the patient; two piercing members coupled to and extending from the base element; two electrochemical sensors for determining at least a physiological characteristic of the patient at a first and a second electrochemical sensor placement site. The piercing members are further disposed on the base in a configuration so as to dispose the first and the second electrochemical sensors in first and second tissue compartments.
摘要翻译：本发明的实施例提供具有优化的元件和/或元件配置的分析物传感器以及使用这种传感器的方法。本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。一个实施例提供了一种用于监测患者中的分析物的装置，所述装置包括适于将装置固定到患者的基座元件; 两个穿刺构件联接到基座元件并从基座元件延伸; 两个电化学传感器，用于在第一和第二电化学传感器放置位置处确定患者的至少生理特性。穿刺构件进一步设置在基部上，以便将第一和第二电化学传感器配置在第一和第二组织隔室中。

8. 发明申请

WO2008150633A3 WIRELESS MONITOR FOR A PERSONAL MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：用于个人医疗设备系统的无线监视器
公开(公告)号：WO2008150633A3
公开(公告)日：2009-02-19
申请号：PCT/US2008063155
申请日：2008-05-09
申请人： MEDTRONIC MINIMED INC , RANKERS ULRICH , ENEGREN BRADLEY J , GOTTLIEB REBECCA K , HAN JINO , HOLTZCLAW KRIS R , HONG PETER I , ISTOC EMILIAN , MASTROTOTARO JOHN J , MOBERG SHELDON B , TALBOT CARY , WILLIAMS GARY , HALPERN ARIEH S
发明人： RANKERS ULRICH , ENEGREN BRADLEY J , GOTTLIEB REBECCA K , HAN JINO , HOLTZCLAW KRIS R , HONG PETER I , ISTOC EMILIAN , MASTROTOTARO JOHN J , MOBERG SHELDON B , TALBOT CARY , WILLIAMS GARY , HALPERN ARIEH S
IPC分类号： A61M5/00
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/411 , A61B5/7275 , A61M5/142 , A61M5/14244 , A61M5/172 , A61M2205/18 , A61M2205/3561 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/505 , A61M2209/01 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： A monitor device (200) for a fluid infusion system (100) and its operating, display, and data processing characteristics are described herein. One embodiment of the monitor device (200) is used in an insulin infusion system (100) having an insulin infusion pump (104) and a continuous glucose sensor transmitter (106). The monitor device (200) is configured as a wireless bedside monitor that wirelessly receives status data from a device in the fluid infusion system (100), such as the infusion pump (104) or the sensor transmitter (106). The monitor device (200) supports a number of user interface features, alarm/alert features, and graphical display features, where such features enhance the overall operation and user-friendliness of the monitor device (200). For example, the monitor device (200) can generate status icons that graphically indicate the time remaining for an exhaustible operating quantity of a device in the infusion system (e.g., a battery charge, a fluid reservoir volume, or a calibration or replacement period). The monitor device (200) can also estimate future measurements of a physiological characteristic of a monitored patient, based upon empirical measurement data received by the monitor device (200).
摘要翻译：本文描述了用于流体输注系统（100）的监视器装置（200）及其操作，显示和数据处理特性。监测装置（200）的一个实施例用于具有胰岛素输注泵（104）和连续葡萄糖传感器发射器（106）的胰岛素输注系统（100）中。监视器装置（200）被配置为从诸如输液泵（104）或传感器发射器（106）的流体输注系统（100）中的装置无线地接收状态数据的无线床旁监视器。监视器设备（200）支持许多用户界面特征，警报/警报特征和图形显示特征，其中这些特征增强了监视器设备（200）的整体操作和用户友好性。例如，监视设备（200）可以生成状态图标，其图形地指示输注系统中的设备的可耗用操作量的剩余时间（例如，电池充电，流体存储器容积或校准或更换周期）。监视器装置（200）还可以基于由监视器装置（200）接收的经验测量数据来估计所监视患者的生理特征的未来测量。

9. 发明申请

WO2007070486A3 BIOSENSORS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：生物传感器及其制备和使用方法
公开(公告)号：WO2007070486A3
公开(公告)日：2007-11-29
申请号：PCT/US2006047271
申请日：2006-12-12
申请人： MEDTRONIC MINIMED INC , SHAH RAJIV , SOUNDARARAJAN GOPIKRISHNAN , GOTTLIEB REBECCA K , HOSS UDO , GROVENDER ERIC A , PENDO SHAUN
发明人： SHAH RAJIV , SOUNDARARAJAN GOPIKRISHNAN , GOTTLIEB REBECCA K , HOSS UDO , GROVENDER ERIC A , PENDO SHAUN
IPC分类号： G01N27/327 , B41M3/00 , C08G77/46 , C08L83/12 , C12Q1/00 , G03F7/00
CPC分类号： C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
摘要翻译：本发明的实施例提供具有优化的选择渗透膜的分析物传感器以及用于制造和使用这种传感器的方法。本发明的实施例还提供分析物传感器，例如具有涂覆有分析物传感组合物的多孔基质的分析物传感器以及用于制造和使用这种传感器的方法。说明性实施例包括具有葡萄糖氧化酶涂层的电化学葡萄糖传感器

10. 发明申请

WO2007070486A8 BIOSENSORS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：生物传感器及其使用方法
公开(公告)号：WO2007070486A8
公开(公告)日：2007-09-20
申请号：PCT/US2006047271
申请日：2006-12-12
申请人： MEDTRONIC MINIMED INC , SHAH RAJIV , SOUNDARARAJAN GOPIKRISHNAN , GOTTLIEB REBECCA K , HOSS UDO , GROVENDER ERIC A , PENDO SHAUN
发明人： SHAH RAJIV , SOUNDARARAJAN GOPIKRISHNAN , GOTTLIEB REBECCA K , HOSS UDO , GROVENDER ERIC A , PENDO SHAUN
IPC分类号： G01N27/327 , C08G77/46 , C08L83/12 , C12Q1/00 , G03F7/00
CPC分类号： C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
摘要翻译：本发明的实施例提供具有优化的选择渗透膜的分析物传感器以及用于制造和使用这种传感器的方法。本发明的实施例还提供分析物传感器，例如具有涂覆有分析物感测组合物的多孔基质的分析物传感器以及用于制造和使用这种传感器的方法。示例性实施方案包括具有葡萄糖氧化酶涂层的电化学葡萄糖传感器。

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