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1. 发明申请

WO2010014959A3 ANALYTE SENSOR APPARATUSES HAVING IMPROVED ELECTRODE CONFIGURATIONS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：具有改进的电极配置的分析仪传感器设备及其制造和使用它们的方法
公开(公告)号：WO2010014959A3
公开(公告)日：2010-03-25
申请号：PCT/US2009052497
申请日：2009-07-31
申请人： MEDTRONIC MINIMED INC , GOTTLIEB REBECCA K , SHAH RAJIV , WOLFE KATHERINE T , SOUNDARARAJAN GOPIKRISHNAN , COOPER KENNETH W , VEJELLA RATNAKER , JIN ENJOO , KANNARD BRIAN T , MASTROTOTARO JOHN J
发明人： GOTTLIEB REBECCA K , SHAH RAJIV , WOLFE KATHERINE T , SOUNDARARAJAN GOPIKRISHNAN , COOPER KENNETH W , VEJELLA RATNAKER , JIN ENJOO , KANNARD BRIAN T , MASTROTOTARO JOHN J
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/6848 , A61B5/6849
摘要： Glucose sensor for implantation within a mammal, the analyte sensor comprising a flexible substrate, a conductive layer disposed on the substrate and comprising a reference electrode, a working electrode and a counter electrode. The sensor further comprises an analyte sensing layer, an analyte modulating layer and a cover layer disposed on the analyte sensor apparatus, wherein the cover layer comprises an aperture positioned on the cover layer so as to facilitate an analyte present in the mammal contacting and diffusing through the analyte modulating layer and contacting the analyte sensing layer. The device further comprises a processor for noise reduction and data processing A fuse element for avoiding overuse, circuitry for generating a pulsed sensing current and means for sensing if the sensor is sufficiently hydrated. Typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：用于在哺乳动物内植入的葡萄糖传感器，所述分析物传感器包括柔性基底，设置在所述基底上并包括参比电极，工作电极和对电极的导电层。传感器还包括分析物感测层，分析物调节层和设置在分析物传感器设备上的覆盖层，其中覆盖层包括定位在覆盖层上的孔，以便于存在于哺乳动物中的分析物接触并扩散通过分析物转化层并接触分析物感测层。该装置还包括用于降噪和数据处理的处理器用于避免过度使用的熔丝元件，用于产生脉冲感测电流的电路和用于感测传感器是否充分水合的装置。本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

2. 发明申请

WO2009154675A3 NEEDLE PROTECTIVE DEVICE FOR SUBCUTANEOUS SENSORS 审中-公开
标题翻译：用于传感器的针头保护装置
公开(公告)号：WO2009154675A3
公开(公告)日：2010-03-04
申请号：PCT/US2009002945
申请日：2009-05-12
申请人： MEDTRONIC MINIMED INC , GOTTLIEB REBECCA K , SHAH RAJIV , WOLFE KATHERINE T , LARSON ERIC ALLAN
发明人： GOTTLIEB REBECCA K , SHAH RAJIV , WOLFE KATHERINE T , LARSON ERIC ALLAN
IPC分类号： A61M5/32 , A61M25/06 , A61M37/00
CPC分类号： A61B5/14532 , A61B5/1473 , A61B5/6849 , A61B17/3496 , A61M5/158 , A61M5/3243 , A61M25/0612 , A61M37/0069 , A61M2005/1585 , A61M2005/3247
摘要： An introducer is provided for introducing a sensor into the body of a patient. The introducer connects to a sensor hub. When the sensor hub and introducer are connected, the introducer needle is exposed. When the sensor hub and introducer are disconnected, a needle cover and the needle move with respect to each other so that the needle cover substantially covers the needle, protecting a user from being injured by the needle.
摘要翻译：提供导引器用于将传感器引入患者体内。导引器连接到传感器集线器。当传感器轮毂和导引器连接时，导引针被暴露。当传感器毂和导引器断开时，针盖和针相对于彼此移动，使得针盖基本上覆盖针，保护使用者免受针受伤。

3. 发明申请

WO2011063259A3 MULTI-CONDUCTOR LEAD CONFIGURATIONS USEFUL WITH MEDICAL DEVICE SYSTEMS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：具有医疗装置系统的多导体引线配置及其制造和使用方法
公开(公告)号：WO2011063259A3
公开(公告)日：2011-08-04
申请号：PCT/US2010057474
申请日：2010-11-19
申请人： MEDTRONIC MINIMED INC , SHAH RAJIV , GOTTLIEB REBECCA K , WOLFE KATHERINE T
发明人： SHAH RAJIV , GOTTLIEB REBECCA K , WOLFE KATHERINE T
IPC分类号： A61B5/145 , H01B7/08
CPC分类号： A61B5/14503 , A61B5/14532 , A61B2562/222 , A61N1/05 , A61N1/08 , Y10T29/49204
摘要： A multiple-conductor electrical lead for use with medical device systems and a method of manufacture is disclosed. The multiple-conductor electrical lead comprises a central core and has at least one conductor, typically in the form of a ribbon cable, coiled around it along its length. Typically one or more ribbon cables coiled around a central core each comprise a plurality of separate electrical conductors both coupled together along their lengths in series and electrically insulated from one another with an insulating material. The material of the central core, e.g. polyester, stainless steel, nickel titanium, and the structural configuration, e.g. wrapping pitch of the ribbon cable around the central core and number of ribbon cables, are selected based on desired mechanical characteristics. Such multiple-conductor electrical leads are useful, for example, with analyte sensor systems such as amperometric glucose sensor systems used in the management of diabetes.
摘要翻译：公开了与医疗装置系统一起使用的多导体电引线和制造方法。多导体电引线包括中心芯，并且具有至少一个通常为带状电缆形式的导体，其沿着其长度卷绕在其周围。典型地，一个或多个缠绕在中心芯上的带状电缆每个都包括多个分开的电导体，这两个电导体都沿着它们的长度串联连接在一起并且用绝缘材料彼此电绝缘。中央核心的材料，例如聚酯，不锈钢，镍钛和结构构造，例如，根据所需的机械特性来选择将带状电缆的节距缠绕在中央芯部和带状电缆的数量上。这种多导体电导线可用于例如分析物传感器系统，例如用于管理糖尿病的安培葡萄糖传感器系统。

4. 发明申请

WO2013177573A3 FOLDOVER SENSORS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： FOLDOVER传感器及其制造和使用方法
公开(公告)号：WO2013177573A3
公开(公告)日：2014-07-10
申请号：PCT/US2013042763
申请日：2013-05-24
申请人： MEDTRONIC MINIMED INC , LITTLE MEGAN E , WOLFE KATHERINE T , RAGHAVENDHAR GAUTHAM , LIANG BRADLEY CHI , SHAH RAJIV
发明人： LITTLE MEGAN E , WOLFE KATHERINE T , RAGHAVENDHAR GAUTHAM , LIANG BRADLEY CHI , SHAH RAJIV
IPC分类号： A61B5/1486
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/125 , A61B2562/166 , A61B2562/222 , C12Q1/001 , C12Q1/006 , G01N27/3272 , Y10T29/49204
摘要： The application disclosed herein includes implantable blood glucose sensors having three dimensional configurations that allow expansive "360°" sensing (i.e. sensing analyte from multiple directions) in the environments in which such sensors are disposed. Disclsed is an analyte sensor apparatus comprising: a base substrate comprising a planar sheet of a flexible material adapted to transition from a first configuration to a second configuration when the base substrate is folded to form a fixed bend; a working electrode, a counter electrode and a reference electrode disposed upon a first surface of the base substrate; a plurality of contact pads disposed upon the first surface of the base substrate; a plurality of electrical conduits disposed upon the first surface of the base substrate, wherein the plurality of electrical conduits are adapted to transmit electrical signals between electrodes and contact pads separated by the fixed bend; and an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; wherein: the base substrate comprises the fixed bend so as to form a configuration in which: at least one electrode is disposed on a first side of the fixed bend; and at least one electrode is disposed on a second side of the fixed bend.
摘要翻译：本文公开的应用包括具有三维结构的可植入血糖传感器，其允许在布置这些传感器的环境中进行膨胀的“360°”感测（即感测来自多个方向的分析物）。分解物是分析物传感器装置，包括：基底基底，其包括柔性材料的平面片，所述平面片适于在所述基底基底被折叠以形成固定弯曲时从第一构型转变到第二构型; 工作电极，对置电极和设置在所述基底基板的第一表面上的参考电极; 设置在所述基底基板的第一表面上的多个接触焊盘; 多个电导管，其设置在所述基底基板的所述第一表面上，其中所述多个电导管适于在电极与由所述固定弯曲部分开的接触垫之间传输电信号; 以及分析物感测层，其设置在所述工作电极之上，其中所述分析物感测层在分析物的存在下可检测地改变所述工作电极处的电流; 其中：所述基底基板包括所述固定弯曲部，以便形成其中：至少一个电极设置在所述固定弯曲部的第一侧上; 并且至少一个电极设置在固定弯管的第二侧上。

5. 发明专利

CA2789814C ANALYTE SENSOR APPARATUSES HAVING IMPROVED ELECTRODE CONFIGURATIONS AND METHODS FOR MAKING AND USING THEM 未知
公开(公告)号：CA2789814C
公开(公告)日：2019-06-25
申请号：CA2789814
申请日：2011-03-15
申请人： MEDTRONIC MINIMED INC
发明人： WOLFE KATHERINE T , KANTAK AMEYA S , LARSON ERIC ALLAN , PESANTEZ DANIEL E , XI DONGJUAN , CHIU CHIA-HUNG , SHAH RAJIV
IPC分类号： G01N27/403 , A61B5/1486 , G01N27/49
摘要： Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes, comprising : a plurality of sensor wires (301, 302, 303, 304) having a first end and second end and each arranged in a substanially common orientation, the plurality of sensor wires being electically conductive and including: a first sensor wire (303, 304) substantially covered by a first electically insulating cover (310), wherein a aperture in the first electrically insulating cover defines a working electrode area (313, 314); a second sensor wire (301) substantially covered by a second electrically insulating cover (310), wherein an aperture in the second electrically insulating cover defines a reference electrode area (311); and a third sensor wire (302) substantially covered by a third electrically insulating insulating cover (310), wherein an aperture in the third electrically insulating cover defines a counter electrode area (312).

6. 发明专利

CA2594641A1 FABRICATION OF MULTI-SENSOR ARRAYS 未知
公开(公告)号：CA2594641A1
公开(公告)日：2006-07-20
申请号：CA2594641
申请日：2006-01-11
申请人： MEDTRONIC MINIMED INC
发明人： BRUSO GIL , WOLFE KATHERINE T , SOUNDARARAJAN GOPIKRISHNAN , PENDO SHAUN , GOTTLIEB REBECCA K , SHAH RAJIV
IPC分类号： G01N27/327 , A61B5/00 , C12Q1/00
摘要： The disclosure provides methods for fabricating a long-term analyte sensor for measuring at least one analyte in the body of a user. The analyte sensors made by these methods include a plurality of analyte contacting sensor elements and at least one structure for relaying information to and from the sensor. The analyte sensor so fabricated further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.

7. 发明专利

CA2787010C COMBINED SENSOR AND INFUSION SETS 未知
公开(公告)号：CA2787010C
公开(公告)日：2018-03-20
申请号：CA2787010
申请日：2011-01-19
申请人： MEDTRONIC MINIMED INC
发明人： VOSKANYAN GAYANE , WOLFE KATHERINE T , SHAH RAJIV , CHUNG BRIAN , LARSON ERIC A , RUELAS JOSE J
IPC分类号： A61M5/158 , A61B5/1486 , A61M5/172
摘要： The present application defines an insertion device (800) that can be used for automatic insertion of a combined sensor (700) and piercing device (900). The insertion device (800) is adapted to connect to sit over the needle hub (900) and sensor set (700) when those pieces are connected. The insertion device (800) is adapted to insert the infusion cannula (910) and sensor needle (920) into the skin of a patient. The insertion device (800) includes a housing (810), a button (840) and an opening (820) in the housing for receiving and covering at least a portion of the sensor set (700).

8. 发明专利

CA2724646C NEEDLE PROTECTIVE DEVICE FOR SUBCUTANEOUS SENSORS 未知
公开(公告)号：CA2724646C
公开(公告)日：2016-03-29
申请号：CA2724646
申请日：2009-05-12
申请人： MEDTRONIC MINIMED INC
发明人： GOTTLIEB REBECCA K , SHAH RAJIV , WOLFE KATHERINE T , LARSON ERIC ALLAN
IPC分类号： A61B5/00 , A61B5/1473 , A61M5/14 , G01D11/24
摘要： An introducer is provided for introducing a sensor into the body of a patient. The introducer connects to a sensor hub. When the sensor hub and introducer are connected, the introducer needle is exposed. When the sensor hub and introducer are disconnected, a needle cover and the needle move with respect to each other so that the needle cover substantially covers the needle, protecting a user from be-ing injured by the needle.

9. 发明专利

DK2293837T3 Nålebeskyttelsesapparat til subkutane sensorer 未知
公开(公告)号：DK2293837T3
公开(公告)日：2013-01-14
申请号：DK09766989
申请日：2009-05-12
申请人： MEDTRONIC MINIMED INC
发明人： GOTTLIEB REBECCA K , SHAH RAJIV , WOLFE KATHERINE T , LARSON ERIC ALLAN
IPC分类号： A61M25/06 , A61M5/32

10. 发明专利

CA2789814A1 ANALYTE SENSOR APPARATUSES HAVING IMPROVED ELECTRODE CONFIGURATIONS AND METHODS FOR MAKING AND USING THEM 未知
公开(公告)号：CA2789814A1
公开(公告)日：2011-09-22
申请号：CA2789814
申请日：2011-03-15
申请人： MEDTRONIC MINIMED INC
发明人： WOLFE KATHERINE T , KANTAK AMEYA S , LARSON ERIC ALLAN , PESANTEZ DANIEL E , XI DONGJUAN , CHIU CHIA-HUNG , SHAH RAJIV
IPC分类号： G01N27/403 , A61B5/1486 , G01N27/49
摘要： Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes, comprising : a plurality of sensor wires (301, 302, 303, 304) having a first end and second end and each arranged in a substanially common orientation, the plurality of sensor wires being electically conductive and including: a first sensor wire (303, 304) substantially covered by a first electically insulating cover (310), wherein a aperture in the first electrically insulating cover defines a working electrode area (313, 314); a second sensor wire (301) substantially covered by a second electrically insulating cover (310), wherein an aperture in the second electrically insulating cover defines a reference electrode area (311); and a third sensor wire (302) substantially covered by a third electrically insulating insulating cover (310), wherein an aperture in the third electrically insulating cover defines a counter electrode area (312).

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