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1. 发明申请

WO2005035046A3 CARDIAC PACING MODALITY HAVING IMPROVED BLANKING, TIMING, AND THERAPY DELIVERY METHODS FOR EXTRA-SYSTOLIC STIMULATION PACING THERAPY 审中-公开
标题翻译：具有改进的护理，时间和治疗方法的心脏瓣膜模型用于超声波刺激治疗
公开(公告)号：WO2005035046A3
公开(公告)日：2005-07-14
申请号：PCT/US2004032906
申请日：2004-10-06
申请人： MEDTRONIC INC , DENO CURTIS D , SPLETT VINCENT E , GILLBERG JEFFERY M , ZILLMER GLENN C , KLEPFER RUTH N , KLECKNER KAREN J
发明人： DENO CURTIS D , SPLETT VINCENT E , GILLBERG JEFFERY M , ZILLMER GLENN C , KLEPFER RUTH N , KLECKNER KAREN J
IPC分类号： A61N20060101 , A61N1/362 , A61N1/365
CPC分类号： A61N1/365 , A61N1/3627
摘要： The present invention relates to the secure delivery of an extra-systolic stimulation (ESS) therapy to treat cardiac dysfunction that employs atrial and/or ventricular extra-systoles via pacing-like stimulation of the heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (benefit) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). Further experience with ESS has led to improved implementation methods that depend on better blanking, ESS stimulation timing (of an "extra-systolic interval" or ESI), and ESS therapy delivery options and guidance. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译：本发明涉及一种收缩期刺激（ESS）疗法的安全递送，以治疗心脏功能障碍，其通过心脏起搏样刺激使用心房和/或心室外的心脏。这些额外的收缩期必须正确定时，以获得对心肌力学（益处）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。 ESS的进一步经验导致改进的实施方法取决于更好的消隐，ESS刺激时间（“收缩期间期”或ESI）和ESS治疗递送选项和指导。这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。

2. 发明申请

WO2004096344A3 IMPLANTABLE LEAD-BASED SENSOR POWERED BY PIEZOELECTRIC TRANSFORMER 审中-公开
标题翻译：由压电变压器驱动的基于导线的传感器
公开(公告)号：WO2004096344A3
公开(公告)日：2005-01-27
申请号：PCT/US2004009842
申请日：2004-03-31
申请人： MEDTRONIC INC , HOUBEN RICHARD P M , CHRISTOPHERSON MARK A , DONDERS ADRIANUS P , LEINDERS ROBERT , DENO CURTIS D
发明人： HOUBEN RICHARD P M , CHRISTOPHERSON MARK A , DONDERS ADRIANUS P , LEINDERS ROBERT , DENO CURTIS D
IPC分类号： A61N1/08 , A61N1/365 , A61N1/362 , A61N1/05
CPC分类号： A61N1/08 , A61N1/36542
摘要： In general, the invention is directed to an IMD having a piezoelectric transformer to power a lead-based sensor. The IMD powers the piezoelectric transformer with a low amplitude signal. The piezoelectric transformer serves to convert the voltage level of the low amplitude signal to a higher voltage level to drive the sensor. produced by a battery in the IMD to voltage levels appropriate for IMD operation. A piezoelectric transformer offers small size and low profile, as well as operational efficiency, and permits the IMD to transmit a low amplitude signal to a remote sensor deployed within an implantable lead. In addition, the piezoelectric transformer provides electrical isolation that reduces electromagnetic interference among different sensors.
摘要翻译：通常，本发明涉及具有压电变压器以为基于铅的传感器供电的IMD。 IMD用低幅度信号为压电变压器供电。压电变压器用于将低振幅信号的电压电平转换为更高的电压电平以驱动传感器。由IMD中的电池产生的电压水平适合于IMD操作。压电变压器提供小尺寸和低轮廓以及操作效率，并允许IMD将低振幅信号传输到部署在可植入导线内的远程传感器。此外，压电变压器提供电隔离，减少不同传感器之间的电磁干扰。

3. 发明专利

AU2004280237A1 Extra-systolic stimulation therapy delivery and sensing via different electrode sets 未知
公开(公告)号：AU2004280237A1
公开(公告)日：2005-04-21
申请号：AU2004280237
申请日：2004-10-07
申请人： MEDTRONIC INC
发明人： SHETH NIRAV VIJAY , ZILLMER GLENN C , DENO CURTIS D
IPC分类号： A61N1/365 , A61N1/362
摘要： Techniques for delivering ESS to a heart of a patient are disclosed. An implantable medical device delivers ESS stimulation, and in some embodiments pacing stimulation, to a chamber of the heart via a first electrode set. The implantable medical device senses electrical activity within the chamber via a second set of electrodes. In some embodiments, the implantable medical device is able to apply a shorter blanking interval than is typical in the pacing art to a sense amplifier coupled to the second set of electrodes, allowing the implantable medical device to better detect arrhythmias and evoked responses. A variety of electrodes may be used in conjunction with the present invention; including without limitation, tip, ring, coil, can-based, endocardial, epicardial, pericardial, cardiac vein-based, subcutaneous, and/or surface electrodes.

4. 发明专利

AU2003224993A8 Electrical stimulation for thrombolytic therapy 未知
公开(公告)号：AU2003224993A8
公开(公告)日：2003-11-03
申请号：AU2003224993
申请日：2003-04-16
申请人： MEDTRONIC INC
发明人： WILLIAMS TERRELL M , SOYKAN ORHAN , DENO CURTIS D , DONOVAN MAURA G , TRESCONY PAUL V , ROBINSON TIMOTHY H
IPC分类号： A61N1/36 , A61N1/04 , A61N1/32
摘要： This invention is an electrical stimulation apparatus for delivering an electrical field or electrical current over a predetermined period of time to a vascular tissue (150) in order to stimulate a cell initiated thrombolytic peptide response in cells within the vascular tissue. The electrical stimulation apparatus includes an electrical field or electrical current generating unit including a power support, a control mechanism interconnected with the power supply, and a plurality of electrodes designed to generate an electrical field or electrical current proximal to, or within to the vascular tissue. The amplitude of the electrical field or electrical current delivered to or generated proximal to, or within the vascular tissue, and the duration of the period of delivery are sufficient to stimulate production of thrombolytic peptides in the vascular tissue. The control mechanism preferably includes a computer processing unit in electronic communication with the power supply, the computer being programmed to cause the electrical stimulation apparatus to deliver a predetermined amount of electrical current or voltage over a predetermined period of delivery to the plurality of electrodes such that the electrical stimulation apparatus can deliver such electrical current or voltage to the vascular tissue when the plurality of electrodes are in contact or proximity with the vascular tissue.

5. 发明专利

DE602004029922D1 GERÄT ZUR OPTIMIERUNG UND BEURTEILUNG DES ANSPRECHENS AUF DIE EXTRASYSTOLISCHE STIMULATIONSTHERAPIE (ESS) 未知
公开(公告)号：DE602004029922D1
公开(公告)日：2010-12-16
申请号：DE602004029922
申请日：2004-10-07
申请人： MEDTRONIC INC
发明人： MULLIGAN LAWRENCE J , DENO CURTIS D , BURNES JOHN E , SHETH NIRAV VIJAY
IPC分类号： A61B5/366 , A61N1/362 , A61N1/365

6. 发明专利

AU2003224993A1 ELECTRICAL STIMULATION AND THROMBOLYTIC THERAPY 未知
公开(公告)号：AU2003224993A1
公开(公告)日：2003-11-03
申请号：AU2003224993
申请日：2003-04-16
申请人： MEDTRONIC INC
发明人： SOYKAN ORHAN , DENO CURTIS D , TRESCONY PAUL V , DONOVAN MAURA G , WILLIAMS TERRELL M , ROBINSON TIMOTHY H
IPC分类号： A61N1/36 , A61N1/04 , A61N1/32
摘要： This invention is an electrical stimulation apparatus for delivering an electrical field or electrical current over a predetermined period of time to a vascular tissue (150) in order to stimulate a cell initiated thrombolytic peptide response in cells within the vascular tissue. The electrical stimulation apparatus includes an electrical field or electrical current generating unit including a power support, a control mechanism interconnected with the power supply, and a plurality of electrodes designed to generate an electrical field or electrical current proximal to, or within to the vascular tissue. The amplitude of the electrical field or electrical current delivered to or generated proximal to, or within the vascular tissue, and the duration of the period of delivery are sufficient to stimulate production of thrombolytic peptides in the vascular tissue. The control mechanism preferably includes a computer processing unit in electronic communication with the power supply, the computer being programmed to cause the electrical stimulation apparatus to deliver a predetermined amount of electrical current or voltage over a predetermined period of delivery to the plurality of electrodes such that the electrical stimulation apparatus can deliver such electrical current or voltage to the vascular tissue when the plurality of electrodes are in contact or proximity with the vascular tissue.

7. 发明专利

CA2535553A1 ELECTRICALLY EFFICIENT NEURALLY-EXCITABLE STIMULATION 未知
公开(公告)号：CA2535553A1
公开(公告)日：2005-02-24
申请号：CA2535553
申请日：2004-08-10
申请人： MEDTRONIC INC
发明人： MULLIGAN LAWRENCE J , EULER DAVID E , DUFFIN EDWIN G , DENO CURTIS D , IGEL DAVID A
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
摘要： A medical device, e.g., an implantable medical device, delivers one or more neurally-excitable stimulation pulses to myocardial tissue during a period when the tissue is refractory. The width of the pulses is less than or equal to approximately one half millisecond. In some embodiments, the current amplitude of the pulses is less than or equal to approximately twenty milliamps. In exemplary embodiments, the medical device delivers a pulse tra in of six or fewer pulses separated from each other by an interval that is greater than or equal to approximately ten milliseconds. In some embodiments , the medical device delivers pulses according to a schedule stored in a memor y, or as a function of a monitored physiological parameter of a patient, such a s an intracardiac pressure. In some embodiments, the medical device suspends o r withholds delivery of neurally-excitable based on detection of cardiac ischemia.

8. 发明专利

CA2482289A1 ELECTRICAL STIMULATION FOR THROMBOLYTIC THERAPY 未知
公开(公告)号：CA2482289A1
公开(公告)日：2003-10-30
申请号：CA2482289
申请日：2003-04-16
申请人： MEDTRONIC INC
发明人： DONOVAN MAURA G , WILLIAMS TERRELL M , ROBINSON TIMOTHY H , SOYKAN ORHAN , TRESCONY PAUL V , DENO CURTIS D
IPC分类号： A61N1/36 , A61N1/04 , A61N1/32
摘要： An electrical stimulation apparatus is provided for delivering an electrical field or electrical current over a predetermined period of time to a vascula r tissue in order to stimulate a cell initiated thrombolytic peptide response in cells within the vascular tissue. The electrical stimulation apparatus includes an electrical field or electrical current generating unit including a power supply, a control mechanism interconnected with the power supply, and a plurality of electrodes designed to generate an electrical field or electric al current proximal to, or within to the vascular tissue. The amplitude of the electrical field or electrical current delivered to or generated proximal to , or within the vascular tissue, and the duration of the period of delivery ar e sufficient to stimulate production of thrombolytic peptides in the vascular tissue. The control mechanism preferably includes a computer processing unit in electronic communication with the power supply, the computer being programmed to cause the electrical stimulation apparatus to deliver a predetermined amount of electricalcurrent or voltage over a predetermined period of delivery to the plurality of electrodes such that the plurality of electrodes are in contact or proximity with the vascular tissue.

9. 发明专利

CA2459408A1 MEDICAL DEVICE FOR TREATING CARDIAC MECHANICAL DYSFUNCTION BY ELECTRICAL STIMULATION 未知
公开(公告)号：CA2459408A1
公开(公告)日：2003-03-13
申请号：CA2459408
申请日：2002-08-28
申请人： MEDTRONIC INC
发明人： EULER DAVID E , HAVEL WILLIAM J , DENO CURTIS D , BENNETT TOM D , STEIN PAUL M
IPC分类号： A61B5/0205 , A61B5/296 , A61N1/36 , A61N1/362 , A61N1/365 , A61N1/37 , A61N1/39 , A61N1/368
摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction.

10. 发明专利

DE602004030102D1 AN EINER LEITUNG INTEGRIERTER UND IMPLANTIERBARER MEDIZINISCHER SENSOR VERSORGT DURCH EINEN PIEZOELEKTRISCHEN TRANSFORMATER 未知
公开(公告)号：DE602004030102D1
公开(公告)日：2010-12-30
申请号：DE602004030102
申请日：2004-03-31
申请人： MEDTRONIC INC
发明人： HOUBEN RICHARD P M , CHRISTOPHERSON MARK A , DONDERS ADRIANUS P , LEINDERS ROBERT , DENO CURTIS D
IPC分类号： A61N1/362 , A61N1/08 , A61N1/365

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